Core Insights - WuXi Biologics reported a 16.1% year-on-year revenue growth in the first half of 2025, reaching 9.95 billion yuan, with net profit attributable to shareholders increasing by 56.1% to 2.34 billion yuan [1] - Adjusted net profit grew by 6.2% year-on-year to 2.39 billion yuan, aligning with expectations, while the overall gross margin improved by 3.7 percentage points to 42.7% [1] Revenue Breakdown - IND pre-service revenue surged by 35.2% year-on-year to 4.15 billion yuan in the first half of 2025 [2] - Early-stage project revenue declined by 29.7% due to large projects transitioning to later development stages, while Phase III and commercial project revenue increased by 24.9% [2] - Revenue from the U.S. grew by 20.1%, accounting for 60.5% of total revenue, while Europe and China saw revenue growth of 5.7% and a decline of 8.5%, respectively [2] Project Pipeline - The company added 86 new projects in the first half of 2025, with over half coming from the U.S. and an improved contribution from China [3] - The total project count reached 864, including 67 Phase III projects and 24 commercial projects, indicating potential for future revenue growth [3] - Adjusted net profit forecasts for 2025 and 2026 were revised down to 4.90 billion yuan and 5.50 billion yuan, respectively, with a new forecast for 2027 set at 6.34 billion yuan [3]

Core Viewpoint - WuXi AppTec (02268.HK) announced a share placement at HKD 58.85 per share, aiming to raise approximately HKD 13.11 billion, with 90% of the proceeds intended for expanding service capacity and production [1][2] Group 1: Share Placement Details - The share placement involves a maximum of 22.28 million shares, with a discount of about 4.00% compared to the last trading day's closing price of HKD 61.3 per share, but a premium of approximately 2.87% over the average closing price of the previous five trading days [1][2] - The controlling shareholder, WuXi Biologics (02269.HK), subscribed to 24.134 million shares, amounting to approximately HKD 14.20 billion [1] Group 2: Company Performance and Market Position - WuXi AppTec's stock price has doubled since the first trading day of the year, reaching a historical high of HKD 61.3 per share [2][3] - The company reported revenue and net profit of CNY 2.701 billion and CNY 746 million for the first half of the year, representing year-on-year growth of 62.2% and 52.7%, respectively, driven by the active bioconjugate drug market [3] - The company has a backlog of unfulfilled orders amounting to USD 1.329 billion, a year-on-year increase of 57.9% [3] Group 3: Industry Outlook - The global ADC (Antibody-Drug Conjugate) market is projected to grow at a compound annual growth rate (CAGR) of 34% from 2020 to 2024 and 31% from 2024 to 2030, potentially reaching USD 66.2 billion by 2032 [5] - The outsourcing rate for ADC production is expected to be around 60%, significantly higher than the 34% for biopharmaceuticals, indicating a strong demand for WuXi AppTec's services [5]

Core Viewpoint - WuXi AppTec (02268) has announced a share placement agreement to raise approximately HKD 1.3 billion, primarily aimed at expanding its service capacity and production capabilities in bioconjugates and active pharmaceutical ingredients [1] Group 1: Share Placement Details - The company has signed a placement agreement with underwriters to fully underwrite up to 22.77 million shares at a price of HKD 58.85 per share, expecting net proceeds of about HKD 1.3 billion [1] - Approximately 90% of the raised funds will be allocated to enhance the group's service capacity and production capabilities, particularly in bioconjugates, active pharmaceutical ingredients, and clinical and commercial production [1] - The remaining 10% of the funds will be used for working capital and general corporate purposes [1] Group 2: Subscription Agreement - WuXi AppTec has also entered into a subscription agreement with its controlling shareholder, WuXi Biologics (02269), to issue 24.134 million subscription shares at the same price of HKD 58.85 per share, with net proceeds expected to be around HKD 1.4 billion [1] - Similar to the placement, about 90% of the subscription proceeds will be directed towards further expanding the group's service capacity and production capabilities, including bioconjugates and active pharmaceutical ingredients [1] - The remaining 10% will be allocated for the group's working capital needs and general corporate purposes [1]

