全球首个高精度完整肝脏三维病理图谱发布，研究团队来自上海 本研究中，上海药物所MOST技术服务部、高召兵课题组联合临港实验室殷宪振课题组构成多学科交叉团队，利用显微光学切片断层成像 （MOST）技术，实现了完整肝脏0.35×0.35×2微米超高分辨率的三维成像，相当于在细胞尺度构建肝脏"数字孪生体"。 这项技术突破不仅完整呈现包含肝脏各叶、胆囊以及中央静脉、门静脉、动脉、胆管、肝血窦和肝细胞的关键结构的空间关系，更首次捕获到传 统手段无法观测的胆管周围微血管丛等精细结构。研究为系统全面从器官到脉管到细胞，跨尺度精确表征肝脏解剖结构和各类疾病病理变化奠定 了基础。 采用MOST和全肝尼氏染色法，获得肝纤维化多结构三维病理全景图 "中国科学院上海药物研究所"微信公众号 图 长久以来，病理学家仅能通过二维切片推测肝脏病变，如同拿着平面地图研究立体城市。如今，肝脏终于能够实现完整的高精度三维成像了，效 果堪比在细胞尺度构建肝脏"数字孪生体"。 高精度完整肝脏三维重建 "中国科学院上海药物研究所"微信公众号 图 3月24日，中国科学院上海药物研究所联合临港实验室研究团队以"Generation of a high-pr ...

Core Insights - Yibin is enhancing its investment fund matrix to attract high-quality industries and create a robust industrial ecosystem, marking a shift from traditional investment attraction methods to a more innovative approach [1][4]. Investment Fund Matrix Development - Yibin signed 130 projects with a total investment of 49.33 billion yuan during the Yangtze River Delta Investment Promotion Conference, indicating strong collaboration with top domestic fund institutions [1][3]. - The city has launched a Fund Investment 2.0 model, focusing on sectors like new energy, new materials, and digital economy, aiming to leverage fund advantages in project recommendations and equity investments [3][5]. - Yibin's industrial investment fund matrix has grown to include 18 funds with a total scale of 30 billion yuan, supporting 34 projects with over 100 billion yuan in agreements since 2022 [5][8]. Advantages of Fund Investment - Fund investment offers a market-oriented risk management mechanism, enhancing efficiency and precision in attracting investments compared to traditional land and policy-based methods [8][9]. - The city emphasizes building connections with leading capital and high-energy enterprises to improve investment efficiency and effectiveness [8][9]. - Yibin's approach to fund investment includes nurturing local professional teams through collaboration with top capital institutions, enhancing local expertise in investment and industry [9][11]. Future Directions and Goals - Yibin plans to expand its fund matrix to exceed 60 billion yuan over the next three years, focusing on new technology and industry trends [13][16]. - The city aims to establish a 1 billion yuan technology achievement transformation fund to support early-stage investments in hard technology [13][15]. - Yibin is targeting future industries such as new energy storage, digital energy, and artificial intelligence, indicating a strategic shift towards nurturing emerging sectors [16][17]. Economic and Infrastructure Development - Yibin has significantly improved its business environment, with a comprehensive transportation system and enhanced service efficiency, which supports industrial growth [18][21]. - The city has achieved notable economic milestones, including a GDP exceeding 400 billion yuan and a tax revenue surpassing 60 billion yuan, driven by both emerging and traditional industries [21][22]. - Yibin's unique geographical advantages, such as abundant green energy resources, facilitate the development of new industries like electric vehicles and solar energy [23].

Core Points - The case of a vice principal accused of attempted rape of a female student has been retried, resulting in a conviction for forced indecency with a sentence of three and a half years in prison [1][10] - The court found that the evidence presented by the prosecution was insufficient to support the charge of attempted rape, leading to a change in the charge to forced indecency [2][9] Group 1 - The defendant, Ma, was previously convicted of attempted rape and sentenced to four and a half years, but this was overturned on appeal due to unclear facts [1][2] - During the retrial, the court noted inconsistencies in the victim's statements and found that the evidence did not support the claim of rape [2][10] - The court emphasized that while some of the victim's statements lacked credibility, this did not invalidate all her claims, leading to the conviction for forced indecency instead [2][11] Group 2 - The prosecution had initially sought a sentence of four to six years for the charge of attempted rape, citing the defendant's abuse of his position [3][5] - The defendant maintained his innocence throughout the proceedings, with his defense arguing that the evidence was contradictory and insufficient [6][8] - The court ultimately ruled that the defendant's actions constituted forced indecency, given the context of his role as a school official and the nature of the offense [10][11]

