股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年10月31日 狀態: 新提交 本月底法定/註冊股本總額： RMB 360,593,720 備註： 第 1 頁 共 11 頁 v 1.1.1 致：香港交易及結算所有限公司 公司名稱: 凱萊英醫藥集團（天津）股份有限公司 呈交日期: 2025年11月4日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06821 | 說明 | H股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 27,553,260 | RMB | | | 1 RMB | | 27,553,260 | | 增加 / 減少 (-) | | | 0 | | | | RMB | | 0 | | 本月底結存 | | | ...

Investment Rating - The report maintains a positive outlook on the pharmaceutical sector, particularly recommending a focus on innovative drugs and sectors with improving performance such as medical devices and CXO [1][10]. Core Insights - The pharmaceutical sector in Q3 2025 showed signs of recovery with a year-on-year revenue growth of 0.6% in Q3, marking the first positive growth in four quarters [1][10]. - Innovative drugs demonstrated a remarkable revenue growth of 36% in Q3 2025, with a turnaround in net profit from a loss of 500 million to a profit of 1.5 billion [10]. - The CXO sector also showed strong performance with a revenue growth of 10.9% and a net profit increase of 47.7% year-on-year, indicating a trend reversal [10]. Summary by Sections Q3 2025 Performance - The A-share pharmaceutical sector, excluding certain companies, achieved total revenue of 1,806.4 billion with a year-on-year decline of 1.9% and a net profit of 139.2 billion, down 5.1% year-on-year [2][11]. - In Q3 2025, total revenue reached 600.4 billion, reflecting a year-on-year increase of 0.6% but a quarter-on-quarter decrease of 0.4% [2][11]. Profitability and Margins - The gross profit for the pharmaceutical sector in Q3 2025 was 189.1 billion, with a gross margin of 31.5%, slightly down from the previous year [5][8]. - The overall net profit margin for Q3 2025 was 6.8%, showing a slight decline compared to the previous year [8]. Cash Flow - The sector reported a net cash inflow from operating activities of 59.1 billion in Q3 2025, representing a year-on-year growth of 17.9% [7][13]. Subsector Performance - The innovative drug sector's revenue growth of 36% and the CXO sector's revenue growth of 10.9% highlight the strong recovery and growth potential within these subsectors [10][11]. - The report emphasizes the importance of focusing on companies such as 恒瑞医药, 长春高新, and 药明康德, which are expected to perform well in the current market environment [1][10].

Investment Rating - The report maintains an "Overweight" rating for the pharmaceutical and biotechnology industry, indicating a positive outlook for the sector compared to the overall market performance [22]. Core Insights - The pharmaceutical sector has shown signs of recovery, with the first positive year-on-year revenue growth in four quarters, driven by strong performances in the innovative drug and CXO segments [2][11]. - Innovative drugs achieved a remarkable 36% revenue growth in Q3 2025, transitioning from a loss of 500 million to a profit of 1.5 billion, highlighting the sector's high growth potential [11]. - The CXO segment has also shown a significant turnaround, with a year-on-year revenue growth of 10.9% and a net profit increase of 47.7%, expected to maintain mid-to-high growth in the coming year [11]. Summary by Sections Industry Performance - In the first three quarters of 2025, the A-share pharmaceutical and biotechnology sector, excluding certain companies, generated total revenue of 1,806.4 billion yuan, a year-on-year decrease of 1.9%, and a net profit of 139.2 billion yuan, down 5.1% [2][3]. - For Q3 2025, total revenue reached 600.4 billion yuan, reflecting a year-on-year increase of 0.6% but a quarter-on-quarter decrease of 0.4% [2][3]. Profitability Metrics - The gross profit for Q3 2025 was 189.1 billion yuan, with a gross margin of 31.5%, showing a slight decline compared to previous periods [5][8]. - The overall net profit margin for the sector in Q3 2025 was 6.8%, down 0.05 percentage points year-on-year and 1.47 percentage points quarter-on-quarter [8]. Cash Flow Analysis - The sector reported a net cash inflow from operating activities of 59.1 billion yuan in Q3 2025, marking a year-on-year increase of 17.9% and achieving positive growth for two consecutive quarters [7][14]. Subsector Performance - The report highlights the strong performance of the innovative drug and CXO subsectors, with innovative drugs showing a significant recovery and CXO experiencing a positive trend reversal [11][12].

