Financial Data and Key Metrics Changes - The company reported adjusted earnings per share of $2.46, which is $0.10 above the guidance midpoint [7][45] - Total net revenues exceeded $13.3 billion, reflecting robust growth of 9.8% on an operational basis, excluding a 1.4% unfavorable impact from foreign exchange [7][45] - The adjusted operating margin ratio was 42.3% of sales, including a 1.9% unfavorable impact from acquired IPR&D expense [46] Business Line Data and Key Metrics Changes - Immunology revenues were over $6.2 billion, with Skyrizi and Rinvoq contributing $5.1 billion in combined sales, reflecting growth of more than 65% [14][20] - Oncology revenues reached $1.6 billion, with Imbruvica global sales at $738 million (down 11.9%) and Venclexta global revenues at $665 million (up 12.3%) [20][21] - Aesthetics delivered global sales of $1.1 billion, down 10.2% on an operational basis, with BOTOX Cosmetic revenues at $556 million (down 10.7%) and Juvederm sales at $231 million (down 20%) [23][24] - Neuroscience revenues were approximately $2.3 billion, up 17% on an operational basis, with VRAYLAR global sales at $765 million (up 10.3%) [26][27] Market Data and Key Metrics Changes - The company anticipates total net revenues of approximately $59.7 billion for the year, an increase of $700 million from previous estimates [47] - Skyrizi global revenues are now expected to be $16.5 billion, an increase of $600 million, while Rinvoq global sales are projected at $8.2 billion, an increase of $300 million [48] - US Humira revenues are expected to decrease to $3.5 billion, reflecting higher erosion from biosimilar competition [49] Company Strategy and Development Direction - The company plans to invest over $10 billion in the US over the next decade to support volume growth and expansion into new areas such as obesity [10][54] - The company is focused on advancing its internal pipeline and pursuing strategic acquisitions to drive growth, including the acquisition of Nimble Therapeutics [11][12] - The company aims for a high single-digit revenue CAGR through 2029, indicating a clear runway for growth [13] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the strong performance across therapeutic areas and raised full-year adjusted EPS guidance by $0.10 [9][54] - The management acknowledged potential impacts from sectoral tariffs but believes any related effects would align with peers due to the company's extensive US manufacturing presence [10][53] - Management highlighted the importance of maintaining a competitive tax policy to encourage sustainable investment in US manufacturing [54][82] Other Important Information - The company is preparing for the global launch of giant cell arteritis for Rinvoq, which is expected to further enhance its rheumatology label [19] - The company is also making significant progress in its pipeline, with several important data readouts and regulatory submissions anticipated throughout 2025 [44] Q&A Session Summary Question: Insights on Skyrizi and Rinvoq's guidance increase - The increase in guidance for Skyrizi and Rinvoq is attributed to strong performance in IBD and rheumatology indications, with specific revenue increases detailed [60][61] Question: Thoughts on Humira's erosion - Management noted faster erosion due to biosimilar competition and expects further declines as the market matures [66] Question: Mitigation strategies regarding tariffs - The company plans to manage inventory and explore cost efficiencies to mitigate potential tariff impacts, while also expanding US manufacturing capacity [75][76] Question: Pricing strategy for BoNT/E - The pricing strategy for BoNT/E will be determined closer to launch, considering its shorter duration of action and potential market dynamics [106][107] Question: Future of emraclidine in schizophrenia - The company sees potential in emraclidine and plans to initiate a multiple ascending dose study to explore higher dosing options [120][121] Question: Manufacturing footprint and investment strategy - The company maintains a robust manufacturing network and plans to continue investing in US operations while ensuring supply chain resilience [123][126]

