Investment Rating - The report maintains an "Overweight" rating for the pharmaceutical and biotechnology industry, expecting the industry index to outperform the market index by over 10% in the next six months [29]. Core Insights - The SW pharmaceutical and biotechnology industry outperformed the CSI 300 index, rising by 5.06% from May 30, 2025, to June 12, 2025, exceeding the CSI 300 index by approximately 4.19 percentage points [10][24]. - Most sub-sectors within the industry recorded positive returns during the same period, with other biological products and raw materials leading with increases of 6.57% and 4.92%, respectively [11][24]. - Approximately 83% of stocks in the industry achieved positive returns, with notable performers such as Yiming Pharmaceutical rising by 94.83% [12][15]. - The overall industry valuation has increased, with the SW pharmaceutical and biotechnology industry index's PE (TTM) at approximately 50.45 times, which is relatively low compared to historical levels [16][24]. Summary by Sections 1. Market Review - The SW pharmaceutical and biotechnology industry outperformed the CSI 300 index, with a rise of 5.06% from May 30, 2025, to June 12, 2025 [10]. - Most sub-sectors recorded positive returns, with significant gains in other biological products and raw materials [11]. - About 83% of stocks in the industry posted positive returns, with Yiming Pharmaceutical showing the highest increase [12][15]. 2. Industry News - The National Medical Insurance Administration announced that Hunan Province completed its annual medical insurance fund settlement ahead of schedule, distributing 9.22 billion yuan to 31,000 medical institutions [22]. - The report highlights the ongoing positive developments in the innovative drug sector, including a significant collaboration between Sanofi and Pfizer worth 6 billion USD [26]. 3. Company Announcements - Chengdu Kanghong Pharmaceutical Group's subsidiary received approval for a clinical trial of a new drug, which is expected to enhance its market competitiveness [23]. 4. Industry Outlook - The report suggests continued focus on investment opportunities within the innovative drug supply chain and related sectors, including medical devices and traditional Chinese medicine [26].

Core Viewpoint - The weight loss drug concept sector has seen a significant increase, with a rise of 4.66% as of June 9, positioning it as the second-highest gaining sector in the market [1]. Group 1: Market Performance - Within the weight loss drug sector, 48 stocks experienced gains, with Changshan Pharmaceutical reaching a 20% limit up [1]. - Notable gainers include Zhongsheng Pharmaceutical, Meinuo Pharmaceutical, and Shuanglu Pharmaceutical, all hitting the limit up, while Xinnoway and *ST Sansheng were among the few decliners [1]. - The sector's performance is reflected in the daily gainers and losers table, highlighting the overall positive trend in the weight loss drug concept [1]. Group 2: Capital Flow - The weight loss drug sector attracted a net inflow of 237 million yuan from major funds, with 27 stocks receiving net inflows [1]. - Zhongsheng Pharmaceutical led the net inflow with 247 million yuan, followed by Zhifei Biological, Shuanglu Pharmaceutical, and Ganli Pharmaceutical, which also saw significant inflows [1][2]. - The net inflow ratios for leading stocks in the sector were notably high, with Zhongsheng Pharmaceutical at 55.08%, indicating strong investor interest [2][3]. Group 3: Stock Performance Metrics - Key stocks in the weight loss drug sector showed impressive daily performance metrics, with Zhongsheng Pharmaceutical and Shuanglu Pharmaceutical both achieving nearly 10% gains [2][3]. - The turnover rates for these stocks also reflect active trading, with Zhongsheng Pharmaceutical at 3.84% and Shuanglu Pharmaceutical at 7.00% [2][3]. - The data indicates a robust interest in the weight loss drug sector, as evidenced by the high net inflow ratios and significant daily price movements [2][3].

