功能细分持续深化 后疫情时代，大众健康意识全面觉醒，"送健康""囤健康"从短期热潮转为日常习惯，保健需求正式进入 常态化阶段。线上渠道的便捷性叠加商家内容种草，更加速了健康理念普及与产品渗透。与此同时，近 几年保健品新兴成分不断涌现，功能越来越细分，从慢病管理、提高免疫力、骨健康、熬夜护肝、抗初 老到肠胃调理、专注力提升、护眼等，实现对不同人群、不同场景健康需求的精准对接。 "过去大家对珍稀药材、明星成分比较敏感，但现在更多的是针对功能改善的需求在攀升，如抗衰、改 善睡眠、护肝、减重等，消费认知与需求又往前走了一步。"中国保健协会市场工作委员会秘书长王大 宏表示，消费端对保健品的刚性需求在上升，对自身的健康问题更愿意靶向寻找产品。 新兴成分水蛭素、麦角硫因产品销售额大增 来自京东健康的数据显示，新年健康消费呈现"营养新趋势"与"礼赠专业化"的双重升级趋势，以水蛭 素、麦角硫因、NAD+为代表的新兴成分增长迅猛。今年1月，水蛭素、麦角硫因的销售额同比分别增 长超3倍、2.6倍， NAD+同比增长超70%。在王大宏看来，麦角硫因是2025年保健品不二的"当红明 星"。 2025年5月，科伦药业（002422）75 ...

Investment Rating - The report assigns an "Accumulate" rating to Kelun Pharmaceutical [13] Core Views - The approval of the fourth indication for the subsidiary's core asset SKB264 in China is a positive development, indicating that the sales of innovative drugs are gradually materializing, and there is an expectation for the recovery of the main business [2][13] - The report anticipates total revenue for 2025-2027 to be 174.2 billion, 197.6 billion, and 225.7 billion yuan, respectively, with year-on-year growth rates of -20.1%, 13.4%, and 14.2% [13] - Expected EPS for 2025-2027 is projected to be 0.93, 1.14, and 1.72 yuan [13] - The report highlights that Kelun Pharmaceutical, as a leading company in the industry, has stable business development, and the first product from Kelun Botai is about to be launched overseas, which supports the outlook for the company's innovative drug business [13] Financial Summary - Total revenue for 2023 is projected at 21,454 million yuan, with a year-on-year increase of 12.7% [5] - Net profit attributable to the parent company is expected to be 2,456 million yuan in 2023, reflecting a significant increase of 44.0% [5] - The report provides a detailed financial forecast, including revenue and net profit projections for the next five years, indicating fluctuations in growth rates [5][16] Market Data - The stock price range over the past 52 weeks is between 26.85 and 40.70 yuan, with a total market capitalization of 51,218 million yuan [8] - The report notes that the company has a total equity of 23,708 million yuan and a net asset per share of 14.84 yuan [9] Clinical Development - Kelun Botai has initiated nine registration clinical studies for SKB264 in China, with significant clinical trial results indicating improved progression-free survival (PFS) and overall survival (OS) rates compared to chemotherapy [13]

Investment Rating - The report assigns an "Accumulate" rating to Kelun Pharmaceutical [13] Core Views - The core asset SKB264 of the subsidiary has received approval for its fourth indication in China, indicating a positive outlook for the sales of innovative drugs and an expectation for the recovery of the main business [2][13] - The report anticipates total revenue for 2025-2027 to be 174.2 billion, 197.6 billion, and 225.7 billion yuan, respectively, with year-on-year growth rates of -20.1%, 13.4%, and 14.2% [13] - Expected EPS for 2025-2027 is projected to be 0.93, 1.14, and 1.72 yuan [13] - The report highlights the stable development of various business segments and the upcoming overseas launch of the first product from Kelun Botai, supporting the continued realization of the company's innovative drug business [13] Financial Summary - Total revenue for 2023 is projected at 21,454 million yuan, with a year-on-year growth of 12.7% [5] - Net profit attributable to the parent company is expected to be 2,456 million yuan in 2023, reflecting a significant increase of 44.0% [5] - The report forecasts a net profit margin of 12.3% for 2023, with a projected increase to 14.0% by 2027 [16] - The company’s total assets are estimated to reach 42,588 million yuan by 2027, with a debt-to-equity ratio of 22.9% [16] Market Data - The stock price range over the past 52 weeks is between 26.85 and 40.70 yuan, with a total market capitalization of 51,218 million yuan [8] - The report sets a target price of 45.41 yuan based on a 40x PE ratio for 2026 [13]

