Summary of Conference Call Notes on China Healthcare CDMOs Industry Overview - The focus is on the Contract Research Organization (CRO) and Contract Development and Manufacturing Organization (CDMO) sectors, particularly in China - Investor interest has increased due to strong performance in the second quarter of 2025, with a 27% growth compared to a 15% growth in the MXCN index [1][2] Key Points and Arguments 1. **Earnings Growth Expectations**: - Earnings growth for 3Q25 may moderate due to a high base effect, but sequential improvement is anticipated as projects progress and new capacity comes online [2][3] - Forecasted sales growth for major players: WuXi Apptec (+10%), Asymchem (+19%), and Pharmaron (+8%) compared to their 2Q25 growth rates of +20%, +28%, and +14% respectively [3] 2. **New Order Momentum**: - New order momentum is expected to remain resilient, supported by CMO projects and emerging modalities such as GLP-1/peptide capacity and Antibody-Drug Conjugates (ADCs) [2][8] - Anticipated improvements in 2026 as funding conditions recover following interest rate cuts [2] 3. **Policy and Geopolitical Factors**: - Ongoing policy uncertainty, particularly related to the US Biosecure Act, is likely to drive near-term share price volatility [2][11] - The Senate passed the FY26 NDAA with the US Biosecure Act included, which may impact companies identified as Chinese military entities operating in the US [11][12] 4. **Operational Excellence**: - Companies are focusing on operational excellence and technological advancements to secure client orders amidst geopolitical uncertainties [2][11] 5. **Capex and Investment**: - Major Chinese CDMO players are expected to maintain their FY25 capital expenditure budgets, continuing investments in peptide, ADCs, and global expansion [3][6] Additional Important Insights - **Backlog and Order Growth**: - WuXi Apptec's backlog growth in peptide and small molecule oral GLP-1 is a key focus area, along with Asymchem's order growth from peptides and ADCs [8] - The recovery in early-stage R&D remains mixed, with expectations of improvement in 2026 driven by funding recovery [8] - **Valuation and Price Targets**: - Target prices for companies such as Asymchem, Pharmaron, WuXi Apptec, WuXi Biologics, and WuXi XDC have been adjusted based on market conditions and company performance [20][23][24][25] - **Risks**: - Key risks include sensitivity to loss of key clients, pricing pressure, regulatory risks, and geopolitical tensions, particularly between the US and China [21][22][23][24][25] - **Expansion Plans**: - Chinese CDMOs are actively expanding operations overseas, with significant investments in the US and Europe [19] This summary encapsulates the critical insights from the conference call regarding the current state and future outlook of the China healthcare CDMO industry, highlighting both opportunities and risks.

Key Points Summary of Kailaiying Conference Call Company Overview - Kailaiying was founded by Dr. Hong in 1998, with a development path similar to WuXi AppTec, listed on Shenzhen Stock Exchange in 2016 and Hong Kong Stock Exchange in 2021 [7][10] Industry and Business Segments - The company operates in the CDMO (Contract Development and Manufacturing Organization) sector, focusing on small molecules and emerging businesses such as large molecule CDMO, formulation CDMO, clinical CRO, and synthetic biology [2][4] - Emerging businesses currently account for approximately 20% of total revenue and are expected to grow rapidly, significantly contributing to overall performance [2][4] Financial Performance - Revenue growth is projected to be in the double digits from 2025 to 2027, with profit growth potentially slightly faster [6][16] - The small molecule CDMO segment is robust, contributing about 70% to 80% of total revenue, with a high gross margin of 90% [3][8] - The company reported a recovery in revenue and profit growth in Q4 2024, with expectations for strong growth in 2025 [5][16] Market Position and Strategy - Kailaiying's overseas revenue dominates, with only 26% from China, approximately 60% from the US, and around 13% from Europe, making it less affected by domestic price wars [9] - The company employs a leasing model for overseas expansion to mitigate financial risks associated with direct acquisitions, reflecting a cautious and stable growth strategy [5][17] Emerging Business Insights - The emerging business segment includes significant growth in the chemical large molecule area, with production capacity expected to reach 30,000 liters by the end of the year, indicating rapid expansion [12] - Key factors for growth in emerging businesses include large clients and orders in the peptide sector, which are crucial for future product sales [15] Management and Governance - Dr. Hong holds 32% of the company's shares and has extensive industry experience, supported by a management team with a strong background [10] - The company has implemented an equity incentive plan for over 600 employees, granting nearly 5 million restricted shares, demonstrating confidence in future growth [10] Clinical and Technological Advancements - Kailaiying has made significant breakthroughs in various clinical fields, including oncology, immunology, and rare diseases, with a strong order growth in large molecules [13][14] - The company is also innovating through CFCT technology and applying synthetic biology across multiple sectors, including food and cosmetics [14] Financial Health - As of the end of 2024, Kailaiying's cash reserves are close to 60 billion RMB, with a high proportion of financial assets [16] - The company is expected to see a revenue growth rate of over 40% in emerging businesses, with profit growth anticipated to outpace revenue growth [16]