Core Viewpoint - The approval of Wantai Biological's nine-valent HPV vaccine marks a significant development in the domestic HPV vaccine market, but the company faces challenges in sales due to increased competition and market saturation [2][5]. Group 1: Market Dynamics - The nine-valent HPV vaccine has become widely available, with sales pressure on Merck and its domestic distributor Zhifei Biological, raising questions about Wantai Biological's ability to sell its product [2][7]. - The market for HPV vaccines has seen a dramatic increase in supply, with the number of approved doses rising from 3.32 million in 2019 to 36.55 million in 2023, leading to a decrease in demand and sales pressure for existing products [7][8]. Group 2: Financial Performance - Wantai Biological's revenue from its two-valent HPV vaccine peaked at over 8.49 billion yuan in 2022 but fell to 5.51 billion yuan in 2023, with projections for further decline in 2024 [5]. - Analysts predict that the nine-valent HPV vaccine could become a core driver of Wantai Biological's performance, with potential peak sales reaching 22.8 billion yuan if penetration among eligible women exceeds 50% [5][8]. Group 3: Competitive Landscape - Wantai Biological's nine-valent HPV vaccine is the first domestically produced version and the second globally, but it will face stiff competition from Merck's Gardasil 9 and other emerging products from companies like Shanghai Bowei and Beijing Kanglaweishi [2][9]. - The market for HPV vaccines is expected to become increasingly competitive, with several companies developing higher-valent vaccines, which may further challenge Wantai Biological's market position [9].

Core Viewpoint - The announcement indicates that Zhifei Biological's subsidiary has received a production registration acceptance notice for a 15-valent pneumococcal conjugate vaccine, which is significant as it is the first of its kind approved for market in China [1] Group 1: Vaccine Development - The 15-valent pneumococcal conjugate vaccine targets the 15 most prevalent serotypes in Asia, aimed at preventing diseases caused by these serotypes [1] - The acceptance of the production registration aligns with the trend of developing multi-valent vaccines, enhancing the company's product portfolio in the pneumococcal vaccine sector [1] Group 2: Market Position and Synergy - If the project progresses smoothly, it will complement the existing 23-valent pneumococcal polysaccharide vaccine and the 26-valent pneumococcal conjugate vaccine currently in I/II clinical trials [1] - This development is expected to strengthen the company's market position and enhance its competitive edge in the vaccine market [1]

证券代码：300122 证券简称：智飞生物 公告编号：2025-31 重庆智飞生物制品股份有限公司 关于 15 价肺炎球菌结合疫苗申请生产注册获得受理的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 重庆智飞生物制品股份有限公司（以下简称"公司"）于近日获悉，由全资子 公司北京智飞绿竹生物制药有限公司（以下简称"智飞绿竹"）研发的 15 价肺炎 球菌结合疫苗申请生产注册获得国家药品监督管理局出具的《受理通知书》（受 理号：CXSS2500059）。现将相关情况公告如下： 一、研发项目简介 肺炎链球菌是引起婴幼儿和老年人急性呼吸道感染的主要病原菌。肺炎链 球菌不仅能引起肺炎，还能导致气管炎、中耳炎、鼻窦炎、脑膜炎、菌血症等疾 病。根据全球疾病负担（GBD）研究，2021 年，肺炎链球菌是全球导致下呼吸 道感染发病和死亡比例最高的病原体，估计导致 9790 万发病病例和 50 万死亡 病例。该疾病临床治疗以抗生素为主，由于抗生素的广泛应用，肺炎链球菌的耐 药性问题日益严重。基于此，WHO 将在全球接种肺炎疫苗以预防肺炎链球菌感 染所致疾病列为优先任务。 智飞 ...

Core Viewpoint - The company announced that its wholly-owned subsidiary, Zhifei Green Bamboo, has received a "Notice of Acceptance" from the National Medical Products Administration for the production registration of the ACYW135 group meningococcal polysaccharide conjugate vaccine (quadrivalent meningococcal vaccine) [1] Group 1: Product Development - Currently, there is only one quadrivalent meningococcal vaccine available in the domestic market [1] - If the vaccine is approved for market sale, it will create a synergistic effect with the company's existing meningococcal vaccine products, strengthening the company's vaccine portfolio [1] Group 2: Market Position - The approval will enhance the company's market position and competitiveness in the meningococcal vaccine sector [1] Group 3: Financial Impact - The acceptance of the production registration application will not have a significant impact on the company's short-term performance due to the high investment, long development cycle, and associated risks in drug development [1]

