Core Viewpoint - The company reported a revenue of HKD 6.107 billion for the first half of 2025, reflecting a year-on-year increase of 0.99%, despite facing significant challenges due to price reductions from centralized procurement [1] Group 1: Financial Performance - Gross profit reached HKD 3.6 billion, up 0.25% year-on-year [1] - Shareholders' profit amounted to HKD 1.169 billion, with basic earnings per share at HKD 0.3338 [1] - The company achieved a compound annual growth rate (CAGR) of 12.1% in revenue over the past five years [1] Group 2: Product and Market Performance - The company’s innovative and barrier products accounted for approximately 51.0% of total revenue, an increase of 14.9 percentage points year-on-year [1] - The nuclear medicine oncology segment saw significant growth, with products like Yttrium-90 microsphere injection and LavaTM liquid embolic agent driving revenue to double [2] - The cardiovascular emergency segment benefited from successful commercialization of products like Coenzyme Q10 tablets, contributing to substantial growth from the acquisition of Tianjin Tianbian Pharmaceutical [2] Group 3: Innovation and R&D - The company maintains high R&D investment, establishing eight major research platforms across three global regions, focusing on cutting-edge technologies such as nuclear medicine and mRNA [3] - The innovation pipeline spans the entire R&D process from early development to clinical trials and regulatory submissions, with projects expanding from China to major global markets [3]

Group 1 - The core viewpoint of the articles highlights the financial performance and strategic initiatives of the company, with a revenue of HKD 6.107 billion for the first half of 2025, reflecting a year-on-year increase of 0.99% [1] - The company achieved a gross profit of HKD 3.6 billion, up 0.25% year-on-year, and a shareholder profit of HKD 1.169 billion, with basic earnings per share at HKD 0.3338 [1] - The company has maintained a compound annual growth rate (CAGR) of 12.1% in revenue over the past five years, despite facing significant pressure from price reductions due to centralized procurement [1] Group 2 - The company has a diverse and differentiated pipeline that establishes its competitive advantage in niche markets, particularly in the nuclear medicine oncology treatment sector, where it has one of the richest product lines globally [2] - The nuclear medicine segment saw a doubling of revenue, driven by the growth of products like Yttrium-90 microsphere injection and liquid embolic agent Lava [2] - In the cardiovascular emergency sector, products such as Coenzyme Q10 tablets continue to lead the market, with significant growth from the recently acquired Tianjin company [2] Group 3 - Innovation is identified as the core driver for the company's future, with substantial investment in R&D and the establishment of eight research platforms across major global markets [3] - The company’s innovation pipeline spans early research, clinical development, and registration processes, with projects extending from China to the US, Australia, and Europe [3] - The focus on cutting-edge technologies such as nuclear medicine, high-end medical devices, glycomics, and mRNA is emphasized as part of the company's strategic direction [3]

Group 1 - The company reported a record revenue of approximately HKD 6,107,320,000 for the six months ending June 30, 2025, representing a year-on-year increase of about 1.0% [1] - Revenue in RMB terms increased by approximately 2.0% year-on-year, and if excluding the impact of the tenth batch of centralized procurement price reductions, the revenue in RMB terms increased by approximately 13.0% [1] - Revenue from innovative and barrier products accounted for about 51.0% of total revenue, an increase of 14.9 percentage points compared to the same period last year [1] Group 2 - The profit attributable to the company's owners for the period was approximately HKD 1,169,020,000, a decrease of about 25.0% compared to the same period in 2024 [2] - Excluding the impact of RMB and HKD exchange rate fluctuations, the profit decreased by approximately 24.2% compared to 2024 [2] - The fair value change and disposal gains from the investment in Telix amounted to approximately HKD 151,730,000, a decrease of HKD 324,910,000 compared to the same period last year [2] Group 3 - The company continued to invest resources in the advancement of research projects and the introduction of innovative projects, with total investment in R&D and related expenditures amounting to approximately HKD 1,022,000,000 [2]

