Jade Biosciences (NasdaqCM:JBIO) 2025 Conference November 17, 2025 10:30 AM ET Company ParticipantsAndrew King - Chief Scientific OfficerTom Frohlich - CEOConference Call ParticipantsAkash Tewari - Farm and Biotech AnalystAkash TewariAkash Tewari. I am a Farm and Biotech Analyst here at Jefferies. Day one of our London Healthcare Conference, and I got the pleasure of hosting the Jade Management Team. Why don't I hand it off to you for some intro remarks, and then we'll get started with Q&A?Tom FrohlichAbsol ...

Core Insights - The pharmaceutical industry is experiencing a structural change driven by the growth cycles of major products, with significant opportunities emerging in innovative drugs, medical devices, and consumer healthcare [3][6][31] - The demand for pharmaceuticals is expected to improve in 2026, supported by policies encouraging innovation and a recovery in domestic consumption [3][7] - The supply side of the pharmaceutical industry is characterized by high entry barriers due to patent protections and government regulations, which helps maintain a stable competitive environment [4][5] Group 1: Industry Trends - The aging population, urbanization, and changing disease patterns are making the pharmaceutical industry a perpetual growth sector [3] - The global pharmaceutical market has seen rapid expansion from 2009 to 2019, followed by a surge in demand due to COVID-19, and is now entering a phase of recovery and growth [3][6] - The Chinese pharmaceutical industry is expected to gradually produce world-class companies, with increasing recognition of Chinese innovative drug assets by multinational corporations (MNCs) [4][5] Group 2: Investment Opportunities - Opportunities in innovative drugs are highlighted, particularly in oncology, metabolic diseases, and autoimmune diseases, with a focus on next-generation therapies and precision medicine [6][31] - The demand for innovative drugs is expected to remain strong, with policies improving medical insurance payments and the upcoming launch of commercial insurance drug catalogs [7][31] - The medical device sector is anticipated to recover, with a focus on domestic demand and international expansion, particularly in areas with low domestic production rates [7][8] Group 3: Company Performance - Major pharmaceutical companies like Eli Lilly, AbbVie, and AstraZeneca are experiencing significant growth driven by key products, with Eli Lilly's Tirzepatide generating $24.8 billion in sales [12][15] - The report identifies specific companies such as Hengrui Medicine, Hansoh Pharmaceutical, and BeiGene as outperformers in the market, with strong pipelines and global competitiveness [7][8] - The report emphasizes the importance of mergers and acquisitions (M&A) and business development (BD) strategies for MNCs, with China becoming a significant source of projects for top global pharmaceutical companies [22][24]

Financial Data and Key Metrics Changes - Total sales increased by 8% for the quarter, with core operating profit up 11% and core earnings per share up 14% to 55p [3][4] - Cash generation for the year so far is £6.3 billion, supporting growth investments and shareholder returns, including a dividend of 16p for the quarter [4][36] - Operating margin improved by 90 basis points in the quarter, driven by SG&A margin improvement [38] Business Line Data and Key Metrics Changes - Specialty medicines sales grew by 16%, with significant contributions from oncology (up 39%) and respiratory immunology (up 15%) [10][12] - HIV portfolio delivered 12% growth, primarily driven by long-acting injectables [21] - Vaccine sales increased by 2%, with strong demand for Shingrix, particularly in Europe [29] Market Data and Key Metrics Changes - In the U.S., Shingrix penetration is now at 43% of the eligible older adult population, with international sales accounting for around 70% of global Shingrix sales [30] - The oncology portfolio is expected to be a material growth driver, with Glenrep approved in eight markets [16][18] Company Strategy and Development Direction - The company is focused on investing for growth, with a pipeline of 15 scale opportunities expected to launch before 2031 [5][7] - Continued emphasis on business development to expand the pipeline, particularly in oncology and respiratory [6][84] - The company is committed to optimizing supply capacity and investing $30 billion in R&D and advanced manufacturing in the U.S. over the next five years [6] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to deliver on long-term commitments for growth, with an upgraded guidance for the year [8][42] - The company remains cautious about the near-term outlook for vaccines in the U.S. but is optimistic about long-term prospects [33] Other Important Information - The company has secured four FDA approvals this year and expects a fifth before year-end [4] - The company is upgrading its full-year sales expectations from 3-5% to 6-7% [42] Q&A Session Summary Question: Revenue gap between market expectations and GSK's target for 2031 - Management acknowledged the gap and highlighted underappreciated assets in oncology and respiratory as key areas for growth [51][54] Question: Future strategy updates - Management indicated that more details on the strategy would be provided at the full-year results, with confidence in achieving the £40 billion target by 2031 [52][58] Question: Shingrix growth expectations - Management confirmed that growth in Europe is expected to continue, with a focus on expanding immunization rates [60][66] Question: Investment in R&D and operational expenses - Management confirmed that R&D investment will continue to grow ahead of sales, with significant investments in new product launches [68] Question: Updates on Glenrep and Depamokimab - Management shared insights on the early experiences with Glenrep in Europe and the competitive landscape for Depamokimab, emphasizing the potential for both products [72][76]

