Core Insights - The innovative drug sector in Hong Kong has experienced significant volatility, with the Hang Seng Healthcare Index dropping 6.33% in a week, marking the largest weekly decline since the second half of 2025 [4][10] - The recent surge in IPOs for innovative drug companies in Hong Kong is attributed to favorable policies and improved market liquidity, with notable companies like Betta Pharmaceuticals and Changchun High-tech expected to achieve "A+H" listings [5][6] - The first domestic IL-36R monoclonal antibody has been submitted for approval to treat adult generalized pustular psoriasis, indicating advancements in innovative drug development [12][13] Market Performance - The pharmaceutical and biotechnology index fell by 1.66% from October 6 to October 10, underperforming the Shanghai Composite Index by 0.72 percentage points, continuing a trend of underperformance for three consecutive weeks [4] - The innovative drug index saw a decline of 1.09% over the same period, with the Hong Kong innovative drug ETF dropping 3.98% [4] IPO Trends - A notable increase in IPO activity for innovative drug companies has been observed, with a focus on various cutting-edge fields such as small molecule drugs and antibody-drug conjugates [5] - The Hong Kong Stock Exchange has relaxed public shareholding requirements for "A+H" companies, facilitating more A-share companies to list in Hong Kong [5] Clinical Trials - Recent data indicates that 85 clinical trial registrations were disclosed by the National Medical Products Administration, with 29 of these being innovative drugs in Phase II or higher, primarily targeting autoimmune diseases and tumors [6] Business Development (BD) Insights - The recent downturn in the innovative drug sector is linked to a cooling off of high-profile business development transactions, with market expectations having been previously overstated [10][11] - The total transaction amount for related deals in the first half of the year reached $60.8 billion, reflecting a 129% year-on-year increase [10] Future Outlook - The upcoming European Society for Medical Oncology (ESMO) annual meeting is expected to showcase 23 studies from China, highlighting the potential for innovative drugs to gain international recognition [11] - The market is advised to focus on clinical data and competitive landscapes as the sector transitions from high BD activity to a more fundamental-driven approach [11]

Market Overview - The chemical pharmaceutical sector experienced a decline of 2.62% on October 14, with Yipinhong leading the drop [1] - The Shanghai Composite Index closed at 3865.23, down 0.62%, while the Shenzhen Component Index closed at 12895.11, down 2.54% [1] Stock Performance - Notable gainers included: - Asia-Pacific Pharmaceutical (002370) with a closing price of 6.24, up 10.05% [1] - Duorui Pharmaceutical (301075) at 42.06, up 4.94% [1] - Deyuan Pharmaceutical (920735) at 37.78, up 3.00% [1] - Major decliners included: - Yipinhong (300723) at 52.98, down 14.30% [2] - Betta Pharmaceuticals (300558) at 58.34, down 10.63% [2] - Zerui Pharmaceutical (688266) at 93.60, down 7.60% [2] Capital Flow - The chemical pharmaceutical sector saw a net outflow of 2.271 billion yuan from institutional investors, while retail investors contributed a net inflow of 1.481 billion yuan [2][3] - The top stocks by net inflow from institutional investors included: - Asia-Pacific Pharmaceutical with a net inflow of 53.03 million yuan [3] - Xiangrikui (300111) with a net inflow of 45.54 million yuan [3] - Conversely, Yipinhong experienced a significant net outflow of 979 million yuan from institutional investors [2][3]

每经AI快讯，10月14日，A股创新药概念股震荡走低，贝达药业跌超10%，金城医药、康辰药业、百利 天恒、欧林生物、长春高新等跌逾5%。 （文章来源：每日经济新闻） ...

