格隆汇10月24日｜A股市场半导体股全线走强，其中，普冉股份20CM涨停，神工股份涨超11%，华虹 公司涨超10%，汇顶科技10CM涨停，明微电子涨9%，联芸科技、聚辰股份、新相微涨超8%，佰维存 储、银河微电涨超7%，北京君正、华海诚科涨超6%，晶合集成、伟测科技、恒烁股份、京仪装备、澜 起科技涨超5%。 ...

10月24日，诺诚健华盘中上涨2.04%，截至09:46，报22.50元/股，成交2892.88万元，换手率0.48%，总 市值397.04亿元。 资料显示，诺诚健华医药有限公司位于北京市昌平区中关村生命科学园生命园路8号院8号楼，成立日期 2015年11月3日，上市日期2022年9月21日，公司主营业务涉及诺诚健华医药有限公司是一家主要从事生 物医药的研发、生产和商业化的中国公司。该公司专注于肿瘤和自身免疫性疾病等存在未满足临床需求 的领域，其产品管线包括ICP-022、ICP-B04、ICP-490、ICP-192、ICP-723、ICP-022等。该公司主要在 中国和美国开展业务。主营业务收入构成为：药品销售87.67%，技术授权12.04%，检测服务0.15%，研 发服务0.15%。 诺诚健华所属申万行业为：医药生物-化学制药-化学制剂。所属概念板块包括：抗癌治癌、抗癌药物、 创新药、生物医药、中盘等。 截至6月30日，诺诚健华股东户数1.52万，较上期增加13.80%；人均流通股0股，较上期增加0.00%。 2025年1月-6月，诺诚健华实现营业收入7.31亿元，同比增长74.26%；归母净利润-3 ...

Core Viewpoint - The Hong Kong stock market's innovative drug sector is experiencing a decline, with the Hong Kong Stock Connect Innovative Drug ETF (520880) dropping over 3.5% as of the report, indicating a potential buying opportunity for investors despite the downturn [1] Group 1: Market Performance - The Hong Kong Stock Connect Innovative Drug ETF (520880) has seen a trading volume exceeding 200 million yuan, continuing to exhibit high premiums in the market [1] - The innovative drug sector faced a significant drop recently, with the ETF attracting over 75 million yuan in a single day, totaling over 120 million yuan in the last four days [1] Group 2: Recent Developments - The ESMO 2025 conference recently showcased positive data for several core projects of Chinese innovative drugs [1] - On October 22, Innovent Biologics announced a global strategic partnership with Takeda Pharmaceutical worth 11.4 billion USD, setting a record for the value of business development (BD) transactions in China's innovative drug sector, involving three product rights and pipeline development [1] Group 3: Future Outlook - Huafu Securities suggests that the recent adjustments in the Hong Kong innovative drug sector may present a significant opportunity for investment in late October [1] - The long-term outlook remains positive for companies with commercialization capabilities and rich pipelines, particularly in BioPharma, potential BD targets, and cutting-edge technology [1] - The innovative drug industry is expected to benefit from interest rate cuts, with performance anticipated to improve, and the end-of-year BD period may act as a catalyst for growth [1] Group 4: Index Composition - The Hong Kong Stock Connect Innovative Drug ETF (520880) and its linked fund (025220) passively track the Hang Seng Hong Kong Stock Connect Innovative Drug Select Index, which includes top ten weighted stocks such as BeiGene, China Biologic Products, Innovent Biologics, and others [1]

