Core Insights - Four Seasons Pharmaceutical (00460) has signed an investment subscription agreement to acquire a stake in Swiss medical aesthetics company Suisselle SA, aiming to enhance their strategic relationship and expand in the global medical aesthetics market [1][2] - The company previously secured exclusive agency rights for the CELLBOOSTER water needle in China in 2022, and this investment will solidify their long-term partnership, granting permanent exclusive agency rights for the product [1] - The collaboration will leverage Suisselle's established platform in Europe to accelerate the promotion and sales of the company's self-developed medical aesthetic products in Europe and other overseas markets [1] - The investment aligns with the company's globalization strategy, aiming to build an international medical aesthetics ecosystem covering research, production, and sales [1] Strategic Developments - The company has been actively pursuing a global strategy in the medical aesthetics sector, having fully acquired American medical aesthetics equipment company Genesis Biosystems in 2021, marking its entry into the North American market [2] - The investment in Suisselle represents a critical step in the company's global strategy, completing its strategic layout in the core medical aesthetics markets of Europe and North America [2] - The company plans to continue driving high-quality medical aesthetic solutions through a dual approach of independent research and international collaboration, aiming to create long-term sustainable value for shareholders and investors [2]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 就 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致之任何損失承擔任何責 任。 Sihuan Pharmaceutical Holdings Group Ltd. 四環醫藥控股集團有限公司 （於百慕達註冊成立的有限公司） （股份代號：0460） 自願公告 四環醫藥投資入股瑞士Suisselle公 司 加速全球化醫美業務布局 CELLBOOSTER®為瑞士制造的創新水光針（歐洲III類醫療器械），憑借其專利CHAC 技 術 實 現 成 分 穩 定 與 高 效 遞 送，涵 蓋 多 維 度 皮 膚 問 題 解 決 方 案： 四 環 醫 藥 控 股 集 團 有 限 公 司（「本公司」或「四環醫藥」，連 同 其 附 屬 公 司，統 稱 為 「本集團」）董 事 會（「董事會」）欣 然 宣 佈，本 集 團 於 二 零 二 五 年 九 月 對 瑞 士 醫 美 公 司Suisselle SA（「Suisselle」）進 行 投 資 入 股，雙 ...

Core Viewpoint - The IPO of Xuan Zhu Bio-B (02575.HK), a subsidiary of Sihuan Pharmaceutical, is a significant step in the company's innovative research and development strategy, attracting market attention amid a favorable environment for the pharmaceutical/biotech sector [1] Business Positioning and Pipeline Layout - Xuan Zhu Bio focuses on innovation-driven drug development and commercialization, targeting areas such as digestive system diseases, oncology, and NASH (non-alcoholic steatohepatitis) [2] - The company has over ten drug assets at various stages, including three products with NDA approval, one project in NDA registration, one in Phase III clinical trials, and several in Phase I or with IND approval [2] - Core products include: - KBP-3571: An innovative proton pump inhibitor for digestive diseases, already commercialized - XZP-3287: A CDK4/6 inhibitor for breast cancer (HR+/HER2−), NDA approved - XZP-3621: An ALK inhibitor for non-small cell lung cancer (NSCLC), NDA approved [2] Financial Status and Operating Conditions - In 2022, the company had negligible revenue, with revenue starting to appear in 2023 at approximately several tens of millions of RMB, and a slight increase expected in 2024, but still not profitable [3] - The company is experiencing significant losses, with high R&D expenditures contributing to the losses, and cash flow issues evident with a negative operating cash flow of -95.76 million RMB as of June 2025 and only about 8.558 million RMB in cash [3] IPO Highlights and Fundraising Arrangements - Key IPO details include: - Offering price: HKD 11.60 per share - Total shares offered: 67.33 million H-shares - Public offering ratio: 10% (approximately 6.73 million shares) - Total fundraising amount: approximately HKD 781 million - Market capitalization post-listing: approximately HKD 6.008 billion [5][6] Valuation Levels and Comparative Perspectives - The IPO pricing corresponds to a total market capitalization of approximately HKD 6.008 billion, indicating a potentially aggressive valuation in the current high-risk/high-expectation environment for new drugs [6][7] Industry Trends - The pharmaceutical sector is increasingly driven by themes and expectations, with new stocks often experiencing significant speculative trading on their debut [8] Competitive Landscape and Barriers - The innovative drug development process is characterized by high risks, long cycles, and high costs, with a high failure rate; delays or failures in pipeline projects can lead to significant expectation risks [9] Summary of Risks - The company is currently unprofitable, and its future profitability remains uncertain, which is critical for market valuation acceptance [10] - The company faces cash flow risks due to weak cash reserves and negative operating cash flow, which could hinder operational progress if financing becomes difficult [12] - There are risks associated with pipeline advancement, clinical trials, and regulatory approvals, as many projects are still in early to mid-stages [12] - The company operates in a highly policy-dependent environment, where changes in healthcare negotiations and pricing policies could impact profit margins [13]