贝达药业（300558.SZ）10月13日在投资者互动平台表示，近期公司产品恩沙替尼术后辅助治疗临床研 究中期数据的分析显示阳性结果，达到预设的主要研究终点，公司正在努力准备，加紧推进NDA申请 工作。公司于2022年参与了禾元生物的战略投资，同时双方已就区域经销达成合作，这是公司发挥生态 圈协同作用的重要成果，将对公司经营带来积极影响，具体收益请关注业务发展情况。 （文章来源：每日经济新闻） 每经AI快讯，有投资者在投资者互动平台提问：贵公司目前的管线预计哪些能于今年底上市？贵公司 参股禾元生物，预计能带来多少收益？贵公司目前很多药品都未能进入医院，贵公司有无计划采取措施 加快推广？ ...

香港交易及結算所有限公司、香港聯合交易所有限公司與證券及期貨事務監察委員會對本公告 的內容概不負責，對其準確性或完整性亦不發表任何意見，並明確表示概不就因本公告全部或 任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責任。 Betta Pharmaceuticals Co., Ltd. （貝達藥業股份有限公司） （於中華人民共和國註冊成立的股份有限公司） 警告 本公告乃根據香港聯合交易所有限公司（「聯交所」）與證券及期貨事務監察委員會 （「證監會」）的要求而刊發，僅用作向香港公眾人士提供資料。 (e) 本公告（及其所載資料）僅供參考，並不構成或組成在美國（包括其領土及屬 地、美國任何州及哥倫比亞特區）或進行有關要約或出售即屬違法的任何其 他司法權區發行或出售本公司任何證券的任何要約，或招攬購買、認購或以 其他方式收購本公司任何證券的任何要約的一部分。本公司認為，其為「外 國私人發行人」（「外國私人發行人」，定義見1933年美國《證券法》（經修訂） （「美國《證券法》」）第405條），並擬盡可能經營其業務以維持其作為外國私人 發行人的地位。本公司證券（「證券」）並無亦將不會根據美國《證券法》或向 美國 ...

Investment Rating - The report maintains a "Market Weight" rating for the pharmaceutical and biotechnology industry [2][24]. Core Viewpoints - The SW pharmaceutical and biotechnology industry underperformed the Shanghai and Shenzhen 300 index, declining by 0.23% from September 26, 2025, to October 9, 2025, lagging behind the index by approximately 2.76 percentage points [9][24]. - Most sub-sectors within the industry recorded negative returns during the same period, with the medical research outsourcing and in vitro diagnostics sectors showing gains of 1.99% and 0.55%, respectively, while the raw materials and chemical preparations sectors fell by 2.23% and 1.73% [10][24]. - Approximately 54% of stocks in the industry achieved positive returns, with the top performer, Zhendemedical, increasing by 21.43%, while the largest decline was seen in Guangshentang, which fell by 21.86% [11][14]. - The overall price-to-earnings (PE) ratio for the SW pharmaceutical and biotechnology industry was approximately 55.04 times as of October 9, 2025, indicating a decrease in industry valuation [15][24]. Summary by Sections 1. Market Review - The SW pharmaceutical and biotechnology industry underperformed the Shanghai and Shenzhen 300 index, with a decline of 0.23% from September 26, 2025, to October 9, 2025 [9]. - Most sub-sectors recorded negative returns, with medical research outsourcing and in vitro diagnostics performing better than others [10]. - About 54% of stocks in the industry recorded positive returns, with significant variations in individual stock performance [11]. 2. Industry News - The 11th batch of national procurement will begin accepting applications on October 21, 2025, with 55 major varieties included [22]. - The National Medical Products Administration issued guidelines for the quality management of medical device online sales [20][21]. 3. Company Announcements - Zhejiang Haizheng Pharmaceutical announced that its product achieved Self-GRAS certification in the U.S., allowing it to enter the U.S. market [23]. 4. Weekly Industry Perspective - The report suggests focusing on investment opportunities in innovative drugs and sectors with expected business development catalysts, including medical devices and pharmaceutical commerce [24][26].