全球投促大会召开央企圆桌会：上海将为央企提供更高品质的营商 环境 会上，10家央企在圆桌会中交流与上海产业合作情况、在沪投资布局意向、提出在沪发展的意见建议。徐汇区区长王华、宝山区区长 邓小冬、浦东新区副区长李慧、市经济信息化委副主任蒲亚鹏出席会议，并围绕央企发展情况、营商环境和促进央地融合发展的政策 措施进行交流回应。 陈杰在座谈中代表上海市政府，对长期关心、支持上海发展的各级央企表示衷心地感谢。陈杰指出，央企在上海经济社会发展中发挥 了不可替代的重要作用，央企的重要机构加速集聚，重大合作项目加快布局，产业创新成果竞相涌现。 陈杰表示，上海正在深入贯彻落实习近平总书记在上海考察时的重要讲话精神，聚焦"五个中心"建设重要使命，加快建成具有世界影 响力的社会主义现代化国际大都市。上海将保持战略敏捷，优化前沿技术和未来产业布局，加快培育龙头企业和高增长企业，营造更 好产业生态。 陈杰强调，上海将为央企提供更高品质的营商环境。上海招商服务一体化机制正逐步建立完善，已形成了"1+6+20+X"工作体系，健全 重大项目协调推进机制和重点企业服务包机制，将进一步为包括央企在内的各类企业提供高效、精准服务。上海真诚欢迎央企 ...

广联达年报审计存问题 立信会计所被警示 原标题：因在广联达年报审计中存在执业问题，立信会计所被出具警示函 因在广联达科技股份有限公司(下称"广联达"，002410.SZ)2023年度财务报表审计项目执业中存在问题， 立信会计师事务所(特殊普通合伙)(下称"立信会计所")及两名签字会计师被北京证监局采取出具警示函 措施。 3月21日，北京证监局公告称，在对立信会计所及徐继凯、苏建国执行的广联达2023年度财务报表审计 项目(信会师报字〔2024〕第ZB10098号)进行检查中，发现执业中存在五方面问题。 一是独立性方面，项目组实习生未签署项目独立性声明。 二是风险评估方面，重要性水平的确定缺少计算过程及说明，对"发放贷款及垫款的减值"风险评估程序 执行不到位。 三是控制测试方面，个别关键控制点识别和控制测试不到位，控制测试样本选取不恰当，未准确识别控 制测试偏差并执行适当的审计程序，对控制缺陷的评价程序执行不到位。 四是实质性测试方面，北京证监局指出，首先，是收入等科目分析性复核程序执行不到位。其次，是细 节测试执行不到位，收入细节测试中对发现的无验收单、验收单时间与收入确认时间不匹配、测算收入 与账面确认收入 ...

秦洪看盘｜窄幅震荡中显露新热点方向 澎湃新闻记者 蒋立冬 AI创意 周二A股市场出现了缩量中窄幅震荡的态势。其中，低波红利主线、军工股、化工股等品种反复活跃。但前期强势的AI主线、人形机器人主线延 续着调整的态势，从而使得科技方向的科创50指数等股指相对疲软一些。但上证综指的震幅收敛，在日K线图上留下一根阴十字星。 信息抑制科创方向弹性 近期AI主线、人形机器人主线等科创方向出现了一定的收缩性的信息，比如说近期代表人工智能新质生产力方向的龙头上市公司在港交所抛出了 大额再融资的公告，由于港股对再融资不是太喜欢，因此，不仅该公司的股价出现了急挫，而且还使得不少动量资金纷纷减持港股科技股，毕竟 这些动量资金担心其他公司也紧随其后，如此就使得港股恒生指数抛压陡增。由于港股在今年以来一直是A股的先行者，所以，港股的调整抑制 了A股的冲劲。 与此同时，关于数据中心的泡沫以及互联网大厂对算力投资额度的低于预期等信息，也使得当前渐趋冷静下来的动量资金开始重新审视AI投资主 线方向的部分细分领域的投资价值以及发展前景。毕竟在2022年AI开始躁动以来，已经出现过业绩的确兑现，但由于爆炒力度过猛，进而使得股 价难以再度大幅上涨 ...

未关电的三轮车蹿出碰伤保时捷：挪车保安被认定全责，已申请复核 近日，深圳市龙岗区玉岭花园小区一保安钟林（化名）向澎湃公众互动平台"服务湃"（https://tousu.thepaper.cn）反映称，自己在为小区内车辆开 道时，挪动一辆停在路中的三轮车，结果未关电的三轮车不受控制蹿出，撞到了前方对向行驶但无法通过的保时捷。 此后，深圳市公安局交通警察支队龙岗大队开具道路交通事故认定书，认为保安钟林需要为该起妨碍道路交通安全的事故负全责，其余二人均无 事故责任。 对于这样的结果，钟林称，自己是该小区保安，有义务维护小区道路畅通，是实施紧急救助的行为；此外，三轮车当时未熄火并停在道路中央， 同样应该担责。此后，他向交警部门申请了复核。 3月19日，保时捷车主陈先生则告诉记者，据前述认定书结果，目前他提出的要求是钟林个人或物业赔偿受损车辆维修费2万元。他称，如果对方 不赔偿，自己的保险理赔后，保险公司也会追偿。 保时捷车身多处被擦伤。 保安挪动占道三轮车时，车辆蹿出撞到保时捷 钟林回忆，2025年3月16日，他当班期间，突然听到外面有车鸣笛的声音，发现是一辆电动三轮车堵住道路导致车辆无法通行，他便出去尝试挪走 电动 ...