Core Viewpoint - The company reported record revenue of approximately HKD 6.11 billion for the first half of 2025, with innovative and barrier products accounting for about 51% of total revenue, reflecting a nearly 15 percentage point increase year-on-year [1] Group 1: Financial Performance - The company's net profit for the period was approximately HKD 1.17 billion [1] - Excluding the impact of centralized procurement and exchange rates, the company's revenue grew by about 13% year-on-year [1] Group 2: Research and Development - The company invested approximately HKD 1.02 billion in research and development during the period, achieving 38 significant milestone advancements [1] - The company currently has 42 innovative projects in its pipeline [1] Group 3: Strategic Focus Areas - The company has established a differentiated innovation pipeline in key strategic areas such as nuclear medicine for cancer treatment, respiratory and critical care, innovative ophthalmic drugs, and cardiovascular emergency care [1] - The nuclear medicine segment achieved a remarkable revenue growth of nearly 106% year-on-year, generating HKD 420 million [1][2] Group 4: Product Development and Market Expansion - The company’s product, Yttrium-90 microsphere injection, continues to demonstrate strong market potential with rapid growth [1] - The FDA granted early approval for the product Yigan Tai for the treatment of unresectable hepatocellular carcinoma (HCC), marking it as the first and only selective internal radiation therapy product approved for both HCC and colorectal cancer liver metastases [2] - The company’s innovative radiopharmaceutical GPN02006 for diagnosing HCC has shown breakthrough results in clinical research, enhancing its global development prospects [2] Group 5: Other Core Strategic Areas - The company’s innovative product STC3141 for treating sepsis has successfully reached the endpoint of its Phase II clinical trial in China [3] - The company is advancing its global clinical development for STC3141, having received approvals for clinical trials in five countries across three continents [3] - In the respiratory and critical care sectors, the company is launching several innovative products that are expected to enhance revenue growth [4]

Core Insights - Company reported record revenue of approximately HKD 6.11 billion for the first half of 2025, with innovative and barrier products accounting for about 51% of total revenue, a year-on-year increase of nearly 15 percentage points [1] - Net profit for the period was approximately HKD 1.17 billion, with a year-on-year revenue growth of about 13% after excluding the impact of centralized procurement and exchange rates [1] - The company achieved significant milestones in its research and development efforts, with total investment in R&D and projects amounting to approximately HKD 1.02 billion, resulting in 38 major milestone advancements [1] Nuclear Medicine Segment - As a leader in nuclear medicine, the company achieved impressive performance in the nuclear medicine oncology diagnosis and treatment sector, generating a record revenue of HKD 420 million, reflecting a year-on-year growth of nearly 106% [1][2] - The product Yttrium-90 microsphere injection (易甘泰®) continues to demonstrate strong market potential, maintaining rapid growth [1][2] - The company received early FDA approval for 易甘泰® for the treatment of unresectable hepatocellular carcinoma (HCC), becoming the first and only selective internal radiation therapy product approved for both unresectable HCC and colorectal cancer liver metastases [2] Innovative Products and Clinical Research - The company’s innovative product STC3141 for treating sepsis has successfully reached the endpoint of its Phase II clinical trial in China, representing a potential breakthrough in sepsis treatment [3] - STC3141 is the first global product aimed at re-establishing immune homeostasis for sepsis treatment, with clinical approvals obtained in five countries across three continents [3] - In the respiratory and critical care sectors, the company is advancing several innovative products, including nasal sprays and coenzyme Q10 tablets, which are expected to enhance commercial performance [4] Overall Growth and Competitive Advantage - The company has established a mature technological innovation development system, continuously reinforcing its differentiated advantages across various sectors [4] - The successful commercialization of innovative products is expected to provide ongoing development momentum, enhancing the company's core competitive advantages and creating value for investors [4]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其 準確性或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而 產生或因倚賴該等內容而引致的任何損失承擔任何責任。 GRAND PHARMACEUTICAL GROUP LIMITED 遠 大 醫 藥 集 團 有 限 公 司* （ 於 百 慕 達 註 冊 成 立 之 有 限 公 司 ） （股份代號：00512） 二零二五年中期業績公佈 財務摘要 — 1 — － 截至二零二五年六月三十日止六個月期間的收益取得歷史新高，錄得約港幣 6,107,320,000元（去年同期：港幣6,047,240,000元），同比增長約1.0%。人民幣口徑1 收益同比上漲約2.0%，如果撇除第十批集采降價的影響，人民幣口徑1 收益同比上 漲約13.0%。創新和壁壘產品2 收益佔總收益的比例約51.0%（去年同期為36.1%），同 比提升了14.9個百分點。報告期內，面對集採降價帶來的巨大壓力與挑戰，公司堅 持創新驅動與產品結構優化，易甘泰®、LavaTM、恩卓潤®比斯海樂®、恩明潤®比斯 海樂®、能氣朗®、合心爽®╱合貝爽®等一系列創新和壁壘 ...