Summary of Conference Call Notes Industry Overview - The focus remains on the innovative drug sector, benefiting from business development (BD) transactions and data catalysts, with companies like Heng Rui continuing to push forward despite recent large transactions not meeting expectations [1][2] - The CRO (Contract Research Organization), CDMO (Contract Development and Manufacturing Organization), and upstream supply chain are benefiting from anticipated interest rate cuts in the U.S. and recovering order performance [1][2] - Medical devices, particularly high-consumption and equipment sectors, are showing signs of reversing performance difficulties, with Q3 expected to show improvement [1][2] Key Investment Strategies - Emphasis on the innovative drug line, with catalysts from the ESMO conference and BD transactions, alongside Q3 performance improvements [1][5] - Attention to the impact of basic drug directory policies and adjustments in traditional Chinese medicine companies, which may provide short-term catalysts [1][5] - Portfolio adjustments in October 2025 included increasing positions in companies like Changchun High-tech, Xianju Pharmaceutical, Betta Pharmaceuticals, and Tengke Pharmaceuticals, as well as companies showing performance inflection points [1][6] Core Recommendations - Recommended stocks based on three criteria: vertical extension capability in the supply chain, realization capability, and systematic early-stage R&D platform capability [9] - Specific recommendations include Changchun High-tech, Betta Pharmaceuticals, Amgen Pharmaceuticals, and Xiansheng Pharmaceuticals [9] - Notable mentions include Amgen, WuXi Biologics, and Miaomei Helian, expected to benefit from strong Taiji business, recovery in monoclonal antibody business, and high growth in ADC projects, with significant earnings growth anticipated in 2025 [1][19] Sector-Specific Insights - The innovative drug sector is viewed as the strongest and most fundamentally sound segment, with a focus on recovery from previous difficulties and policy changes [3][4] - CROs are showing early signs of recovery, with significant performance from WuXi and similar companies [3][4] - Medical devices are also recovering, with various companies performing well across different segments [4] Company-Specific Developments - **Betta Pharmaceuticals**: Notable for strong financial performance and ongoing business development, including an IPO process in Hong Kong expected to bring positive momentum [10] - **Amgen Pharmaceuticals**: Recently introduced strategic investment from Haizheng Pharmaceuticals, enhancing future growth prospects [11] - **Miaomei Helian**: Positioned as a leader in the ADC CRDMO sector, with significant growth expected from backend projects [20] - **Tianyu Co.**: Anticipated to maintain strong growth due to a diverse product pipeline and CDMO business expansion [25] - **Lianbang Pharmaceuticals**: Focused on innovative drugs, with several promising projects in clinical trials expected to drive future growth [26][27] Market Performance - The recommended portfolio showed an average increase of 5.5 percentage points in September, outperforming the broader pharmaceutical sector by 7.2 percentage points [6] - Specific stocks like Changchun High-tech and WuXi Biologics saw significant price increases of 26% and 23%, respectively [6] Conclusion - The innovative drug sector remains a key focus for investment, with several companies showing promising signs of recovery and growth potential. The overall sentiment is positive, with expectations for continued performance improvements in Q3 and beyond, driven by strategic investments and favorable market conditions [1][2][5]