Core Points - The Bioeconomy Index (970038) closed at 2319.65 points, up 1.32%, with a trading volume of 23.929 billion yuan and a turnover rate of 1.64% [1] - Among the index constituents, 39 stocks rose while 11 fell, with Boteng Co., Ltd. leading the gainers at 6.85% and Dabo Medical leading the decliners at 2.94% [1] Index Constituents Summary - The top ten constituents of the Bioeconomy Index include: - Mindray Medical (sz300760) with a weight of 13.81%, latest price at 230.50, and a market cap of 279.468 billion yuan [1] - Changchun High-tech (sz000661) with a weight of 5.41%, latest price at 127.16, and a market cap of 51.873 billion yuan [1] - Kanglong Chemical (sz300759) with a weight of 4.66%, latest price at 31.35, and a market cap of 55.746 billion yuan [1] - Other notable constituents include Taige Pharmaceutical, Deep Technology, and Muyuan Foods, each with varying weights and market caps [1] Capital Flow Analysis - The Bioeconomy Index constituents experienced a net inflow of 265 million yuan from institutional investors, while retail investors saw a net outflow of 72.932 million yuan [3] - Key stocks with significant capital flow include: - Mindray Medical with a net inflow of 79.5868 million yuan from institutional investors [3] - Xintai (002294) with a net inflow of 66.974 million yuan, but a net outflow of 87.6434 million yuan from retail investors [3] - Changchun High-tech also saw a net inflow of 66.9424 million yuan from institutional investors, with a notable outflow from retail investors [3]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 Asymchem Laboratories (Tianjin) Co., Ltd. 凱萊英醫藥集團（天津）股份有限公司 （於中華人民共和國註冊成立的股份有限公司） 於本公告日期，本公司董事會由董事長兼執行董事Hao Hong博士，執行董事楊蕊 女士、張達先生及洪亮先生，非執行董事Ye Song博士及張婷女士，以及獨立非 執行董事孫雪嬌博士、侯欣一博士及謝維愷先生組成。 董事會會議日期 凱萊英醫藥集團（天津）股份有限公司（「本公司」）董事會（「董事會」）謹此公佈， 董事會會議將於2025年10月30日（星期四）舉行，藉以（其中包括）考慮及批准本 公司及其附屬公司截至2025年9月30日止九個月的第三季度業績及其發佈，以及 處理其他事項（如有）。 承董事會命 凱萊英醫藥集團（天津）股份有限公司 Hao Hong博士 董事長、執行董事兼首席執行官 中國天津，2025年10月15日 （股份代號：6821） ...

格隆汇10月15日丨凯莱英(06821.HK)公布，董事会会议将于2025年10月30日（星期四）举行，藉以（其 中包括）考虑及批准本公司及其附属公司截至2025年9月30日止九个月的第三季度业绩及其发布，以及 处理其他事项（如有）。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚 賴該等內容而引致的任何損失承擔任何責任。 凱萊英醫藥集團（天津）股份有限公司（「本公司」）董事會（「董事會」）謹此公佈， 董事會會議將於2025年10月30日（星期四）舉行，藉以（其中包括）考慮及批准本 公司及其附屬公司截至2025年9月30日止九個月的第三季度業績及其發佈，以及 處理其他事項（如有）。 承董事會命 凱萊英醫藥集團（天津）股份有限公司 Hao Hong博士 董事長、執行董事兼首席執行官 中國天津，2025年10月15日 於本公告日期，本公司董事會由董事長兼執行董事Hao Hong博士，執行董事楊蕊 女士、張達先生及洪亮先生，非執行董事Ye Song博士及張婷女士，以及獨立非 執行董事孫雪嬌博士、侯欣一博士及謝維愷先生組成。 Asymchem Laboratories (Tianjin) Co., Ltd. 凱萊英醫藥集團（天津）股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：6821） 董事會會議日期 ...

