关于控股股东股份解押及再质押公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈 述或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示: 通化东宝药业股份有限公司（以下简称"公司"或"本公司"）控股股东东 宝实业集团股份有限公司（以下简称"东宝集团"）及其一致行动人合计持有公 司股份 631,511,775 股，占公司目前股份总额的 32.24%；东宝集团及其一致行 动人持有公司股份累计质押数量（本次解押及再质押后）为 565,939,472 股，占 其及一致行动人所持有公司股份总额的 89.62%，占公司目前股份总额的 28.90%。 其中：东宝集团持有公司股份 609,649,596 股，占公司目前股份总额的 31.13%， 东宝集团持有公司股份累计质押数量（本次解押及再质押后）为 565,939,472 股， 占其所持有公司股份总额的 92.83%，占公司目前股份总额的 28.90%。 2025 年 7 月 25 日,本公司接到东宝集团关于股份解押及再质押相关情况的 告知函,具体情况如下: 一、公司控股股东本次股份质押解除的具体情况 证券代码：600867 证 ...

Summary of Key Points from the Conference Call Industry Overview - **Industry Focus**: The conference call primarily discusses the healthcare sector in China, particularly the medical technology (Medtech), in vitro diagnostics (IVD), retail pharmacies, hospitals, vaccines, and insulin markets [1][2]. Core Insights and Arguments Medtech - **Key Areas of Focus**: 1. Progress of capital equipment value-based procurement (VBP) and the trade-in policy [1] 2. Channel destocking trends [1] 3. Import substitution trends post-VBP, including intraocular lenses (IOLs) and IVD [1] - **VBP Impact**: The June bidding value data showed a year-on-year growth rate of 49%, but a month-on-month decline of 3%, indicating lower unit prices due to VBP [10]. IVD Market - **Weak Demand**: The IVD sector continues to face challenges, with a projected 20% year-on-year decline in the CLIA reagent market size for 2025 [19]. - **AmoyDx Performance**: AmoyDx is expected to grow against the trend due to its strong presence in compliant in-hospital sales channels, benefiting from the anti-corruption campaign [21]. Insulin Market - **Domestic Substitution**: The insulin industry has seen significant growth, particularly for insulin analogs from companies like Gan & Lee and THDB, which reported rapid revenue growth in 1Q25 [22]. Retail Pharmacies - **Market Pressure**: Retail pharmacies are under pressure due to strict reimbursement policies and weak consumer spending. However, there is a potential market-clearing trend expected by year-end [31]. Hospitals - **New Product Feedback**: Hospitals are seeing new product introductions, such as the new version of SMILE surgery and new PIOL products, which are expected to drive consumption recovery [1]. Vaccine Market - **Anti-Corruption Campaign**: The ongoing anti-corruption campaign within the CDC system is impacting vaccine demand and distribution channels [1]. Financial Performance and Estimates Earnings Revisions - **Mindray**: Annual earnings estimates revised down by 2.1% to 5.0% for 2025E-27E due to industry headwinds in medical equipment and IVD [2][37]. - **United Imaging**: Revenue and earnings forecasts adjusted down to reflect lower-than-expected bidding data [39]. - **SNIBE**: Earnings estimates revised down by 1.4% to 7.1% for 2025E-27E due to policy headwinds in the IVD sector [40]. Revenue Growth Expectations - **High Growth Companies**: THDB and Gan & Lee are expected to achieve the highest revenue growth due to a low base from VBP renewal in 2Q24 [6]. - **Mindray's Decline**: Mindray's China business is expected to decline by 26% year-on-year in 2Q25 due to IVD weakness [9]. Other Important Insights - **Trade-in Policy Concerns**: The trade-in stimulus fund is expected to run out, leading to a decline in applications and a reduced stimulus effect in the second half of 2025 [10]. - **Market Dynamics**: The healthcare market is experiencing a shift with increasing government support for procurement and a focus on innovative products [47][48]. Conclusion - The healthcare sector in China is facing various challenges, including policy headwinds, weak demand in certain segments, and the impact of ongoing reforms. However, there are also opportunities for growth, particularly in innovative products and domestic substitution trends. Companies like AmoyDx, Gan & Lee, and THDB are positioned to benefit from these trends, while others like Mindray and SNIBE are facing headwinds that may impact their performance in the near term.

