一、协议签署背景 证券代码：603658 证券简称：安图生物 公告编号：2025-056 郑州安图生物工程股份有限公司 关于《和解协议》履行完毕的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 2024年4月，郑州安图生物工程股份有限公司（以下简称"安图生物"或"公 司"）及子公司与被申请人Mobidiag Oy（以下简称"Mobidiag"）就双方之间 的《合资协议》（JVC）、《许可、开发和分销协议》（LDDA）履行产生分歧， 故向国际商会国际仲裁院（ICC International Court of Arbitration）提交了仲裁申 请书并被受理。该仲裁案未开庭审理前，经友好协商，双方达成和解并签订《和 解协议》，公司及子公司作为申请人向国际商会国际仲裁院申请撤案，仲裁庭终 止了国际商会第 28609/XZG 号案件的诉讼程序。详见公司分别于2024年4月30 日、2024年10月11日、2024年12月13日披露的《安图生物关于仲裁事项暨对外投 资进展的公告》（公告编号：2024-036）、《安图生物关于仲 ...

证券代码：603658 证券简称：安图生物 公告编号：2025-055 郑州安图生物工程股份有限公司 关于使用闲置募集资金进行现金管理 赎回及进展的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者 重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： 1 现金管理种类：大额存单； 现金管理金额：13,000 万元非公开发行股票闲置募集资金； 履行的审议程序：郑州安图生物工程股份有限公司（以下简称"公司"）于 2024 年 12 月 11 日召开第五届董事会第二次会议、第五届监事会第二次会 议，审议通过《关于使用部分闲置募集资金进行现金管理的议案》，同意 公司在确保不影响募集资金投资项目建设和募集资金使用的情况下，公司 拟分别使用不超过 1.7 亿元公开发行可转换公司债券闲置募集资金和不超 过 17 亿元非公开发行股票闲置募集资金进行现金管理，分别用于购买单次 持有期限不超过 12 个月的结构性存款、大额存单、国债逆回购、券商收益 凭证、券商理财产品等安全性高、流动性好的保本型产品。在上述额度范 围内，资金可在 12 个月内滚动使用。具体内容详见公司于 2024 ...

证券代码：603658 证券简称：安图生物 公告编号：2025-054 郑州安图生物工程股份有限公司 第五届董事会第六次会议决议公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： 一、董事会会议召开情况 郑州安图生物工程股份有限公司（以下简称"安图生物"或"公司"）第五 届董事会第六次会议的会议通知和材料于2025年7月22日以电子邮件方式发出，会 议于2025年7月25日在公司会议室以现场和通讯相结合的方式召开，会议应参加董 事11名，实际参加表决董事11名（其中董事张亚循、独立董事袁华刚、乔海灵以 通讯方式参会，董事付光宇以委托方式参会）。会议由公司董事长苗拥军先生主 持，公司监事和部分高级管理人员列席了本次会议。 会议的召集和召开程序符合《公司法》等有关法律、行政法规、部门规章、 规范性文件和《公司章程》的相关规定，会议形成的决议合法、有效。 二、董事会会议审议情况 经与会董事认真审议，以记名投票表决方式一致通过以下议案： 2025年7月25日 审议通过《关于新增非公开发行股票募集资金专项账户的议案》 ...

Group 1 - Company AnTuo Bio closed at 39.87 yuan, up 3.32%, with a rolling PE ratio of 19.98, marking a new low in 63 days, and a total market value of 22.783 billion yuan [1] - The average PE ratio for the medical device industry is 54.56, with a median of 37.54, placing AnTuo Bio at 42nd in the industry ranking [1] - As of the first quarter of 2025, three institutions hold shares in AnTuo Bio, with a total of 12.716 million shares valued at 477 million yuan [1] Group 2 - AnTuo Bio specializes in the research, manufacturing, integration, and service of in vitro diagnostic reagents and instruments, with key products including immunodiagnostic reagents, microbiological testing reagents, molecular diagnostic reagents, biochemical reagents, and instruments [1] - The company was listed among the "Top 100 Pharmaceutical Companies in China for 2023" and achieved second place in the "Top 100 Pharmaceutical Companies R&D Index" due to its outstanding performance in R&D results and support indices [1] - In the latest performance report for the first quarter of 2025, AnTuo Bio reported revenue of 996 million yuan, a year-on-year decrease of 8.56%, and a net profit of 270 million yuan, down 16.76%, with a gross profit margin of 65.07% [1]

