Core Viewpoint - Hunan Fangsheng Pharmaceutical Co., Ltd. announced that its innovative traditional Chinese medicine, Zhilong Tongluo Tablets, has obtained the Phase II clinical trial summary report, indicating progress in its development for treating ischemic stroke recovery [1][3]. Group 1: Basic Information - Drug Name: Zhilong Tongluo Tablets - Dosage Form: Tablets - Research Type: Phase II Clinical Trial - Clinical Approval Number: 2011L01961 - Clinical Approval Date: November 5, 2011 - Cumulative R&D Expenditure: Approximately 13.566 million RMB (unaudited) [1][2]. - Indication: Aimed at treating ischemic stroke recovery symptoms such as numbness, pain, and fatigue [1]. Group 2: Clinical Research Details - The Phase II clinical trial was conducted across seven national drug clinical trial institutions in Tianjin, Guangxi, Liaoning, Sichuan, Heilongjiang, and Anhui, with a total of 240 planned participants, of which 214 were actually enrolled [2][4]. - The trial design was randomized, double-blind, and included a placebo control, with participants assigned to high-dose (7.5g/day), low-dose (4.5g/day), and placebo groups [4]. Group 3: Clinical Results - The trial results indicated that both high and low doses of Zhilong Tongluo Tablets showed better efficacy compared to the placebo in improving neurological function and quality of life, with no significant difference in safety across groups [4][5]. - The low-dose group demonstrated comparable efficacy to the high-dose group, suggesting it may be suitable for further Phase III clinical research [5]. Group 4: Market Context - Zhilong Tongluo Tablets are classified as a Class 1 innovative traditional Chinese medicine and are currently the company's exclusive product, with no other companies holding production approval for it [6]. - Competing traditional Chinese medicines for treating ischemic stroke include Naoxin Tong Capsules and Tongxinluo Capsules, with reported sales figures for 2024 indicating significant market presence for these products [6].

Core Viewpoint - Fangsheng Pharmaceutical announced that its innovative traditional Chinese medicine, Zhilong Tongluo Tablets, has obtained the Phase II clinical research report as of September 22, 2025 [2] Company Summary - Fangsheng Pharmaceutical released an announcement regarding the progress of its research and development efforts [2] - The company is focusing on innovative traditional Chinese medicine, indicating a strategic direction towards enhancing its product pipeline [2] Industry Summary - The announcement reflects ongoing developments in the traditional Chinese medicine sector, particularly in the context of clinical research and innovation [2] - The successful completion of Phase II clinical trials is a significant milestone that may influence market perceptions and investment interest in the traditional Chinese medicine industry [2]

Core Viewpoint - Fangsheng Pharmaceutical (603998.SH) announced the completion of Phase II clinical research for its innovative traditional Chinese medicine, Zhilong Tongluo Pian, which shows promising results for treating ischemic stroke recovery [1] Group 1: Clinical Research Findings - The drug is indicated for conditions such as post-stroke recovery, including symptoms like hemiplegia, speech difficulties, and fatigue [1] - Safety results indicate no statistically significant differences in severe adverse events or reactions among groups, with all severe events related to acute stroke recurrence and no fatalities reported [1] - Zhilong Tongluo Pian demonstrated effectiveness in improving the Rankin scale for disability, enhancing neurological function, and increasing daily living capabilities [1] Group 2: Efficacy and Recommendations - The drug is effective for symptoms related to blood stasis and Qi deficiency, including upper limb paralysis and fatigue, with a trend towards efficacy in lower limb paralysis and speech difficulties [1] - Both low-dose and high-dose groups showed comparable efficacy, with a recommendation to continue Phase III clinical research for the low-dose group [1]