Core Viewpoint - The Chinese innovative drug industry is experiencing a significant moment in the first half of 2025, driven by policy benefits and international breakthroughs, with three companies expected to turn losses into profits [1]. Group 1: Company Performance - Tonghua Dongbao expects to achieve a net profit of approximately 217 million yuan for the first half of 2025, marking a turnaround from losses in the previous year [2]. - The main reason for Tonghua Dongbao's performance improvement is the significant growth in sales of insulin analog products, leading to a substantial increase in domestic sales revenue [4]. - The internationalization strategy has also shown significant results, with noticeable growth in export revenue [5]. Group 2: Other Companies' Performance - Zhaoyan New Drug anticipates a net profit of between 50.32 million and 75.49 million yuan for the first half of 2025, recovering from a loss of 169 million yuan in the same period last year [6]. - The decline in Zhaoyan New Drug's operating income is attributed to intensified competition, which has compressed order profits and exacerbated losses in laboratory services [8]. - The fair value changes of biological assets have offset some business losses, contributing to the overall turnaround [9]. Group 3: BoTeng Co. Performance - BoTeng Co. expects a net profit ranging from 0 to 30 million yuan for the first half of 2025, recovering from a loss of 170 million yuan in the previous year [10]. - The company anticipates achieving revenue of 1.55 billion yuan, representing a year-on-year growth of 15% to 20% [12]. - The improvement in BoTeng Co.'s performance is driven by robust revenue growth, enhanced gross margins, effective cost control, and a reduction in losses from new businesses, along with non-recurring investment income of approximately 18.21 million yuan [13][14]. Group 4: Overall Industry Insights - The performance turnaround of Tonghua Dongbao, Zhaoyan New Drug, and BoTeng Co. reflects the positive progress of different segments within the biopharmaceutical industry in overcoming challenges and seeking growth and profitability restoration [15]. - However, the specific paths and sustainability of these improvements depend on each company's business model and future operating environment [15].

Group 1 - The core viewpoint of the articles emphasizes that as the A-share market enters the mid-year performance reporting period, the focus is shifting back to fundamentals, with sectors showing stable profits likely to see valuation increases [1][2] - The CSI A500 ETF (563800) has shown strong performance, with a net asset value increase of 7.60% over the past six months, and its latest scale exceeding 17 billion yuan as of July 20 [1] - Among the CSI A500 index constituents, 129 companies have issued earnings forecasts, with 94 expected to be profitable and 85 anticipating year-on-year net profit growth, indicating a significantly better outlook than the overall market [1][2] Group 2 - The strong performance of the CSI A500 index constituents is attributed to its innovative compilation scheme, which selects leading companies across three industry segments while maintaining industry balance and over-allocating to new productivity sectors [2] - Analysts predict that from 2025 to 2027, the average annual growth rate of net profit attributable to the parent company for the CSI A500 index will reach 10.6%, significantly higher than other broad-based indices [2] - The current phase of the A-share market is characterized by a "profit bottom + policy bottom" resonance, with the CSI A500 index expected to build long-term support above 3,500 points [2]

