Core Viewpoint - WuXi AppTec's revenue for the first half of 2025 was 106.3 million yuan, with sales of its CAR-T drug, Regiokyuran, amounting to 81 million yuan, which is lower than the sales figures from the same period in 2024 and 2023 [1][2]. Group 1: Company Performance - WuXi AppTec's CAR-T drug sales of 81 million yuan in the first half of 2025 were below the 86.8 million yuan in 2024 and 87.7 million yuan in 2023 [2]. - Legend Biotech reported a global sales figure of 439 million USD (approximately 3.1 billion yuan) for its CAR-T drug in Q2 2025, with total sales for the first half reaching 808 million USD (approximately 5.7 billion yuan), marking a year-on-year growth of 100% [4]. - Legend Biotech's CAR-T product, Carvykti, achieved sales of 4.39 billion yuan in Q2 2025, outperforming major competitors [18]. Group 2: Market Dynamics - The Chinese CAR-T market has seven approved products, with Legend Biotech's sales being significantly higher than its competitors, indicating a strong market presence [3]. - The high cost of CAR-T treatments remains a barrier to market penetration in China, with most patients unable to afford the treatment priced over one million yuan [29]. - The lack of a mature commercialization path for CAR-T products in China is a common challenge faced by companies in this sector [7]. Group 3: Regulatory and Insurance Landscape - Companies are attempting to improve payment capabilities for CAR-T treatments in China, with some products undergoing dual-line applications for basic medical insurance and commercial insurance [31]. - WuXi AppTec's Regiokyuran is priced at 1.29 million yuan, making it one of the most expensive CAR-T products in the market [28]. - The ongoing efforts to include CAR-T products in insurance coverage highlight the industry's struggle to balance pricing and accessibility for patients [30][34]. Group 4: Future Outlook - Legend Biotech's CEO anticipates the company will achieve profitability by 2026, indicating a positive outlook for future financial performance [20]. - The industry is exploring innovative production methods to reduce costs, with WuXi AppTec beginning to source key raw materials from domestic suppliers [35]. - The emergence of in-body CAR-T cell preparation technology may offer new avenues for cost reduction and accessibility in the future [36][37].

Core Viewpoint - The CAR-T therapy market in China is facing challenges with high costs and limited market penetration, but there is potential for price reductions and increased insurance coverage in the future [2][16]. Group 1: Company Performance - WuXi AppTec reported a revenue of 106.3 million yuan in the first half of 2025, with sales of its CAR-T drug, Regiokyron, amounting to 81 million yuan [2]. - Legend Biotech's CAR-T drug achieved global sales of 439 million USD (approximately 3.1 billion yuan) in Q2 2025, with total sales for the first half reaching 808 million USD (approximately 5.7 billion yuan), marking a year-on-year growth of 100% [3][10]. - CStone Pharmaceuticals reported a revenue of approximately 51 million yuan in the first half of 2025, a year-on-year increase of about 703.8%, primarily driven by CAR-T products [6]. Group 2: Market Challenges - Legend Biotech has reportedly canceled its sales and marketing team in China, focusing instead on more profitable overseas markets due to underwhelming domestic sales [4]. - The high cost of CAR-T treatments remains a significant barrier to market penetration, with prices exceeding 1 million yuan per treatment, making it unaffordable for most patients in China [15][16]. - The lack of a clear commercial path for CAR-T products in China is a common challenge faced by companies in this sector [4]. Group 3: Pricing and Insurance - The pricing of CAR-T products varies, with WuXi AppTec's Regiokyron priced at 1.29 million yuan, while the lowest-priced product, CStone's Nakiokyron, is priced at 999,000 yuan [8][15]. - Efforts are being made to improve insurance coverage for CAR-T therapies, with several companies submitting applications for inclusion in basic medical insurance and commercial insurance directories [16]. - The development of commercial insurance in China is seen as a key factor in enhancing payment capabilities for CAR-T treatments, which could lead to price reductions in the next five years [16][17]. Group 4: Technological Innovations - Recent advancements in CAR-T technology, such as in vivo production methods, are gaining attention and may offer solutions to the high costs associated with traditional CAR-T therapies [18]. - The production cost of CAR-T therapies is significant, with estimates indicating that the material cost for each treatment is around 43,000 USD, highlighting the need for cost-effective production methods [17][18].