Core Viewpoint - The stock price of Yuan Da Pharmaceutical (00512) surged over 7% ahead of its earnings announcement, reflecting positive market sentiment driven by recent FDA approval of its radioactive product for treating unresectable hepatocellular carcinoma (HCC) [1] Company Developments - Yuan Da Pharmaceutical plans to hold a board meeting on August 19 to approve its interim results [1] - The company announced that its yttrium-90 microsphere injection has received FDA approval for a new indication, making it the first and only selective internal radiation therapy product approved for both unresectable HCC and colorectal cancer liver metastases [1] - The company has established a complete industrial chain in the nuclear medicine sector, with its core product, Yttrium-90 microsphere injection, rapidly gaining market traction since its domestic approval in 2022 [1] Market Performance - As of the report, Yuan Da Pharmaceutical's stock rose by 6.92%, trading at HKD 8.96, with a transaction volume of HKD 283 million [1] - Tianfeng Securities projected that by the end of 2024, the product will have treated nearly 2,000 patients and is expected to generate nearly 500 million yuan in sales revenue [1] Strategic Focus - The company aims to build a comprehensive layout in tumor interventional therapy and the RDC platform, actively advancing multiple nuclear medicine products in clinical research [1] - The outlook for the company is positive as it enters an accelerated development phase [1]

Core Viewpoint - The stock price of Yuan Da Pharmaceutical (00512) surged over 7% ahead of its earnings announcement, reflecting positive market sentiment following the FDA approval of its radioactive product for treating unresectable hepatocellular carcinoma (HCC) [1] Company Developments - Yuan Da Pharmaceutical plans to hold a board meeting on August 19 to approve its interim results [1] - The company announced that its yttrium-90 microsphere injection has received FDA approval for a new indication, making it the first and only selective internal radiation therapy product approved for both unresectable HCC and colorectal cancer liver metastases [1] - The company has established a complete industrial chain in the nuclear medicine sector, with its core product, Yttrium-90 microsphere injection, rapidly gaining market traction since its domestic approval in 2022 [1] Market Performance - As of the report, Yuan Da Pharmaceutical's stock rose by 6.92%, trading at 8.96 HKD with a transaction volume of 283 million HKD [1] - Tianfeng Securities noted that the product has treated nearly 2,000 patients by the end of 2024, projecting sales revenue of nearly 500 million RMB for that year [1] Future Outlook - The company aims to build a comprehensive layout in tumor interventional therapy and the RDC platform, actively advancing multiple nuclear medicine products in clinical research [1] - The firm is expected to enter an accelerated development phase, supported by its innovative product offerings and market positioning [1]