Core Viewpoint - Tonghua Dongbao, a leading insulin manufacturer, reported a loss of approximately 42.72 million yuan in 2024, marking its first loss in nearly 20 years, attributed to a combination of legal issues, project terminations, and significant price reductions in insulin due to national procurement policies [1][3][8] Financial Performance - In 2024, Tonghua Dongbao achieved revenue of 2.01 billion yuan, a significant decline of 34.66% year-on-year [3] - The net profit attributable to shareholders was -42.72 million yuan, a decrease of 103.66% compared to the previous year [3][8] - The company's earnings forecast changed dramatically within three months, from an initial profit forecast of 40.53 million yuan to a confirmed loss [1][3] Legal Issues - The company lost a long-standing trademark infringement lawsuit against Ganli Pharmaceutical, resulting in a compensation payment of 61.31 million yuan [4][5] - The lawsuit, which began in 2011, concluded with a ruling that Tonghua Dongbao acted with "malice" in using the "Changshulin" trademark [4][5] R&D Challenges - The termination of the soluble insulin project led to impairment losses and prepayment losses totaling approximately 320 million yuan [3][6] - The decision to halt the project was influenced by the high costs of clinical trials and the competitive landscape, which diminished its commercial viability [6] Market Strategy - In response to national procurement policies, the company adopted a "price for volume" strategy, resulting in an average price reduction of 15% across its product line [7] - Despite the price cuts, the company's gross margin for biological products decreased by 5.92 percentage points [7] Future Outlook - In the first quarter of 2025, Tonghua Dongbao showed signs of recovery, with overseas revenue reaching 103 million yuan, a nearly 80% increase year-on-year [8] - The company is exploring international markets and has formed a strategic partnership with Jianyou Co. to enter the U.S. insulin market [8] - The company anticipates a net profit of approximately 21.7 million yuan for the first half of 2025, indicating a potential turnaround [8] R&D Investment - In 2024, the company invested 450 million yuan in R&D, a year-on-year increase of 7.15%, representing 22.42% of its revenue [8][9] - Currently, four products are in Phase III clinical trials, and three innovative drugs are in Phase II trials [9]

Core Viewpoint - Tonghua Dongbao, a leading insulin manufacturer, faced significant challenges in 2024, resulting in a net loss of approximately 42.72 million yuan, marking its first loss in nearly 20 years due to a combination of legal issues, project terminations, and price reductions from national procurement policies [2][4]. Financial Performance - In 2024, the company reported revenue of 2.01 billion yuan, a substantial decline of 34.66% year-on-year [4]. - The net profit attributable to shareholders was -42.72 million yuan, a decrease of 103.66% compared to the previous year [4]. Legal Issues - The company lost a long-standing trademark infringement lawsuit against Ganli Pharmaceutical, resulting in a compensation payment of 61.31 million yuan [4][6]. - The lawsuit, which began in 2011, concluded in February 2025 with a ruling that found Tonghua Dongbao's use of the "Changshulin" trademark constituted unfair competition [4][5]. R&D Challenges - The termination of the soluble insulin project, which required an additional investment of 50 to 70 million yuan for clinical trials, led to a total impairment loss of approximately 318 million yuan [6]. - The decision to halt the project was influenced by the competitive landscape and the diminishing commercial value of the product due to price reductions in the market [6]. Pricing Strategy - In response to national procurement policies, the company implemented a "price for volume" strategy, resulting in an average price reduction of 15% across its product line, with the price of Aspart insulin dropping by 43% [7]. - Despite increasing sales volume by 73%, the low pricing strategy negatively impacted the gross margin of biological products by 5.92 percentage points [7]. Future Outlook - Early 2025 data indicates signs of recovery, with a projected net profit of approximately 21.7 million yuan for the first half of 2025 [8][9]. - The company is exploring international markets, reporting a nearly 80% increase in overseas revenue in 2024, and has formed a strategic partnership to enter the U.S. insulin market [9]. - Domestic sales of Aspart insulin surged over 260% in the first quarter of 2025 compared to the previous year, indicating potential for market recovery [9]. R&D Investment - In 2024, the company invested 450 million yuan in R&D, a year-on-year increase of 7.15%, representing 22.42% of its revenue [10]. - The company has four products in Phase III clinical trials and three in Phase II, indicating a commitment to innovation and development in the pharmaceutical sector [10].