Group 1: AbbVie Inc (NYSE:ABBV) - AbbVie reported adjusted first-quarter earnings of $2.46 per share on $13.3 billion in revenue, exceeding analyst expectations [2] - The company raised its full-year outlook, projecting $16.5 billion in sales for its psoriasis drug Skyrizi [2] - AbbVie shares are up 1.1% to $182.53, and are now 10% higher over the last 12 months despite a 12% pullback this quarter [2][3] Group 2: Options Activity for AbbVie - Over 9,000 call options for AbbVie have been traded, which is quadruple the average intraday volume [4] - The most popular option is the weekly 4/25 190-strike call, with new positions being opened at the weekly 5/2 200-strike call [4] Group 3: Gilead Sciences Inc (NASDAQ:GILD) - Gilead's first-quarter revenue of $6.7 billion fell short of the forecasted $6.8 billion, leading to a 3.9% drop in share price to $102.45 [5] - RBC and Morgan Stanley raised their price targets to $92 and $135, while Oppenheimer lowered its target from $132 to $125 [5] - Gilead shares are 11% higher year-to-date but have been consolidating below the all-time high of $119.96 [6] Group 4: Options Activity for Gilead - Gilead call options are trading at five times the average intraday volume, with notable sell-to-open activity in the weekly 5/2 109-strike call [6] - The weekly 4/25 108-strike call is also seeing significant activity, expiring at the close today [6]

Core Insights - AbbVie reported quarterly earnings of $2.46 per share, exceeding the Zacks Consensus Estimate of $2.39 per share, and showing an increase from $2.31 per share a year ago, representing an earnings surprise of 2.93% [1] - The company achieved revenues of $13.34 billion for the quarter, surpassing the Zacks Consensus Estimate by 3.39% and increasing from $12.31 billion year-over-year [2] - AbbVie has consistently outperformed consensus EPS and revenue estimates over the last four quarters [2] Earnings Outlook - The future performance of AbbVie’s stock will largely depend on management's commentary during the earnings call and the trends in earnings estimate revisions [3][4] - The current consensus EPS estimate for the upcoming quarter is $3.09 on revenues of $14.8 billion, and for the current fiscal year, it is $12.20 on revenues of $59.58 billion [7] Industry Context - The Large Cap Pharmaceuticals industry, to which AbbVie belongs, is currently ranked in the top 21% of over 250 Zacks industries, indicating a favorable outlook compared to the bottom 50% [8] - The performance of AbbVie’s stock may also be influenced by the overall industry outlook and trends [8] Competitor Insights - Eli Lilly, a competitor in the same industry, is expected to report quarterly earnings of $3.52 per share, reflecting a year-over-year increase of 36.4%, with revenues anticipated to be $12.62 billion, up 43.9% from the previous year [9][10]

Group 1 - Proactive provides fast, accessible, informative, and actionable business and finance news content to a global investment audience [2] - The news team covers medium and small-cap markets, as well as blue-chip companies, commodities, and broader investment stories [3] - Proactive's content includes insights across various sectors such as biotech, pharma, mining, natural resources, battery metals, oil and gas, crypto, and emerging technologies [3] Group 2 - Proactive is committed to adopting technology to enhance workflows and content production [4] - The company utilizes automation and software tools, including generative AI, while ensuring all content is edited and authored by humans [5]

Core Viewpoint - AbbVie is positioned for sustained growth and is expected to reach new all-time highs due to its well-diversified portfolio and strong management [1][2]. Financial Performance - AbbVie reported an 8.4% increase in revenue, surpassing MarketBeat's consensus by over 300 basis points, with Immunology leading the growth at 16.6% [2][6]. - The adjusted EPS was $2.46, reflecting a 6.5% year-over-year increase and exceeding forecasts by $0.06 [6]. - The company improved its guidance, aligning the adjusted EPS target with analysts' expectations for a 20% year-over-year increase [7]. Product Performance - Immunology remains the core segment, with Humira sales declining by 50% year-over-year, but this was offset by strong performances from Skyrizi and Rinvoq, which grew by 72% and 57.2%, respectively [4][5]. - Neuroscience saw a 16.1% increase, while Oncology grew by 5.8%, and Aesthetics experienced an 11.7% decline [5]. Dividend and Shareholder Returns - AbbVie has a dividend yield of 3.63% and an annual dividend of $6.56, with a track record of 53 years of dividend increases [8][10]. - The company is expected to pay 3% of its earnings in dividends in 2025 and maintain annual growth in distributions [10]. Market Sentiment and Analyst Trends - Analysts have increased coverage and sentiment towards AbbVie, maintaining a Moderate Buy rating and raising the consensus price target by nearly 20% year-over-year [9][10]. - Following the Q1 release, AbbVie's stock price confirmed an uptrend, with potential to retest all-time highs before mid-year [11].

