Group 1 - The stock price of药捷安康 (02617.HK) increased by 42.82% [1] - 创胜集团-B (02268.HK) saw a rise of 8.15% [1] - 映恩科技-B (09606.HK) experienced a growth of 6.18% [1] - 荣昌生物 (09995.HK) rose by 5.59% [1]

Summary of the Conference Call for Yinglun Biotech Company Overview - **Company**: Yinglun Biotech - **Current Valuation**: Approximately 25 billion HKD, considered to be at a low level, presenting investment value [2][3] Industry and Market Dynamics - **Industry**: Biopharmaceuticals, focusing on ADC (Antibody-Drug Conjugates) development - **Market Potential**: Significant market opportunities in various cancer treatments, particularly for HER2 ADC, B7H3 ADC, and HER3 ADC [7][8][9] Key Pipeline Projects 1. **B7H3 ADC** - Potential in small cell lung cancer and CRPC (Castration-Resistant Prostate Cancer) - Data presented at ESMO and ASCO indicates BIC (Best-in-Class) potential, with a projected peak sales exceeding 1 billion USD [8] 2. **HER2 ADC** - Rapid progress in indications for endometrial cancer and HR-positive HER2-negative breast cancer - Phase II clinical trial results expected to be disclosed in the second half of this year, with potential FDA submission - Estimated annual new cases around 10,000, with treatment costs between 200,000 to 300,000 USD, leading to a potential market size of 1 billion USD [7] 3. **HER3 ADC** - Superior design compared to competitors, showing promising data in mutated non-small cell lung cancer - Potential breakthroughs in breast cancer treatment, with significant market potential [9][10] Collaborations and Clinical Trials - Collaborations with GSK, BeiGene, and Avanza to advance multiple ADC projects - Anticipated data readouts within the next 12 to 18 months, which could enhance valuation and licensing opportunities [4][15] Clinical Data and Future Prospects - **Clinical Data Release**: Yinglun Biotech is positioned to release multiple clinical data sets in the coming months, which could significantly impact its valuation [6][16] - **Early Assets**: Includes BDCA2 ADC for SLE, with preliminary safety data expected by late 2025 [13][14] Investor Sentiment and Stock Liquidity - Recent share unlock increased liquidity from 0.13 billion shares to 0.88 billion shares - Majority of long-term investors are expected to hold their positions, indicating confidence in the company's future [3][16] Conclusion - Yinglun Biotech is viewed as a quality investment opportunity with a reasonable valuation and significant upcoming clinical data that could drive future growth and market presence [16]

Market Performance - The pharmaceutical and biotechnology index declined by 1.66% from October 6 to October 10, underperforming the Shanghai Composite Index by 0.72 percentage points, marking three consecutive weeks of underperformance [1] - The innovative drug sector (BK1106) also fell by 1.09% during the same period, continuing its three-week downward trend [1] IPO Trends - A surge in IPO applications from innovative drug companies has been observed in Hong Kong, with notable companies like Betta Pharmaceuticals, Changchun High-tech, Baillie Gifford, and Borui Pharmaceuticals expected to achieve "A+H" listings [2] - The influx of A-share companies listing in Hong Kong is attributed to multiple factors, including policy support and improved market liquidity [2] - The Hong Kong Stock Exchange has relaxed public shareholding restrictions for "A+H" companies, which has created opportunities for A-share companies to list in Hong Kong [2] Clinical Trials - From October 6 to October 10, the National Medical Products Administration (NMPA) disclosed 85 clinical trial registration information, with 29 of these being new registrations for innovative drugs in Phase II or above [3] - Following the National Day and Mid-Autumn Festival holidays, the innovative drug sector experienced a significant downturn, with the Hong Kong innovative drug index dropping sharply [3] Business Development (BD) Trends - BD transactions have been a highlight for domestic innovative drugs this year, with total transaction amounts reaching $60.8 billion in the first half of the year, exceeding the total for the entire year of 2024 by $3.7 billion [3] - The market has shown a tendency for stock prices to decline following BD transactions, attributed to market expectations being overly optimistic [3] - The upcoming European Society for Medical Oncology (ESMO) annual meeting in Berlin will feature 23 research projects from China, indicating ongoing innovation in the sector [3] New Drug Approvals - The first IL-36R monoclonal antibody, HB0034, developed by Huazhong Tai Biological, has been submitted for market approval to treat adult generalized pustular psoriasis (GPP) [4] - GPP is a rare and potentially life-threatening skin disease, and currently, only one drug has been approved globally for its treatment [4] Industry Insights - The innovative drug sector is experiencing a return to a bubble-like state, with significant fluctuations in stock prices driven by BD news [4] - The founder of InnoCare Pharma expressed optimism about the industry's future, envisioning a time when Chinese companies will be recognized for their contributions to global health rather than just for their pipeline sales [4]