Core Viewpoint - WuXi AppTec (02268) has announced a share placement agreement to raise approximately HKD 1.3 billion, primarily aimed at expanding its service capacity and production capabilities in bioconjugates and APIs [1] Group 1: Share Placement Details - The company signed a placement agreement to fully underwrite up to 22.77 million shares at a price of HKD 58.85 per share [1] - The expected net proceeds from this placement are approximately HKD 1.3 billion, with about 90% allocated for expanding service capacity and production, particularly in bioconjugates, APIs, and commercial production [1] - The remaining 10% of the funds will be used for working capital and general corporate purposes [1] Group 2: Subscription Agreement - WuXi AppTec has also entered into a subscription agreement with its controlling shareholder, WuXi Biologics (02269), to issue 24.134 million subscription shares at the same price of HKD 58.85 per share [1] - The net proceeds from this subscription are expected to be around HKD 1.4 billion, with a similar allocation of approximately 90% for expanding service capacity and production [1] - The remaining 10% will also be directed towards working capital needs and general corporate purposes [1]

Core Viewpoint - WuXi AppTec (02268.HK) has entered into a subscription agreement with WuXi Biologics (02269.HK) to issue and allocate 24.134 million shares at a subscription price of HKD 58.85 per share, raising approximately HKD 14.20 billion [1] Group 1 - The subscription price of HKD 58.85 represents a discount of about 4.00% compared to the last closing price of HKD 61.30 [1] - The total expected proceeds from the subscription are approximately HKD 14.20 billion, equivalent to about USD 1.82 billion [1] - The net proceeds from the subscription are expected to be around HKD 14.14 billion, or approximately USD 1.81 billion, with a net price per share of about HKD 58.61 [1] Group 2 - Approximately 90% of the net proceeds will be used to further expand the group's service capabilities and production capacity, including but not limited to clinical and commercial production capacity for antibody-drug conjugates, active pharmaceutical ingredients, and drugs [1] - About 10% of the net proceeds will be allocated for the group's working capital needs and general corporate purposes [1]

Core Viewpoint - WuXi AppTec (02268) has entered into a subscription agreement with its controlling shareholder WuXi Biologics (02269) to issue 24.134 million subscription shares at a price of HKD 58.85 per share, raising approximately HKD 1.42 billion [1] Group 1 - The net proceeds from the subscription are approximately HKD 1.414 billion [1] - About 90% of the proceeds will be used to further expand the group's service capabilities and production capacity, including but not limited to clinical and commercial production capacity for bioconjugated drugs, active pharmaceutical ingredients, and pharmaceuticals [1] - Approximately 10% of the proceeds will be allocated for the group's working capital needs and general corporate purposes [1] Group 2 - The subscriber is the controlling shareholder of the company, thus classified as a related party under the listing rules [1]

Core Viewpoint - WuXi AppTec (02268) announced a subscription agreement with WuXi Biologics (02269) to issue 24.134 million subscription shares at a price of HKD 58.85 per share, totaling approximately HKD 1.42 billion [1] Group 1 - The net proceeds from the subscription are approximately HKD 1.414 billion, with about 90% allocated for expanding the group's service capabilities and production capacity, including clinical and commercial production of bioconjugates, active pharmaceutical ingredients, and drugs [1] - Approximately 10% of the proceeds will be used for the group's working capital needs and general corporate purposes [1] - The subscriber is the controlling shareholder of the company, qualifying as a related party under the listing rules [1]