29 October 2025 Q3 2025 Results Conference call and webcast for investors and analysts gsk.com Agenda Q3 2025 strong performance improves further Emma Walmsley Performance: growth drivers 2 Cautionary statement regarding forward-looking statements Luke Miels and Deborah Waterhouse Q3 2025 financial performance Julie Brown Summary and Q&A Emma Walmsley, Luke Miels, Deborah Waterhouse, Julie Brown, Tony Wood and David Redfern This presentation may contain forward-looking statements. Forward-looking statements ...

Core Insights - GSK has raised its full-year profit and sales forecasts due to increased demand for its HIV and immunology drugs [1] - The company reported Q3 revenue of £8.55 billion, a 4.9% year-over-year increase, exceeding expectations by £300 million [1] - GSK anticipates a growth of up to 12% in adjusted earnings per share for the year, surpassing the previous maximum forecast of 8% [1] Financial Performance - Q3 revenue reached £8.55 billion, exceeding analyst expectations by £300 million [1] - Adjusted earnings per share grew by 11% to £0.55, compared to the expected £0.47 [1] - Revenue growth is projected to be as high as 7%, above prior estimates [1] Leadership Transition - Luke Mills will take over as CEO in January, facing challenges similar to those of current CEO Emma Walmsley [1] - The new CEO is tasked with convincing investors that the company's pipeline can achieve over £40 billion ($53 billion) in sales by 2031 [1] Product Portfolio and Market Performance - GSK's specialty drug portfolio, including treatments for HIV, cancer, and lupus, is expected to drive growth [1] - Demand in Europe for drugs like Dovato and Benlysta has boosted sales, alongside a strong performance in the vaccine business [1] - GSK has entered two early-stage deals to enhance its product pipeline ahead of the patent expiration of its best-selling HIV drug [1] Regulatory Environment - Unlike local competitor AstraZeneca, GSK has not reached an agreement with the Trump administration regarding price reductions in exchange for immunity from new industry tariffs [2] - The company has factored in the impact of existing tariffs and a potential 15% tariff in Europe into its full-year guidance [2]

Q2 2025 Performance Highlights - Q2 2025 sales reached £7,986 million, a 6% increase[9] - Core EPS increased by 15% to 465 pence[9] - Core operating profit increased by 12% to £2,631 million[10] - Cash generated from operations year-to-date is £37 billion[10] Specialty Medicines Growth - Specialty Medicines sales increased by 15%[9] - Specialty medicines largest business: 40% sales[14] - HIV sales increased by 12% to £1,880 million[56] - Vaccines sales increased by 22%[71] Financial Outlook and Guidance - Expect to deliver towards the top end of 2025 guidance range[9] - Sales growth is projected at 3-5%[24] - Core OP growth is projected at 6-8%[24] - Expect sales of >£40 billion in 2031[18]

Core Insights - Capricor Therapeutics has appointed Dr. Michael Binks as Chief Medical Officer, effective immediately, to lead the advancement of deramiocel for Duchenne muscular dystrophy (DMD) and future pipeline opportunities [1][2] - Dr. Binks has 25 years of experience in clinical development and has held senior roles at Pfizer and GlaxoSmithKline, contributing to the advancement of several first-in-class therapies [2] - Capricor's lead product candidate, deramiocel, is in late-stage development and has shown potent immunomodulatory and anti-fibrotic actions in preserving cardiac and skeletal muscle function in dystrophiopathies [3] Company Overview - Capricor Therapeutics is focused on developing cell and exosome-based therapeutics for rare diseases, with a commitment to innovative treatments [3] - The company has entered into an agreement with Nippon Shinyaku Co., Ltd. for the exclusive commercialization and distribution of deramiocel for DMD in the United States and Japan, pending regulatory approval [6]