齐鲁晚报.齐鲁壹点孙淑玉通讯员李成修李凌峰 长期以来，肿瘤治疗一直是医学领域的难题。近日，烟台毓璜顶医院放疗科率先开展后装插植放疗技术，成功填补了烟威地区肿瘤内照 射插植治疗领域的空白，标志该院在肿瘤精准治疗方面迈出了关键性的一步。这一技术的引入，不仅体现了烟台毓璜顶医院在医疗技术 创新上的积极探索和勇于担当，更彰显了医院以患者为中心，致力于提升医疗服务水平的坚定决心。 内"爆"技术优势显著 何谓后装插植放疗技术？烟台毓璜顶医院放疗科主任宋轶鹏介绍，该技术犹如肿瘤治疗领域的一把"精准手术刀"，具有很多令人瞩目的 优势。借助先进的影像引导(CT/MRI)，医生能够将施源器精准植入肿瘤内部，实现"零距离"的杀伤效果。局部剂量可达传统外照射的数 倍，大大提高了肿瘤控制率，同时施源器固定于肿瘤内部，避免了呼吸运动或体位变化导致的剂量偏差，确保了治疗的精准性和有效 性。 后装插植放疗与外照射结合，通过剂量互补(外照射打范围、后装插植补剂量)和分阶段增效(外照射先行缩小瘤体、后装插植精准打击残 余病灶)的策略，突破了剂量瓶颈，在提升局部控制率的同时保护了正常器官。这种联合模式尤其适用于解剖结构复杂、需高剂量根治的 肿瘤， ...

Investment Rating - The report initiates coverage with a "Buy" rating for the company, targeting a market value of HKD 5.8 billion, which corresponds to a target price of HKD 8.57 [3]. Core Insights - The company has a strong cash flow support from its commercialized product, Selinexor, which has expanded its indications and market presence [2]. - The clinical pipeline includes ATG-022, a differentiated CLDN18.2 ADC, and ATG-037, a CD73 small molecule inhibitor, both showing promising efficacy in treating various cancers [2][3]. - The second-generation TCE platform is expected to enhance safety and efficacy, with the first product, 25H2, submitted for IND [3]. Company Overview - The company focuses on oncology and immunology, with a pipeline that includes one commercialized product and five clinical candidates [8][9]. - Selinexor, the first commercial product, has been approved in multiple Asia-Pacific markets and is expected to see significant revenue growth in 2024 [8][9]. Clinical Pipeline - The company has five clinical-stage assets, including ATG-022 (CLDN18.2 ADC) and ATG-037 (CD73), which are positioned to address unmet medical needs in oncology [11][51]. - ATG-022 has shown efficacy across various CLDN18.2 expression levels in gastric cancer patients, with ongoing clinical trials [34][39]. - ATG-037 is advancing in clinical trials for melanoma and non-small cell lung cancer, demonstrating encouraging safety and efficacy signals [51]. Financial Performance - The company reported a revenue of HKD 92 million in 2024, a 36.7% increase year-on-year, primarily driven by Selinexor's inclusion in the medical insurance directory [23]. - The adjusted annual loss significantly narrowed from HKD 534 million in 2023 to HKD 305 million in 2024, reflecting improved operational efficiency [23]. - Cash reserves at the end of 2024 stood at HKD 900 million, sufficient to support operations for the next three years at the current spending rate [23].

| 证券分析师： | 周豫 | | --- | --- | | 分析师登记编号： | S1190523060002 | | 证券分析师： | 霍亮 | | 分析师登记编号： | S1190523070002 | | 研究助理： | 戎晓婕 | | 一般证券业务登记编号： | S1190123070050 | P2 医药行业|公司深度研究报告 证券研究报告 2025/06/04 德琪医药深度报告—— 聚焦肿瘤领域的创新先锋，TCE 2.0蓄势待发 报告摘要 德琪医药核心推荐逻辑：1） 塞利尼索已实现商业化，随着适应症扩增和上市地区增加，为公司提供稳定的现金流支撑。 2）临床管线： ATG-022是具备差异化竞争优势的CLDN18.2 ADC，CD73小分子抑制剂ATG-037在免疫检查点抑制剂耐药肿瘤中展现出积极疗效；3）早 研管线中，第二代TCE平台具备更高安全性和更强疗效，首款产品25H2递交IND。 估值和投资建议：基于NPV和DCF法，我们测算目标市值为58亿港元（汇率0.92），对应目标价为8.57港元，首次覆盖给予"买入"评级。 请务必阅读正文之后的免责条款部分 守正 出奇 宁静 致远 ◼ ATG- ...

Core Viewpoint - Xinhua Medical (600587) is a representative enterprise of high-end medical equipment for radiotherapy in China, participating in the "China-Brazil Business Seminar" hosted by the Brazilian presidential delegation in Beijing, and officially signing a strategic cooperation memorandum with Brazilian business representatives to collaborate on innovative technologies for precise cancer treatment and upgrading public health service systems in Brazil [1] Group 1 - Xinhua Medical is recognized as a leading company in the field of radiotherapy medical equipment in China [1] - The company has engaged in a strategic partnership with Brazilian enterprises, indicating a commitment to international collaboration [1] - The focus of the cooperation will be on cancer treatment technologies and public health service improvements in Brazil [1]

首次覆盖：专注于小分子肿瘤精准治疗，扭亏为盈迎来拐点 Focusing on Precision Therapy with Small Molecules in Oncology, Achieving Profitability and Reaching an Turning Point: Initiation [Table_yemei1] 观点聚焦 Investment Focus 研究报告 Research Report 14 May 2025 和誉-B Abbisko (2256 HK) [Table_Info] 首次覆盖优于大市 Initiate with OUTPERFORM 评级 优于大市 OUTPERFORM 现价 HK$8.06 目标价 HK$13.40 HTI ESG 4.8-4.8-4.5 - -G: 0- , (Please refer to the Appendix for ESG comments) 市值 HK$5.48bn / US$0.70bn 日交易额 (3 个月均值) US$5.95mn 发行股票数目 680.11mn 自由流通股 (%) 67% 年股价最高最低值 HK$8. ...