珍宝岛药业没有止步于传统中药业务，特别是随着近年来中医药获得全方位政策支持，国务院办公厅 2025年印发《关于提升中药质量促进中医药产业高质量发展的意见》，为中医药产业高质量发展提供了 政策支撑。国内中医药产业也正沿着高质量发展的轨道前行，中药领域的科技创新也展现出不俗的发展 动能。 今年，珍宝岛药业1.1类中药创新药清降和胃颗粒迎来关键节点，其Ⅱ期临床试验在长沙市第三医院实 现全国首例患者入组。该品种主要针对非糜烂性胃食管反流病（NERD）寒热错杂证这一西医治疗手段 匮乏的复杂证型，借助整体调节优势，有望填补中医证候治疗市场空白。Ⅱ期临床的启动，也标志着其 研发正式迈入验证有效性与安全性的成药性转化核心阶段，如果能够成功上市，按照现有规定，该品种 将享有市场独占期与价格优势。不仅将打开十亿级细分市场，也有望提升公司管线整体估值溢价。 另据东方财富Choice数据，由于上述Ⅱ期临床试验的启动，珍宝岛药业今年9月25日还新增"创新药"概 念，不难看出业界对该产品的认可。 生物药赛道投资进入价值兑现期 中药业务夯实基本盘，重磅品种清降和胃颗粒有望填补中医证候治疗空白，潜在市场超十亿元；数年前 就着手布局的生物药赛 ...

Core Viewpoint - Zhenbaodao, a well-known high-end traditional Chinese medicine company, faces challenges in revenue and profitability, ranking low in the industry despite its strong R&D capabilities and full industry chain advantages [1][2]. Group 1: Company Overview - Established on October 28, 1996, Zhenbaodao was listed on the Shanghai Stock Exchange on April 24, 2015, and is headquartered in Heilongjiang Province [1]. - The company specializes in high-end traditional Chinese medicine formulations, with a diverse range of products and dosage forms [1]. Group 2: Financial Performance - For Q3 2025, Zhenbaodao reported revenue of 918 million yuan, ranking 44th out of 69 in the industry, significantly lower than the top competitors, Baiyunshan (61.606 billion yuan) and Yunnan Baiyao (30.654 billion yuan) [2]. - The net profit for the same period was -376 million yuan, placing the company last in the industry, while the industry leaders reported net profits of 4.789 billion yuan and 3.398 billion yuan, respectively [2]. Group 3: Financial Ratios - As of Q3 2025, Zhenbaodao's debt-to-asset ratio was 38.22%, an increase from 35.06% year-on-year, exceeding the industry average of 32.81% [3]. - The gross profit margin was 35.71%, down from 53.10% year-on-year and below the industry average of 52.44%, indicating a decline in profitability [3]. Group 4: Executive Compensation - The chairman, Fang Tonghua, received a salary of 2.6798 million yuan in 2024, a slight decrease from 2.6936 million yuan in 2023 [4]. - The general manager, Yan Jiujiang, earned 1.1708 million yuan in 2024, a marginal increase from 1.1705 million yuan in 2023 [4]. Group 5: Shareholder Information and Market Outlook - As of September 30, 2025, the number of A-share shareholders decreased by 2.72% to 20,900, while the average number of shares held per shareholder increased by 2.80% to 45,000 [5]. - Huaxin Securities predicts that Zhenbaodao's revenue will grow to 1.984 billion yuan in 2025, 2.823 billion yuan in 2026, and 3.066 billion yuan in 2027, with corresponding EPS of 0.07, 0.50, and 0.54 yuan [5].

Investment Rating - The report assigns a "Buy" rating for the company, marking it as the first recommendation [1]. Core Insights - The company is expected to face short-term impacts from centralized procurement, but sales are anticipated to improve post-implementation. The net profit for the first half of 2025 is projected to be between -77 million and -66 million yuan, primarily due to delayed procurement timelines and price reductions on core products, leading to a 57% decline in revenue and a 64% drop in gross profit year-on-year [3][4]. - The company has made significant progress in the development of innovative traditional Chinese medicine, with a key milestone achieved in the clinical trial of Qingjiang Hewei Granules, which targets a complex syndrome of non-erosive gastroesophageal reflux disease [5]. - The company holds a 17.0211% stake in Zhejiang Tereis, which is developing a first-in-class ADC product, TRS005, showing promising clinical results for treating relapsed or refractory CD20-positive diffuse large B-cell lymphoma [6][7]. Summary by Sections Financial Performance - The company is expected to see a revenue decline in 2025, with projections of 1.984 billion yuan, followed by a recovery to 2.823 billion yuan in 2026 and 3.066 billion yuan in 2027. The earnings per share (EPS) are forecasted to be 0.07 yuan in 2025, 0.50 yuan in 2026, and 0.54 yuan in 2027, with corresponding price-to-earnings (P/E) ratios of 185.9, 24.8, and 23 respectively [8][10]. Market Position and Growth Drivers - The company’s core products are expected to regain sales momentum following the implementation of centralized procurement, which is anticipated to positively impact revenue in the latter half of 2025 [4]. - The innovative drug development and the ADC platform are seen as potential growth drivers for the company, with the ADC product expected to receive regulatory approval in 2024 [6][8]. Investment Outlook - The report suggests that despite short-term challenges due to procurement policies, the company’s innovative drug pipeline and strategic partnerships could lead to significant growth in the coming years, justifying the "Buy" rating [8].

Investment Rating - The report maintains a strong rating for the pharmaceutical and biotechnology sector, indicating it is expected to outperform the market [6]. Core Insights - The report highlights the breakthrough therapy of TRS005, an ADC targeting CD20, which shows potential to outperform existing treatments for DLBCL [4][40]. - The DLBCL market is projected to grow significantly, with the Chinese market expected to increase from RMB 58 billion in 2019 to RMB 186 billion by 2024, and further to RMB 369 billion by 2030, reflecting a CAGR of 26.2% [21][24]. - The report emphasizes the importance of innovative drugs and suggests focusing on companies with strong performance and potential catalysts in the upcoming quarters [4][5]. Summary by Sections 1. Market Review - The CITIC Pharmaceutical Index rose by 1.5% during the week of June 23-27, 2025, underperforming the CSI 300 Index by 0.5 percentage points [3][49]. - The top five performing stocks included Shenzhou Cell (+30.5%), Haooubo (+27.1%), and Huaren Health (+26.0%) [3][63]. 2. DLBCL and ADC Treatment - DLBCL accounts for approximately 30-40% of all NHL cases, with a significant portion of patients remaining untreated despite existing therapies [4][17]. - The report discusses the transition from traditional chemotherapy to targeted therapies, highlighting the introduction of ADCs as a promising treatment avenue [24][27]. - TRS005 has shown promising results in early trials, with an overall response rate (ORR) of 59.4% in the 1.8 mg/kg dosage group [42][46]. 3. Investment Recommendations - The report suggests a focus on innovative drugs as a long-term investment strategy, particularly in companies that are expected to report strong Q2 earnings [4][5]. - Recommended stocks include Innovent Biologics, Kintor Pharmaceutical, and Zhenbao Island, among others [5][13]. 4. Industry Trends - The report notes that the ADC sector is gaining traction, with TRS005 being a key focus due to its potential advantages over existing therapies [40][47]. - The overall pharmaceutical sector is experiencing a shift towards innovative treatments, driven by advancements in technology and an aging population [21][24].