四环医药(00460.HK)旗下中国生物制药公司轩竹生物-B(02575.HK)10月6日至10月10日招股。截至周三 （8日）晚上10时多，轩竹生物获券商借出至少858亿港元孖展，较下午的350亿港元增1.5倍；以公开发 售起初集资额7811万港元计，超额认购1097.5倍。轩竹生物每手500股，一手入场费为5858.5港元，轩竹 生物预期将于10月15日挂牌买卖，中金公司为独家保荐人。 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 就 因 本 公 告 全部或任何部份內容而產生或因倚賴該等內容而引致之任何損失承擔任何責 任。 本 公 告 僅 供 參 考，並 不 構 成 收 購、購 買 或 認 購 任 何 證 券 的 邀 請 或 要 約。 本公告並不構成在美國境內或在任何其他司法管轄區提呈出售要約或招攬購 買 任 何 證 券 的 要 約，倘 未 根 據 任 何 該 等 司 法 管 轄 區 的 證 券 法 辦 理 登 記 或 未 獲 批 准 而 於 上 述 地 區 進 行 上 述 要 約、招 攬 或 出 售 即 屬 違 法。本 公 告 所 述 的 證 券 將 不會根據經修訂的1933年 美 國 證 券 法（「證券法」）登 記，亦 不 得 在 美 國 境 內 作 出 要 約 或 出 售，惟 根 據 證 券 法 登 記 規 定 獲 豁 免 或 毋 須 遵 守 證 券 法 的 登 記 規 定 進 行 的 交 易 除 外。於 美 國 公 開 發 售 任 何 證 券 將 須 以 招 ...

Group 1 - The core stock price of Sihuan Pharmaceutical (00460) increased by 4.47%, reaching HKD 1.87, with a trading volume of HKD 66.5181 million [1] - Xuan Zhu Biotechnology is set to launch its IPO from October 6 to October 10, planning to globally offer 67.3335 million shares, with trading expected to commence on October 15 [1] - Xuan Zhu Biotechnology is a spin-off from Sihuan Pharmaceutical [1] Group 2 - Sihuan Pharmaceutical's subsidiary, Meiyan Space, has developed a new product, "Frozen Beauty," which is an injectable sodium hyaluronate composite solution that recently received a Class III medical device registration from the National Medical Products Administration [1] - This marks the introduction of the first domestic water-light needle containing L-carnosine composite solution into the capital market [1]

Group 1 - The core point of the article is that Sihuan Pharmaceutical (00460) has seen its stock price increase by over 4%, currently trading at HKD 1.87 with a transaction volume of HKD 66.5181 million [1] - Xuan Zhu Biotechnology is set to launch an initial public offering (IPO) from October 6 to October 10, planning to globally offer 67.335 million shares, with trading expected to commence on October 15 [1] - Xuan Zhu Biotechnology is a spin-off from Sihuan Pharmaceutical, indicating a strategic move to enhance its market presence [1] Group 2 - Sihuan Pharmaceutical's subsidiary, Meiyan Space, has developed a new product, "Frozen Beauty," which is an injectable sodium hyaluronate composite solution that has recently received a Class III medical device registration certificate from the National Medical Products Administration [1] - This product marks the first domestic launch of a water-light needle containing L-carnosine composite solution, highlighting innovation in the medical aesthetics market [1]

