Financial Performance Highlights - Revenue reached RMB 41,067 million, a year-on-year decrease of 080%[5] - R&D expense was RMB 3,644 million, a year-on-year decrease of 1615%[6] - Net profit attributable to shareholders was RMB 2,770 million, a year-on-year increase of 1608%[7] - Net operating cash flow reached RMB 4,470 million, a year-on-year increase of 3113%[6] Key Products and R&D - Serplulimab Injection (PD-1) achieved revenue of RMB 1,313 million in 2024[68, 130] - Pharma R&D expenditure was RMB 4,910 million, accounting for 1698% of Pharma revenue[63, 67] - Axicabtagene Ciloleucel Injection has benefited over 800 patients since approval in 2021[43, 75, 132] Global Operations and Internationalization - Revenue from countries and regions outside Chinese mainland reached RMB 11,297 million, a year-on-year increase of 893%[30] - Sisram's direct sales revenue increased to 87%[36, 100] Medical Devices - Sisram Medical's revenue was USD 3590 million in 2024[99] - 58 Da Vinci Surgical Systems were installed in China in 2024[108] Sinopharm Performance - Pharmaceutical distribution segment revenue recorded RMB 444,365 million, a year-on-year increase of 075%[121] - Medical device distribution segment revenue recorded RMB 117,915 million, a year-on-year decrease of 944%[121] - Retail pharmacy segment revenue recorded RMB 35,981 million, a year-on-year increase of 082%[121]

Financial Performance - Revenue reached RMB 9,420 million, a decrease of 726% year-over-year[6] - R&D expense was RMB 737 million, down 1110% year-over-year[7] - Net profit attributable to shareholders was RMB 765 million, an increase of 2542% year-over-year[8] - Net operating cash flow increased to RMB 1,056 million, up 1508% year-over-year[7] - 2024 Pharma R&D expenditure was RMB 4,910 million, accounting for 1698% of Pharma revenue[61] Key Products & Pipelines Progress - Serplulimab Injection (PD-1) received EMA approval for ES-SCLC treatment[12] - Tenapanor Hydrochloride Tablets approved by NMPA for serum phosphorus control in adult dialysis patients with chronic kidney disease[13] - Fosun Pharma achieved a revenue of RMB 11,297 million (+893% YoY) from countries and regions outside Chinese mainland in 2024[26] Med Tech Segment - Med Tech segment revenue reached RMB 4,390 million[87] - Sisram Medical's revenue was USD 3590 million in 2024[96] Healthcare Services - Healthcare Services segment revenue was RMB 6,672 million[108] Sinopharm Performance - Pharmaceutical distribution segment revenue recorded RMB 444,365 million (+075% YoY)[116] - Medical device distribution segment revenue recorded RMB 117,915 million (-944% YoY)[116] - Revenue of the retail pharmacy segment recorded RMB 35,981 million (+082% YoY)[116]

Core Viewpoint - Fosun Pharma's subsidiary, Fuhong Hanlin, has signed a licensing agreement with FBD to collaborate on the development, production, and commercialization of the investigational drug HCB101, a SIRPα-Fc fusion protein for cancer treatment [1][2]. Group 1: Licensing Agreement Details - Fuhong Hanlin will pay up to $59 million to FBD and up to $143 million in milestone payments based on annual net sales of the licensed product in specific regions [1]. - The agreement includes royalty payments based on a one to two-digit percentage of annual net sales of the licensed product, with potential reductions under certain conditions [1]. - The agreement allows Fuhong Hanlin to terminate the contract if FBD reaches major financial terms with third parties regarding the licensed product [1]. Group 2: Product Information - HCB101 is a SIRPα-Fc fusion protein that enhances macrophage phagocytosis of tumor cells by binding with high affinity to CD47 [2]. - The HCB101 injection has shown preliminary efficacy in early clinical trials for tumor patients, including those with solid tumors, and is currently in the Ib/IIa clinical trial phase in China [2]. Group 3: Company Background - FBD, established in 2021 and based in Hong Kong, is a subsidiary of Hanchor Bio Inc., which focuses on new drug development in the field of cancer immunotherapy [3]. - As of December 31, 2024, Hanchor Bio Inc. reported total assets of approximately NT$5.42 billion, equity of about NT$2.31 billion, and total liabilities of around NT$3.11 billion, with a net loss of approximately NT$1.354 billion and no operating revenue for 2024 [3]. - The collaboration aims to leverage both companies' strengths in drug development and commercialization to enhance Fosun Pharma's product pipeline in oncology and provide more treatment options for patients [3].