证券代码：300122 证券简称：智飞生物 公告编号：2025-30 重庆智飞生物制品股份有限公司 关于四价流脑结合疫苗申请生产注册获得受理的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 重庆智飞生物制品股份有限公司（以下简称"公司"）于近日获悉，由全资子 公司北京智飞绿竹生物制药有限公司（以下简称"智飞绿竹"）研发的 ACYW135 群脑膜炎球菌多糖结合疫苗（以下简称"四价流脑结合疫苗"）申请生产注册获得 国家药品监督管理局出具的《受理通知书》（受理号：CXSS2500056）。现将相 关情况公告如下： 一、研发项目简介 流行性脑脊髓膜炎是由脑膜炎奈瑟菌引起的急性化脓性脑膜炎，具有起病 急、进展快、传染性强、病死率高、致残率高等特点。智飞绿竹研发的四价流脑 结合疫苗为预防用生物制品，可以预防由 A、C、Y、W135 群脑膜炎球菌引起的 流行性脑脊髓膜炎。 二、获得受理的意义 截至本公告披露日，经查询国家药品监督管理局网站，国内有 1 款四价流脑 结合疫苗上市。 公司是国内流脑类疫苗产品种类较为完善的公司之一，现已搭建起流脑疫 苗矩阵。若未来该疫苗获批 ...

Group 1 - The National Vaccine and Biotechnology Index (980015) has seen a strong increase of 2.39% as of May 29, 2025, with notable gains in constituent stocks such as Zhaoyan New Drug (603127) up 9.99%, Yifan Pharmaceutical (002019) up 9.17%, and Dizhe Pharmaceutical (688192) up 8.73% [1] - The Biovaccine ETF (159657) rose by 2.28%, with the latest price reported at 0.63 yuan [2] - The 2025 American Society of Clinical Oncology (ASCO) Annual Meeting will take place from May 30 to June 3, 2025, in Chicago, showcasing the development of oncology research in China, with over 70 studies from Chinese scholars selected for presentation [2] Group 2 - The top ten weighted stocks in the National Vaccine and Biotechnology Index (980015) as of April 30, 2025, include Fosun Pharma (600196), Changchun High-tech (000661), and others, collectively accounting for 63.18% of the index [3] - The Biovaccine ETF closely tracks the National Vaccine and Biotechnology Index, which consists of 50 companies involved in the biotechnology industry, reflecting the overall performance of quality listed companies in the sector [2]

Group 1 - The event "Rational Investment Companion" focused on the company Zhifei Biological Products Co., Ltd. (300122), which is a component of the ChiNext 50 Index, aimed at enhancing investor services and promoting investment quality [2][3] - Zhifei Biological, established in 2002, is a comprehensive biopharmaceutical company engaged in the research, production, sales, and distribution of vaccines and biological products, and was the first private vaccine company listed on the ChiNext in September 2010 [3][4] - The company’s main products include various vaccines such as recombinant COVID-19 protein vaccine, tuberculosis vaccines, and meningococcal polysaccharide vaccines, with a recent collaboration with GSK for the exclusive distribution of a recombinant shingles vaccine [4][5] Group 2 - The event agenda includes a tour of Zhifei Biological's exhibition hall, an introduction to the Shenzhen Stock Exchange, sharing of ETF investment strategies, discussion on index investment value, and interactive communication with investors [4][6] - The company operates under the mission of "preventing diseases before they occur and treating existing diseases," aiming to build a world-class biopharmaceutical enterprise [3][4]

证券代码：300122 证券简称：智飞生物 公告编号：2025-29 重庆智飞生物制品股份有限公司 关于公司控股股东部分股份质押的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 重庆智飞生物制品股份有限公司（以下简称"公司"）近日接到公司控股 股东、实际控制人蒋仁生先生的通知，获悉蒋仁生先生将其所持有的本公司部 分股份进行了质押，具体事项如下： 一、控股股东股份质押的基本情况 | 股东 名称 | 是否为 控股股 东或第 一大股 | 本次质押 股数 | 占其所 持股份 比例 | 占公司 总股本 比例 | 是否 为限 | 是否 为补 充质 | 质押起始日 质押到期日 | 质权人 | 质押 | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | 东及其 | （股） | | | 售股 | | | | 用途 | | | 一致行 | | （%） | （%） | | 押 | | | | | | 动人 | | | | | | | | | | | | | | | | | | 重庆农 村商业 | ...