Core Insights - The article highlights the significant performance of certain funds in the third quarter, particularly the "Yongying Technology Smart Selection" fund, which achieved a remarkable 194% increase, making it the top-performing fund of the year [1][2] - The report indicates a substantial growth in fund size, with "Yongying Technology Smart Selection" increasing from 1.166 billion to 11.521 billion yuan, nearly a ninefold increase in a single quarter [2] - The article also discusses the ongoing optimism in the innovative pharmaceutical sector, with funds like "Great Wall Pharmaceutical Industry Selection" showing over 100% growth [1][4] Fund Performance - "Yongying Technology Smart Selection" fund's top holdings include leading optical module stocks such as "Yizhongtian" (Xinyi Sheng, 300502), Zhongji Xuchuang (300308), and Tianfu Communication (300394), which significantly contributed to its net value [2] - The fund's share count surged from 700 million to 3.466 billion, resulting in a profit of 4.715 billion yuan for investors in the third quarter [2] - The "Great Wall Pharmaceutical Industry Selection" fund also saw its size grow from 1.132 billion to 1.790 billion yuan, with a share increase from 678 million to 932 million [5] Sector Insights - The global cloud computing industry remains a focal point, with AI model valuations increasing and a notable 100% quarter-on-quarter growth in token numbers [3] - The innovative pharmaceutical sector continues to attract attention, with funds maintaining high stock positions despite recent market adjustments [6][8] - The article suggests that the technology and pharmaceutical sectors may still have upward potential, although careful stock selection is advised [8] Future Outlook - The article indicates that the technology sector, particularly AI and cloud computing, is expected to see increased investment, with potential for new opportunities in the industry chain [9] - The innovative pharmaceutical sector is projected to strengthen its global competitiveness, supported by upcoming industry conferences and positive data trends [8] - The article emphasizes the importance of not solely relying on past performance to predict future outcomes in the cloud computing sector, highlighting the need for caution [9]

CT19 单抗（明诺凯）已获批上市，用于联合来那度胺治疗复发难治 DLBCL，但由于是进口药物且定价较高，其商业化贡献可能相对有限。 摘要 奥布替尼销售额持续增长，2024 年国内销售额达 10 亿元，同比增长 49%，2025 年上半年达 6.37 亿元，同比增长超 50%，预计全年增速 将达 30%以上，受益于新增适应症和纳入医保。 诺诚健华正积极推进奥布替尼在自免适应症领域的开发，首个 IDP 适应 症预计 2027 年获批上市，SLE 的 RB 阶段研究预计年底读出 RB7 数据， 与 Zena 合作的多发性硬化症（MS）三期临床试验已启动。 血液肿瘤领域，BCL-2 抑制剂联合奥布替尼一线治疗 CLL/SLL 的三期临 床获批，单药治疗 BTK 抑制剂经治 MCL 的注册性临床试验正在进行， BCL-2 抑制剂联合阿扎胞苷用于 AML 和 MDS 的临床试验获 FDA 批准。 实体肿瘤领域，二代 TRK 抑制剂 ICP723 用于 NTRK 融合基因晚期实体 瘤的上市申请已获 CDE 受理，有望明年获批，同时积极布局 B7H3 ADC 产品，并计划拓展 ADC 平台。 未来半年至一年内，诺诚健华将迎 ...

10月22日，诺诚健华盘中下跌2.01%，截至11:03，报23.38元/股，成交7490.69万元，换手率1.18%，总 市值412.57亿元。 资金流向方面，主力资金净流出1292.02万元，特大单买入129.50万元，占比1.73%，卖出712.57万元， 占比9.51%；大单买入944.42万元，占比12.61%，卖出1653.37万元，占比22.07%。 诺诚健华今年以来股价涨90.39%，近5个交易日跌4.57%，近20日跌14.39%，近60日跌25.92%。 机构持仓方面，截止2025年6月30日，诺诚健华十大流通股东中，中欧医疗健康混合A（003095）位居 第六大流通股东，持股1304.78万股，相比上期增加398.07万股。富国精准医疗灵活配置混合A （005176）位居第七大流通股东，持股1258.20万股，持股数量较上期不变。鹏华医药科技股票A （001230）位居第八大流通股东，持股1020.21万股，相比上期减少501.14万股。易方达医疗保健行业混 合A（110023）位居第九大流通股东，持股918.57万股，为新进股东。汇添富创新医药混合A （006113）位居第十大流通股东 ...

Core Viewpoint - Nuo Cheng Jian Hua's stock price has seen a significant increase of 93.24% year-to-date, but has recently experienced a decline of 2.94% over the past five trading days and 20.66% over the past 60 days [2][3] Company Overview - Nuo Cheng Jian Hua, established on November 3, 2015, and listed on September 21, 2022, is based in Beijing and focuses on the research, production, and commercialization of biopharmaceuticals, particularly in oncology and autoimmune diseases [2] - The company's revenue composition includes 87.67% from drug sales, 12.04% from technology licensing, and 0.15% each from testing and research services [2] Financial Performance - For the first half of 2025, Nuo Cheng Jian Hua reported a revenue of 731 million yuan, representing a year-on-year growth of 74.26%, while the net profit attributable to shareholders was -30.09 million yuan, an increase of 88.51% year-on-year [3] Shareholder Information - As of June 30, 2025, the number of shareholders increased by 13.80% to 15,200, with an average of 0 circulating shares per person [3] - Notable institutional shareholders include China Europe Medical Health Mixed A and others, with changes in their holdings reflecting market dynamics [3]

