关于重组抗人 IL-17A/F 人源化单克隆抗体 健康元药业集团 IL-17A/F 人源化单克隆抗体注射液Ⅲ期临床试验达到主要研究终点的提示性公告 证券代码：600380 证券简称：健康元 公告编号：临 2025-054 健康元药业集团股份有限公司 注射液Ⅲ期临床试验达到主要研究终点的提示性公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 健康元药业集团股份有限公司（以下简称：本公司）控股子公司丽珠医药集 团股份有限公司（以下简称：丽珠集团）控股附属公司珠海市丽珠单抗生物技术 有限公司（以下简称：丽珠单抗）与北京鑫康合生物医药科技有限公司联合开发 的"重组抗人 IL-17A/F 人源化单克隆抗体注射液"（以下简称：LZM012 或本品） 的Ⅲ期临床试验达到主要研究终点。现将有关详情公告如下： 一、药品基本情况 药品名称：重组抗人 IL-17A/F 人源化单克隆抗体注射液 英文名/拉丁名：Recombinant anti-human IL-17A/F Humanized Monoclonal Antibody Injecti ...

健康元（600380）公告，控股子公司丽珠集团（000513）控股附属公司珠海市丽珠单抗生物技术有限公 司与北京鑫康合生物医药科技有限公司联合开发的"重组抗人IL-17A/F人源化单克隆抗体注射 液"(LZM012)的Ⅲ期临床试验达到主要研究终点。该临床试验是一项在中重度斑块型银屑病患者中开展 的多中心、随机、双盲、阳性对照(司库奇尤单抗)的临床试验，主要疗效终点为第12周时达到银屑病面 积与严重程度指数(PASI)100的受试者比例。结果显示，LZM012的第12周PASI100应答率为49.5%，对 照组司库奇尤单抗为40.2%，显示出LZM012非劣效于司库奇尤单抗且优效于司库奇尤单抗。第4周 PASI75应答率，LZM012为65.7%，对照组司库奇尤单抗为50.3%，显示出LZM012起效速度更快；第52 周PASI100应答率，LZM012320mg Q4W和320mg Q8W维持治疗组分别为75.9%和62.6%，显示银屑病患 者可持续提升获益。安全性方面，本品整体安全性良好，常见不良事件发生率与对照组各类不良事件发 生率相当。丽珠集团近期已就LZM012治疗成人中重度斑块状银屑病适应症，向国家 ...

近期，港股创新药板块再掀涨停潮。三叶草生物-B四天暴涨65%，中生制药、石药集团等传统药企纷纷 走强，市场情绪陡然升温。上证创新药指数自4月以来涨幅已超过50%，成为年内最强主题之一。在这 样一片火热中，健康元和旗下丽珠医药的股价涨幅却仅约20%，显得"异常冷静"。但冷静的背后，或许 正孕育一场价值重估的暗涌。 在资本竞逐传统大赛道之际，健康元选择了一条看似"冷门"的吸入制剂之路，却悄然搭建起一个潜力巨 大的呼吸版图。这种"不凑热闹"的坚持，正在随着全球巨头的举动被重新认知。 默沙东收购激起千层浪，健康元踩对"呼吸节奏" 6月，默沙东以100亿美元收购呼吸药企Verona Pharma，成为全球医药圈最轰动的事件。这家标的公司 的核心产品Ohtuvayre?，是20年来首个用于COPD（慢性阻塞性肺病）的新机制疗法——PDE3/4双靶点 吸入抑制剂。收购消息一出，吸入制剂这一相对冷门的领域被瞬间拉入主流视野，投资者也开始将目光 投向那些早已布局此赛道的企业。 健康元便是其中的佼佼者。早在默沙东收购消息之前，公司就已构建出全球领先的吸入制剂矩阵。旗下 PDE4吸入制剂聚焦轻中度COPD患者，旨在精准抑制肺部炎症 ...

