Simcere Pharmaceutical Group Limited 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負 責，對其準確性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部 或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 先聲藥業集團有限公司 （於香港註冊成立的有限公司） （股份代號：2096） 自願公告 收到與AbbVie就SIM0500海外許可選擇權協議 的近期里程碑付款 本公告由先聲藥業集團有限公司（「本公司」，連同其附屬公司統稱「本集團」）自 願作出，以告知本公司股東及潛在投資者本集團最新業務更新。 –1– 關於SIM0500 SIM0500是一款人源化GPRC5D-BCMA-CD3三特異性抗體，由本集團通過其專有 的T細胞銜接器多特異性抗體技術平臺開發。該分子結合了低親和力而高靶向啟動 的CD3抗體，以及抗G蛋白偶聯受體C家族5組成員D(GPRC5D)和抗B細胞成熟抗 原(BCMA)的兩種抗腫瘤相關抗體。SIM0500通過多種抗腫瘤機制，表現出了針對 MM細胞的強大T細胞毒性效應。 關於本集團 本公司是一家創新與研發驅動的製藥公司，且本集 ...

"这个领域已经证明，中国效率比美国要高。" 现在，潮水已经退去。目前，还在中国开展CDMO业务的跨国企业几乎只有德国的勃林格殷格翰了。 进退之间 2025年，昭衍生物向前一步。 2025年9月份，昭衍生物技术（广州）有限公司开业。它的制造基地位于广州知识城，聚焦于大分子药物的CDMO。这一基地拥有17000平方米的实验室及 生产车间，配备国际领先的模块化生产设施,建有多条200升、500升、2000升一次性原液生产线，及水针、冻干高端制剂线，并具备连续化生产工艺及数 字化控制系统。 "不光是在收缩，是在消失。"澳斯康创始人罗顺近期接受第一财经记者采访时，这样评价跨国CDMO在华业务。 CDMO是指合同研发和生产组织，它是制药产业链分工日益专业化的结果。2020年左右，一大批知名跨国企业如龙沙、赛默飞世尔、默克等都在中国投资 了CDMO业务，并对中国业务寄予厚望。 当时，广州昭衍生物总经理贺涛表示，这一制造基地的投运，标志着昭衍生物"南北协同、中外联动"战略迈出实质性一步。该基地提升昭衍生物在大湾区 的产能供给，更为集团打造辐射东南亚及其他海外地区的生物医药创新协同平台打下基础。 2025年，龙沙（Lonza） ...

据悉，本次合作是先声药业在自身免疫疾病领域的第2个创新药海外授权项目，也是该公司第5个实现对 外技术授权许可的自研创新药早研项目，潜在交易总金额累计已超过46亿美元。 根据协议，勃林格殷格翰获得该项目在大中华区以外的全球权益。先声药业可获得首付款，以及基于开 发、注册和商业里程碑的成功，最高可达10.58亿欧元的付款，此外还可获得大中华区以外净销售额提 成的特许权使用费。 北京商报讯（记者 王寅浩 宋雨盈）1月27日，先声药业宣布，与德国勃林格殷格翰达成一项独家许可与 合作协议，双方将共同开发先声药业自研的TL1A/IL-23p19双特异性抗体SIM0709，用于炎症性肠病的 治疗。 ...

