Core Viewpoint - The company, Ying'en Biotechnology (09606.HK), experienced a significant opening on its first trading day, with a rise of 91.33%, reaching a price of 181 HKD [1] Company Summary - Ying'en Biotechnology's stock opened at a high, indicating strong investor interest and market confidence in the company's potential [1]

Group 1: New Listings and Filings - Five companies submitted applications for listing on the Hong Kong Stock Exchange from April 7 to April 13, 2023 [2] - Hantian Technology (Xiamen) Co., Ltd. is a global leader in the silicon carbide (SiC) epitaxy industry, with a projected market share exceeding 30% in 2024 [2] - IFBH Limited, a rapidly growing beverage and food company based in Thailand, has a market share of approximately 34% in the coconut water market in mainland China for 2024 [3] - Jihong Co., Ltd. focuses on cross-border social e-commerce and packaging solutions, ranking second in the B2C export e-commerce sector in China with a market share of 1.3% [3] - Jiangxi Biological Products Research Institute is the largest provider of human tetanus antitoxin in China, with a market share of 65.8% in 2024 [4] Group 2: Financial Performance - Hantian Technology's projected revenues for 2022, 2023, and 2024 are approximately RMB 441 million, RMB 1.143 billion, and RMB 974 million, respectively [2] - IFBH Limited's revenues for 2023 and 2024 are expected to be approximately RMB 87.44 million and about USD 158 million, with net profits of RMB 16.75 million and USD 33.32 million [3] - Jihong Co., Ltd. anticipates revenues of approximately RMB 5.376 billion, RMB 6.695 billion, and RMB 5.529 billion for 2022, 2023, and 2024, respectively [3] - Jiangxi Biological's projected revenues for 2022, 2023, and 2024 are approximately RMB 142 million, RMB 198 million, and RMB 221 million, respectively [4] - Ming Kee Hospital Group, the largest private hospital group in East China, expects revenues of approximately RMB 2.336 billion, RMB 2.688 billion, and RMB 2.659 billion for 2022, 2023, and 2024 [5] Group 3: Upcoming IPOs - Zhengli New Energy plans to offer 121.5 million H-shares at an IPO price of HKD 8.27, with net proceeds of HKD 928 million [5] - Ying'en Biotechnology-B is set to offer 15.0716 million shares with a price range of HKD 94.6 to HKD 103.2, expected to start trading on April 15, 2025 [6]

Core Viewpoint - The successful IPO of InnoCare Pharma (映恩生物) marks the largest scale IPO in the Hong Kong 18A biotech sector since 2022, raising a total of $211 million, significantly exceeding initial plans, indicating strong market confidence in its innovation capabilities [1] Group 1: IPO Details - The IPO achieved a threefold increase in valuation, making it the project with the largest valuation increase among Hong Kong 18A biotech companies that raised over $50 million [1] - The international placement was oversubscribed by 14.9 times, the highest subscription multiple for 18A biotech since 2022 [1] - The company attracted 15 top international long-term funds and leading domestic public funds, with cornerstone investors agreeing to subscribe for a total of $65 million (approximately HKD 505 million) under certain conditions [1] Group 2: Company Overview - InnoCare Pharma, operational since 2020, is a global leader in the field of antibody-drug conjugates (ADC), conducting seven global clinical trials across 230 clinical trial centers in 17 countries, enrolling over 2,000 patients, with 50% of patients from overseas [2] - The company has two core products in development: DB-1303/BNT323 targeting HER2 cancers and DB-1311/BNT324 targeting B7-H3 cancers [2] Group 3: Regulatory Approvals and Collaborations - Five clinical-stage assets have received Investigational New Drug (IND) approvals from the FDA and the National Medical Products Administration of China [3] - The company's innovative ADC assets have attracted leading global biopharmaceutical companies, establishing several global partnerships with a total transaction value exceeding $6 billion [3] - The "platform technology output + global clinical collaboration" model accelerates the R&D process and reduces financial pressure, generating approximately $500 million in upfront revenue as of the end of 2024 [3] Group 4: Financial Performance and Market Recognition - The company is expected to achieve revenues of approximately RMB 1.787 billion and RMB 1.941 billion for 2023 and 2024, respectively, benefiting from the international expansion of ADCs [3] - The successful issuance of shares signifies international capital's recognition of the global capabilities of Chinese innovative pharmaceutical companies, providing a new path for 18A companies to break through valuation bottlenecks [4] - As the ADC sector continues to heat up, leading companies with platform technology and clinical differentiation advantages are likely to see further value reassessment [4]

Investment Rating - The investment rating for the company is set at ★★★☆☆ [5] Core Insights - The company is a key leader in the global antibody-drug conjugate (ADC) field, focusing on developing innovative ADC drugs for cancer and autoimmune diseases [1] - The company has established four global innovative ADC technology platforms, with the DITAC platform showing a broad therapeutic window, potentially improving efficacy and safety in clinical settings [2] - The ADC market has shown significant growth, expanding from USD 2 billion in 2018 to USD 10.4 billion in 2023, with a projected compound annual growth rate (CAGR) of 38.6% [4] Summary by Sections Company Overview - The company has two core products: DB-1303/BNT323, targeting HER2 for cancers like endometrial and breast cancer, and DB-1311/BNT324, targeting B7-H3 for cancers such as small cell lung cancer and prostate cancer [1] Technology Platforms - The DITAC platform targets topoisomerase, an enzyme crucial for DNA replication and transcription, indicating potential for treating various solid tumors by inducing DNA damage in cancer cells [2] Clinical Trials and Partnerships - The company is conducting seven global multi-regional clinical trials across 230 clinical trial centers in 17 countries, with over 2,000 patients enrolled [3] - Strategic partnerships have been established with leading biopharmaceutical companies, including BioNTech and GSK, with a total transaction value exceeding USD 6 billion [3] Market Potential - The ADC market is expected to continue strong growth, with projections of reaching USD 115.1 billion by 2032, driven by increasing exploration in non-oncological indications [4] Financial Data - For the fiscal year ending December 31, 2023, the company reported other income of RMB 1.787 billion and a shareholder loss of RMB 358 million, with projections for 2024 showing an increase in other income to RMB 1.941 billion and a deeper loss of RMB 1.050 billion [5]