来源：新浪证券-红岸工作室 9月30日，君实生物涨0.90%，成交额3.57亿元。两融数据显示，当日君实生物获融资买入额3763.25万 元，融资偿还5328.34万元，融资净买入-1565.09万元。截至9月30日，君实生物融资融券余额合计13.89 亿元。 融资方面，君实生物当日融资买入3763.25万元。当前融资余额13.83亿元，占流通市值的4.35%，融资 余额超过近一年90%分位水平，处于高位。 机构持仓方面，截止2025年6月30日，君实生物十大流通股东中，华夏上证科创板50成份ETF （588000）位居第六大流通股东，持股2971.67万股，相比上期减少53.67万股。易方达上证科创板 50ETF（588080）位居第七大流通股东，持股2221.32万股，相比上期增加63.00万股。香港中央结算有 限公司位居第十大流通股东，持股1312.91万股，相比上期减少186.65万股。 资料显示，上海君实生物医药科技股份有限公司位于上海市浦东新区平家桥路100弄6号7幢16层,香港铜 锣湾希慎道33号利园1期19楼1918室，成立日期2012年12月27日，上市日期2020年7月15日，公司主营业 ...

资料显示，上海君实生物医药科技股份有限公司位于上海市浦东新区平家桥路100弄6号7幢16层,香港铜 锣湾希慎道33号利园1期19楼1918室，成立日期2012年12月27日，上市日期2020年7月15日，公司主营业 务涉及单克隆抗体药物和其他治疗型蛋白药物的研发与产业化,单克隆抗体药物研发的技术服务与技术 转让等。主营业务收入构成为：药品销售90.67%，技术许可及特许权使用收入8.74%，技术服务及其他 0.59%。 来源：新浪证券-红岸工作室 10月9日，君实生物盘中下跌2.03%，截至10:03，报40.62元/股，成交1.93亿元，换手率0.61%，总市值 417.04亿元。 资金流向方面，主力资金净流出3038.12万元，特大单买入1470.52万元，占比7.62%，卖出3328.90万 元，占比17.25%；大单买入5172.48万元，占比26.81%，卖出6352.22万元，占比32.92%。 君实生物今年以来股价涨48.63%，近5个交易日跌2.52%，近20日跌12.40%，近60日涨7.09%。 君实生物所属申万行业为：医药生物-生物制品-其他生物制品。所属概念板块包括：生物医药、创新 药 ...

Core Insights - The Chinese immune checkpoint inhibitor industry is rapidly developing, with a projected market size of approximately 52.734 billion yuan in 2024, representing a year-on-year growth of 44.14% [1][4][8] - The primary driver of this growth is the innovative therapeutic mechanism of immune checkpoint inhibitors, which reactivate the immune system to identify and attack tumor cells, providing revolutionary treatment options for cancer patients with limited traditional therapies [1][4] Industry Overview - Immune checkpoint inhibitors enhance the immune system's ability to attack cancer cells by blocking immune checkpoint proteins, which are used by tumor cells to evade immune responses [2][5] - The industry has evolved through three stages: initiation, rapid development, and mature expansion, with significant policy support and market entry of domestic products since 2018 [3][4] Market Size - The immune checkpoint inhibitor market in China is expected to reach approximately 52.734 billion yuan in 2024, with a significant increase in clinical application driving market demand [1][8] Key Companies - Leading companies in the industry include Junshi Biosciences, Hengrui Medicine, Innovent Biologics, and BeiGene, which collectively hold over half of the market share [8] - Junshi Biosciences' core product, Toripalimab, has been approved for 12 indications and is the first domestic PD-1 inhibitor to receive FDA approval for kidney cancer treatment [9] - Akeso's dual antibody technology has led to significant advancements, with its PD-1/CTLA-4 dual antibody achieving notable efficacy in cervical cancer [11] Industry Development Trends 1. Continuous technological innovation is driving breakthroughs in precision treatment and combination therapies, with dual antibodies and ADCs becoming more prominent [12] 2. Market expansion and the shift of indications towards early-stage treatments are accelerating internationalization, with several domestic products gaining traction in overseas markets [13] 3. Policy and regulatory developments are promoting industry standardization, with support for new biological agents and reforms in medical insurance payment methods [13]