Summary of the Conference Call Records Company Overview - **Company**: Xiansheng Pharmaceutical (先声药业) - **Industry**: Biopharmaceuticals, specifically focusing on innovative drug development for inflammatory bowel disease (IBD) Key Points and Arguments Partnership and Collaboration - On January 27, 2026, Xiansheng Pharmaceutical announced a licensing and collaboration agreement with Boehringer Ingelheim to jointly develop the preclinical dual-specific antibody SIM0709 targeting TL1A and IL-23 for the treatment of IBD [1] - Xiansheng Pharmaceutical will receive an upfront payment of €42 million, with potential milestone payments reaching up to €1.016 billion based on development, registration, and commercial success [1] Product Development and Pipeline - SIM0709 is developed from Xiansheng's multi-antibody technology platform and has shown superior efficacy in both in vitro and in vivo studies compared to the combination of two single drugs [2] - The company has 10 approved innovative drugs and over 60 projects in its R&D pipeline, with expectations to approve 2-3 new innovative drugs annually [2] - Upcoming approvals include Enlitaz (injection of rituximab β) and Xianbixin sublingual tablets in 2024, and Enzeshun (injection of suvezatamab, VEGF) and the insomnia treatment Daliresheng in 2025 [2] Business Development and Market Position - As of January 2026, Xiansheng Pharmaceutical has achieved 5 technology licensing agreements for early-stage self-developed innovative drugs, with a total potential transaction value exceeding $4.6 billion [2] - The company has successfully established its ADC (Antibody-Drug Conjugate) and TCE (T-cell Engager) platforms, with ongoing clinical pipeline advancements and business development collaborations [3] Financial Performance and Shareholder Returns - Xiansheng Pharmaceutical maintains a solid core business with high dividend payouts and shareholder returns, indicating strong R&D contributions and potential for upward elasticity [3] Additional Important Information - Over 3 million people globally are affected by inflammatory bowel disease (IBD), highlighting the significant market potential for SIM0709 and similar treatments [2] - The innovative drug matrix of Xiansheng Pharmaceutical is rich, with multiple blockbuster products expected to be approved in the near future, reinforcing the company's growth trajectory [2]

Core Viewpoint - The announcement of an exclusive licensing agreement between the company and Boehringer Ingelheim for the dual-specific antibody SIM0709 has positively impacted the company's stock price, reflecting investor confidence in its innovative capabilities in the autoimmune research field [1] Group 1: Licensing Agreement Details - The company’s subsidiary, Jiangsu Xiansheng, signed an exclusive licensing agreement with Boehringer Ingelheim on January 26, 2026, granting Boehringer global exclusive rights to SIM0709 outside Greater China [1] - The agreement includes an upfront payment of €42 million and potential milestone payments up to €1.016 billion based on development progress, regulatory approvals, and commercialization [1] - The company will also receive tiered royalties on net sales outside Greater China [1] Group 2: Product Information - SIM0709 is a long-acting humanized dual-specific antibody developed by the company’s proprietary multi-specific antibody platform [1] - The antibody targets TL1A and IL-23, which are key pathways involved in the onset and progression of inflammatory bowel disease [1] - Preclinical studies have shown that SIM0709 exhibits superior synergistic effects compared to the combination of two single agents in both in vitro and in vivo experiments [1]

Core Viewpoint - The collaboration between Xiansheng Pharmaceutical and Boehringer Ingelheim aims to develop the dual-specific antibody SIM0709 for the treatment of inflammatory bowel disease, with potential milestone payments reaching up to €1.058 billion [1][2] Group 1: Collaboration Details - Xiansheng Pharmaceutical has entered into an exclusive licensing and collaboration agreement with Boehringer Ingelheim for the development of SIM0709 [1] - Boehringer Ingelheim will obtain global rights outside Greater China, while Xiansheng Pharmaceutical will receive an upfront payment and milestone payments based on development, registration, and commercialization [1] - The total potential transaction amount for this collaboration could exceed €1.058 billion, along with royalties from net sales outside Greater China [1][2] Group 2: Product Information - SIM0709 is a long-acting humanized dual-specific antibody developed on Xiansheng Pharmaceutical's multi-antibody technology platform, targeting TNF-like cytokine 1A and IL-23 to block key pathways in inflammatory bowel disease [1] - Existing data shows that SIM0709 has demonstrated excellent synergistic effects in both in vitro primary cell experiments and in vivo animal studies [1] Group 3: Company Strategy and Financials - This collaboration marks Xiansheng Pharmaceutical's second overseas licensing project for an innovative drug in the field of autoimmune diseases and the fifth self-developed innovative drug to achieve external technology licensing [2] - The cumulative potential transaction amount from these licensing agreements has exceeded $4.6 billion [2] - Xiansheng Pharmaceutical has significantly increased its R&D investment, totaling approximately ¥9 billion over the past five years, with the proportion of revenue from innovative drugs rising from 45% in 2020 to 77% in the first half of 2025 [2]

