股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年9月30日 狀態: 新提交 II. 已發行股份及/或庫存股份變動 致：香港交易及結算所有限公司 公司名稱: 歐康維視生物 (「本公司」) （於開曼群島註冊成立的有限公司） 呈交日期: 2025年10月8日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 不適用 | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 01477 | 說明 普通股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 5,000,000,000 | USD | | 0.00001 USD | | 50,000 | | 增加 / 減少 (-) | | | 0 | | | USD | | | | 本月底結存 | | | 5,000,000,000 | USD | | 0.00001 ...

中期報告 Ocumension Therapeutics 歐康維視生物 (Incorporated in the Cayman Islands with limited liability) ( 於開曼群島註冊成立的有限公司 ) Stock code 股份代號 : 1477 Virtus et Lumen 勇氣和光明 2025 INTERIM REPORT 中期報告 Ocumension Therapeutics 歐康維視生物 INTERIM REPORT 2025 目錄 | 公司資料 | 2 | | --- | --- | | 財務概要 | 4 | | 公司概覽 | 5 | | 管理層討論與分析 | 6 | | 業務回顧 | 6 | | 財務回顧 | 9 | | 其他資料 | 18 | | 簡明綜合財務報表審閱報告 | 32 | | 簡明綜合損益及其他全面收益表 | 33 | | 簡明綜合財務狀況表 | 34 | | 簡明綜合權益變動表 | 35 | | 簡明綜合現金流量表 | 36 | | 簡明綜合財務報表附註 | 38 | | 釋義及縮略詞 | 64 | 公司資料 董事會 執行董事 Ye LIU先生 （ ...

Core Insights - The article highlights the changes in the Hong Kong Stock Connect holdings, with notable increases and decreases in ownership percentages for various companies [1][2]. Group 1: Increased Holdings - Heng Rui Medicine (01276) saw the largest increase in ownership percentage, rising by 1.49% to a total of 13.84% [2]. - Kanglong Chemical (03759) experienced a 1.35% increase, bringing its ownership to 60.51% [2]. - Zhaoyan New Drug (06127) increased by 1.27%, reaching a holding of 43.70% [2]. - Other companies with significant increases include Junshi Biosciences (01877) at +1.24% (59.08%) and China Pacific Insurance (02601) at +1.20% (44.16%) [2]. Group 2: Decreased Holdings - Shandong Molong (00568) had the largest decrease, with a drop of 1.99% to 57.67% [2]. - Yisou Technology (02550) decreased by 0.99%, now holding 37.95% [2]. - Nanjing Panda Electronics (00553) saw a reduction of 0.98%, bringing its ownership to 42.65% [2]. - Other notable decreases include Kailai Ying (06821) at -0.95% (43.35%) and Meizhong Jiahe (02453) at -0.95% (32.06%) [2]. Group 3: Five-Day Changes - In the last five trading days, China Merchants Energy (01138) had the highest increase in ownership, up by 6.19% to 65.63% [3]. - Shandong Molong (00568) also saw a significant increase of 3.74% [3]. - Other companies with notable increases include Zhongchu Innovation (03931) at +3.62% (10.35%) and Youbao Online (02429) at +3.33% (17.38%) [3]. Group 4: Twenty-Day Changes - Over the past twenty days, Anjiren Food (02648) experienced the largest increase, up by 12.29% to 20.54% [4]. - China Merchants Energy (01138) also saw a significant increase of 9.07% [4]. - Other companies with notable increases include Yimai Sunshine (02522) at +7.70% (43.02%) and Lens Technology (06613) at +7.56% (13.64%) [4].

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年8月31日 狀態: 重新提交 致：香港交易及結算所有限公司 公司名稱: 歐康維視生物 (「本公司」) （於開曼群島註冊成立的有限公司） 呈交日期: 2025年9月9日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 01477 | 說明 | 普通股 | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 5,000,000,000 | USD | 0.00001 | USD | | 50,000 | | 增加 / 減少 (-) | | | | 0 | | USD | | | | 本月底結存 | | | 5,000,000,000 | USD | 0.00001 | USD | | 50,000 | FF ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年8月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 歐康維視生物 (「本公司」) （於開曼群島註冊成立的有限公司） 呈交日期: 2025年9月3日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 01477 | 說明 | 普通股 | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 5,000,000,000 | USD | 0.00001 | USD | | 50,000 | | 增加 / 減少 (-) | | | | 0 | | USD | | | | 本月底結存 | | | 5,000,000,000 | USD | 0.00001 | USD | | 50,000 | 本月底 ...

