Core Insights - The company shows signs of short-term recovery with revenue and profit growth, but long-term growth challenges and structural issues are becoming apparent [2][3] - The core business, particularly the dura mater patch segment, faces multiple pressures including pricing impacts from centralized procurement policies and competition from domestic products [2][9] - The company is struggling with a lack of innovation and slow product iteration, which hampers the emergence of a second growth curve [2][11] Financial Performance - In the first half of 2025, the company reported revenue of 201 million yuan, a slight increase of 5.89% year-on-year, and a net profit of 20.4 million yuan, with a growth rate of only 1.27% [3][4] - Over a five-year period, revenue has declined from 437 million yuan in 2020 to 377 million yuan in 2024, with a cumulative decrease of 13.7% [4] - The first half of 2025 revenue is only 53.3% of the total revenue for 2024, indicating potential challenges in achieving annual revenue targets [4] Business Segment Challenges - The dura mater patch business, which is the main revenue driver, generated 74.44 million yuan in the first half of 2025, accounting for 50.6% of the medical device segment's revenue [5][7] - Despite high gross margins of around 90%, the revenue growth for dura mater patches has stagnated, with a cumulative decline of 15.1% from 2022 to 2024 [8][9] - The company’s reliance on a single product line exposes it to risks, as other product lines have not been able to significantly contribute to revenue [12][13] Competitive Landscape - The dura mater patch market is highly competitive, with international giants holding 60% market share, and domestic competitors are rapidly advancing in technology [13] - The company’s market share for dura mater patches is approximately 30%, but it faces pressure from centralized procurement and declining prices [13] - The lack of significant product upgrades over the past decade has resulted in a stagnation of growth, with competitors making advancements in areas such as biodegradable materials [10][11] Research and Development Issues - The company has reduced R&D spending from 57.9 million yuan in 2022 to 42.31 million yuan in 2024, with R&D expenses as a percentage of revenue dropping from 15.4% to 9.6% [11] - The R&D team remains stable at 60-70 personnel, but the lack of capitalized projects indicates a slow transition from research to revenue-generating products [11] - The company’s focus on advanced fields like artificial liver and CAR-T lacks synergy with its core dura mater patch business, leading to a disconnect in innovation [11]

Company Overview - Crown Bio is located in Huangpu District, Guangzhou, Guangdong Province, and was established on October 22, 1999. The company was listed on July 6, 2011. Its main business involves the research, production, and sales of regenerative medical materials and regenerative medical implants, as well as research and clinical applications of cell therapy technology and immune cell storage [1][2]. Financial Performance - For the first half of 2025, Crown Bio achieved operating revenue of 201 million yuan, representing a year-on-year growth of 5.89%. The net profit attributable to the parent company was 20.40 million yuan, an increase of 1.27% year-on-year [2]. - Since its A-share listing, Crown Bio has distributed a total of 86.66 million yuan in dividends, with no dividends paid in the last three years [3]. Stock Performance - As of September 22, Crown Bio's stock price was 15.37 yuan per share, with a market capitalization of 4.075 billion yuan. The stock has increased by 27.66% year-to-date but has seen a decline of 4.36% over the last five trading days, 11.41% over the last 20 days, and 5.30% over the last 60 days [1]. - The stock experienced a net outflow of 7.55 million yuan in principal funds, with significant selling pressure observed [1]. Shareholder Information - As of September 10, the number of shareholders for Crown Bio was 28,200, a decrease of 2.37% from the previous period. The average number of circulating shares per person increased by 2.43% to 9,407 shares [2]. Business Segments - The revenue composition of Crown Bio is as follows: medical devices account for 73.28%, pharmaceuticals for 15.21%, and leasing and other services for 11.51% [1]. - The company operates within the pharmaceutical and biological industry, specifically in the medical device and consumables sector, and is involved in various concept sectors including medical consumables, small-cap stocks, medical beauty, and biomedicine [2].

Group 1: Financial Performance and Dividend Policy - The company has not distributed dividends for 7 consecutive years due to negative distributable profits, which complies with relevant regulations [3][18] - The management is focused on improving operational efficiency and resource allocation to meet future dividend conditions [7][18] - The company emphasizes the importance of shareholder returns and plans to develop a cautious dividend policy based on actual profit distribution conditions [3][18] Group 2: Core Business Areas - The company focuses on three main business segments: materials, pharmaceuticals, and cell therapy [3][11] - Key products in the materials segment include biological dura mater patches and sterile biological dressings, applicable in various medical fields [3][11] - The pharmaceutical segment features products like Bimekizumab, which treats inflammatory and autoimmune diseases [3][11] Group 3: Research and Development Progress - The company is actively advancing research in stem cell therapy and has ongoing projects in various medical fields, including liver disease and skin conditions [5][9] - The biological artificial liver project is currently in the preclinical research stage [9][18] - The company collaborates with several hospitals for clinical studies in areas such as cartilage repair and severe psoriasis treatment [5][9] Group 4: Market and Investor Relations - The company acknowledges the need for improved communication with investors regarding clinical results and project updates [6][9] - There are no current plans for share buybacks, but the company will adhere to regulations if such plans arise in the future [9][18] - The management is committed to maintaining transparency and fulfilling information disclosure obligations as required by regulations [6][9]

