（编辑 姚尧） 证券日报网讯 智飞生物9月19日在互动平台回答投资者提问时表示，公司打造了完善的科技创新平台体 系，形成智飞绿竹、智飞龙科马、重庆宸安三大研产基地和北京创新孵化中心的战略布局，不断强化公 司研发综合实力。截至目前，公司多款创新疫苗产品已进入申报上市及临床后期阶段：15价肺炎球菌结 合疫苗、ACYW135群流脑结合疫苗等四个产品处于上市审评阶段；福氏宋内氏痢疾双价结合疫苗、四 价重组诺如病毒疫苗等五个产品处于临床试验Ⅲ期。此外，公司治疗性生物制品在研管线的利拉鲁肽注 射液已位于申报上市阶段，司美格鲁肽注射液（降糖）已完成Ⅲ期临床试验，司美格鲁肽注射液（减 重）正位于Ⅲ期临床试验阶段。 ...

Core Viewpoint - The company emphasizes its commitment to AI in product development and has established a comprehensive technology innovation platform to enhance its R&D capabilities [1] Group 1: AI Investment and R&D - The company has built a strategic layout consisting of three major research and production bases and an innovation incubation center in Beijing [1] - Multiple innovative vaccine products are in various stages of regulatory approval and clinical trials, including the 15-valent pneumococcal conjugate vaccine and the ACYW135 group meningococcal conjugate vaccine [1] - The company is advancing therapeutic biological products, with liraglutide injection at the application stage and semaglutide injection (for diabetes) having completed phase III clinical trials [1]

Core Viewpoint - The vaccine industry is currently facing multiple challenges, including weak market demand, declining public vaccination willingness, intensified price competition, and policy adjustments, leading to widespread performance pressure among domestic and international vaccine companies [1][2]. Group 1: Company Performance - Zhifei Biological's mid-year report shows a significant revenue decline, with a net loss of 597 million yuan, a shift from profit to loss year-on-year [1]. - The company has invested over 5.1 billion yuan in R&D over the past five years, with R&D expenditure reaching 635 million yuan in the first half of this year, an increase compared to the previous year [2]. Group 2: Market Dynamics - The competitive landscape is intensifying, particularly among leading companies in popular vaccine categories, with domestic alternatives like Wantai Biological's HPV vaccine priced at 499 yuan, only 40% of the price of Zhifei's previously popular HPV vaccine [1]. - The biopharmaceutical industry is transitioning from a post-pandemic adjustment phase to a structural growth phase, driven by technological breakthroughs, pipeline advancements, and internationalization [2]. Group 3: Innovation and Collaboration - The company is focusing on technological innovation to navigate the current market challenges, with several projects in clinical trials and registration stages, including vaccines for rabies, influenza, and pneumonia [2]. - Zhifei is optimizing its supply chain and collaborating closely with partners like GSK and Merck to adapt to market changes and enhance supply chain resilience [3]. Group 4: Market Outlook - The recent launch of a higher-standard quadrivalent influenza vaccine has begun commercial rollout, with successful entry into multiple provinces, indicating a positive market outlook [3]. - Analysts predict a new wave of data catalysts in China's biopharmaceutical sector, enhancing the global competitiveness of innovative drug products and improving the outlook for innovation-driven companies [3].

Core Viewpoint - The Chinese vaccine industry is facing unprecedented challenges, with major companies like Zhifei Biological expressing concerns over declining public vaccination willingness and changing market demands. However, Zhifei is increasing its R&D investment, indicating strategic resilience amidst industry difficulties [1][2]. Industry Challenges - The vaccine industry is experiencing a structural crisis, with major companies reporting over 20% declines in performance due to factors such as public neglect of routine vaccinations and the "vaccine hesitancy" phenomenon. This market contraction is unlikely to reverse in the short term through single policies or market adjustments [2][3]. Company Strategy - Despite financial pressures, Zhifei Biological is demonstrating resilience through strategic initiatives, including an 11.47% increase in R&D investment to 635 million yuan, surpassing its revenue from self-developed products. The company has 34 R&D projects, with 21 in clinical trials or registration stages, creating a multi-tiered product pipeline [2][4]. Vaccine Development Focus - Zhifei's focus on pneumonia vaccines is a key aspect of its R&D strategy. The 15-valent pneumococcal conjugate vaccine has submitted for production registration, while the 26-valent vaccine has entered Phase I clinical trials in Australia. This comprehensive pneumonia vaccine portfolio aims to provide stable revenue and competitive advantages [3][4]. International Expansion - Zhifei is pursuing a dual-track international strategy, registering existing products overseas while advancing innovative products through clinical trials. This approach targets emerging markets with high disease burdens, allowing the company to establish a differentiated international presence [6][8]. Transformation into a Comprehensive Biopharmaceutical Platform - The acquisition of a 51% stake in Chen'an Biological marks Zhifei's transition from a vaccine-only company to a "prevention + treatment" biopharmaceutical platform. This move aligns with global trends in the GLP-1 drug market, which has significant growth potential [6][7]. Long-term Growth Potential - The GLP-1 drug market is expanding, with applications extending beyond diabetes and obesity to conditions like MASH and Alzheimer's disease. Zhifei's investment in Chen'an Biological enhances its capabilities in therapeutic biopharmaceuticals, providing a buffer against vaccine market fluctuations [7][8]. Future Outlook - As public health awareness increases and government vaccination programs advance, vaccine demand is expected to recover. Zhifei's R&D advantages, therapeutic strategies, and international capabilities position it favorably for competitive recovery in the industry [8].