Core Viewpoint - The company reported a revenue of 294 million yuan for the first half of 2025, representing a year-on-year growth of 75.4%, while the loss narrowed to 132 million yuan compared to the same period in 2024, aligning with expectations [1][2]. Development Trends - The pipeline research and development is progressing steadily, with accelerated clinical and registration advancements for core products. Key updates include: 1. OT-1001 (Zhiwei Tai, 0.24% Azelastine Eye Drops) has been approved for commercialization by the National Medical Products Administration, featuring dual mechanisms for anti-allergy and anti-inflammation [1]. 2. OT-101 (Low-concentration Atropine) has completed a two-year administration for all subjects, with the Phase III clinical trial expected to be unblinded by June 2026 [1]. 3. OT-802 (Pilocarpine) has received approval for Phase III clinical trial application, anticipated to start in early 2026, potentially filling a market gap for innovative drugs in the presbyopia field in China [1]. 4. OT-301 (Latanoprost) has achieved primary endpoint indicators in a global multi-center Phase III clinical trial, surpassing Latanoprost, and is a potential BIC lowering intraocular pressure drug [1]. 5. OT-703 (0.19mg Fluocinolone Vitreous Implant) has been approved for real-world research application in Hainan Boao Lecheng and has completed patient enrollment [1]. Commercialization and Sales Network - The company has demonstrated significant commercial synergy, with rapid expansion of its sales network and channel coverage. In the first half of 2025, the company achieved a revenue of 294 million yuan, with substantial growth in ophthalmic product sales due to successful integration of products from Alcon and the contribution of new products like Zhiwei Tai [2]. - The company has established coverage in 21,535 hospitals nationwide, including 2,799 tertiary hospitals, with a commercial team exceeding 290 members, achieving a nationwide commercial network layout [2]. - The company is actively promoting market access for new products like Zhiwei Tai to enhance market share and build the brand influence of OcuVist, creating new growth points for performance [2]. Production System and Localization - The production system is gradually improving, with enhanced local manufacturing capabilities. During the reporting period, six products received production approval, and commercial batch production is progressing smoothly [2]. - The local production of the core product Yushi Ying has entered the review and public announcement stage, marking a breakthrough in supply assurance and cost control [2]. - Leveraging advanced processes and supply chain management at the Suzhou factory, the company's "OcuVist Manufacturing" model is gradually being implemented, which is expected to ensure supply stability and product quality while strengthening scale advantages, potentially improving production efficiency and reducing costs [2]. Profit Forecast and Valuation - The company maintains its profit forecast for 2025 and 2026. The rating of outperforming the industry is upheld, and considering the recent upward adjustment of the sector's valuation, the target price based on DCF has been raised by 35.5% to 10.16 HKD, indicating a 3.4% upside potential compared to the current stock price [2].

Market Overview - The Hong Kong stock market experienced a significant decline in the afternoon, with the Hang Seng Index dropping by 1.27%, losing over 300 points. The Hang Seng China Enterprises Index and the Hang Seng Tech Index fell by 1.4% and 1.47% respectively, with the former barely holding above the 9000-point mark [2] - Major technology stocks, which serve as market indicators, continued to decline in the afternoon. Kuaishou and Meituan fell over 3%, while JD.com dropped by 2.5%. Baidu, NetEase, and Tencent saw declines close to 2%, and Xiaomi fell by 0.56%. Alibaba managed to stay slightly positive [3] Sector Performance - The financial sector, including banks, insurance companies, and Chinese brokerage firms, collectively underperformed, contributing to the overall market decline. The performance of individual stocks continued to be affected by ongoing earnings reports, with property management and real estate stocks experiencing significant drops [3] - Biopharmaceutical stocks faced a collective downturn, particularly in the innovative drug sector, following comments from Trump regarding the rapid imposition of tariffs on pharmaceuticals. This led to notable declines in various biopharma stocks [3] Specific Stock Movements - Several biopharmaceutical companies saw substantial declines, including Kanghao Ya-B (-8.59%), Qiansirui Biotechnology (-7.42%), and Kangfang Biotechnology (-7.10%). Other notable decliners included Xiansheng Pharmaceutical (-6.79%) and Shiyao Group (-6.36%) [3] - In contrast, the rare earth sector remained strong, benefiting from the implementation of supply reforms and multiple catalysts. Apple’s upcoming event on September 9, where the iPhone 17 series is expected to be launched, led to a rise in Apple-related stocks, with Lens Technology (300433) surging nearly 8% and reaching a new high since its listing [4]