湖南方盛制药股份有限公司 HUNANFANGSHENG PHARMACEUTICAL CO., LTD. 证券代码：603998 证券简称：方盛制药 公告编号：2025-082 湖南方盛制药股份有限公司 关于蛭龙通络片获得II期临床试验总结报告的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重 大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 2025 年 9 月 22 日，湖南方盛制药股份有限公司（以下简称 "公司"）研发的中药创新药蛭龙通络片取得了 II 期临床研究报 告。为保证所有投资者获取信息的公平、准确、完整，并及时了 解公司经营动态，根据上海证券交易所《上市公司行业信息披露 指引第六号——医药制造》相关规定，公司现将有关内容公告如 下： 一、基本情况 药品名称：蛭龙通络片 剂型：片剂 研究类型：II 期临床试验 临床批件号：2011L01961 获得临床批复时间：2011 年 11 月 5 日 公司于 2013 年 6 月受让北京同御康泰科技有限公司的蛭龙 通络片临床试验批件、处方、生产工艺、质量标准等相关原始研 究资料和技术。2014 年 5 月 20 日， ...

Core Viewpoint - Fangsheng Pharmaceutical (603998.SH) announced the completion of Phase II clinical research for its innovative traditional Chinese medicine, Zhilong Tongluo Pian, which shows promising results for treating ischemic stroke recovery [1] Group 1: Clinical Research Findings - The drug is indicated for conditions such as post-stroke recovery, including symptoms like hemiplegia, speech difficulties, and fatigue [1] - Safety results indicate no statistically significant differences in severe adverse events or reactions among groups, with all severe events related to acute stroke recurrence and no fatalities reported [1] - Zhilong Tongluo Pian demonstrated effectiveness in improving the Rankin scale for disability, enhancing neurological function, and increasing daily living capabilities [1] Group 2: Efficacy and Recommendations - The drug is effective for symptoms related to blood stasis and Qi deficiency, including upper limb paralysis and speech issues, with a trend towards efficacy in lower limb paralysis and other symptoms [1] - Both low-dose and high-dose groups showed comparable efficacy, with a recommendation to continue Phase III clinical research for the low-dose group [1]

Core Viewpoint - Fangsheng Pharmaceutical announced that its innovative traditional Chinese medicine, Zhilong Tongluo Tablets, has obtained the Phase II clinical research report, demonstrating significant efficacy in treating recovery from cerebral infarction (ischemic stroke) with good safety profile [1] Company Summary - Zhilong Tongluo Tablets are currently the company's exclusive product, with no other enterprises having obtained production approval for this product [1] - The clinical trial results indicate that both high-dose and low-dose groups show comparable efficacy [1] Market Summary - The sales revenue for traditional Chinese medicines treating cerebral infarction, such as Naoxintong Capsules and Tongxinluo Capsules, is projected to be 2.927 billion yuan and 2.273 billion yuan respectively in 2024 [1]

Market Overview - The Shanghai Composite Index closed at 3781.61 points, below the five-day moving average, with a decline of 1.23% [1] - The total trading volume of A-shares reached 171.35 billion yuan [1] Stocks Performance - A total of 119 A-shares broke through the five-day moving average today [1] - Notable stocks with significant deviation rates include: - Chuangyuan Xinke (创远信科) with a deviation rate of 11.34% and a daily increase of 20.09% [1] - Teruid (特锐德) with a deviation rate of 10.64% and a daily increase of 13.85% [1] - Niutai Ge (纽泰格) with a deviation rate of 7.97% and a daily increase of 9.93% [1] Additional Stocks with Minor Deviations - Stocks with smaller deviation rates that just crossed the five-day moving average include: - Xinghua New Materials (星华新材) and Haixing Power (海兴电力) [1] - Other stocks with notable performance include: - Ningbo Haiyun (宁波海运) with a daily increase of 9.95% and a deviation rate of 7.96% [1] - Xusheng Group (旭升集团) with a daily increase of 10.03% and a deviation rate of 7.83% [1]

