Core Viewpoint - Health元 demonstrates resilient performance in Q1 2025 with revenue of 4.089 billion yuan and net profit of 436 million yuan despite overall market pressures [1] Group 1: Financial Performance - The company reported a revenue of 40.89 billion yuan and a net profit of 4.36 billion yuan for Q1 2025, indicating strong operational resilience [1] - In the context of a challenging environment, Health元's net profit adjustment was significantly lower than revenue adjustment, showcasing its robust profitability [2] - The average decline in net profit for 49 chemical pharmaceutical companies was 70.31%, highlighting Health元's relatively stable performance [2] Group 2: Market Position and Product Development - Health元 has established itself in the respiratory sector, achieving over 1 billion yuan in revenue and breaking the long-standing monopoly of multinational companies [2] - The company is expected to benefit from the gradual release of products like Tobramycin inhalation solution and Marpatsavir, which will drive revenue growth in the inhalation segment [3] - Health元 has a diverse product matrix across various sectors, including digestion, reproductive health, and pain management, contributing to stable operations [4] Group 3: Innovation and Future Prospects - The company is focusing on innovation with a robust pipeline, including TSLP monoclonal antibody and IL-4R monoclonal antibody, which are in phase II clinical trials [5] - The anticipated approval of the flu drug Marpatsavir in the second half of the year is expected to tap into the lucrative flu market [3] - Health元's strategic focus on innovation and product development is expected to drive high-quality growth in the future [5]

事件： 公司发布2024 年度报告。根据2024 年公司年报，公司实现营业收入156.19 亿元，同比下降6.17%；归 母净利润 13.87 亿元，同比下降 3.90%；扣非归母净利润为 13.19 亿元，同比下降 3.99%；EPS 为0.74 元/股，同比下降2.63%，基本符合预期。 核心要点： 抗感染恢复增长，呼吸业务集采影响显现，保健及 OTC 增长53.91%近几年处方药业务存量核心品种相 继受到集采影响，从影响节奏来看，抗感染集采影响消退，恢复增长，同比增长9.69%。左沙丁胺醇集 采报表影响显现，同时叠加2023 年呼吸疾病高基数因素，导致呼吸业务收入同比下滑36.98%。预计 2025 年集采影响边际逐步减弱。 保健食品及 OTC 板块保持快速增长，受益于品牌数字营销体系建设，板块实现营业收入6.97 亿元，同 比增长53.91%。 原料药及中间体板块整体保持相对稳定，实现营业收入20.25 亿元，同比下降2.63%。其中，7-ACA 价 格呈现稳定增长态势，美罗培南原料药受价格下滑，市场竞争加剧等因素影响，收入有所下滑。 丽珠单抗（持股54.52%）较去年同期减亏 3.18 亿元。丽珠单 ...

Core Viewpoint - The company Health元 (600380.SH) continues to face operational pressure due to a complex external environment, with both revenue and net profit declining for the second consecutive year in 2024 [1][6]. Financial Performance - In 2024, Health元 reported revenue of 15.619 billion and a net profit attributable to shareholders of 1.387 billion, representing a year-on-year decline of 6.17% and 3.90% respectively [4][6]. - The company has experienced a rare occurrence of consecutive declines in revenue and net profit, with the last similar instance occurring in 2023 [6][7]. - Quarterly revenue for 2024 showed a consistent decline across all four quarters, with figures of 4.340 billion, 3.895 billion, 3.664 billion, and 3.721 billion, reflecting year-on-year decreases of 4.81%, 6.39%, 6.80%, and 6.87% respectively [7][8]. Research and Development - Despite increasing focus on innovative drug development, Health元's R&D investment has been decreasing, with 2024 R&D spending at 1.532 billion, down 318 million from 2021 [2][11]. - The proportion of R&D investment relative to revenue has also declined, from 11.63% in 2021 to 9.81% in 2024 [11]. - The company has reduced its R&D personnel by 70 in 2024, with the total number of R&D staff at 1,670, accounting for 11.63% of total employees [10][11]. Dividend Policy - Health元's dividend distribution remains low, with a proposed cash dividend of 366 million for 2024, resulting in a dividend payout ratio of 26.39% [2][12]. - The company has maintained a dividend payout ratio below 30% for five consecutive years [3][13]. Cost Management - Health元 has managed to reduce sales and management expenses, totaling a decrease of 755.6 million in 2024 compared to 2023 [8][9]. - Despite the reduction in expenses, the company's net profit continued to decline, indicating challenges in reversing the downward trend in operational performance [9]. Cash Position - As of the end of 2024, Health元 reported cash and cash equivalents of 14.852 billion, with interest-bearing liabilities of 5.276 billion, indicating a strong liquidity position [15].

Core Insights - Health元 reported a total revenue of 15.619 billion yuan and a net profit attributable to shareholders of 1.387 billion yuan for the year 2024, with a net operating cash flow of 3.636 billion yuan [1] - The company has established a strong position in the respiratory drug market, achieving a 22-fold growth in respiratory products since the launch of its first high-end inhalation formulation in 2019 [1][2] - Health元 is advancing its innovative drug pipeline in the respiratory field, with over 10 innovative drugs in development, including the flu drug "Marpacisavir," which has completed Phase III clinical trials [2][3] Revenue and Profitability - The company achieved an operating revenue of 15.619 billion yuan and a net profit of 1.387 billion yuan for 2024 [1] - The net profit after deducting non-recurring items was 1.319 billion yuan, indicating a strong financial performance [1] Product Development and Innovation - Health元 has developed over 10 first-class innovative drugs in the respiratory field, covering inhalation, oral, and injection forms [2] - The flu drug "Marpacisavir" has shown superior treatment effects, significantly shortening the duration of flu symptoms and demonstrating rapid relief for adolescents [2] - The company is also focusing on chronic obstructive pulmonary disease (COPD) with multiple first-in-class drugs, including TSLP monoclonal antibody and IL-4R monoclonal antibody, both in Phase II clinical trials [2] Strategic Collaborations - Health元 is collaborating with Bayer to develop a novel oral drug for COPD, which is a global first in its class, targeting the PREP enzyme to control inflammation [3] Embracing AI Technology - The company has begun integrating AI technology across its business operations to enhance efficiency and accelerate drug development processes [5] - Health元 has deployed advanced AI models for target identification, molecular design, and screening, significantly reducing research and development timelines [5] Future Outlook - The global pharmaceutical industry is undergoing significant transformation, with AI technology reshaping drug development paradigms [6] - Health元 aims to position itself as a leader in innovative respiratory drugs in the Chinese A-share market [3][6]