[Form 8-K Filing: Financial Guidance Update](index=1&type=section&id=Form%208-K%20Filing%20April%203%2C%202025) This Form 8-K filing provides an update on preliminary Q1 2025 financial results, revised EPS guidance due to an IPR&D expense, and details related exhibits [Results of Operations and Financial Condition](index=2&type=section&id=Item%202.02%20Results%20of%20Operations%20and%20Financial%20Condition) AbbVie announced preliminary Q1 2025 results, highlighting an expected acquired In-Process Research and Development (IPR&D) and milestones expense of $248 million, consequently updating its full-year and Q1 2025 adjusted diluted EPS guidance to incorporate this impact, while noting that the results are not yet final - Preliminary Q1 2025 results are expected to include a pre-tax acquired IPR&D and milestones expense of **$248 million**, which will unfavorably impact both GAAP and adjusted non-GAAP diluted EPS by **$0.13**[5](index=5&type=chunk) Updated 2025 Adjusted Diluted EPS Guidance | Guidance Period | Updated Adjusted Diluted EPS Range | Notes | | :--- | :--- | :--- | | Q1 2025 | $2.34 - $2.38 | Includes $0.13/share impact from IPR&D expense | | Full-Year 2025 | $11.99 - $12.19 | Includes Q1 IPR&D expense; original guidance from Jan 31, 2025 excluded this | - The updated guidance does not reflect the impact from the licensing agreement with Gubra for GUB014295, as that transaction closed after the first quarter of 2025[6](index=6&type=chunk) [Financial Statements and Exhibits](index=2&type=section&id=Item%209.01%20Financial%20Statements%20and%20Exhibits) The report includes Exhibit 99.1, which provides detailed guidance including the impact of the acquired IPR&D and milestones expense, and Exhibit 104 for XBRL data - The filing includes the following key exhibits: * **Exhibit 99.1:** Detailed guidance including the impact of acquired IPR&D and milestones expense * **Exhibit 104:** Cover page data formatted in Inline XBRL[10](index=10&type=chunk) [Forward-Looking Statements](index=2&type=section&id=Forward-Looking%20Statements) The report contains forward-looking statements subject to risks and uncertainties, with AbbVie cautioning that actual results may differ materially and directing investors to its Form 10-K and other SEC filings for a detailed discussion of these risks, without undertaking an obligation to update these statements - Forward-looking statements are subject to risks including, but not limited to, challenges to intellectual property, competition, R&D difficulties, adverse litigation or government action, and changes in laws and regulations[9](index=9&type=chunk) - For more detailed information on risks and uncertainties, the company refers to Item 1A, 'Risk Factors,' of its 2024 Annual Report on Form 10-K and subsequent SEC filings[9](index=9&type=chunk)