Investment Rating - The report maintains a "Buy" rating for Wuxi Biologics [5][17][28] Core Insights - Wuxi Biologics reported a revenue of Rmb 9.95 billion for the first half of 2025, representing a year-on-year growth of 16.1%, and a net profit of Rmb 2.34 billion, which is a 56.1% increase year-on-year [8][14] - The adjusted net profit reached Rmb 2.39 billion, reflecting a 6.2% year-on-year growth, aligning with expectations [8][14] - The blended gross margin increased by 3.7 percentage points to 42.7%, while the adjusted net profit margin rose by 1.2 percentage points to 45.6% [8][14] Revenue Breakdown - Pre-IND service revenue grew by 35.2% year-on-year to Rmb 4.15 billion in the first half of 2025 [9][15] - Revenue from early-phase projects (Phase I & II) declined by 29.7% year-on-year, primarily due to large projects moving to later stages [9][15] - Revenue from Phase III and commercial projects increased by 24.9% year-on-year [9][15] - Revenue from the US market grew by 20.1%, accounting for 60.5% of total revenue, while revenue from Europe and China increased by 5.7% and decreased by 8.5%, respectively [9][15] Order Backlog - The total backlog reached US$ 20.4 billion, a 1.2% year-on-year increase, including a service backlog of US$ 11.4 billion (down 13% year-on-year) and potential milestone fees backlog of US$ 9.0 billion (up 27% year-on-year) [9][15] - The backlog within three years increased by 16% year-on-year to US$ 4.2 billion, representing 21% of the total backlog [9][15] Project Pipeline - The number of new projects added in the first half of 2025 was 86, with over 50% from the US [10][16] - The total number of integrated projects reached 864, including 67 Phase III and 24 commercial projects, indicating potential future revenue growth [10][16] Financial Forecasts - Adjusted net profit forecasts for 2025 and 2026 have been revised down to Rmb 4.90 billion and Rmb 5.50 billion, respectively, with a new forecast of Rmb 6.34 billion for 2027 [10][17] - Revenue projections for 2025, 2026, and 2027 are Rmb 21.38 billion, Rmb 24.64 billion, and Rmb 28.57 billion, respectively, with year-on-year growth rates of 14.49%, 15.23%, and 15.95% [12][19]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因倚賴該等內容而引致的任何損失承擔任何責任。 茲提述(1)藥明合聯招股章程；及(2)本公司日期為二零二四年三月三十一日的 公告，內容有關（其中包括）日期為二零二三年十一月三日的二零二三年連接 子及有效載荷主服務協議，就連接子及有效載荷向藥明合聯集團提供研發及 製造服務，並向藥明合聯集團供應其ADC CRDMO服務使用的相關中間產品。 在行業快速擴張的推動下，市場對本集團ADC CRDMO服務的需求持續大幅 增長。預計對藥明合聯集團服務的需求將進一步增長，因其業務於二零二五 年繼續呈上升態勢。考慮到藥明合聯的強勁表現及藥明合聯集團於截至二零 二五年六月三十日止六個月的最近期未經審核簡明綜合中期業績，預計二零 二三年連接子及有效載荷主服務協議的交易金額於二零二五年將超過其原 定年度上限，因此，建議就二零二三年連接子及有效載荷主服務協議採納經 修訂年度上限。此外，由於二零二三年連接子及有效載荷主服務協議將於二 零二五年十二月三十一日到期，藥明合聯建議訂立 ...

Core Viewpoint - The innovative drug sector is experiencing strong performance due to favorable policies and positive earnings reports, with significant gains in Hong Kong-listed innovative drug stocks [1][2]. Policy Aspects - The National Healthcare Security Administration has introduced a "newly listed drug initial pricing mechanism" to encourage drug research and innovation, marking the first public announcement of this mechanism since last year's consultation [1]. - The mechanism aims to ensure that high-level innovative drugs can achieve returns that correspond to their high investment and risk during the initial listing period [1]. Performance Aspects - In the first half of this year, among 80 listed companies in the innovative drug sector, 34 companies reported year-on-year growth in net profit attributable to shareholders, excluding companies that turned losses into profits or reduced losses [2]. - For instance, Heng Rui Medicine achieved revenue of 15.76 billion yuan, a year-on-year increase of 15.88%, and a net profit of 4.45 billion yuan, up 29.67% [2]. - In the medical device sector, United Imaging Healthcare reported revenue of 6.02 billion yuan, a 12.79% increase, and a net profit of 998 million yuan, up 5.03% [2]. - The continuous optimization of the medical insurance catalog adjustment mechanism by the government has stimulated companies' enthusiasm for innovation, as they see increased chances of their products entering insurance and commercial insurance catalogs [2].