Core Insights - The in vitro diagnostics (IVD) industry is a crucial component of modern healthcare, providing essential data for disease prevention, diagnosis, and treatment through various testing methods [1][5][10] - China's IVD market has surpassed 120 billion yuan in 2024, with a projected growth to 165 billion yuan by 2029, reflecting a compound annual growth rate of 5-8% [1][10][19] - The industry is experiencing significant domestic substitution, with over 80% of Class III diagnostic products being domestically produced, while the share of imported products has decreased from 29.3% to 19.5% from 2021 to 2024 [1][14] Industry Overview - IVD encompasses several testing methods, including biochemical, immunological, molecular, microbiological, blood diagnostics, and point-of-care testing (POCT) [2][5] - The industry is transitioning from scale expansion to high-quality development, driven by government policies and technological innovations [5][21] Policy and Regulatory Environment - Recent government policies, such as the "14th Five-Year Plan for Bioeconomic Development" and the "Comprehensive Action Plan for Improving Medical Quality (2023-2025)," provide a strong impetus for the IVD industry [5][7] - The introduction of the "List of In Vitro Diagnostic Reagents Exempt from Clinical Trials (2025)" has expanded the range of products available in the market [7] Market Dynamics - The IVD industry is characterized by a multi-tiered market structure, with foreign giants dominating the high-end market and domestic leaders gradually increasing their market share [15][19] - The competitive landscape is evolving, with leading companies like Mindray Medical and New Industry Bio showing strong performance, while former leaders in COVID-19 testing, such as Da An Gene and BGI, are seeking business transformation [19][20] Growth Trends - The IVD industry is witnessing a shift towards precision and intelligent diagnostics, with advancements in molecular diagnostics, chemiluminescence, and POCT technologies [21][22] - The integration of AI and big data is enhancing diagnostic efficiency, while the demand for home health management and early cancer screening is rising due to an aging population [21][24] Competitive Landscape - The first tier of the market is dominated by international giants like Roche and Abbott, while domestic leaders such as Mindray and New Industry Bio are gaining traction in immunological and molecular diagnostics [15][19] - The market is seeing increased consolidation, with leading companies acquiring smaller firms to enhance their technological capabilities [23] Registration and Product Development - The registration of IVD products has been robust, with a compound annual growth rate of 25.3% from 2021 to 2024, indicating a vibrant development in the sector [14] - In 2024, the registration of domestic Class III diagnostic products reached 533, accounting for 80.5% of total IVD product registrations [14]

Core Viewpoint - The 2025 Global MedTech Top 100 (GMT100) list highlights the dominance of major players in the medical technology industry while showcasing the rise of Chinese and Asia-Pacific companies in the global market [3][4][5]. Global Overview - The top 10 companies continue to dominate the market, with Medtronic leading at a revenue of 239.45 billion RMB for 2024. The total revenue of the top 10 exceeds 1.6 trillion RMB, accounting for over 60% of the total revenue of the list [5][14]. - The list reflects a "pyramid" structure in the medical technology industry, where smaller companies focus on niche markets but show significant innovation and growth potential [10][11]. Regional Distribution - North American companies hold a significant share of the list, with the top 10 generating over 16 trillion RMB in revenue. Asian companies, particularly from China, are increasingly making their presence felt [11][14]. - Chinese companies have shown remarkable performance, with 12 firms making it to the top 100, collectively generating over 200 billion RMB in revenue for 2024, marking a further increase from the previous year [4][14]. Industry Concentration and Future Outlook - The medical technology industry exhibits a "Matthew Effect," where the top 10 companies control over 60% of the market share, while emerging companies challenge traditional players with innovative technologies [13][14]. - The future of the industry is expected to witness significant technological changes and market reshuffling, with the GMT100 serving as a record of these developments [13][14].

Company Overview - Antu Biology closed at 37.99 yuan, up 1.12%, with a rolling PE ratio of 19.04 times and a total market value of 21.708 billion yuan [1] - The company ranks 42nd in the medical device industry, which has an average PE ratio of 51.87 times and a median of 37.48 times [1] - As of the first quarter of 2025, 10 institutions held shares in Antu Biology, including 6 funds, with a total holding of 43.5189 million shares valued at 18.139 billion yuan [1] Business Performance - Antu Biology specializes in the research, manufacturing, integration, and service of in vitro diagnostic reagents and instruments, with key products including immunodiagnostic reagents, microbiological testing reagents, molecular diagnostic reagents, biochemical reagents, and instruments [1] - The company was listed among the "Top 100 Pharmaceutical Companies in China for 2023" and achieved second place in the "Top 100 Pharmaceutical Enterprises R&D Index" due to its outstanding performance in R&D results and support indices [1] - In the latest performance report for the first quarter of 2025, the company reported revenue of 996 million yuan, a year-on-year decrease of 8.56%, and a net profit of 270 million yuan, down 16.76%, with a gross profit margin of 65.07% [1] Industry Comparison - The PE ratio of Antu Biology is significantly lower than the industry average of 51.87 times and the median of 37.48 times, indicating potential undervaluation compared to peers [2] - The industry average market value is 108.06 billion yuan, while Antu Biology's market value is 21.708 billion yuan, suggesting a smaller scale within the industry [2]