Core Insights - AbbVie reported strong first-quarter results for 2025, exceeding expectations and indicating a solid start to the year, with a focus on pipeline advancements and strategic investments [2][3] Financial Performance - First-quarter diluted EPS was $0.72 on a GAAP basis, a decrease of 6.5%, while adjusted diluted EPS was $2.46, an increase of 6.5% [3][19] - Net revenues for the first quarter reached $13.343 billion, an increase of 8.4% on a reported basis and 9.8% on an operational basis [3][4] - The immunology portfolio generated global net revenues of $6.264 billion, up 16.6% on a reported basis and 18.1% operationally [3][4] - Skyrizi net revenues were $3.425 billion, reflecting a 70.5% increase on a reported basis, while Rinvoq net revenues were $1.718 billion, up 57.2% [4][19] - Humira net revenues decreased by 50.6% to $1.121 billion [4][19] - Neuroscience portfolio revenues were $2.282 billion, an increase of 16.1% [4][19] - Oncology portfolio revenues reached $1.633 billion, up 5.8% [4][19] - Aesthetics portfolio revenues were $1.102 billion, a decrease of 11.7% [4][19] Guidance and Outlook - AbbVie raised its 2025 adjusted diluted EPS guidance from $11.99 - $12.19 to $12.09 - $12.29, accounting for an unfavorable impact of $0.13 per share related to acquired IPR&D and milestones expense [3][9] Recent Developments - The European Commission granted marketing authorization to Rinvoq for treating giant cell arteritis in adults, marking the eighth approved indication for the drug in the EU [7] - AbbVie announced a collaboration with Xilio Therapeutics to develop novel immunotherapies for cancer [7] - A Biologics License Application was submitted to the FDA for trenibotulinumtoxinE for treating moderate to severe glabellar lines, which could be the first neurotoxin of its kind available [7][8]

NEW YORK, April 25, 2025 /PRNewswire/ -- Levi & Korsinsky, LLP notifies investors in Cerevel Therapeutics Holdings, Inc. ("Cerevel Therapeutics Holdings, Inc." or the "Company") (NYSE: ABBV) of a class action securities lawsuit.CLASS DEFINITION: The lawsuit seeks to recover losses on behalf of Cerevel Therapeutics Holdings, Inc. investors who were adversely affected by alleged securities fraud. This lawsuit is on behalf of all persons or entities that: (a) sold or otherwise disposed of the publicly-traded c ...

Core Viewpoint - A class action securities lawsuit has been filed against Cerevel Therapeutics Holdings, Inc. due to alleged securities fraud affecting investors during a specific time frame [1][2]. Group 1: Lawsuit Details - The lawsuit aims to recover losses for investors who sold or held shares of Cerevel from October 11, 2023, to August 1, 2024, and were affected by the alleged fraud [2]. - The complaint alleges that Cerevel's October 16, 2023, secondary stock offering omitted critical information regarding AbbVie's interest in acquiring Cerevel at a significantly higher price than the offering price of $22.81 per share [3]. - Bain Capital, Cerevel's controlling shareholder, is accused of acquiring shares at an artificially low price while possessing nonpublic information about AbbVie's acquisition interest [3]. Group 2: Financial Implications - AbbVie announced its agreement to acquire Cerevel for $45 per share on December 6, 2023, resulting in Bain Capital receiving over $120 million in windfall profits from shares purchased at the depressed offering price [3]. - Cerevel's January 18, 2024, Proxy statement allegedly misled investors regarding the timing and nature of AbbVie's interest in the company [3]. Group 3: Next Steps for Investors - Investors who suffered losses during the relevant period have until June 3, 2025, to request appointment as lead plaintiff, although participation in any recovery does not require this [4]. - Class members may be entitled to compensation without incurring out-of-pocket costs or fees [4]. Group 4: Legal Representation - Levi & Korsinsky, LLP has a strong track record in securities litigation, having secured hundreds of millions for shareholders over the past 20 years [5].

–TrenibotE is a first-in-class botulinum neurotoxin serotype E characterized by a rapid onset of action as early as 8 hours after administration (earliest assessment time) and shorter duration of effect of 2-3 weeks. –If approved, TrenibotE will be the first neurotoxin of its kind available to patients.–Submission is supported by data from over 2,100 patients treated with TrenibotE throughout the clinical program. NORTH CHICAGO, Ill., April 24, 2025 /PRNewswire/ -- AbbVie (NYSE: ABBV) today announced submis ...