Group 1 - The report highlights a marginal recovery in China's manufacturing PMI in September, indicating a rebound in production activities, with new orders and export orders showing upward trends [1] - The report suggests three main investment directions based on economic recovery and market liquidity: breakthroughs in technology AI, resonance between domestic and international markets, and the continued rise of undervalued assets [1] - In the A-share market, major indices maintained upward momentum in September, with the ChiNext index rising over 12% and net inflows from southbound funds reaching 172.65 billion yuan [3] Group 2 - The global small nucleic acid drug market is projected to grow at a compound annual growth rate of 26.1%, reaching 46.7 billion USD by 2033, driven by technological advancements and increasing clinical approvals [10] - The report details the clinical progress of small nucleic acid drugs in various therapeutic areas, indicating significant potential for growth in this sector [10] - The report recommends focusing on both international and domestic companies involved in small nucleic acid drugs, highlighting key players in the market [10] Group 3 - The report on Lian Microelectronics indicates a stable revenue growth of 14.18% year-on-year for H1 2025, driven by technological innovation and an integrated supply chain [12] - Despite the revenue growth, the company reported a significant increase in net losses, indicating ongoing profitability challenges [12] - The report emphasizes the importance of capacity expansion and integrated industry chain advantages for the company's stable operations [12] Group 4 - The report on Solon Technology highlights the opportunities created by electrification and domestic substitution trends in the nylon pipeline sector, with potential revenue growth driven by increased demand from electric vehicles [18] - The company has established long-term partnerships with over 30 automotive manufacturers, positioning itself well in the market [18] - Revenue projections for 2025-2027 indicate a growth trajectory, with expected revenues of 1.57 billion, 1.96 billion, and 2.39 billion yuan respectively [18] Group 5 - The report on Yuheng Pharmaceutical shows a decline in revenue by 9.97% in H1 2025, while net profit increased by 7.56%, indicating effective cost management [37] - The company has signed promotional agreements for new drug products, enhancing its market presence and potential revenue streams [37] - The introduction of Pemabet tablets is expected to strengthen the company's product pipeline and competitive position in the cardiovascular sector [38]

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年9月30日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 上海君實生物醫藥科技股份有限公司 FF301 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 01877 | 說明 | | | | | | | | | 已發行股份（不包括庫存股份）數目 | | 庫存股份數目 | | 已發行股份總數 | | | 上月底結存 | | | 260,295,700 | | 0 | | 260,295,700 | | 增加 / 減少 (-) | | | 0 | | 0 | | | | 本月底結存 | | | 260,295,700 | | 0 | | 260,295,700 | 呈交日期: 2025年10月8日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | | 於香港聯交所上市 (註1) | ...

Investment Rating - The report maintains a "Buy" rating for the company, indicating an expected relative return of over 20% within the next six months [5]. Core Insights - The company reported a revenue of 1.168 billion yuan for H1 2025, representing a year-on-year growth of 48.64%. The net loss was 413 million yuan, a reduction in loss of 36.01% compared to the previous year [1]. - The sales revenue of the company's core product, Tislelizumab, in the domestic market reached approximately 954 million yuan in H1 2025, showing a year-on-year increase of about 42%. The product has received approval for 12 indications, with four new indications added to the medical insurance directory in 2025 [2]. - The PD-1/VEGF dual antibody, JS207, is currently in Phase II clinical trials, demonstrating strong anti-tumor activity in preclinical studies. It is being explored in various tumor types in combination with other therapies [3]. - The company has a rich pipeline of oncology drugs, with the anti-BTLA monoclonal antibody, Tifcemalimab (JS004), currently in Phase III clinical trials for LS-SCLC, having enrolled nearly 400 patients [4]. Financial Summary - The company's revenue projections for 2025 and 2026 have been revised down to 2.584 billion yuan and 3.441 billion yuan, respectively. The expected net loss for 2025 is adjusted to 675 million yuan [5]. - The company’s total market capitalization is approximately 31.77 billion yuan, with a total share capital of 766.39 million shares [6]. - The earnings per share (EPS) is projected to improve from -2.32 yuan in 2023 to 0.18 yuan in 2027, indicating a potential turnaround in profitability [9].