马上评｜心肌炎猝死不能理赔？霸道的保险条款应 纠正 上海的张女士在女儿满月后为其购买了一款重疾险，保额为50万元，年保费为4632元。今年2月，3岁的 孩子因流感诱发暴发性心肌炎，不幸离世，从确诊到去世仅3小时。张女士申请理赔时，保险公司却表 示：孩子的心肌炎不符合"严重心肌炎理赔条款"，而无法理赔。 按保险公司提供的合同条款：心肌炎要同时满足"心功能衰竭程度达到纽约心脏病学会的心功能分级标 准之心功能Ⅳ级，或左室射血分数低于30%；持续不间断180天以上"等三个条件，才构成"严重心肌 炎"，而孩子因暴发性心肌炎而猝死，反而不算"严重心肌炎"。之后本案在律师介入、反复交涉之后， 保险公司最终才同意赔付。 被保险人明明死于心肌炎，保险公司却搬出保险合同认为"致死的心肌炎不是心肌炎"。"白马非马"问题 在保险业内存在已久，也饱受舆论诟病。 有业内人士直言，保险公司设置严苛条款实质是保险精算模型控制下的风险规避方式。以少儿险为例， 身故仅退保费的设计，将公司成本压缩至极限。虽然保险赔付标准≠医学标准，但保险公司不能滥用自 己提供格式保险合同的便利设置霸王条款。对此，保险业监管部门是有明确态度的。 但是，在相当多的案 ...

上海静安今年计划供应4幅优质地块，涉衡复风貌区、苏河湾等 大宁板块的静安区N070302单元111-21地块，单元核心范围东至共和新路，南至广中西路，西至彭越浦，北至灵石路-汶水路，为重点商务更新项 目集聚范围，总用地面积约1.5平方公里，交通便捷、生活配套一应俱全。 苏河湾商务单元的静安区C070102单元32街坊，地跨静安、黄浦两区，紧邻外滩、北外滩，位于中央活动区北部，是以商务功能为主，有机融合 商业、休闲、居住等多元功能的高品质滨水综合城区。景观优越，有潜力打造苏河湾新地标。 静安区C050202 单元053-b-1地块（66街坊）鸟瞰效果图 东斯文里片区的静安区C050202单元053-b-1地块毗邻自然博物馆和静安雕塑公园，可进一步融入苏州河南岸滨水岸线，共享开放场域。 衡山路-复兴路历史文化风貌区的107街坊（旧改地块范围），位于静安"巨富长"黄金地段，经典的"梧桐树下、闹中取静"，将打造为具有优越历 史和居住氛围的风貌住宅区。 活动现场 本文图片均为静安区供图 3月25日，"投资静安，共享未来"2025上海市静安区土地推介会在苏河湾中心举办，静安区优质地块首次集中亮相。本次推介会也是今年"潮涌 ...

Core Viewpoint - The shipping industry is actively deploying emission reduction strategies in response to increasingly stringent carbon emission standards from the International Maritime Organization and the European Union, focusing on transitional technologies and financial support to achieve gradual decarbonization [1][11]. Transitional Technologies Development and Innovation - Transitional technologies for decarbonization in the shipping industry can be categorized into three types: efficiency improvement technologies, transitional fuels, and carbon-neutral enabling technologies [2]. - Specific examples of transitional technologies include hull optimization, waste heat recovery, and the use of liquefied natural gas and biofuels [3][4]. Innovation Technology Cases - Various innovative technologies have been developed to enhance emission reduction effectiveness, such as air lubrication technology and hydrogen-powered vessels, which significantly improve the reduction rates compared to traditional methods [4][5]. - The economic benefits of transitional technologies are notable, as they often involve lower costs compared to zero-carbon technologies, making them more feasible for implementation [5]. Financing Transitional Technologies - Financial support is crucial at all stages of transitional technology development, with different financing tools and models needed based on the risk and return profiles of the technologies [6][9]. - Examples of financing cases include the use of policy-based financial tools, transformation loans, and mixed financing models to support various projects in the shipping industry [7][8]. Domestic and International Financing Cases - International financing cases demonstrate the effectiveness of equity and mixed financing in incubating innovative technologies, while domestic cases show a lack of diversity and granularity in financing tools [10][11]. - The limited number of domestic financing cases highlights the need for improved structures and verification of financing models to support the shipping industry's decarbonization efforts [10]. Recommendations for Future Development - The industry should focus on advancing transitional technologies and recognizing their importance in achieving decarbonization goals, leveraging successful international practices [11][12]. - A comprehensive approach involving risk assessment, appropriate financing tools, and government support is essential for fostering innovation and investment in transitional technologies [12][13][14].