2025 年 10 月 20 日 证券研究报告 行业周报 行业评级： | 报告期：2025.10.9-2025.10.19 | | | --- | --- | | 投资评级 | 看好 | | 评级变动 | 维持评级 | 分析师： huchenxi@gwgsc.com 执业证书编号：S0200518090001 联系电话：010-68085205 分析师 魏钰琪 weiyuqi@gwgsc.com 执业证书编号：S0200525060001 联系电话：010-68099389 公司地址：北京市丰台区凤凰嘴街 2 号院 1 号楼中国长城资产大厦 16 层 医药生物行业双周报 2025 年第 21 期总第 144 期 政策规范临床研究路径 重磅创新成果集中亮相 2025ESMO 大会 行业回顾 本报告期医药生物行业指数跌幅为 3.65%，在申万 31 个一级行业中 位居第 21，跑输沪深 300 指数（-2.73%）。从子行业来看，中药、 线下药店涨幅居前，涨幅分别为 1.90%、0.88%；医疗研发外包、医 疗设备跌幅居前，跌幅分别为 11.40%、5.54%。 行业走势： 估值方面，截至 2025 年 10 月 ...

Core Viewpoint - The article discusses the recent licensing agreement between Innovent Biologics and Zenas, highlighting market concerns regarding the low upfront payment and the financial stability of Zenas, a relatively new player in the biopharmaceutical industry [1][2]. Group 1: Transaction Overview - Innovent Biologics announced a licensing agreement with Zenas for the global exclusive rights to the BTK inhibitor, Oubatinib, with a potential total transaction value exceeding $2 billion [1]. - The upfront payment from Zenas consists of $35 million in cash, $65 million in milestone payments, and approximately $146 million worth of Zenas stock, with the remaining over $1.7 billion contingent on future milestones [2]. Group 2: Market Reaction - The market reacted negatively to the transaction, with Innovent's stock price dropping approximately 21.8% over two trading days following the announcement, primarily due to the low upfront payment, which constitutes only 1.75% of the total deal value [1][2]. - Concerns about Zenas's ability to fulfill its commitments arise from its status as a clinical-stage company with only $10 million in revenue and a net loss of approximately $8.58 million in the first half of 2025 [2]. Group 3: Product Background - Oubatinib is a key product for Innovent, being the first and only approved BTK inhibitor for the treatment of relapsed or refractory marginal zone lymphoma in China, with significant sales growth reported [3]. - The product has been previously licensed to Biogen, which later terminated the agreement, raising questions about the product's market viability and the reliability of future revenue from Zenas [3]. Group 4: Strategic Implications - Innovent's management emphasized the importance of business development (BD) as a priority for the next three years, indicating a strategic focus on international expansion [5]. - The company retains core rights to Oubatinib in oncology while licensing non-core rights, reflecting a strategy to balance risk and reward in its international ventures [5].

Group 1 - A-shares and Hong Kong stocks in the innovative pharmaceutical sector have rebounded, with significant gains in related stocks and ETFs [1][3][5] - The largest medical ETF in A-shares (512170) saw a trading volume of 589 million yuan, recovering 1.34% on the day [1] - The innovative drug sector is experiencing a collective rise, with notable stocks like Huahai Pharmaceutical increasing by 7.59% [3] Group 2 - The Hong Kong innovative drug ETF (520880) rose by 2.12%, with 35 out of 37 constituent stocks gaining, led by Green Leaf Pharmaceutical with an 8.31% increase [5][7] - Recent funding trends indicate a significant inflow into the innovative drug sector, with over 1.29 billion yuan added in the last three days [7] - Upcoming catalysts include the European Society for Medical Oncology (ESMO) annual meeting, which may showcase significant research results from Chinese innovative drugs [7] Group 3 - Investment strategies suggest focusing on innovative drugs, with specific ETFs like the Hong Kong innovative drug ETF (520880) and the A-share drug ETF (562050) highlighted for their potential [8] - The medical ETF (512170) is noted for its inclusion of CXO companies, which account for 26.77% of its weight [8] - The medical ETF is the largest in the market, with a scale of 26.4 billion yuan, while the drug ETF is the only one tracking the China Pharmaceutical Index [9]