Core Viewpoint - The company Zhifei Biological (300122) has announced that its wholly-owned subsidiary, Beijing Zhifei Green Bamboo Biological Pharmaceutical Co., Ltd., has independently developed a 26-valent pneumococcal conjugate vaccine, which is currently undergoing Phase I clinical trials in Australia [1] Group 1: Company Developments - The 26-valent pneumococcal conjugate vaccine is designed to prevent invasive diseases caused by various serotypes of Streptococcus pneumoniae, covering the most common serotypes [1] - The vaccine aims to address a significant health issue, as Streptococcus pneumoniae is a major pathogen responsible for acute respiratory infections in infants and the elderly [1] Group 2: Industry Context - According to the Global Burden of Disease (GBD) study, in 2021, Streptococcus pneumoniae was responsible for approximately 97.9 million cases of illness and 500,000 deaths globally [1]

Core Viewpoint - The announcement indicates that Zhifei Biological's subsidiary has received a production registration acceptance notice for a 15-valent pneumococcal conjugate vaccine, which is significant as it is the first of its kind approved for market in China [1] Group 1: Vaccine Development - The 15-valent pneumococcal conjugate vaccine targets the 15 most prevalent serotypes in Asia, aimed at preventing diseases caused by these serotypes [1] - The acceptance of the production registration aligns with the trend of developing multi-valent vaccines, enhancing the company's product portfolio in the pneumococcal vaccine sector [1] Group 2: Market Position and Synergy - If the project progresses smoothly, it will complement the existing 23-valent pneumococcal polysaccharide vaccine and the 26-valent pneumococcal conjugate vaccine currently in I/II clinical trials [1] - This development is expected to strengthen the company's market position and enhance its competitive edge in the vaccine market [1]

智飞生物（300122）2024年度克服行业整体景气周期下行的不利影响，展现出坚韧不拔的经营韧性和稳健的发展态势——公司2024年实现营业收入260.70 亿元、实现归母净利润20.18亿元，继续保持较高水平；当期综合毛利率27.38%，同比逆势走高。 值得指出的是，2024年智飞生物研发投入高达13.91亿元，占营业收入的5.34%，占自主产品营业收入的比例高达117.68%；期末研发人员数量进一步提升 至1072人，无论是研发投入规模还是研发人员总数均创新高，充分展现出公司在研发方面的决心和担当。 必须看到，研发创新正持续为智飞生物守护大众健康注入强劲动力，并引领生物制药行业迈向新高度。 在市场拓展方面，智飞早已赢得了包括默沙东和葛兰素史克的青睐与长期合作，"硬实力"不断成为其创新驱动可持续发展的鲜明底色。 事实上，最近五年智飞生物累计研发投入已突破51亿元。高强度的研发投入正为公司带来源源不断的管线突破：截至2024年末，公司自主研发项目共计34 项(不含新冠系列项目)，其中处于临床试验及申请注册阶段的项目已有19项。2024年以来，公司在肺炎疫苗矩阵、流脑疫苗矩阵、肠道疫苗矩阵、成人疫 苗矩阵等多个关 ...