Core Viewpoint - The recent half-year reports from domestic insulin manufacturers, Ganli Pharmaceutical and Tonghua Dongbao, reveal ongoing industry differentiation following the centralized procurement of insulin, with Ganli showing a recovery while Tonghua continues to struggle financially [1][3]. Group 1: Financial Performance - Ganli Pharmaceutical reported a net profit of 600 million yuan for the first half of the year, while Tonghua Dongbao projected a net profit of approximately 217 million yuan, marking a turnaround from losses in the previous year [1]. - Tonghua Dongbao's revenue and net profit for the first half of 2024 were 740 million yuan and -230 million yuan, respectively, reflecting a year-on-year decline of 45.84% and 147.54% [1]. - In the first quarter, Tonghua Dongbao's revenue was 650 million yuan, while Ganli's was 1 billion yuan, indicating a significant gap in performance [8]. Group 2: Market Position and Strategy - Ganli Pharmaceutical has regained its position as a leader in the industry, while Tonghua Dongbao has been lagging behind since the centralized procurement began [3][6]. - The sales of insulin analog products at Tonghua Dongbao have seen significant growth, contributing to a substantial increase in domestic sales revenue [1]. - Tonghua Dongbao plans to focus on increasing sales of insulin analog products and has introduced new products like Liraglutide and Empagliflozin to accelerate market penetration [8]. Group 3: Industry Context - The insulin market in China has been impacted by centralized procurement, which has led to significant changes in the financial health of both companies, with Ganli experiencing a sharp decline in revenue and profits initially but showing recovery in subsequent years [6][9]. - The GLP-1 receptor agonists are emerging as a key product in the diabetes treatment market, with both companies incorporating these products into their portfolios [9]. - Clinical applications indicate that GLP-1 receptor agonists and insulin can be used together for better efficacy, highlighting the importance of both product types in diabetes management [9].

Core Viewpoint - The performance forecasts of A-share listed pharmaceutical companies for the first half of 2025 reveal a mixed outlook, with some companies showing significant profit growth while others are expected to incur losses, highlighting both opportunities and challenges in the sector [1][5]. Group 1: Performance Highlights - As of July 15, 97 pharmaceutical stocks have disclosed their performance forecasts, with 20 companies expecting a net profit increase of over 100% and 53 companies anticipating year-on-year profit growth [1]. - WuXi AppTec (药明康德) is projected to have the highest net profit among the disclosed forecasts, expecting approximately 8.561 billion yuan, a year-on-year increase of 101.92% [4]. - Asia-Pacific Pharmaceutical (亚太药业) is noted as the "profit growth king," with an expected net profit increase of 1726.42% to 1909.06%, primarily due to the sale of a subsidiary [3]. Group 2: Loss Forecasts - A total of 42 pharmaceutical stocks are expected to report losses in the first half of 2025, with notable companies like Da An Gene (达安基因) and Hainan Haiyao (海南海药) projecting significant losses [5][7]. - Da An Gene anticipates a loss of 140 million to 200 million yuan, although this represents a reduction in losses compared to the previous year [5]. - 18 companies, including Wantai Biological Pharmacy (万泰生物) and Lianhuan Pharmaceutical (联环药业), are expected to report their first-ever half-year losses since listing [7][9]. Group 3: Market Dynamics - Wantai Biological attributes its expected loss to industry policy adjustments and market competition affecting its vaccine sales, while also banking on the launch of its domestically developed nine-valent HPV vaccine to improve future performance [7][8]. - Lianhuan Pharmaceutical's loss is linked to multiple factors, including national drug procurement policies and increased international market competition, which have pressured its gross margins [9].

