Core Viewpoint - The A-share market is experiencing a historic moment with the Shanghai Composite Index recording a 14-day winning streak, while the Hong Kong market shows weakness, particularly in technology stocks. However, innovative drug ETFs are performing well, indicating strong investor interest in the healthcare sector [1][3][4]. ETF Performance - The Hong Kong Stock Connect Innovative Drug ETF (520880) has risen over 3%, marking three consecutive days of gains, while the overall market shows mixed results. The Pharmaceutical ETF (562050) also recorded three consecutive daily gains, indicating a strong performance in the pharmaceutical sector [1][3][4]. - The largest medical ETF in the market (512170) is approaching its six-month line, reaching a new 20-day high, reflecting positive momentum in the healthcare sector [1][3][4]. Sector Highlights - The pharmaceutical sector is significantly outperforming the broader market, with leading innovative drug companies like Rongchang Bio surging over 11%. The overall performance of the pharmaceutical ETF indicates a strong bullish sentiment among investors [3][4]. - The AI application sector is also gaining traction, with the Entrepreneurial Board AI ETF (159363) reaching a new high, supported by strong performance in AI hardware and applications [9][11]. Market Outlook - Huaxi Securities suggests that the current market dynamics indicate an early spring rally, maintaining a bullish outlook. Key investment themes include emerging growth sectors and opportunities arising from anti-involution trends, particularly in AI, robotics, and renewable energy [2][20]. - The outlook for the metals sector remains optimistic, driven by macroeconomic factors such as potential interest rate cuts by the Federal Reserve and strong demand in traditional and emerging industries [13][15]. Investment Recommendations - Analysts recommend focusing on sectors benefiting from policy support, such as AI computing chains, robotics, and domestic replacements, as well as sectors poised for price increases like chemicals and non-ferrous metals [2][20]. - The innovative drug and medical device sectors are highlighted as key areas for investment, with a focus on companies that are expected to maintain strong growth trajectories through 2026 [7][20].

芯片股走强，纳芯微涨超13%，华虹半导体涨5%。 | 名称 | 现价 | 涨跌幅 ◆ | | --- | --- | --- | | 纳芯微 | 142.900 | 13.14% | | 2676.HK | | | | 壁仍科技 | 33.120 | 6.84% | | 6082.HK | | | | ASMPT | 90.500 | 6.16% | | 0522.HK | | | | 华虹半导体 | 89.300 | 5.00% | | 1347.HK | | | | 天岳先进 | 62.900 | 3.37% | | 2631.HK | | | | 宏光半导体 | 0.490 | 2.08% | | 6908.HK | | | 编辑 ｜ 钉钉 | 名称 | 现价 | 涨跌幅 ◆ | | --- | --- | --- | | 腾讯音乐-SW | 67.050 | -5.50% | | 1698.HK | | | | 比亚迪股份 | 95.300 | -3.93% | | 1211.HK | | | | 蔚来-SW | 37.580 | -3.34% | | 9866.HK | | | | 阿里巴巴-W | ...

Group 1 - The CRO (Contract Research Organization) sector in the Hong Kong stock market has shown strong performance, with notable gains across various companies [1] - Specifically, Kailaiying has increased by over 7%, while Tigermed and Zhaoyan Pharmaceutical have risen by over 5% [1] - Other companies such as WuXi AppTec and Kanglong Chemical have seen increases of over 3%, and WuXi Biologics and Kingsoft have gained over 2% [1]

Core Viewpoint - The CRO and CDMO sectors are experiencing a collective rise in stock prices, driven by a combination of recovering demand and supply-side improvements, with expectations for profitability and valuation to increase simultaneously, referred to as a "Davis Double Play" [1][2] Group 1: Stock Performance - Key stocks in the CRO sector have seen significant gains, with Kelaiying up 6.27% to HKD 82.2, Tigermed up 5.48% to HKD 48.92, and Zhaoyan New Drug up 5.19% to HKD 23.52 [1] - Other notable increases include Kanglong Chemical up 3.37% to HKD 22.68 and WuXi AppTec up 3.12% to HKD 109.1 [1] Group 2: Industry Outlook - According to Zhongtai Securities, the CRO and CDMO industries are expected to benefit from a combination of external and internal demand recovery, with supply gradually clearing [1] - The anticipated easing of monetary policy in late 2024 and subsequent geopolitical negotiations in 2025 are expected to improve market sentiment and drive demand recovery [1] - The industry is projected to see significant policy support and the realization of large-scale domestic innovative drug business development starting in 2025 [1] Group 3: Order Growth and Market Dynamics - Industrial insights from Xingye Securities indicate that many CROs are experiencing accelerated order signing, with project volumes achieving double-digit growth [2] - There is a noted upward trend in pricing for experimental monkeys, safety evaluation quotes, and clinical project costs since Q4, reflecting strong customer demand [2] - The global positioning of Chinese CDMOs in the supply chain remains irreplaceable, and the anticipated Federal Reserve interest rate cuts are expected to boost early-stage global R&D demand [2]