Core Viewpoint - Fangsheng Pharmaceutical's stock price has shown fluctuations, with a year-to-date increase of 12.39% and a recent decline over the past 20 days, indicating mixed market sentiment [2]. Company Overview - Fangsheng Pharmaceutical, established on October 13, 1997, and listed on December 5, 2014, is located in Changsha, Hunan Province. The company specializes in the research, production, and sales of traditional Chinese medicine for cardiovascular, orthopedic, pediatric, and anti-infection treatments [2]. - The company's revenue composition is primarily from product sales (94.62%) and service provision (5.38%) [2]. - As of June 30, 2025, the company had 33,100 shareholders, a slight increase of 0.37% from the previous period, with an average of 13,245 circulating shares per shareholder, down by 0.36% [2]. Financial Performance - For the first half of 2025, Fangsheng Pharmaceutical reported a revenue of 834 million yuan, a year-on-year decrease of 8.35%. However, the net profit attributable to shareholders increased by 23.67% to 169 million yuan [2]. - The company has distributed a total of 689 million yuan in dividends since its A-share listing, with 484 million yuan distributed over the past three years [3]. Shareholder Structure - As of June 30, 2025, the top three circulating shareholders include ICBC Medical Health Stock (000831) with 5.40 million shares, unchanged from the previous period, and Rongtong Health Industry Flexible Allocation Mixed A/B (000727) with 5.00 million shares, which increased by 500,000 shares [3]. - Notably, E Fund Healthcare Industry Mixed A (110023) and Anxin Pharmaceutical Health Stock A (010709) have exited the top ten circulating shareholders list [3].

Core Viewpoint - Fangsheng Pharmaceutical's stock has experienced fluctuations, with a recent decline of 2.09% on September 19, 2023, reflecting a total market value of 4.742 billion yuan and a year-to-date increase of 7.89% [1] Financial Performance - For the first half of 2025, Fangsheng Pharmaceutical reported operating revenue of 834 million yuan, a year-on-year decrease of 8.35%, while net profit attributable to shareholders increased by 23.67% to 169 million yuan [2] - The company has distributed a total of 689 million yuan in dividends since its A-share listing, with 484 million yuan distributed over the past three years [3] Shareholder Structure - As of June 30, 2025, the number of shareholders increased to 33,100, with an average of 13,245 circulating shares per person, a slight decrease of 0.36% [2] - The top three circulating shareholders include Industrial Bank Medical Care Stock, holding 5.3997 million shares, and Rongtong Health Industry Flexible Allocation Mixed A/B, which increased its holdings by 500,000 shares to 5 million [3]

Core Viewpoint - Fangsheng Pharmaceutical's stock has shown mixed performance in recent trading, with a year-to-date increase of 13.69% but a recent decline over the past 20 days of 9.11% [2] Group 1: Stock Performance - As of September 18, Fangsheng Pharmaceutical's stock price rose by 2.25% to 11.38 CNY per share, with a trading volume of 1.29 billion CNY and a turnover rate of 2.64%, resulting in a total market capitalization of 4.997 billion CNY [1] - The stock has increased by 2.61% over the last five trading days and by 18.42% over the last 60 days [2] Group 2: Financial Performance - For the first half of 2025, Fangsheng Pharmaceutical reported operating revenue of 834 million CNY, a year-on-year decrease of 8.35%, while the net profit attributable to shareholders increased by 23.67% to 169 million CNY [2] - The company has distributed a total of 689 million CNY in dividends since its A-share listing, with 484 million CNY distributed over the last three years [3] Group 3: Shareholder Information - As of June 30, 2025, the number of shareholders for Fangsheng Pharmaceutical was 33,100, an increase of 0.37% from the previous period, with an average of 13,245 circulating shares per shareholder, a decrease of 0.36% [2] - The top three circulating shareholders include Industrial Bank Medical Health Stock, holding 5.3997 million shares, and Rongtong Health Industry Flexible Allocation Mixed A/B, which increased its holdings by 500,000 shares to 5 million [3]