Market Overview - A-shares maintained a narrow fluctuation on July 16, with the Shanghai Composite Index closing at 3503.78 points, down 0.03% [1] - The Shenzhen Component Index and the ChiNext Index both fell by 0.22% to 10720.81 points and 2230.19 points, respectively [1] - The total trading volume in the Shanghai and Shenzhen markets was 146.19 billion yuan, a decrease of over 170 billion yuan from the previous day [1] Sector Performance - Financial stocks collectively declined, while the steel, non-ferrous metals, and coal sectors showed weakness [1] - The automotive supply chain stocks surged, with companies like Rongtai Co., Fuda Co., and Zhejiang Rongtai hitting the daily limit [1] - The innovative drug concept saw significant activity, with stocks like Guosheng Tang and Iwu Biotech rising approximately 16% [5][6] - The humanoid robot concept remained hot, with companies like Shangwei New Materials achieving a six-day limit increase [2][4] Notable Company Movements - Huadian New Energy, which debuted on the Shanghai main board, closed up 125.8%, reaching a market value of over 300 billion yuan at one point [1] - Weiyali, a Hong Kong-based electronic component distributor, saw its stock surge by 288% upon resuming trading, with an intraday increase exceeding 900% [1] Humanoid Robot Sector Insights - The humanoid robot industry is in its early stages, with significant growth expected in the next 3 to 5 years across various applications [4] - The current phase is described as the "dawn" of humanoid robot industrialization, with mass production and large-scale application becoming feasible [4] - Cost reduction is crucial for the widespread adoption of humanoid robots, and companies that master core component technologies are recommended for investment [4] Innovative Drug Sector Insights - The innovative drug sector experienced strong gains, with several companies hitting the daily limit [5][6] - The recent launch of the 11th batch of national drug centralized procurement is expected to impact the market, focusing on mature "old drugs" rather than innovative drugs [7] - The introduction of measures to support the high-quality development of innovative drugs indicates a growing role for commercial insurance in the healthcare system [7] Pet Economy Sector Insights - The pet economy concept gained traction, with companies like Weike Technology rising over 10% [8] - The pet food sector is viewed as a growing market with significant long-term growth potential, particularly for domestic brands [8]

A股创新药板块午后再度异动，万邦德、哈三联午后封板，丽珠集团、健康元、金石亚药跟涨。 ...

这几只票暗盘资金正在偷偷流入，立即查看>> 创新药板块持续活跃，万邦德（002082）、哈三联（002900）午后封板，丽珠集团（000513）、健康元 （600380）、金石亚药（300434）跟涨。 ...

Core Viewpoint - The acquisition of Verona Pharma by Merck for $10 billion highlights the significant value in the respiratory field, while Health元 has already established a comprehensive strategic layout that surpasses Verona in several key innovative directions [1][15][17]. Group 1: COPD Market Insights - COPD, known as the "silent killer," ranks among the top three causes of death globally [2]. - The disease is characterized by its slow progression and limited treatment options, leading to persistent symptoms in nearly half of the patients [3][5]. - Traditional treatments have not effectively controlled symptoms, necessitating a shift in focus towards chronic local inflammation rather than solely bronchial dilation [6][4]. Group 2: Health元's Strategic Innovations - Health元 is pursuing three innovative solutions for COPD: 1. An inhaled PDE4 inhibitor, aligning with Verona's approach to enhance safety and anti-inflammatory effects [7]. 2. A globally unique oral PREP inhibitor, which is currently in Phase II clinical trials [9][10]. 3. A new generation of inhaled corticosteroids (ICS) that optimizes structure and delivery to address traditional issues of efficacy and side effects [11][12]. - This multi-faceted strategy positions Health元 as a leader in the COPD innovation matrix, combining global uniqueness, cutting-edge mechanisms, and deep innovation in traditional areas [13][14]. Group 3: Market Positioning and Future Outlook - Health元's strategic foresight in recognizing the respiratory market as a future growth area has led to a robust pipeline of 12 drugs targeting various pathways, including TSLP, IL-4, PREP, PDE4, and β inhibitors [14]. - The recent acquisition by Merck signals a clear market trend towards respiratory innovation, particularly products that combine PDE mechanisms, inhalation delivery, and anti-inflammatory capabilities [15]. - Health元's proactive approach has transitioned it from a follower to a leader in the respiratory sector, positioning it well for future opportunities [16][17].