FF301 截至月份: 2025年9月30日 狀態: 新提交 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 致：香港交易及結算所有限公司 公司名稱: 上海君實生物醫藥科技股份有限公司 呈交日期: 2025年10月8日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | | 於香港聯交所上市 (註1) | 是 | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 01877 | 說明 | | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 260,295,700 | RMB | | 1 | RMB | | 260,295,700 | | 增加 / 減少 (-) | | | 0 | | | | RMB | | 0 | | 本月底結存 | | | 260,295,700 | RMB | | 1 | RMB | | 260,295,700 | 第 2 ...

Core Insights - Junshi Biosciences experienced a slight increase in stock price by 0.22% on September 29, with a trading volume of 531 million yuan [1] - The company reported a net financing outflow of 599.84 million yuan on the same day, indicating a higher level of financing activity compared to the past year [1][2] - As of June 30, 2025, Junshi Biosciences achieved a revenue of 1.168 billion yuan, marking a year-on-year growth of 48.64% [2] Financing and Margin Trading - On September 29, Junshi Biosciences had a financing buy-in amount of 44.49 million yuan, with a total financing balance of 13.99 billion yuan, representing 4.44% of its market capitalization [1] - The financing balance is above the 90th percentile of the past year, indicating a high level of investor interest [1] - The company also had a margin trading balance of 599.84 million yuan, which is above the 60th percentile of the past year [1] Shareholder Structure - As of June 30, 2025, the number of shareholders for Junshi Biosciences increased to 31,200, a rise of 5.88% from the previous period [2] - The average number of circulating shares per shareholder decreased by 5.56% to 24,543 shares [2] - Major institutional shareholders include Huaxia SSE STAR 50 ETF and E Fund SSE STAR 50 ETF, with varying changes in their holdings [3]

Group 1 - The company has elected Ms. Li Xin as the employee representative director for the fourth board of directors, with her term starting from the approval date of the election and lasting until the end of the board's term [1][2][4] - Ms. Li Xin was previously a non-employee representative director and her election ensures that the number of directors who are also senior management or employee representatives does not exceed half of the total number of directors [2][5] Group 2 - The company held its first extraordinary general meeting of shareholders on September 29, 2025, where all proposed resolutions were approved without any being rejected [8][10] - The meeting was conducted in compliance with the Company Law and the company's articles of association, with all 14 current directors and 3 supervisors present [9][22] Group 3 - The company approved the adjustment of its 2025 A-share stock option incentive plan, reducing the number of initial grant recipients from 251 to 235 and the total number of stock options from 25.36 million to 25.15 million [23][39] - The stock options will be granted at a price of 46.67 yuan per share, with the total number of options granted representing approximately 2.45% of the company's total share capital [35][42] Group 4 - The company conducted a self-examination regarding insider trading related to the stock option incentive plan, confirming that no insider information was leaked and that all trading activities were based on public market information [18][19][58] - The company has established a comprehensive approval process for the stock option incentive plan, ensuring compliance with relevant laws and regulations [61][62]

SHANGHAI JUNSHI BIOSCIENCES CO., LTD.* 上海君實生物醫藥科技股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1877） 調整激勵對象名單及擬授予數量 及根據2025年A股股票期權計劃 向激勵對象首次授予A股股票期權 茲提述上海君實生物醫藥科技股份有限公司（「本公司」）日期為2025年9月2日的 公告及日期為2025年9月5日的通函（「該通函」），內容有關（其中包括）本公司 2025年A股股票期權激勵計劃及建議向熊先生授予。除非文義另有所指，否則本 公告所用詞彙與該通函所界定者具有相同涵義。 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 調整首次授予A股股票期權之激勵對象名單及擬授予數量 由於16名激勵對象因離職失去激勵資格或因其他原因自願放棄激勵資格，董事會 及薪酬與考核委員會已決議根據股東於臨時股東大會的授權，對2025年A股股票 期權激勵計劃首次授予激勵對象名單、授予數量進行了調整。本 ...