证券代码：603658 证券简称：安图生物 公告编号：2025-053 郑州安图生物工程股份有限公司 关于公司及全资子公司获得医疗器械注册证的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 郑州安图生物工程股份有限公司（以下简称"公司"或"安图生物"）及全 资子公司安图实验仪器（郑州）有限公司（以下简称"安图仪器"）于近日收到 河南省药品监督管理局颁发的医疗器械注册证，具体如下： 2025 年 7 月 4 日 编 号 产品名称 注册证编号 注册证 有效期 适用范围 / 预期用途 所属 公司 1 纤溶酶-α 2 纤溶酶抑制 剂复合物检测试剂盒 （磁微粒化学发光法） 豫械注准 20252400515 5 年 本产品用于体外定量检测人血 浆中纤溶酶-α 2 纤溶酶抑制剂 复合物（PIC）的含量。 安图 生物 2 凝血酶-抗凝血酶Ⅲ复 合物检测试剂盒（磁微 粒化学发光法） 豫械注准 20252400516 5 年 本产品用于体外定量检测人血 浆中凝血酶-抗凝血酶Ⅲ复合物 （TAT）的含量。 3 β-胶原特殊序列检测试 剂盒（磁微 ...

Core Viewpoint - The company is utilizing idle funds from its non-public stock issuance for cash management to enhance the value of raised funds and increase company earnings while ensuring the normal implementation of investment projects and the safety of raised funds [1][3]. Cash Management Purpose - The cash management aims to better preserve and increase the value of the raised funds, thereby benefiting all shareholders [1]. Cash Management Amount - The company plans to use 100 million yuan (10,000 million) of idle funds from its non-public stock issuance for cash management [1][3]. Fund Source - The funds are sourced from the net proceeds of a non-public stock issuance approved by the China Securities Regulatory Commission, totaling approximately 3.05 billion yuan [1][2]. Investment Project Progress - As of December 31, 2024, the investment projects funded by the non-public stock issuance are as follows: - Expansion of in vitro diagnostic product capacity: Adjusted total investment of 1.43 billion yuan, with cumulative investment of 523.92 million yuan - In vitro diagnostic product R&D center: Adjusted total investment of 833 million yuan, with cumulative investment of 349.66 million yuan - Diagnostic instrument industrial park: Adjusted total investment of 201.89 million yuan, with cumulative investment of 162.18 million yuan [2]. Cash Management Types and Procedures - The cash management products include structured deposits, large certificates of deposit, treasury reverse repos, broker income certificates, and broker wealth management products, all of which are low-risk and have high liquidity [3][5]. Cash Management Duration - The duration of the cash management products will not exceed 12 months [5]. Financial Data Overview - As of March 31, 2025, the company reported total assets of approximately 1.20 billion yuan and total liabilities of approximately 299.82 million yuan, with net assets attributable to shareholders of approximately 887.69 million yuan [7]. Impact of Cash Management - The cash management is expected to improve the efficiency of fund utilization and generate certain investment returns for shareholders, without affecting the normal operation of investment projects [7].

证券代码：603658 证券简称：安图生物 公告编号：2025-052 郑州安图生物工程股份有限公司 关于使用闲置募集资金进行现金管理的进展公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者 重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： 一、非公开发行股票闲置募集资金进行现金管理情况 1 现金管理种类：券商收益凭证； 现金管理金额：10,000 万元非公开发行股票闲置募集资金； 履行的审议程序：郑州安图生物工程股份有限公司（以下简称"公司"）于 2024 年 12 月 11 日召开第五届董事会第二次会议、第五届监事会第二次会 议，审议通过《关于使用部分闲置募集资金进行现金管理的议案》，同意 公司在确保不影响募集资金投资项目建设和募集资金使用的情况下，公司 拟分别使用不超过 1.7 亿元公开发行可转换公司债券闲置募集资金和不超 过 17 亿元非公开发行股票闲置募集资金进行现金管理，分别用于购买单次 持有期限不超过 12 个月的结构性存款、大额存单、国债逆回购、券商收益 凭证、券商理财产品等安全性高、流动性好的保本型产品。在上述额度范 围内，资金可在 12 ...