Core Viewpoint - Company maintains its earnings forecast for 2025 and 2026, with a target price increase of 35.5% to HKD 10.16, indicating a 3.4% upside potential from the current stock price [1] Group 1: Pipeline Development - The company's pipeline is progressing steadily, with accelerated clinical and registration advancements for core products [2] - OT-1001 has received approval for commercialization, featuring dual mechanisms for allergy and inflammation [2] - OT-101 has completed a two-year dosing period for all subjects, with III phase clinical unblinding expected by June 2026 [2] - OT-802's III phase clinical trial application has been approved, set to start in early 2026, aiming to fill a market gap in innovative drugs for presbyopia [2] - OT-301 has met primary endpoint indicators in a global multi-center III phase clinical trial, surpassing latanoprost, positioning it as a potential BIC lowering eye pressure drug [2] - OT-703 has been approved for real-world research application in Hainan Boao Lecheng, with patient enrollment completed [2] Group 2: Commercialization and Sales Network - In the first half of 2025, the company achieved revenue of CNY 294 million, a 75.4% year-on-year increase, driven by significant growth in ophthalmic product sales [3] - The company has established coverage across 21,535 hospitals, including 2,799 tertiary hospitals, with a commercial team exceeding 290 members [3] - The company is actively promoting market access for new products, enhancing market share and brand influence [3] Group 3: Manufacturing and Supply Chain - The production system is gradually improving, with local manufacturing capabilities being enhanced [4] - Six products have received production approval, and commercial batch production is progressing smoothly [4] - The local production of the core product has entered the review and public announcement stage, indicating advancements in supply assurance and cost control [4] - The company's "OcuManufacturing" model is being implemented, ensuring supply stability and product quality while enhancing production efficiency and reducing costs [4]

Core Viewpoint - The company maintains its earnings forecast for 2025 and 2026, with an upgraded DCF target price of HKD 10.16, reflecting a 35.5% increase and a 3.4% upside potential from the current stock price [1] Pipeline Development - The company's pipeline is progressing steadily, with key products advancing in clinical and registration phases, including: - OT-1001 (Zhiwei Tai) approved for commercialization by the National Medical Products Administration, featuring dual mechanisms for allergy and inflammation [2] - OT-101 (low-concentration atropine) completing a two-year dosing for all subjects, with Phase III clinical unblinding expected by June 2026 [2] - OT-802 (pilocarpine) receiving approval for Phase III clinical trial application, expected to start in early 2026, potentially filling a market gap in innovative drugs for presbyopia [2] - OT-301 (Gepanoprost) achieving primary endpoint in global multi-center Phase III clinical trials, surpassing Latanoprost, and is a potential BIC lowering eye pressure drug [2] - OT-703 (0.19mg fluocinolone vitreous implant) approved for real-world research application in Hainan Boao Lecheng, with patient enrollment completed [2] Commercialization and Sales Network - The company reported a revenue of CNY 294 million for the first half of 2025, a 75.4% year-on-year increase, driven by significant growth in ophthalmic product sales from the Alcon product portfolio and new product launches [3] - The company has established coverage across 21,535 hospitals, including 2,799 tertiary hospitals, with a commercial team exceeding 290 members, achieving a nationwide commercial network layout [3] - The company is actively promoting market access for new products like Zhiwei Tai to enhance market share and brand influence, creating new growth points for performance [3] Production System Enhancement - The company has received production approvals for six products, with commercial batch production progressing smoothly [4] - The localization of the core product Yushi Ying has entered the review and public announcement stage, indicating breakthroughs in supply assurance and cost control [4] - The company's "Oukang Manufacturing" model, leveraging advanced processes and supply chain management from its Suzhou factory, is expected to enhance supply stability and product quality, while improving production efficiency and reducing costs [4]

Core Viewpoint - The company reported a significant revenue increase in the first half of 2025, driven by strong sales of ophthalmic products, despite a net loss that has narrowed compared to the previous year [1][2]. Financial Performance - Revenue for the first half of 2025 reached 294 million yuan, representing a year-on-year increase of 75.41% [1]. - The net loss for the period was 132 million yuan, a reduction of 12.57% year-on-year, while the adjusted net loss was 108 million yuan, reflecting a year-on-year increase in losses of 7.18% [1]. - Gross margin was reported at 35.93%, a decrease of 23.25 percentage points, primarily due to amortization of product licensing rights and changes in business models [1]. - The net profit margin was -45.00%, an improvement of 45.28 percentage points year-on-year, while the adjusted net profit margin was -36.73%, an improvement of 23.39 percentage points [1]. Product and Market Development - Sales of ophthalmic products generated 285 million yuan, a substantial increase of 89.77%, attributed to the growth of products from partnerships and licensing agreements [2]. - The company has made significant progress in its product pipeline, with several key products receiving regulatory approvals, including OT1001, OT703, and OT802, which are expected to enhance the company's market position [3]. - The company is focused on commercializing its rich pipeline of ophthalmic products, with revenue projections for 2025-2027 estimated at 820 million, 1.192 billion, and 1.556 billion yuan respectively [3].