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦不 發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚賴該等內容而引致的任何損 失承擔任何責任。 上 海 復 星 醫 藥（ 集 團 ）股 份 有 限 公 司 Shanghai Fosun Pharmaceutical (Group) Co., Ltd.* （於中華人民共和國註冊成立的股份有限公司） （股份代號：02196） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條而作出。 茲載列上海復星醫藥（集團）股份有限公司（「本公司」）在上海證券交易所網站刊登的《關於 控股子公司簽署許可協議的公告》，僅供參閱。 承董事會命 上海復星醫藥（集團）股份有限公司 董事長 陳玉卿 中國，上海 2025 年6 月3 0 日 於本公告日期，本公司之執行董事為陳玉卿先生、關曉暉女士、文德鏞先生及王可心先生；本公司之非執行 董事為陳啟宇先生、潘東輝先生及吳以芳先生；本公司之獨立非執行董事為余梓山先生、王全弟先生、Chen Penghui先生及楊玉成先生；以及本公司之職工董事為嚴佳女士。 * ...

上海复星医药（集团）股份有限公司 关于控股子公司签署许可协议的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 证券代码：600196 股票简称：复星医药 编号：临 2025-110 重要内容提示 ●协议类型：合作开发、生产及商业化许可等 ●协议内容：复宏汉霖与 FBD 将就 FBD 在研的（1）分子 HCB101（即 SIRPα-Fc 融合蛋白）、及（2）任何含有该分子作为其活性成分的药物于约定许可区域及领域 内（即用于人类疾病治疗）的开发、生产及商业化开展合作。 ●特别风险提示： 1、许可产品于许可区域的临床开发、注册、生产（如有）、商业化等还须得到 相关监管机构（包括但不限于国家药监局等）的批准。根据国内外药品研发经验， 药品研发是项长期工作，需要经过临床前研究、临床试验、注册等诸多环节，具有 不确定性。因此，许可产品于许可区域能否完成相关临床试验、以及能否获得上市 批准，均存在不确定性。 2、许可产品上市后的销售情况可能受到（包括但不限于）用药需求、市场竞争、 销售渠道等因素影响，存在不确定性。 一、本次合作概述 ...

Core Viewpoint - Fosun Pharma's subsidiary, Fuhong Hanlin, has signed a licensing agreement with FBD to collaborate on the development, production, and commercialization of the SIRPα-Fc fusion protein (HCB101) and related drugs in specified regions and fields [1] Group 1: Licensing Agreement Details - The agreement involves Fosun Pharma's subsidiary paying up to $59 million to FBD [1] - Additionally, Fosun Pharma will pay up to $143 million in commercial milestone payments based on the annual net sales of the licensed product in Region 1 [1] Group 2: Market Considerations - The sales performance of the licensed product may be influenced by factors such as drug demand, market competition, and sales channels, indicating potential uncertainties [1]

FF305 翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) | 表格類別： | 股票 狀態： 新提交 | | --- | --- | | 公司名稱： | 上海復星醫藥(集團)股份有限公司 Shanghai Fosun Pharmaceutical (Group) Co., Ltd. (於中華人民共和國註冊成立的股份有限公司) | | 呈交日期： | 2025年6月30日 | 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 A | | 於香港聯交所上市 | 否 | | | 證券代號 (如上市) | | 說明 | | | | | | A. 已發行股份或庫存股份變動 | | ...