Core Viewpoint - Zhifei Biological's 26-valent pneumococcal conjugate vaccine (PCV26) has initiated Phase I clinical trials in Australia, marking a significant step in enhancing the global influence of Chinese vaccines [1] Group 1: Vaccine Development - The PCV26 is the only high-valent vaccine developed independently in China that has entered clinical trials [1] - The vaccine is progressing smoothly in domestic clinical trials, indicating strong development capabilities [1] Group 2: Market Positioning - The PCV26 is expected to synergize with Zhifei's existing 23-valent pneumococcal polysaccharide vaccine and the 15-valent pneumococcal conjugate vaccine, covering the entire age spectrum from infants to the elderly [1] - This strategic positioning aims to enhance Zhifei's status in the global pneumococcal vaccine market [1] Group 3: International Expansion - The initiation of overseas clinical trials signifies a multi-dimensional upgrade in Zhifei's pneumonia product matrix, establishing a more complete and competitive product system [1] - This move is a solid step towards internationalization, laying a stable foundation for market expansion and deepening in the global arena [1]

北京经济技术开发区（简称"北京经开区"，也称"北京亦庄"）2025年上半年经济数据已"出炉"，多项指 标表现亮眼：地区生产总值（GDP）同比增长12.3%；工业总产值突破3400亿元，同比增长15.6%，高 于全市平均增速9.8个百分点；大中型企业研发费用同比增长25.3%，高于全市平均增速21.2个百分点； 信息服务业营业收入、批零业销售额、金融业两项净收入增速均超20%。数据显示，北京亦庄正以科技 创新为核心引擎，加速培育和壮大新质生产力，推动经济"含新量"持续攀升，高质量发展取得新突破。 新产业加速增长，工业增加值占全市比重近四成 上半年，北京亦庄作为北京先进制造业"压舱石"作用愈发凸显，实现产值3478.7亿元，同比增长 15.6%，增速大幅领先全市平均水平9.8个百分点，工业增加值占全市比重37.7％。尤为突出的是，以集 成电路、新能源汽车、新一代信息技术等为代表的新兴产业和以人形机器人、商业航天为代表的未来产 业加速增长，成为驱动区域经济高质量发展的核心引擎。 今年以来，北京亦庄新兴产业和未来产业领域捷报频传，小米汽车累计交付量已突破30万辆；京东方第 6代新型半导体显示器件生产线全面量产；优必选 ...

Group 1 - Changan Automobile's indirect controlling shareholder will change to a newly established central enterprise after the separation of its automotive business from the Equipment Group, with no significant impact on the company's operations [1] - Zhifei Biological's 15-valent pneumococcal conjugate vaccine application for production registration has been accepted, which could enhance the company's market position and competitiveness [2] - Wanda Film is launching a shareholder return activity, allowing eligible shareholders to purchase movie ticket packages at a significantly reduced price [3] Group 2 - InSail Group plans to acquire 80% of the equity of Zhizhe Brand through a combination of issuing shares and cash payment [4] - Muyuan Foods reported May sales of 6.406 million pigs, with a revenue of 12.258 billion yuan, reflecting a year-on-year increase of 26.93% [6] - Shenzhou Cell plans to raise up to 900 million yuan through a private placement to supplement working capital [7] Group 3 - China Oil Engineering's subsidiary received a contract worth approximately 2.94 billion USD for a gas pipeline project in Iraq [8] - Dongfeng Motor reported a 31.26% year-on-year decrease in May sales of new energy vehicles, totaling 1,270 units [14] - Huazhong Pharmaceutical's subsidiary received a drug registration certificate for a new antidepressant, which has been in development since 2021 [24] Group 4 - Juhua Technology won a bid for a 197 million yuan project from the State Grid [27] - Zhaojin Mining announced plans to acquire a controlling stake in Zhixue Cloud, which may constitute a significant asset restructuring [26] - Mypo Medical intends to acquire 100% of Yijie Medical's equity, expanding its capabilities in the interventional field [13]