Core Viewpoint - The approval of "Frozen" marks a significant milestone for the company, indicating the successful implementation of its "medical beauty + biopharmaceutical" dual-engine strategy, which is expected to enhance the company's investment value across multiple dimensions [1][10]. Product Value - "Frozen" is positioned in a high-growth market, specifically the water light needle segment, which is recognized as a "golden track" in the medical beauty sector, driven by increasing consumer demand for skin quality management [1][2]. - The market for water light needle products in China is projected to grow from approximately 4.5 billion RMB in 2025 to 8 billion RMB in 2027, with a compound annual growth rate (CAGR) of 21.5%, significantly outpacing the global market's 10.8% CAGR [2]. - The regulatory tightening in the medical beauty sector presents a historic opportunity for compliant innovative products like "Frozen," allowing it to capture both incremental and existing market shares [2][3]. Financial Value - The launch of "Frozen" is expected to create substantial incremental revenue, enhancing the company's profit structure and providing a strong, predictable new growth driver for its medical beauty segment [5][6]. - "Frozen" is anticipated to contribute significantly to net profit, with its profit structure offering considerable advantages, leading to potential exponential growth in net profit rather than linear increases [6]. - The introduction of "Frozen" signifies an upgrade in the company's profit model, enhancing sustainability and maximizing customer lifetime value, which is crucial for long-term profitability [6]. Strategic Value - The successful launch of "Frozen" indicates that the company's dual-track strategy of self-research and business development (BD) has entered an efficient execution phase, establishing a long-term competitive barrier in the medical beauty sector [7][10]. - The company has developed a dual-engine model combining regenerative products and skin quality management, creating a self-reinforcing ecosystem within its medical beauty business [8]. - The company has a robust pipeline of products in development, with five regenerative micro-sphere products and eight hyaluronic acid products in the registration phase, ensuring continuous growth and market presence [9]. Summary - The success of "Frozen" represents a new phase in the company's medical beauty strategy, reflecting its strong research and development capabilities and substantial pipeline reserves, which are critical for long-term value [10][11]. - The investment logic surrounding the company is shifting from a focus on profitability to high-quality growth, as the medical beauty segment now accounts for over 50% of revenue and continues to grow [11][12]. - The company has transitioned from relying on a single blockbuster product to becoming a platform-based medical beauty enterprise, enhancing its growth potential and valuation premium [12].

Core Viewpoint - Four Seasons Pharmaceutical (00460) saw a nearly 9% increase in stock price, reaching HKD 1.75 with a trading volume of HKD 137 million, following the approval of its product "Frozen Beauty" by the National Medical Products Administration of China [1] Group 1: Product Approval - The company announced that its subsidiary, Meiyan Space Biotechnology (Jilin) Co., Ltd., received a Class III medical device registration certificate for its self-developed injectable transparent sodium hyaluronate composite solution, branded as "Frozen Beauty" [1] - "Frozen Beauty" is the first approved product in China that contains L-carnosine, designed for temporary improvement of skin dryness and dull complexion [1] Group 2: Strategic Development - The approval of "Frozen Beauty" marks another milestone for Meiyan Space, following the earlier launches of "Youthful Needle" and "Girl Needle" within the year [1] - The company is building a strategic product matrix focused on compliant regenerative materials (Youthful Needle, Girl Needle) and skin quality management (Water Light Needle), enhancing its position in the light medical beauty sector [1] Group 3: Product Portfolio - Meiyan Space has over 30 approved products, establishing a comprehensive product layout in the light medical beauty field [1] - The company aims to provide an integrated solution from skin quality improvement to contour modification, reinforcing its leading position in comprehensive anti-aging solutions [1]

Core Viewpoint - Four Seasons Pharmaceutical (00460) experienced a nearly 9% increase in stock price, closing at 1.75 HKD, following the announcement of its product approval by the National Medical Products Administration of China [1] Group 1: Product Approval - The company’s subsidiary, Meiyan Space Biotechnology (Jilin) Co., Ltd., received a Class III medical device registration certificate for its self-developed injectable transparent sodium hyaluronate composite solution, branded as "Dongyan" [1] - "Dongyan" is the first approved compound solution in China that contains L-carnosine, designed for temporary improvement of skin dryness and dull complexion [1] Group 2: Strategic Product Matrix - The approval of "Dongyan" marks another milestone for Meiyan Space, following the earlier launches of "Tongyan Injection" and "Shaonian Injection" within the year [1] - The company is building a strategic product matrix that combines compliant regenerative materials (Tongyan and Shaonian injections) with skin quality management (water light needle) as dual engines [1] Group 3: Market Position - Meiyan Space has over thirty approved products, establishing a comprehensive product layout in the light medical beauty sector [1] - The company has achieved an integrated layout from skin quality improvement to contour modification, reinforcing its leading position in comprehensive anti-aging solutions [1]