Core Insights - The innovative drug sector in Hong Kong has experienced significant volatility, with the Hang Seng Healthcare Index dropping 6.33% in a week, marking the largest weekly decline since the second half of 2025 [4][10] - The recent surge in IPOs for innovative drug companies in Hong Kong is attributed to favorable policies and improved market liquidity, with notable companies like Betta Pharmaceuticals and Changchun High-tech expected to achieve "A+H" listings [5][6] - The first domestic IL-36R monoclonal antibody has been submitted for approval to treat adult generalized pustular psoriasis, indicating advancements in innovative drug development [12][13] Market Performance - The pharmaceutical and biotechnology index fell by 1.66% from October 6 to October 10, underperforming the Shanghai Composite Index by 0.72 percentage points, continuing a trend of underperformance for three consecutive weeks [4] - The innovative drug index saw a decline of 1.09% over the same period, with the Hong Kong innovative drug ETF dropping 3.98% [4] IPO Trends - A notable increase in IPO activity for innovative drug companies has been observed, with a focus on various cutting-edge fields such as small molecule drugs and antibody-drug conjugates [5] - The Hong Kong Stock Exchange has relaxed public shareholding requirements for "A+H" companies, facilitating more A-share companies to list in Hong Kong [5] Clinical Trials - Recent data indicates that 85 clinical trial registrations were disclosed by the National Medical Products Administration, with 29 of these being innovative drugs in Phase II or higher, primarily targeting autoimmune diseases and tumors [6] Business Development (BD) Insights - The recent downturn in the innovative drug sector is linked to a cooling off of high-profile business development transactions, with market expectations having been previously overstated [10][11] - The total transaction amount for related deals in the first half of the year reached $60.8 billion, reflecting a 129% year-on-year increase [10] Future Outlook - The upcoming European Society for Medical Oncology (ESMO) annual meeting is expected to showcase 23 studies from China, highlighting the potential for innovative drugs to gain international recognition [11] - The market is advised to focus on clinical data and competitive landscapes as the sector transitions from high BD activity to a more fundamental-driven approach [11]

Core Insights - The stock price of InnoCare Pharma (映恩生物) reached a historical high of HKD 563.50 per share after being included in the Hang Seng Composite Index and successful Phase III clinical trial results for its core product DB-1303, but has since dropped to HKD 305 per share [2] - The Hong Kong innovative drug index surged from 666.91 to 1660.66 in the first nine months of the year, indicating a potential return to a bubble era for Chinese innovative drugs [2] - The founder and CEO, Zhu Zhongyuan, believes that industry development is akin to wine fermentation, where bubbles are a natural occurrence, and emphasizes that business development (BD) is a means to an end, not the goal [2][11] Company Overview - InnoCare Pharma, known as the "first ADC stock in China," has emerged as a strong player in the ADC (antibody-drug conjugate) sector, with 10 ADC clinical-stage pipelines [3] - The company went public on the Hong Kong Stock Exchange after a significant increase in stock price on its first day, raising the largest financing amount in the Hong Kong biotech sector [3] - The company’s lead product, DB-1303, has shown significant advantages over the established T-DM1 drug in clinical trials, and it is approaching the stage of market application [3][4] Clinical Development - DB-1303 is being developed for endometrial cancer, a condition with limited treatment options, and has received breakthrough therapy designation from both the FDA and CDE [3][4] - Another core product, DB-1311, targets B7-H3 and has entered global I/IIa clinical trials, with the company aiming to catch up with competitors in the ADC space [5][6] - InnoCare Pharma has initiated clinical trials in 20 countries, with over 2,700 patients enrolled, positioning itself among the leaders in the domestic biotech sector [6] Strategic Vision - Zhu Zhongyuan envisions a future where Chinese ADC companies will be globally recognized, focusing on the impact of their drugs on patient lives rather than merely on pipeline sales [7][12] - The company has established a "flywheel model" to leverage its experience in ADC development, aiming for partnerships with multinational pharmaceutical companies to secure funding and expand its network [8][9] - InnoCare Pharma has successfully completed multiple BD transactions with notable partners, including BioNTech and GSK, which has positioned it as a leading player in the domestic biotech landscape [9][10] Market Dynamics - The innovative drug market in Hong Kong has seen significant investment from multinational companies, with over 52.5% of global BD transactions related to Chinese innovative drugs as of August 2023 [10] - The stock price fluctuations in the biotech sector are influenced by market sentiment towards BD activities, with a notable correlation between overseas market rights and stock performance [11] - Despite current losses, the company is optimistic about its future, projecting significant milestone payments from existing BD agreements over the next two years [11][13]