内容概要：人工硬脑膜是用生物材料制成人体脑膜的替代物，用于因颅脑、脊髓损伤、肿瘤及其他颅脑 疾病引起的硬脑膜或脊膜缺损的修补，防止脑脊液外漏、颅内感染、脑膨出、脑粘连和疤痕等严重并发 症，以恢复其完整性。人工硬脑膜属于植介入耗材，伴随着国民可支配收入增加、老龄化程度加深，脑 血管疾病发病率上升，神经外科介入类手术需求增加，推动人工硬脑膜的需求放量增长。但2021年以来 随着集采的稳步推进，国内人工硬脑膜产品价格下降较为明显。2024年，我国人工硬脑膜需求量从2017 年的44.63万片增长至94.61万片，产品价格从2017年的1775元/片下降至800元/片，人工硬脑膜市场规模 则从2020年的10.26亿元下降至2024年的7.57亿元。 关键词：人工硬脑膜行业政策、人工硬脑膜产业链、人工硬脑膜需求量、人工硬脑膜行业均价、人工硬 脑膜市场规模、人工硬脑膜市场竞争格局、人工硬脑膜行业发展趋势 一、人工硬脑膜行业基本概况 神经外科作为医学领域最为复杂的学科之一，是以手术为主要手段，医治中枢神经系统（脑、脊髓）、 周围神经系统和植物神经系统疾病的一门临床外科专科。作为高精尖的前沿学科之一，神经外科对应用 在手术 ...

证券代码：300238 证券简称：冠昊生物 公告编号：2025-052 为进一步加强与投资者的互动交流，冠昊生物科技股份有限公司（以下简称 "公司"）将参加由广东证监局、广东上市公司协会联合举办的"向新提质 价值 领航——2025 年广东辖区投资者集体接待日暨辖区上市公司中报业绩说明会" 活动，现将相关事项公告如下： 本次投资者网上集体接待日活动将采用网络远程的方式举行，投资者可登录 "全景路演"网站（https://rs.p5w.net）参与本次互动交流，活动时间为 2025 年 9 月 19 日（星期五）15:30-17:00。届时公司高管将在线就公司 2025 年中报业绩、 公司治理、发展战略、经营状况和可持续发展等投资者关心的问题，与投资者进 行沟通与交流，欢迎广大投资者踊跃参与。 特此公告。 冠昊生物科技股份有限公司董事会 2025 年 9 月 17 日 冠昊生物科技股份有限公司 关于参加广东辖区 2025 年投资者网上集体接待日暨中报业绩说 明会活动的公告 本公司及董事会全体人员保证信息披露的内容真实、准确和完整，没有虚 假记载、误导性陈述或者重大遗漏。 ...

Core Viewpoint - Guanxiao Biological (300238) announced that neither the company nor its controlling subsidiaries provide guarantees to entities outside the scope of consolidated financial statements, nor do they have overdue guarantees, guarantees involved in litigation, or losses due to judgments against guarantees [1] Summary by Relevant Categories - **Company Guarantees** - The company and its controlling subsidiaries do not provide guarantees to any entities outside the consolidated financial statement scope [1] - There are no overdue guarantees reported [1] - **Legal and Financial Standing** - The company is not involved in any litigation related to guarantees [1] - There are no losses incurred from judgments against guarantees [1]

关于全资子公司为公司提供担保的公告 证券代码：300238 证券简称：冠昊生物 公告编号：2025-051 冠昊生物科技股份有限公司 本公司及董事会全体人员保证信息披露的内容真实、准确和完整，没有虚 假记载、误导性陈述或者重大遗漏。 一、担保情况概述 近日，为满足冠昊生物科技股份有限公司(以下简称"公司")经营发展需要， 公司向中国工商银行股份有限公司广州天平架支行申请人民币壹仟万元整 （¥10,000,000.00）银行贷款，公司全资子公司冠昊生命健康科技园有限公司（以 下简称"冠昊科技园"）和广东冠昊再生医学科技开发有限公司（以下简称"再 生医学公司"）为上述贷款提供连带责任保证担保。 根据《深圳证券交易所创业板股票上市规则》《深圳证券交易所上市公司自 律监管指引第 2 号——创业板上市公司规范运作》《公司章程》等相关规定，本 次担保事项属于上市公司全资子公司为上市公司提供的担保，担保人冠昊科技园 和再生医学公司已分别履行了相应的内部审议程序，无需提交公司董事会或股东 会审议。 二、被担保人的基本情况 公司名称：冠昊生物科技股份有限公司； 统一社会信用代码：91440000707688515X； 成立日期 ...

Group 1 - The company, Guanhao Biological (300238), clarified on September 10 that it is not involved in the brain-computer interface business [1] - The main products related to neurosurgery include biological dura (spinal) membrane patches and type B dura membrane patches [1]

Core Viewpoint - The company, Guanhao Biological (300238.SZ), clarified that it is not involved in the brain-computer interface business, focusing instead on neurosurgical products [1] Group 1: Company Products - The main products related to neurosurgery include biological dura (spinal) membrane patches and type B dura membrane patches [1]

Summary of Key Points Core Viewpoint - Guanhao Biological has experienced a decline in the number of shareholders for the second consecutive period, indicating potential concerns regarding investor confidence and stock performance [2]. Financial Performance - For the first half of the year, the company reported a total revenue of 201 million yuan, representing a year-on-year growth of 5.89% [2]. - The net profit for the same period was approximately 20.4 million yuan, with a year-on-year increase of 1.27% [2]. - The basic earnings per share were recorded at 0.0800 yuan, and the weighted average return on net assets was 3.68% [2]. Shareholder Dynamics - As of August 31, the number of shareholders stood at 28,869, which is a decrease of 2,484 from the previous period (August 20), reflecting a month-on-month decline of 7.92% [2]. - The stock price closed at 16.80 yuan, showing a slight increase of 0.30%, but the cumulative decline since the concentration of shares began is 3.11% [2]. - The stock has experienced 4 days of increases and 4 days of decreases during the reporting period [2].