Group 1: Macro Strategy and Market Overview - The three major equity indices continued to rise in early August, with the Shanghai Composite Index and Shenzhen Component Index both increasing by over 2%, and the ChiNext Index rising by 4.88% [20][21] - The central bank's net cash injection was 163.5 billion yuan, maintaining stable liquidity in early August, with the 7-day reverse repo rate (DR007) hovering around 1.45% [21][22] - Commodity prices showed mixed trends, with non-ferrous metals rebounding, crude oil slightly declining, and precious metals rebounding again [21] Group 2: Fixed Income and Bond Market - The upcoming issuance of 20-year special government bonds is expected to peak, presenting trading opportunities during the issuance process [2] - The new and old bond yield spread for 20-year bonds typically narrows by 0.4-1.5 basis points, with notable exceptions during significant market events [2] Group 3: Export Growth and Trade Analysis - China's exports showed steady growth in the first seven months of 2025, with a cumulative year-on-year increase of 6.1%, surpassing the 5.8% growth rate for the entire year of 2024 [23][24] - The global trade volume is expected to cool down in the second half of the year, influenced by preemptive demand in the U.S. and a decline in imports [23][24] - China's share of global exports has been increasing, with a notable rise in exports to non-U.S. regions compensating for declines in U.S. exports [24][25] Group 4: Company-Specific Insights - Yuan Da Pharmaceutical achieved a revenue of 10.784 billion yuan in 2024, a year-on-year increase of 10.59%, and a net profit of 2.286 billion yuan, up 31.28% [28][31] - The company is pioneering a new treatment for sepsis, STC3141, which has shown promising results in clinical trials [29][30] - Yuan Da's nuclear medicine segment is expanding, with significant sales growth expected from its core product, yttrium-90 microspheres, which has treated nearly 2,000 patients [30][31] Group 5: Industry Trends and Recommendations - The semiconductor industry is projected to continue its optimistic growth trajectory in 2025, driven by AI and high-performance computing [7] - The demand for storage solutions, particularly HBM and DDR5, is expected to remain strong, with price increases anticipated in the third quarter [7] - The construction materials sector, particularly cement and explosives, is expected to benefit from major infrastructure projects like the New Tibet Railway [34]

Investment Rating - The report assigns a "Buy" rating for the company with a target price of 13.07 HKD, based on a 20x PE for 2025 [5]. Core Insights - The company is positioned for accelerated growth through a dual strategy of "independent research and global expansion," which enhances its international transformation potential [1][12]. - In 2024, the company achieved a revenue of 10.784 billion RMB, a year-on-year increase of 10.59%, and a net profit of 2.286 billion RMB, up 31.28% year-on-year, driven by increased demand for core products in nuclear medicine and cardiovascular precision intervention [21]. Summary by Sections 1. Company Overview - Founded in 1939, the company operates across three main sectors: nuclear medicine for tumor diagnosis and treatment, cardiovascular precision intervention, and pharmaceutical technology [1][12]. - The company has over 10,000 employees globally and more than 30 subsidiaries, with a diverse product portfolio exceeding 200 items in the medical insurance directory [1][12]. 2. Pharmaceutical Technology - The company is focused on developing innovative drugs in respiratory and critical care, with STC3141 showing promise as a new treatment for sepsis [2][31]. - The global market for sepsis treatment is projected to grow from 12.54 billion USD in 2024 to 19.37 billion USD by 2032, indicating significant unmet clinical needs [40]. 3. Nuclear Medicine - The company has established a complete industrial chain in nuclear medicine, with its core product, Yttrium-90 microsphere injection, rapidly gaining market traction since its approval in 2022 [3][4]. - The company is advancing multiple nuclear medicine products through clinical trials, including TLX591 for prostate cancer and GPN02006 for liver cancer diagnosis, positioning itself in the global first-tier of development [4][12]. 4. Financial Forecast - Revenue projections for 2025-2027 are 12.405 billion RMB, 13.729 billion RMB, and 15.113 billion RMB, respectively, with net profits expected to be 2.121 billion RMB, 2.396 billion RMB, and 2.773 billion RMB [5].