Core Viewpoint - Kailaiying's stock performance shows a slight increase, with significant trading activity and a notable balance in margin financing and securities lending, indicating investor interest and market dynamics [1][2]. Group 1: Stock Performance and Trading Activity - On January 6, Kailaiying's stock rose by 0.76%, with a trading volume of 384 million yuan [1]. - The margin financing data for January 6 indicates a financing buy amount of 43.63 million yuan and a financing repayment of 48.73 million yuan, resulting in a net financing outflow of 5.10 million yuan [1]. - As of January 6, the total margin financing and securities lending balance for Kailaiying was 913 million yuan, with the financing balance exceeding 50% of the one-year percentile level, indicating a high position [1]. Group 2: Company Financials and Shareholder Information - As of September 30, Kailaiying reported a total revenue of 4.63 billion yuan for the first nine months of 2025, reflecting a year-on-year growth of 11.82% [2]. - The net profit attributable to shareholders for the same period was 800 million yuan, showing a year-on-year increase of 12.66% [2]. - The number of shareholders increased to 60,100, a rise of 45.37% compared to the previous period [2]. Group 3: Dividend and Institutional Holdings - Kailaiying has distributed a total of 2.40 billion yuan in dividends since its A-share listing, with 1.70 billion yuan paid out in the last three years [2]. - Among the top ten circulating shareholders as of September 30, notable changes include an increase in holdings by China Europe Medical Health Mixed A and Hong Kong Central Clearing Limited, while a decrease was observed in holdings by Huabao CSI Medical ETF [2].

转自：前瞻产业研究院 以下数据及分析来自于前瞻产业研究院医药研发外包(CRO)研究小组发布的《中国医药研发外包（CRO） 行业市场前瞻与投资战略规划分析报告》。 行业主要上市公司：目前国内CRO行业主要的上市公司有药明康德(603259.SH)、康龙化成(300759.SZ)、泰 格医药(300347.SZ)、凯莱英(002821.SZ)、昭衍新药(603127.SH)、九洲药业(603456.SH)、皓元医药 (688131.SH)、博腾股份(300363.SZ)、成都先导(688222.SH)、药石科技(300725.SZ)等。 本文核心数据：企业主营业务收入、企业经营毛利率 1、中国CRO产业链全景梳理 中国CRO产业链贯穿研发阶段、生产阶段和产品销售整个药品生命周期，分别对应药物研发服务(CRO)、 医药生产服务(CMO/CDMO)以及医药销售服务(CSO)。研发阶段覆盖临床前与临床两大核心环节，其中临 床前主要做有关药物发现、化合物合成、合成工艺研发及制剂研发等早期基础研发工作;临床阶段主要进行 临床试验、医学统计、数据整理与数据分析等流程。生产阶段，针对不同药物类型提供生产服务，化学原 料药包含了 ...