Group 1: Hong Kong Stocks - MicroPort Scientific Corporation-B (02252) rose over 3% as it announced that its commercialization process has accelerated, with overseas orders exceeding 60 units [1] - COSCO Shipping Energy Transportation Co., Ltd. (01138) increased over 3% following new sanctions announced by the U.S. OFAC against companies related to Iranian oil exports [1] - InnoCare Pharma-B (09606) gained over 3% as the company is expected to submit its first ADC for listing within the year [1] - Zijin Mining Group International (02259) rose over 4% after completing the acquisition of the Raygorodok gold mine project in Kazakhstan [1] - Hong Kong Travel International (00308) surged over 8% after announcing a proposal for the physical distribution of its tourism real estate business, which is expected to reduce the drag from non-core assets [1] - Kingsoft Corporation (03888) increased over 10% following the Chinese Ministry of Commerce's announcement of export controls on certain overseas rare earth-related items containing Chinese components [1] Group 2: Solar and Insurance Stocks - Solar stocks collectively declined, with Flat Glass Group Co., Ltd. (06865) down over 8%, Xinyi Solar Holdings Limited (00968) down over 7%, and Xinyi Glass Holdings Limited (00868) down over 6%, as the market focuses on capacity clearing and future installation demand [2] - Domestic insurance stocks fell across the board, with New China Life Insurance Co., Ltd. (01336) down over 5%, China Pacific Insurance (Group) Co., Ltd. (02328) down over 3%, and China Life Insurance Company Limited (02628) down nearly 4%, following Tianan Insurance's announcement of a 5.3 billion yuan debt default [2] Group 3: U.S. Stocks - Beike (BEKE.US) fell 3.87% as a report indicated that the sales of the top 100 real estate companies in September increased month-on-month, driven by seasonal factors and policy relaxations [3] - Stellantis (STLA.US) dropped 7.37% after preliminary third-quarter sales data showed a 13% year-on-year increase in global deliveries to 1.3 million units [3] - Intel (INTC.US) decreased 3.78% after revealing details about its new Core Ultra series processors [3] - Venture Global (VG.US) plummeted 24.88% after losing a legal dispute related to LNG cargo sales with BP [4] - Nokia (NOK.US) rose 2.70% after announcing a technology asset licensing agreement with HPE to enhance its AI wireless access network capabilities [4]

Core Viewpoint - The ADC market in China is expected to exceed 100 billion RMB in the next five years, positioning it as the second-largest ADC market globally, driven by advancements in technology from Chinese companies like Innovent Biologics-B [1][1][1] Company Summary - Innovent Biologics-B's stock rose over 5% during trading, currently at 308.4 HKD with a trading volume of 104 million HKD [1][1][1] - The company's DB-1419 (B7-H3/PD-L1 dual antibody ADC) has shown excellent efficacy in clinical trials for solid tumors, indicating a significant technological breakthrough in the dual antibody ADC field [1][1][1] - Innovent plans to submit applications for DB-1303 (HER2 ADC) for endometrial cancer in the U.S. and for breast cancer in China by 2025 [1][1][1] - The DB-1311 (B7-H3 ADC) shows potential as a best-in-class treatment for prostate cancer, while DB-1310 (HER3 ADC) is expected to follow suit [1][1][1] - The company is leading global advancements in the exploration of combination therapies involving DB-1305 (TROP2 ADC) and dual antibodies [1][1][1] Industry Summary - According to Frost & Sullivan, the global ADC market was approximately 10.4 billion USD in 2023 and is projected to reach 115.1 billion USD by 2032 [1][1][1] - The ADC market in China is anticipated to grow significantly, reflecting the increasing investment and innovation in the biopharmaceutical sector [1][1][1]