Core Points - The company announced a cash dividend of 0.20 RMB per share for its A shares, totaling approximately 365.89 million RMB to be distributed to shareholders [1][2] - The dividend distribution plan was approved at the annual general meeting held on June 6, 2025 [1] - Key dates for the dividend distribution include the record date on July 17, 2025, and the ex-dividend date on July 18, 2025 [1][2] Dividend Distribution Details - The total number of shares for the dividend calculation is 1,829,453,386 [2] - The cash dividend will be distributed through China Securities Depository and Clearing Corporation Limited, Shanghai Branch, to shareholders registered by the record date [2] - Shareholders who have not completed designated transactions will have their dividends held by the clearing company until the transactions are completed [2] Taxation Information - For individual shareholders and securities investment funds, no personal income tax will be withheld at the time of dividend distribution [3] - The tax implications vary based on the holding period of the shares, with different tax rates applicable [3] - For qualified foreign institutional investors (QFII), a 10% withholding tax will be applied, resulting in a net dividend of 0.18 RMB per share [5][6] - Hong Kong investors through the Stock Connect will also face a 10% withholding tax, with similar provisions for tax treaty benefits [6][7] - Other institutional investors will not have taxes withheld by the company, and they are responsible for their own tax obligations [8]

●相关日期 | 股份类别 | 股权登记日 | 最后交易日 | 除权（息）日 | 现金红利发放日 | | --- | --- | --- | --- | --- | | Ａ股 | 2025/7/17 | － | 2025/7/18 | 2025/7/18 | 健康元药业集团股份有限公司2024年年度权益分派实施公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者 重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： ●每股分配比例 A 股每股现金红利0.20元 健康元药业集团 2024 年年度权益分派实施公告 证券代码：600380 证券简称：健康元 公告编号：临 2025-053 ●差异化分红送转： 否 一、通过分配方案的股东大会届次和日期 本次利润分配方案经健康元药业集团股份有限公司（以下简称：本公司）2025 年 6 月 6 日的2024年年度股东大会审议通过。 二、分配方案 3、分配方案： 本次利润分配以方案实施前的公司总股本1,829,453,386股为基数，每股派发现金 红利0.20元（含税），共计派发现金红利365,890,677.20元。 三、相关日 ...

Policy Developments - The Ministry of Finance announced measures regarding the procurement of medical devices imported from the EU, stating that for procurement budgets over 45 million yuan, EU companies (excluding EU-funded enterprises in China) must be excluded if import products are required [1] Drug and Device Approvals - Weikang Pharmaceutical's Anruini capsules have been submitted for market approval, targeting adult and adolescent patients with specific solid tumors carrying NTRK fusion genes [2] - AstraZeneca's Imfinzi (Durvalumab) has received EU approval for use in muscle-invasive bladder cancer (MIBC) as an adjuvant treatment following radical cystectomy [3] Capital Market Activities - Micot announced the completion of over 100 million yuan in Series D financing, led by Zhejiang Merchants Venture Capital, with funds aimed at core pipeline development and the establishment of a formulation industrialization base [4] - Opcon Vision plans to use 334 million yuan to acquire 75% of Shanyang Qicheng Hospital Management Co., with part of the funds redirected from a community eye care service project [5] Industry Developments - Tengsheng Bo Pharmaceutical has reached a BD licensing agreement with Health元 for BRII-693, with Health元 responsible for development and commercialization in Greater China [7][8] - Nengte Technology has adjusted the listing price for the sale of its subsidiary, Ankang Shenqian Mining Co., to 114 million yuan, a 15% decrease from the previous listing price [9] - Ever Union, a shareholder of Mindray Medical, plans to reduce its stake by up to 0.41% through various legal means [10]