Core Viewpoint - The announcement indicates that Zhifei Biological's subsidiary has received a production registration acceptance notice for a 15-valent pneumococcal conjugate vaccine, which is significant as it is the first of its kind approved for market in China [1] Group 1: Vaccine Development - The 15-valent pneumococcal conjugate vaccine targets the 15 most prevalent serotypes in Asia, aimed at preventing diseases caused by these serotypes [1] - The acceptance of the production registration aligns with the trend of developing multi-valent vaccines, enhancing the company's product portfolio in the pneumococcal vaccine sector [1] Group 2: Market Position and Synergy - If the project progresses smoothly, it will complement the existing 23-valent pneumococcal polysaccharide vaccine and the 26-valent pneumococcal conjugate vaccine currently in I/II clinical trials [1] - This development is expected to strengthen the company's market position and enhance its competitive edge in the vaccine market [1]

Core Viewpoint - The vaccine industry is undergoing significant adjustments, and the company is focusing on high R&D investment, risk mitigation, and diversified business layout to navigate through the industry volatility and share in the market recovery benefits [1][2]. Financial Performance - In 2024, the company achieved operating revenue of 26.07 billion yuan and a net profit attributable to shareholders of 2.018 billion yuan; in Q1 2025, the operating revenue was 2.374 billion yuan [2]. - The company's self-developed product revenue reached 1.182 billion yuan in 2024, a year-on-year increase of 14.98%; the net cash flow from operating activities in Q1 2025 was 304 million yuan, up 107.12% year-on-year [3]. - The accounts receivable balance decreased from 27.059 billion yuan at the beginning of 2024 to 14.645 billion yuan in Q1 2025, addressing a common industry issue [3]. R&D Investment and Product Pipeline - The company invested 1.391 billion yuan in R&D in 2024, with the number of R&D personnel increasing to 1,072, and cumulative R&D investment exceeding 5.1 billion yuan over the past five years [3]. - Significant progress has been made in self-developed pipelines, including the approval of the quadrivalent influenza virus split vaccine and the acceptance of production registration applications for the freeze-dried human rabies vaccine and trivalent influenza virus split vaccine [3][4]. Market Strategy and Risk Mitigation - The company has optimized its strategic cooperation with GlaxoSmithKline (GSK) to enhance flexibility in procurement and supply of the shingles vaccine, extending exclusive rights until the end of 2034 [5][6]. - Adjustments in collaboration with Merck have been made to phase the delivery schedule based on consumer demand, improving supply chain efficiency and risk resilience [6]. - The company has taken significant steps to gain control over Chanan Bio, expanding its pipeline in GLP-1 and insulin analogs to mitigate single-business risks [6][7]. Global Expansion - The company is actively pursuing overseas clinical trials and registrations, with products like the tuberculosis diagnostic reagent "Yika" approved in Indonesia and the 23-valent pneumonia vaccine receiving GMP certification in the Philippines [7].

Core Insights - In 2024, Zhifei Biological achieved a revenue of 26.07 billion yuan and a net profit of 2.018 billion yuan despite industry challenges, showcasing its resilience and long-term development potential [1][2][3] Financial Performance - The company reported a 14.98% year-on-year increase in revenue from self-developed products, totaling 1.182 billion yuan, while agency products faced significant demand fluctuations, with a 95.49% drop in the issuance of Merck's quadrivalent HPV vaccine [2][3] - Accounts receivable decreased from 27.059 billion yuan at the beginning of 2024 to 14.645 billion yuan in Q1 2025, indicating effective financial risk management [3] - The net cash flow from operating activities in Q1 2025 was 304 million yuan, a 107.12% increase year-on-year, reflecting a shift from expansion to refined operations [3] Strategic Initiatives - Zhifei Biological restructured core partnerships to enhance market resilience, extending the exclusive distribution rights for the shingles vaccine with GSK until 2035 and exploring a 10-year collaboration for RSV vaccines [2][3] - The company is adjusting the delivery schedule for Merck's products to optimize inventory management while meeting consumer demand [2][3] Research and Development - In 2024, R&D investment reached 1.391 billion yuan, with cumulative investment exceeding 5.1 billion yuan over five years, leading to significant advancements in its innovation pipeline [4][5] - The company has 34 self-developed projects, with 19 in clinical and registration stages, indicating a potential peak in product launches in the next 3-5 years [7] International Expansion - Zhifei Biological's overseas operations are gaining traction, with its tuberculosis diagnostic reagent "Yika" approved for use in Indonesia and other markets, and the 23-valent pneumonia vaccine receiving GMP certification in the Philippines [6][7] - The company is positioned to benefit from the approval of male indications for Merck's quadrivalent and nine-valent HPV vaccines, expanding its market reach [6][7] Future Outlook - The company aims to continue its commitment to social benefits while pursuing technological innovation and market promotion, positioning itself to play a significant role in public health and the vaccine industry [7][8]