Summary of Key Points from the Conference Call Industry Overview - The pharmaceutical sector is currently in a left-side layout phase after adjustments in 2025, with both institutional holdings and valuations positioned for upward elasticity, particularly in innovative drugs and their supply chains for 2026, benefiting from China's strengthening innovation competitiveness [1][4] - The recovery of the innovative industry chain is expected to continue, with CDMO orders and performance starting to recover from 2024, further improving in 2025 and expected to sustain into 2026 [1][9] Core Insights and Arguments - The driving forces behind the enhancement of China's innovation competitiveness include the successful implementation of business development (BD), overseas clinical progress, and commercialization, along with breakthroughs in new technologies such as XDC, dual antibodies, and small nucleic acids [5] - Investment opportunities in 2026 are concentrated in globally competitive assets, including innovative drugs, high-end manufacturing, and domestic demand-related sectors, particularly those with recovery logic [2] - The domestic demand recovery trend is clear, strengthening quarter by quarter in 2025, driven by high domestic innovation BD, a warming primary and secondary market, and an increase in IPOs in both A-shares and Hong Kong stocks [20] Notable Companies and Technologies - Key companies to watch include Innovent Biologics, Botai Biological Products, and Engen Biologics, which are core recommended assets due to their potential for significant data readouts and BD catalysts [6][10] - In the CRO sector, companies like Tigermed and Zhaoyan New Drug are expected to see performance turning points in 2026, supported by a recovery in domestic demand [3][21] - The CDMO sector is projected to continue its growth trajectory, with leading companies such as WuXi AppTec and Kelun Biotech expected to perform well due to increasing orders from overseas [22][23] Emerging Technologies and Investment Opportunities - Emerging technologies such as brain-computer interfaces and AI in pharmaceuticals are anticipated to bring new investment opportunities, with potential IPOs in these areas [12][29] - The central OTC sector is expected to see marginal recovery in 2026, with key companies like China Resources and Dong'e Ejiao being highlighted for their potential growth [13][30] Upcoming Catalysts and Key Events - Important upcoming events include the JPMorgan conference, which may provide data updates and BD changes, and significant data readouts expected in Q1 and April from major conferences [8][10] - The performance of companies in the first quarter of 2026 is anticipated to show significant elasticity and fundamental support, particularly in the CRO and innovative drug sectors [11][20] Conclusion - The pharmaceutical industry is positioned for a recovery phase with significant investment opportunities in innovative drugs, CDMO, and CRO sectors, driven by domestic demand recovery and technological advancements. Key companies and upcoming events will play a crucial role in shaping the market dynamics in 2026 [1][2][4][20]

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年12月31日 狀態: 新提交 致：香港交易及結算所有限公司 FF301 公司名稱: 凱萊英醫藥集團（天津）股份有限公司 呈交日期: 2026年1月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06821 | 說明 | H股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 27,553,260 | RMB | | | 1 RMB | | 27,553,260 | | 增加 / 減少 (-) | | | 0 | | | | RMB | | 0 | | 本月底結存 | | | 27,553,260 | RMB | | | 1 RMB | | 27,553,260 | | 2 ...

股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 截至月份: 2025年12月31日 狀態: 新提交 致：香港交易及結算所有限公司 公司名稱: 凱萊英醫藥集團（天津）股份有限公司 呈交日期: 2026年1月5日 I. 法定/註冊股本變動 | 1. 股份分類 | 普通股 | 股份類別 | H | | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 06821 | 說明 | H股 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | | 法定/註冊股本 | | | 上月底結存 | | | 27,553,260 | RMB | | | 1 RMB | | 27,553,260 | | 增加 / 減少 (-) | | | 0 | | | | RMB | | 0 | | 本月底結存 | | | 27,553,260 | RMB | | | 1 RMB | | 27,553,260 | | 2. 股份分類 ...

1月5日，凯莱英盘中上涨2.01%，截至10:00，报94.80元/股，成交1.10亿元，换手率0.37%，总市值 341.84亿元。 资金流向方面，主力资金净流入407.38万元，特大单买入257.29万元，占比2.35%，卖出0.00元，占比 0.00%；大单买入1865.67万元，占比17.03%，卖出1715.57万元，占比15.66%。 截至9月30日，凯莱英股东户数6.01万，较上期增加45.37%；人均流通股0股，较上期增加0.00%。2025 年1月-9月，凯莱英实现营业收入46.30亿元，同比增长11.82%；归母净利润8.00亿元，同比增长 12.66%。 分红方面，凯莱英A股上市后累计派现24.05亿元。近三年，累计派现17.01亿元。 机构持仓方面，截止2025年9月30日，凯莱英十大流通股东中，中欧医疗健康混合A（003095）位居第 三大流通股东，持股1631.89万股，相比上期增加3.46万股。香港中央结算有限公司位居第四大流通股 东，持股1328.77万股，相比上期增加62.64万股。华宝中证医疗ETF（512170）位居第六大流通股东， 持股564.67万股，相比上期减少10 ...