Investment Rating - The industry investment rating is "Overweight (Maintain)" [4] Core Insights - The recent results of the national centralized procurement for batches 1-8 have been released, which is expected to benefit leading companies with scale effects, particularly those integrated in raw material and formulation production [6] - The procurement process involved 5.1 million medical institutions and 1,091 domestic and foreign companies, with 4,163 products selected from 1,020 companies, indicating a high participation rate and a stable supply of selected products [6] - The procurement cycle is set to last until the end of 2028, allowing selected companies to secure a three-year national market, which is beneficial for capacity planning and cost optimization [6] Summary by Sections Industry Overview - The industry comprises 502 listed companies with a total market value of 73,023.15 billion yuan and a circulating market value of 67,026.08 billion yuan [2] Procurement Results - The procurement covers 316 commonly used drugs across 26 therapeutic areas, with a high selection rate of 93% for participating companies [6] - The average number of selected companies per product is 14, ensuring a diverse supply base and rich clinical choices [6] Competitive Landscape - The procurement reflects a shift in policy from "price reduction and expansion" to "price stability and quality assurance," favoring leading companies with compliance capabilities and scale advantages [6] - Companies like Huahai Pharmaceutical and Kelun Pharmaceutical have significant advantages in their respective fields, with high selection rates for major products [6] Future Outlook - The procurement process is expected to stabilize prices and industry expectations, moving the focus from "lowest price competition" to a comprehensive competition based on quality, capacity, compliance, and brand [6] - The new requirements for production experience and compliance are likely to accelerate the exit of smaller, weaker companies from the market [6]

Group 1 - The core point of the article is that the controlling shareholder of Kelun Pharmaceutical, Liu Gexin, has recently released the pledge on 10.19 million shares of the company [1]

证券代码：002422 证券简称：科伦药业 公告编号：2026-009 四川科伦药业股份有限公司 关于公司控股股东部分股份质押及解除质押的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假记载、误 导性陈述或重大遗漏。 四川科伦药业股份有限公司（以下简称"公司"）于近日收到公司控股股东 刘革新先生关于其持有的公司部分股份质押及解除质押的通知，相关情况具体如 下： | 股东姓 | 是否为控股股 东或第一大股 | 本次解除质 | 占其所持股 | 占公司总股 | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 名 | 东及其一致行 | 押股份数量 | 份比例 | 本比例 | 起始日 | 解除日 | 质权人 | | | 动人 | （股） | | | | | | | 刘革新 | 是 | 10,190,000 | 2.69% | 0.64% | 2025/2/20 | 2026/2/10 | 华泰证券（上海） 资产管理有限公司 | | 合计 | - | 10,190,000 | 2.69% | 0.64% | - | - | - | ...

Core Viewpoint - The approval of the new indication for TROP2 ADC drug Sacituzumab (sac-TMT) marks a significant advancement in the treatment of HR+/HER2- breast cancer, highlighting its clinical value and market urgency [1][5][13]. Group 1: Drug Approval and Indications - Sacituzumab has been approved for treating adults with unresectable locally advanced or metastatic HR+ and HER2- breast cancer who have previously received endocrine therapy and other systemic treatments [1][5]. - The approval is based on positive data from the OptiTROP-Breast02 Phase III study, which demonstrated significant survival benefits and manageable safety in a difficult-to-treat patient population [7][13]. Group 2: Drug Characteristics and Development - Sacituzumab is an innovative ADC targeting TROP2, composed of a humanized monoclonal antibody, a cleavable linker, and a novel topoisomerase I inhibitor, with a drug-antibody ratio (DAR) of 7.4, indicating strong drug delivery capabilities [5]. - The drug has multiple approved indications, including treatment for adult patients with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC) [5][6]. Group 3: Global Collaboration and Market Strategy - In May 2022, a strategic collaboration was established with MSD, granting exclusive rights for development and commercialization of Sacituzumab outside Greater China, indicating a global expansion strategy [8]. - MSD has initiated 16 global Phase III clinical studies across various cancer types, aiming to position Sacituzumab as a broad-spectrum ADC [8]. Group 4: Competitive Landscape - Currently, three TROP2 ADCs have been approved globally, including Sacituzumab, highlighting the competitive nature of the ADC market [9]. - In the domestic market, in addition to Sacituzumab, three other products are in Phase III clinical trials, intensifying competition [10]. Group 5: Market Demand and Future Outlook - HR+/HER2- breast cancer accounts for approximately 70% of all breast cancer cases, with significant unmet clinical needs due to treatment resistance and multiple lines of therapy failures [13]. - The approval of Sacituzumab not only enhances treatment options for this patient population but also strengthens the position of domestic ADCs in the international market [13][14]. - The future of the ADC industry will focus on maintaining first-mover advantages, expanding combination therapies, and improving patient accessibility [14].