Summary of WuXi AppTec's Conference Call Company Overview - **Company**: WuXi AppTec (药明巨诺) - **Industry**: Biotechnology and Pharmaceuticals Key Financial Highlights - Total revenue for the first half of 2025 reached **1.06 billion RMB**, a **22.5%** increase year-on-year, primarily driven by sales of Benodda and technology licensing income from Juno [2][15] - Gross profit amounted to **651.1 million RMB**, reflecting a **48.9%** year-on-year growth, with Benodda's gross margin at **51.1%** [2][15] - Significant reduction in operating expenses: - Sales expenses decreased by **23.2%** to **58.5 million RMB** - General and administrative expenses fell by **45.7%** to **32.19 million RMB** - R&D expenses dropped by **39.1%** to **92 million RMB** [3][15] - Cash and cash equivalents stood at **647 million RMB**, with a net cash outflow of **110 million RMB** [4][15] Product Development and Commercialization - **Benodda**: - Sales revenue for the first half of 2025 was approximately **81 million RMB**, with inclusion in **90 commercial insurance** and **104 public health insurance** plans, enhancing patient affordability [2][6][17] - New drug application for Benodda for the treatment of relapsed or refractory large B-cell lymphoma has been submitted, with approval expected by mid-2026 [2][5][10] - Clinical trial data shows an objective response rate of **81.3%** and complete response rate of **54.2%** [10] - **SLE (Systemic Lupus Erythematosus)**: - Phase I clinical study initiated, with early data indicating significant efficacy and safety [3][11][21] - Plans to present data at the American College of Rheumatology (ACR) conference in October 2025 [21] - **Maja Four TCRT Project**: - Collaboration with Regeneron, currently in dose escalation phase [5][13] - **JW CAR 201**: - Self-developed CD19/CD20 dual-target CAR-T product has entered the IIT phase, with promising initial safety data [3][8][14] Strategic Partnerships and Licensing - A technology licensing agreement with BMS subsidiary Juno was signed, valued at nearly **10 million USD**, enhancing cash reserves and recognizing the company's technical capabilities [2][7][30] Future Plans and Challenges - Plans to complete the domestic production of viral vectors by mid-2026 to further reduce costs [2][18] - Focus on expanding indications for Benodda and exploring partnerships in the silver marker field while maintaining a cautious approach [25][18] - The company aims to optimize production costs, with current costs for Benodda reduced from **780,000 RMB** to **500,000 RMB** per quarter [3][18][31] - Anticipates challenges in commercialization, particularly in the CAR-T therapy sector, but is building a robust commercialization team [16][17] Market Position and Outlook - The company is optimistic about the future of cell therapy and aims to leverage its early research layout to capitalize on market opportunities [20][22] - Plans to explore financing options in the medium to long term, with a focus on maintaining strong cash management [26][27] Additional Insights - The dual-target approach of CD19/CD20 is expected to enhance tumor-killing efficiency and reduce relapse rates, although it may come with increased adverse event rates [19] - The company is actively engaging with regulatory bodies to ensure compliance and safety in clinical trial designs [28] This summary encapsulates the key points from the conference call, highlighting the financial performance, product development, strategic partnerships, and future outlook of WuXi AppTec.

Group 1 - The Hong Kong biotechnology stocks experienced a collective decline, with notable drops in several companies [1] - WuXi AppTec (02126) saw a decrease of 12.95%, closing at 4.840 [2] - BioNTech (06952) fell by 12.53%, with a latest price of 13.750 [2] Group 2 - Other companies such as Valiant (09887) and Beihai Kangcheng (01228) also reported significant declines of 9.93% and 9.75% respectively [2] - The decline extended to companies like Saint Noble (02257) and MIRXES (02629), which dropped by 9.64% and 8.43% [2] - Overall, the biotechnology sector is facing downward pressure, impacting multiple firms [1]

Group 1 - Hong Kong biopharmaceutical stocks weakened again in the afternoon on August 28, with WuXi AppTec and Bionet falling over 12% [1] - The decline in these stocks indicates a potential trend in the biopharmaceutical sector within the Hong Kong market [1] - The performance of these companies may reflect broader market sentiments and investor confidence in the biopharmaceutical industry [1]

Core Viewpoint - WuXi AppTec's revenue for the six months ending June 30, 2025, reached RMB 106.3 million, representing a year-on-year increase of 22.5% driven by sales of its commercialized product, Benauda®, and a non-exclusive license granted to Juno for JW sLVV production technology and related patents [1] Financial Performance - Revenue for the period was RMB 106.3 million, up 22.5% year-on-year [1] - Gross profit increased by 48.9% to RMB 65.1 million, primarily due to incremental contributions from the sLVV licensing [1] - The gross margin from product sales improved from 50.4% for the six months ending June 30, 2024, to 51.1% for the current period [1] Operational Efficiency - The company is focused on enhancing production operational efficiency, exploring new technologies for process improvement, and implementing cost reduction plans [1]