Core Viewpoint - A new wave of pharmaceutical companies is applying for listings on the Hong Kong Stock Exchange (HKEX), with 11 companies submitting applications in a two-day period, indicating a significant uptick in market activity [1][3]. Group 1: Listing Activity - Approximately 25 pharmaceutical companies have submitted listing applications to HKEX since September, with a notable concentration of 11 applications on September 29-30 [3]. - Companies such as Sichuan Good Doctor Cloud Medical Technology Group and Annoroad Gene Technology are among those applying, with some indicating they are unprofitable biotech firms under the HKEX Chapter 18A rules [1][3]. - The trend of "A+H" dual listings is emerging, with several companies already listed on A-shares also seeking to list on HKEX, enhancing their financing capabilities [5][6]. Group 2: Market Drivers - The HKEX's 18A listing rules, introduced in 2018, have created a pathway for unprofitable biotech companies to go public, while the "Tech Company Fast Track" launched in 2025 further streamlines the listing process for tech firms [4]. - Increased demand for healthcare services due to population aging and accelerated regulatory approvals from domestic drug monitoring agencies are contributing to a favorable environment for pharmaceutical companies [4]. Group 3: Financial Performance - Many of the companies applying for listings are currently unprofitable, with significant losses reported. For instance, Meikang Aote and its subsidiary Blue Nancheng reported losses of approximately 195 million yuan and 112 million yuan, respectively, in recent financial periods [9][10]. - The trend of unprofitable companies seeking listings under the 18A rules highlights the role of HKEX as an "innovation incubator" for the biotech sector [10]. Group 4: Future Implications - The rise of "A+H" listings is expected to reshape the competitive landscape of the domestic biotech industry, potentially accelerating industry consolidation and enhancing the market position of well-capitalized firms [7]. - Increased capital influx is anticipated to boost the development of innovative drugs and technologies, thereby improving overall industry innovation efficiency [7].

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [1] Core Insights - The pharmaceutical and biotechnology industry index experienced a decline of 2.72%, ranking 23rd among 31 primary industries, underperforming the CSI 300 index which declined by 2.62% [4][16] - The industry valuation as of September 30, 2025, is a PE (TTM overall method, excluding negative values) of 31.23x, down from 31.79x in the previous period, indicating a downward trend and below the average [21] - The top three sub-industries in terms of PE (TTM overall method, excluding negative values) are vaccines (55.74x), medical devices (41.29x), and hospitals (39.51x), with the median at 33.19x, while pharmaceutical circulation has the lowest valuation at 14.34x [21] Industry Review - The report highlights that during the reporting period, 51 listed companies in the pharmaceutical and biotechnology sector had a net reduction in shareholders amounting to 2.435 billion yuan, with 14 companies increasing their holdings by 681 million yuan and 37 companies reducing their holdings by 3.116 billion yuan [4] - The report emphasizes the importance of upcoming clinical data and the strong fundamentals of companies ahead of the ESMO 2025 conference, which is expected to showcase significant clinical research results from various domestic pharmaceutical companies [7][8] Important Industry News - AstraZeneca plans to list on the New York Stock Exchange [6] - The report mentions the approval of a new oral SERD drug by Eli Lilly, marking it as the second such drug approved globally [8][45] - The approval of the first domestic quadrivalent HPV vaccine in China is expected to expand the coverage population and potentially be priced lower than imported versions [8][50][52]

Market Overview - The chemical pharmaceutical sector experienced a decline of 0.66% on October 9, with Nanjing New Pharmaceutical leading the drop [1] - The Shanghai Composite Index closed at 3933.97, up 1.32%, while the Shenzhen Component Index closed at 13725.56, up 1.47% [1] Stock Performance - Notable gainers in the chemical pharmaceutical sector included: - Haichen Pharmaceutical (300584) with a closing price of 63.81, up 13.76% and a trading volume of 155,800 shares, totaling 973 million yuan [1] - Changshan Pharmaceutical (300255) closed at 49.29, up 8.21% with a trading volume of 394,400 shares, totaling 1.916 billion yuan [1] - Conversely, Nanjing New Pharmaceutical (688189) saw a significant drop of 19.96%, closing at 9.10 with a trading volume of 32,300 shares, totaling 29.426 million yuan [2] Capital Flow - The chemical pharmaceutical sector experienced a net outflow of 1.108 billion yuan from institutional investors, while retail investors saw a net inflow of 544 million yuan [2] - The capital flow for specific stocks showed: - Changshan Pharmaceutical had a net inflow of 14.6 million yuan from institutional investors, but a net outflow of 14 million yuan from retail investors [3] - Haichen Pharmaceutical recorded a net inflow of 85.3 million yuan from institutional investors, with retail investors showing a net outflow of 68 million yuan [3]