翌日披露報表 (股份發行人 ── 已發行股份或庫存股份變動、股份購回及/或在場内出售庫存股份) | 表格類別： | 股票 狀態： 新提交 | | --- | --- | | 公司名稱： | 上海復星醫藥(集團)股份有限公司 Shanghai Fosun Pharmaceutical (Group) Co., Ltd. (於中華人民共和國註冊成立的股份有限公司) | | 呈交日期： | 2025年6月30日 | 如上市發行人的已發行股份或庫存股份出現變動而須根據《香港聯合交易所有限公司（「香港聯交所」）證券上市規則》(「《主板上市規則》」)第13.25A條 / 《香港聯合交易所有限公司GEM證券 上市規則》(「《GEM上市規則》」)第17.27A條作出披露，必須填妥第一章節 。 | 第一章節 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | | 1. 股份分類 | 普通股 | 股份類別 A | | 於香港聯交所上市 | 否 | | | 證券代號 (如上市) | | 說明 | | | | | | A. 已發行股份或庫存股份變動 | | | | | ...

Group 1 - The core stock price of Fosun Pharma (600196) closed at 24.74 RMB on June 27, 2025, with a slight increase of 0.37% and a trading volume of 99,200 shares, resulting in a total transaction amount of 246 million RMB [1] - On June 27, 2025, the capital flow for Fosun Pharma showed a net inflow of 3.72 million RMB from institutional investors, accounting for 1.51% of the total transaction amount, while retail investors experienced a net outflow of 9.23 million RMB, representing 3.76% of the total transaction amount [2][4] - The company announced the repurchase of 810,300 H-shares at a price of 24.68 RMB per share on June 26, 2025, with a total expenditure of approximately 19.998 million RMB [3][4] Group 2 - As of June 19, 2025, Fosun Pharma had 2,100,531,773 shares issued (excluding treasury shares) and 17,957,052 treasury shares [3] - After the repurchase, the number of issued shares (excluding treasury shares) decreased to 2,099,721,473, while the total number of issued shares remained unchanged at 2,118,488,825 [3]

Core Viewpoint - Shanghai Fosun Pharmaceutical (Group) Co., Ltd. plans to adopt an equity incentive program for its subsidiary, WuXi Biologics, which includes a stock option plan and a restricted stock unit plan aimed at attracting and retaining skilled personnel [2][7][30]. Group 1: Overview of the Equity Incentive Plan - The equity incentive plan consists of two independent programs: (1) a stock option plan and (2) a restricted stock unit plan [2][7]. - The total number of stock options and restricted stock units to be granted under these plans will not exceed 8% of WuXi Biologics' total shares (excluding treasury shares) as of the adoption date [3][8]. - As of the announcement date, WuXi Biologics has a total of 543,494,853 shares, with the group holding 63.43% of the shares [3][28]. Group 2: Initial Grant Details - The initial grant will involve issuing a total of 6.985 million stock options and 6.985 million restricted stock units to 279 qualified individuals, with an exercise price of HKD 50.25 per share for stock options and a vesting price of RMB 1 per restricted stock unit [3][24][25]. - The initial grant is subject to approval by WuXi Biologics' shareholders and will not constitute a related party transaction [4][10][27]. Group 3: Purpose and Conditions of the Plan - The purpose of the equity incentive plan is to attract, motivate, and retain skilled personnel, recognizing their contributions and encouraging them to enhance the value of WuXi Biologics [11][30]. - The plan's effectiveness requires approval from WuXi Biologics' shareholders and compliance with the Hong Kong Stock Exchange's listing rules [13][32]. Group 4: Financial Overview of WuXi Biologics - WuXi Biologics, established in February 2010 and listed on the Hong Kong Stock Exchange in September 2019, focuses on the research, production, and sales of monoclonal antibody drugs [28]. - As of December 31, 2024, WuXi Biologics reported total assets of RMB 1,059.75 million, total liabilities of RMB 758.39 million, and a net profit of RMB 82.05 million [29].