Core Viewpoint - WuXi AppTec's subsidiary, WuXi Biologics, reported significant growth in its mid-term performance, highlighting advancements in its cell immunotherapy products and operational efficiency [1][2] Group 1: Financial Performance - The company reported revenue of 106 million RMB for the six months ending June 30, 2025, representing a year-on-year increase of 22.5% [1] - Gross profit reached 65.12 million RMB, showing a year-on-year increase of 48.86% [1] - Research and development expenses amounted to 92.04 million RMB [1] Group 2: Product Development and Regulatory Progress - The leading product, Benauda, continues to make progress in commercialization, with successful patient enrollment for a clinical trial in second-line treatment for relapsed or refractory large B-cell lymphoma (LBCL) [2] - The National Medical Products Administration granted Benauda "Breakthrough Therapy Designation" in January 2025, and a supplemental new drug application (sNDA) was submitted in May 2025 [2] - The company has developed its own platform technology and successfully produced lentiviral vectors for Benauda manufacturing, reducing product costs while achieving comparable results to existing lentiviral vectors [2]

Group 1 - The company reported a revenue of 106 million RMB for the six months ending June 30, 2025, representing a year-on-year increase of 22.5% [1] - Gross profit reached 65.12 million RMB, showing a year-on-year increase of 48.86% [1] - Research and development expenses amounted to 92.04 million RMB, indicating a focus on innovation and product development [1] Group 2 - The leading product, Benaoda®, has made continuous progress in commercialization [2] - The company completed patient enrollment for a clinical trial of Benaoda® as a second-line treatment for relapsed or refractory large B-cell lymphoma (LBCL) patients [2] - The National Medical Products Administration granted Benaoda® "Breakthrough Therapy Designation" in January 2025, and a supplemental new drug application (sNDA) was submitted in May 2025 [2] - The company developed its own platform technology and successfully produced lentiviral vectors for Benaoda®, reducing product costs [2] - Clinical studies have shown comparable results to existing lentiviral vectors, and patient enrollment for the investigational new drug application (IND) has been completed [2] - Significant progress has been made in developing innovative products with global commercialization potential [2]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不就因本公告全部或任何部分內容而產生或 因倚賴該等內容而引致的任何損失承擔任何責任。 JW (Cayman) Therapeutics Co. Ltd 藥明巨諾（開曼）有限公司* （於開曼群島註冊成立的有限公司） （股份代號：2126） 截至2025年6月30日止六個月之中期業績公告 及 上市所得款項淨額用途變更 藥明巨諾（開曼）有限公司（「本公司」）之董事（「董事」）會（「董事會」）欣然公佈 本公司及其附屬公司（統稱「本集團」或「我們」）截至2025年6月30日止六個月（「報 告期間」）之未經審核簡明綜合中期業績，連同2024年相應期間之比較數字。該 等中期業績已由本公司審核委員會（「審核委員會」）及核數師德勤 • 關黃陳方 會計師行審閱。 中期業績摘要 國際財務報告準則計量： – 1 – ‧ 收入於截至2025年6月30日止六個月為人民幣106.3百萬元，較截至2024年 6月30日止六個月的人民幣86.8百萬元增加22.5%。該收入來自(i)我們目 前處於商業化的產品倍諾達®的銷售 ...

Group 1 - The biotechnology sector in the Hong Kong stock market experienced a significant decline, with several companies reporting substantial drops in their stock prices [1] - Notable declines include Clover Biopharmaceuticals, which fell by 14.13%, and Beigene, which dropped by 8.33% [2] - Other companies such as Innovent Biologics and WuXi Biologics also saw declines exceeding 5%, indicating a broader trend of negative performance in the sector [1][2] Group 2 - The following companies reported specific percentage declines: Clover Biopharmaceuticals (-14.13%), Beigene (-8.33%), and Innovent Biologics (-6.50%) [2] - Additional companies with notable declines include Kintor Pharmaceutical (-6.38%), CanSino Biologics (-5.98%), and Zai Lab (-5.50%) [2] - The overall trend suggests a challenging environment for biotechnology stocks in the Hong Kong market [1]