Core Viewpoint - The ADC market in China is expected to exceed 100 billion RMB in the next five years, positioning it as the second-largest ADC market globally, driven by advancements in technology from Chinese companies like Innovent Biologics-B [1] Company Summary - Innovent Biologics-B (09606) saw its stock price increase by over 5%, currently trading at 308.4 HKD with a transaction volume of 104 million HKD [1] - The company's DB-1419 (B7-H3/PD-L1 dual antibody ADC) has shown excellent efficacy in clinical trials for solid tumors, indicating a significant technological breakthrough in the dual antibody ADC field [1] - Innovent plans to submit a market application for DB-1303 (HER2 ADC) for endometrial cancer in the U.S. and for breast cancer in China by 2025 [1] - The company’s DB-1311 (B7-H3 ADC) shows potential as a best-in-class treatment for prostate cancer, while DB-1310 (HER3 ADC) is expected to follow suit [1] - Innovent is leading global exploration in the combination of DB-1305 (TROP2 ADC) and dual antibodies, pushing the frontiers of next-generation ADCs [1] Industry Summary - According to a report by Frost & Sullivan, the global ADC market was valued at approximately 10.4 billion USD in 2023 and is projected to reach 115.1 billion USD by 2032 [1] - The ADC market in China is anticipated to grow significantly, reflecting the increasing investment and innovation in the biopharmaceutical sector [1]

Summary of Duality Bio Conference Call Company Overview - **Company**: Duality Biotherapeutics Inc - **Industry**: Biotechnology - **Focus**: Development of antibody-drug conjugates (ADCs) for cancer and autoimmune diseases Key Takeaways Strategic Partnerships - Duality Bio has formed a strategic partnership with BioNTech (BNT) to enhance global development capabilities. Duality retains rights for ADC programs in China while granting ex-China rights to BNT, which covers development costs outside China. This structure allows Duality to co-fund 50% of U.S. development for the B7-H3 ADC, providing significant upside potential [2][6][11]. Product Pipeline and Development - The B7-H3 ADC is positioned as a cornerstone asset, demonstrating strong safety at 6mg and efficacy across various tumor types, including non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), and hormone-sensitive prostate cancer (HSPC). The program is exploring both monotherapy and combination therapy opportunities with immuno-oncology (IO) agents [3][21][22]. - Duality is also advancing Trop-2 ADC for first-line combination settings, focusing on indications with unmet needs and sufficient safety margins [3][4]. Innovative Technologies - The company is pioneering bispecific ADCs (BsADCs) that integrate tumor-targeting and immune activation. Early clinical data indicate strong biomarker-driven activity at higher doses compared to competitors, suggesting potential for best-in-class differentiation [4][24]. - Additional innovations include the BDCA2 ADC for autoimmune indications and next-generation steroid payloads, with multiple data disclosures expected by year-end [4][30]. Clinical Trials and Execution - Duality is actively running multiple global pivotal trials, including HER2 ADC programs in breast and endometrial cancers. China-only studies have shown positive results, with global Phase 3 readouts pending [5][29]. - The company aims to close the gap with front-runners in ADC therapeutics by leveraging strategic alliances and focusing on execution [5][28]. Financial Projections - For FY 2024A, Duality projects revenues of approximately $1.94 billion, with net losses expected to reach $1.05 billion. EPS is projected at -11.90 [6]. - The price target for Duality is set at HK$500, representing a 46% upside from the current price of HK$343.40 [7][14]. Risks and Considerations - Key risks include the development of drug candidates, dependence on third parties, manufacturing and commercialization challenges, and regulatory hurdles [34]. - The company is also focused on integrating environmental, social, and governance (ESG) considerations into its strategic planning [18][19]. Future Directions - Duality is exploring the integration of cancer vaccines into its pivotal designs and is open to triplet combinations involving IO, ADC, and vaccines [27]. - The company is prioritizing indication differentiation and advancing novel targets and payload technologies beyond traditional therapies [11][34]. Conclusion Duality Bio is well-positioned in the biotechnology sector with a robust pipeline of ADCs and strategic partnerships that enhance its development capabilities. The focus on innovative technologies and combination therapies, along with a clear financial outlook, presents a compelling investment opportunity despite inherent risks in drug development and market competition.

第 1 頁 共 10 頁 v 1.1.1 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 | 截至月份: | 2025年9月30日 | | | | | 狀態: | 新提交 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 致：香港交易及結算所有限公司 | | | | | | | | | | 公司名稱: | 映恩生物 (「本公司」) | | | | | | | | | 呈交日期: | 2025年10月8日 | | | | | | | | | I. 法定/註冊股本變動 | | | | | | | | | | 1. 股份分類 | 普通股 | 股份類別 | 不適用 | | 於香港聯交所上市 (註1) | | 是 | | | 證券代號 (如上市) | 09606 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 200,000,000 | USD | | 0.0001 USD | | 20,000 | 增加 / 減少 ...