Group 1 - The stock price of Kailaiying has dropped 3.24% to 102.00 CNY per share, with a total market capitalization of 36.781 billion CNY, marking a cumulative decline of 10.29% over the last four days [1] - Kailaiying Pharmaceutical Group, established on October 7, 1998, specializes in providing CMO pharmaceutical outsourcing services, with revenue composition of 76.19% from small molecule CDMO solutions and 23.71% from emerging services [1] Group 2 - Huisheng Fund holds a significant position in Kailaiying, with its Huisheng Medical Health 6-Month Holding Period Mixed Fund reducing its holdings by 88,700 shares, now holding 345,300 shares, which constitutes 5.08% of the fund's net value [2] - The fund has experienced a floating loss of approximately 1.1809 million CNY today and a total floating loss of 4.0398 million CNY during the four-day decline [2] - The Huisheng Medical Health 6-Month Holding Period Mixed Fund was established on December 22, 2020, with a current size of 600 million CNY, achieving a year-to-date return of 23.82% and a one-year return of 19.48% [2]

Market Overview - The medical services sector experienced a decline of 2.91% on October 13, with Haoyuan Pharmaceutical leading the drop [1] - The Shanghai Composite Index closed at 3889.5, down 0.19%, while the Shenzhen Component Index closed at 13231.47, down 0.93% [1] Stock Performance - Notable gainers in the medical services sector included: - Meinian Health: closed at 5.29, up 3.52% with a trading volume of 2.2848 million shares [1] - ST Biological: closed at 9.15, up 2.69% with a trading volume of 23,400 shares [1] - International Medical: closed at 4.98, up 2.26% with a trading volume of 356,400 shares [1] - Major decliners included: - Haoyuan Pharmaceutical: closed at 75.50, down 6.79% with a trading volume of 75,700 shares [2] - Boteng Co.: closed at 23.34, down 6.27% with a trading volume of 224,900 shares [2] - Kailaiying: closed at 105.42, down 5.04% with a trading volume of 57,800 shares [2] Capital Flow - The medical services sector saw a net outflow of 870 million yuan from institutional investors, while retail investors contributed a net inflow of 601 million yuan [2][3] - Key stocks with significant capital flow included: - Sanbo Brain Science: net inflow of 21.51 million yuan from institutional investors [3] - International Medical: net inflow of 20.51 million yuan from institutional investors [3] - Jiuzhou Pharmaceutical: net inflow of 10.59 million yuan from institutional investors [3]

Group 1 - Pharmaceutical stocks continue to decline, with CRO sector leading the drop, including significant declines in Junshi Biosciences (down 7.98%), Kanglong Chemical (down 6.3%), Kelaiying (down 5.69%), and Tigermed (down 3.48%) [1] - Recent market trends in the pharmaceutical sector are attributed to several factors, including a deal between the Trump administration and Pfizer to lower drug prices in the U.S., which is seen as a reconciliation signal between U.S. pharmaceutical companies and the government [1] - The U.S. Senate's consideration of a bill to prohibit certain Chinese biotech companies from receiving federal funding has led to a significant pullback in the CXO sector [1] Group 2 - Recent tensions in U.S.-China trade relations have escalated, with a renewed tariff war expected; however, the pharmaceutical market is not overly concerned as the industry has shown resilience since the first tariff war in April [2] - The innovative drug and CXO sectors have outperformed other sub-industries, driven by China's rising independent innovation and ongoing overseas business development, which are less affected by tariffs [2] - The CXO sector benefits from strong upstream and downstream relationships and a service pricing model that allows companies to pass on tariff pressures relatively freely [2]

Core Viewpoint - 凯莱英's stock price has shown significant growth this year, with a year-to-date increase of 48.57%, indicating strong market performance and investor interest [1][2]. Financial Performance - For the first half of 2025, 凯莱英 reported revenue of 3.188 billion yuan, representing a year-on-year growth of 18.20%, and a net profit attributable to shareholders of 617 million yuan, up 23.71% [2]. - CMO services account for 76.19% of 凯莱英's main business revenue, while emerging services contribute 23.71% [1]. Stock Market Activity - As of October 9, 凯莱英's stock price was 111.42 yuan per share, with a market capitalization of 40.177 billion yuan [1]. - The stock has experienced a net outflow of 21.6685 million yuan in principal funds, with significant trading activity reflected in the buying and selling volumes [1]. Shareholder Information - As of June 30, 2025, 凯莱英 had 41,300 shareholders, a decrease of 5.16% from the previous period [2]. - The top ten circulating shareholders include notable funds, with 中欧医疗健康混合A holding 16.2843 million shares, a decrease of 27,500 shares from the previous period [3].