Core Viewpoint - Tonghua Dongbao (stock code: 600867.SH) is expected to achieve a net profit of 217 million yuan in the first half of 2025, marking a turnaround from losses in the same period last year, primarily driven by significant sales growth of its third-generation insulin products and successful internationalization strategies [1][2]. Group 1: Financial Performance - The company anticipates a net profit of 217 million yuan for the first half of 2025, compared to a loss in the same period last year, with a non-recurring net profit of approximately 220 million yuan [1]. - The sales revenue from third-generation insulin products has significantly increased, contributing to the overall domestic sales growth [1][2]. Group 2: Market Strategy - The company adopted a "price for volume" strategy in the April 2024 national insulin procurement, achieving A-class selection for its entire product line, with key products like glargine insulin and premixed aspart insulin receiving A1 class selection [1]. - This procurement result secures an annual procurement volume of approximately 45 million units for the next three years, representing a 73% increase compared to the first procurement [1]. Group 3: International Expansion - The company has made significant progress in international markets, with notable increases in export revenue and successful product registrations in Uzbekistan and Nicaragua, as well as obtaining GMP certification for liraglutide injection in Colombia [2]. - The international revenue trend from 2024 has continued positively into 2025, indicating the effectiveness of the company's internationalization strategy [2]. Group 4: Research and Development - The company is advancing its product pipeline, with successful clinical trial results for various drugs, including THDBH151 and THDBH120, and has received marketing approval for a gout medication [3]. - Strategic agreements have been signed with Shanghai Kangdelai and Dongfulong Group to enhance collaboration and resource synergy [3]. Group 5: Future Outlook - The company is positioned for a new growth phase from 2025 to 2027, driven by the launch of key products like degludec insulin-liraglutide combination and semaglutide, alongside continued breakthroughs in international markets [3].

[Current Period Performance Forecast (2025 Semi-Annual)](index=1&type=section&id=I.%20Current%20Period%20Performance%20Forecast) The company anticipates a return to profitability in the first half of 2025, with net profit attributable to shareholders estimated at approximately RMB 217.35 million and non-recurring net profit at approximately RMB 220.15 million, based on unaudited preliminary figures Estimated Performance (2025 Semi-Annual) | Metric | Estimated Amount (RMB) | Notes | | :--- | :--- | :--- | | Net Profit Attributable to Shareholders | Approx. 217.35 million | Return to Profitability | | Net Profit Attributable to Shareholders (Excluding Non-recurring Items) | Approx. 220.15 million | - | - This performance forecast has not been audited by a certified public accountant[5](index=5&type=chunk) [Prior Period Operating Performance (2024 Semi-Annual)](index=1&type=section&id=II.%20Prior%20Period%20Operating%20Performance%20and%20Financial%20Status) In the corresponding period of 2024, the company reported a net loss attributable to shareholders of RMB 230.49 million, a non-recurring net loss of RMB 13.30 million, and earnings per share of RMB -0.12 Prior Period Operating Performance (2024 Semi-Annual) | Metric | Amount (RMB) | | :--- | :--- | | Net Profit Attributable to Shareholders | -230.49 million | | Net Profit Attributable to Shareholders (Excluding Non-recurring Items) | -13.30 million | | Earnings Per Share | -0.12 | [Primary Reasons for Current Period Profit Forecast](index=2&type=section&id=III.%20Primary%20Reasons%20for%20Current%20Period%20Profit%20Forecast) The primary driver for the return to profitability in the first half of 2025 is the increased revenue from the company's insulin product series, attributed to significant growth in domestic sales of insulin analogs and notable increases in export revenue from successful internationalization efforts - The main reason for the return to profitability is the **growth in revenue from the company's insulin product series**, driving profit growth[9](index=9&type=chunk) - In the domestic market, **significant sales growth of insulin analog products** led to a substantial increase in domestic sales revenue[9](index=9&type=chunk) - In the international market, the company's **internationalization strategy achieved remarkable results**, leading to a significant increase in export revenue[9](index=9&type=chunk) [Risk Warning and Other Disclosures](index=2&type=section&id=IV.%20Risk%20Warning) The company states there are no significant uncertainties affecting the accuracy of this performance forecast, but emphasizes that the disclosed data are preliminary financial estimates, unaudited, and subject to the final 2025 semi-annual report - The company confirms there are **no uncertain factors** that would significantly impact the accuracy of this performance forecast[10](index=10&type=chunk) - This performance forecast is based on **preliminary calculations by the company's finance department** and has not been audited by a certified public accountant; the final data will be subject to the official semi-annual report for 2025[10](index=10&type=chunk)[11](index=11&type=chunk)