Core Viewpoint - Kailaiying's stock price has experienced fluctuations, with a year-to-date increase of 29.29% but a recent decline of 11.92% over the past 60 days, indicating potential volatility in the market [1][2]. Financial Performance - For the period from January to September 2025, Kailaiying achieved a revenue of 4.63 billion yuan, representing a year-on-year growth of 11.82%. The net profit attributable to shareholders was 800 million yuan, reflecting a growth of 12.66% [2]. - Since its A-share listing, Kailaiying has distributed a total of 2.405 billion yuan in dividends, with 1.701 billion yuan distributed over the past three years [3]. Shareholder Information - As of September 30, 2025, the number of Kailaiying's shareholders reached 60,100, an increase of 45.37% compared to the previous period. The average circulating shares per person remained at 0 shares [2]. - The top ten circulating shareholders include notable funds such as China Europe Medical Health Mixed A and Hong Kong Central Clearing Limited, with varying changes in their holdings [3]. Market Activity - On November 4, Kailaiying's stock price fell by 2.02%, trading at 96.96 yuan per share, with a total market capitalization of 34.963 billion yuan. The stock saw a net outflow of 3.0292 million yuan in principal funds [1]. - The stock has appeared on the "Dragon and Tiger List" once this year, with the most recent occurrence on August 8, where it recorded a net buy of -180 million yuan [1]. Business Overview - Kailaiying Pharmaceutical Group, established on October 7, 1998, and listed on November 18, 2016, primarily provides CMO pharmaceutical outsourcing services. The revenue composition includes 76.19% from small molecule CDMO solutions and 23.71% from emerging services [1][2]. - The company operates within the pharmaceutical and biotechnology sector, specifically in medical services and medical research outsourcing [2].

Group 1 - Norges Bank increased its stake in Kailaiying (06821.HK) by purchasing 213,700 shares at an average price of HKD 86.6001 per share, totaling approximately HKD 18.5064 million [1] - Following the purchase, Norges Bank's total shareholding rose to 3.7222 million shares, increasing its ownership percentage from 12.73% to 13.51% [1]

Group 1 - Norges Bank increased its stake in Kelaiying (002821) (06821) by 213,700 shares at a price of HKD 86.6001 per share, totaling approximately HKD 18.5064 million [1] - After the increase, Norges Bank's total shareholding in Kelaiying reached 3.7222 million shares, representing a holding percentage of 13.51% [1]

Core Viewpoint - Schroders PLC has reduced its stake in Kelaiying (002821) to 21.94% after selling 28,100 shares at a price of HKD 86.1644 per share, totaling approximately HKD 2.4212 million [1] Summary by Category Shareholding Changes - Schroders PLC sold 28,100 shares of Kelaiying on October 30, resulting in a decrease in its shareholding [1] - After the sale, Schroders PLC's total shareholding in Kelaiying is now 6.0458 million shares [1] - The new ownership percentage of Schroders PLC in Kelaiying is 21.94% [1]

Group 1 - Schroders PLC reduced its stake in Kelaiying (06821) by 28,100 shares at a price of HKD 86.1644 per share, totaling approximately HKD 2.4212 million [1] - After the reduction, Schroders PLC's latest holding is 6.0458 million shares, representing a holding percentage of 21.94% [1]

Core Viewpoint - Norges Bank increased its stake in Kairong (06821) by purchasing 213,700 shares at a price of HKD 86.6001 per share, totaling approximately HKD 18.5064 million, raising its total holdings to 3.7222 million shares, which represents 13.51% of the company [1] Summary by Category - **Share Purchase Details** - Norges Bank acquired 213,700 shares of Kairong at HKD 86.6001 per share [1] - The total investment amounted to approximately HKD 18.5064 million [1] - **Ownership Status** - Following the purchase, Norges Bank's total shareholding in Kairong increased to 3.7222 million shares [1] - The new ownership percentage stands at 13.51% [1]

Investment Rating - The report assigns a "Buy-A" investment rating to the company, with a 6-month target price of 128.10 CNY per share [5][6]. Core Insights - The company achieved a revenue of 4.63 billion CNY in the first three quarters of 2025, representing a year-on-year growth of 11.82%. The net profit attributable to shareholders was 800 million CNY, up 12.66% year-on-year [2][3]. - The revenue for 2025 is expected to grow by 13%-15%, driven by a significant increase in the order delivery scale in Q4 compared to Q3 [2][3]. - The company is actively expanding its market presence, resulting in double-digit growth in new orders, particularly in the fields of peptides, oligonucleotides, and ADCs [3][4]. - The company has a rich pipeline of mid-to-late stage projects, which is expected to support long-term stable growth. There are 11 small molecule projects in the validation batch stage and 9 emerging business projects expected in the second half of 2025 [4]. Summary by Sections Financial Performance - For the first three quarters of 2025, the company reported revenues of 4.63 billion CNY, with a year-on-year increase of 11.82%. The net profit was 800 million CNY, reflecting a growth of 12.66% [2][3]. - The projected net profits for 2025 to 2027 are 1.13 billion CNY, 1.32 billion CNY, and 1.52 billion CNY, with year-on-year growth rates of 19.4%, 16.6%, and 15.1% respectively [5][11]. Market Expansion - The company is increasing its market development efforts, leading to a significant rise in new orders. The global investment in innovative drugs has seen a notable recovery, with VC&PE funding in 2025 increasing by 32% globally, 33% in the U.S., and 72% domestically [3]. Project Pipeline - The company has a strong project pipeline with over 10 mid-to-late stage clinical projects in popular targets such as peptides and small nucleic acids. Additionally, there are 8 NDA projects for toxin conjugates [4].