Core Viewpoint - The announcement by the company regarding the exclusive licensing agreement with Boehringer Ingelheim for the dual-specific antibody SIM0709, which targets inflammatory bowel disease, highlights a significant strategic partnership aimed at global development and commercialization opportunities [1] Group 1: Licensing Agreement Details - The agreement grants Boehringer Ingelheim exclusive rights to SIM0709 outside of the Greater China region [1] - The company is entitled to receive an upfront payment of €42 million, with potential milestone payments reaching up to €1.016 billion based on development progress, regulatory approvals, and commercialization [1] - Additionally, the company will receive tiered royalties on net sales outside of Greater China [1] Group 2: Product Development and Market Potential - SIM0709 is developed using the company's multi-antibody technology platform and is considered to have "first-in-class" potential in the treatment of inflammatory bowel disease [1] - The partnership is the company's second overseas licensing project for innovative drugs in the autoimmune disease sector and the fifth self-developed innovative drug project to achieve external technology licensing [1] - The total potential transaction value for the company has exceeded $4.6 billion to date [1] Group 3: R&D Investment and Revenue Growth - The company has been increasing its R&D investment, with the proportion of revenue from innovative drugs rising from 45% in 2020 to 77% by the first half of 2025 [1]

Core Viewpoint - The collaboration between Xiansheng Pharmaceutical and Boehringer Ingelheim aims to develop the dual-specific antibody SIM0709 for the treatment of inflammatory bowel disease, highlighting the potential for innovative therapies in this area [1] Group 1: Partnership Details - Xiansheng Pharmaceutical has entered into an exclusive licensing and collaboration agreement with Boehringer Ingelheim for the development of SIM0709 [1] - Boehringer Ingelheim will acquire global rights outside Greater China for the project [1] - Xiansheng Pharmaceutical will receive an upfront payment and milestone payments that could total up to €1.058 billion, along with royalties on net sales outside Greater China [1] Group 2: Product Development - SIM0709 is developed using Xiansheng Pharmaceutical's multi-antibody technology platform and is considered to have "first-in-class" potential in the treatment of inflammatory bowel disease [1] - The collaboration is expected to leverage Boehringer Ingelheim's extensive experience in global immunotherapy to establish a solid foundation for the global development of SIM0709 [1]

Core Insights - The collaboration between Sihuan Pharmaceutical and Boehringer Ingelheim aims to develop the dual-specific antibody SIM0709 for the treatment of inflammatory bowel disease (IBD) [2][3] - The agreement grants Boehringer Ingelheim global rights outside Greater China, with Sihuan Pharmaceutical receiving an upfront payment of €42 million and potential milestone payments up to €1.016 billion [2][4] - The partnership is expected to leverage Sihuan's innovative research capabilities and Boehringer Ingelheim's global development and commercialization strengths to accelerate the development of this innovative therapy [3][4] Company Developments - SIM0709 is developed from Sihuan's multi-antibody technology platform and targets two key pathways involved in IBD, showing superior efficacy in preclinical studies compared to existing therapies [3] - This collaboration marks Sihuan's second overseas licensing project in the autoimmune disease sector and the fifth self-developed innovative drug to be licensed out, with total potential transaction amounts exceeding $4.6 billion [4] - Sihuan has significantly increased its R&D investment, totaling approximately 9 billion RMB over the past five years, with the proportion of revenue from innovative drugs rising from 45% in 2020 to 77% in the first half of 2025 [4] Market Context - Over 3 million people globally are affected by IBD, highlighting a significant unmet clinical need in this therapeutic area [2] - The collaboration is positioned to redefine effective treatment methods and improve the quality of life for patients suffering from IBD [2][3]

截至2026年1月，先声药业集团共实现5项自研创新药早研项目对外技术授权许可，潜在交易总金额超46 亿美元。 1月27日，先声药业(02096.HK)与勃林格殷格翰宣布达成一项许可与合作协议，双方将共同开发先声药 业的临床前阶段TL1A/IL23p19双特异性抗体SIM0709，用于炎症性肠病的治疗。 根据协议，勃林格殷格翰获得该项目在大中华区以外的全球权益。先声药业可获得首付款，以及基于开 发、注册和商业里程碑的成功，最高可达10.58亿欧元的付款，此外还可获得大中华区以外净销售额提 成的特许权使用费。 ...