Investment Rating - The report maintains an "Accumulate" rating for the pharmaceutical and biotechnology industry [1] Core Insights - The pharmaceutical index in A-shares has shown a slight increase of 0.14% this week and 3.28% year-to-date, outperforming the CSI 300 by 1.41% and 0.85% respectively [3][8] - The report highlights the emergence of molecular glue as a significant trend in the industry, with several successful stocks like RVMD, GLU, and KYMR, and substantial business development (BD) activities [3][15] - The report suggests that molecular glue has the potential to create new blockbuster drugs in oncology and autoimmune diseases, urging investors to focus on domestic companies involved in this area [3][11] Summary by Sections 1. Market Performance - The A-share pharmaceutical index has outperformed the CSI 300 index, with notable gains in traditional Chinese medicine (2.56%), medical services (1.31%), and raw materials (0.64%) [3][8] - The report lists top-performing stocks, including Guangsheng Tang (+29.83%) and HaiXiang Pharmaceutical (+18.64%), while noting declines in stocks like Changshan Pharmaceutical (-15.78%) [8] 2. Molecular Glue - Molecular glue is defined as a class of small molecule drugs that facilitate the binding of E3 ubiquitin ligases to previously unrecognized pathogenic target proteins, leading to their degradation [15] - The report mentions that BMS has two marketed molecular glues with peak sales exceeding $16 billion, and ongoing research into new iterations [3][15] - Domestic companies such as Yuan Dong Biology and Jin Fang Pharmaceutical are noted for their potential in molecular glue development [3][11] 3. R&D Progress and Corporate Developments - The report highlights significant clinical research milestones, including Pfizer's initiation of a Phase II/III trial for its PD-1/VEGF bispecific antibody SSGJ-707 [3] - It also notes that Novartis has submitted its BAFF-R monoclonal antibody for approval in China, and AbbVie has started a Phase II trial for its Bcl-2 inhibitor Venetoclax [3] 4. Recommended Stocks - The report provides a list of recommended stocks across various sectors, including: - CXO and upstream research services: WuXi AppTec, Hao Yuan Pharmaceutical, and Aopumai [11] - Traditional Chinese medicine: Zuo Li Pharmaceutical and Fang Sheng Pharmaceutical [11] - PD-1 PLUS: 3SBio, KANGFANG Biologics, and Innovent Biologics [11] - ADC: Ying En Biologics and Kelong Biotechnology [11] - AI drug development: Jing Tai Holdings [11]

证券研究报告·行业跟踪周报·医药生物 医药生物行业跟踪周报 分子胶海外风起，国内管线蓄势破局 2026 年 02 月 09 日 增持（维持） [Table_Tag] [Table_Summary] 投资要点 证券分析师 朱国广 执业证书：S0600520070004 zhugg@dwzq.com.cn 行业走势 -8% -4% 0% 4% 8% 12% 16% 20% 24% 2025/2/10 2025/6/10 2025/10/8 2026/2/5 医药生物 沪深300 相关研究 《降息等多因素支持科研上游持续复 苏，重点推荐皓元医药、奥浦迈等》 2026-02-01 《mRNA 疫苗龙头释放积极临床数据 信号，建议关注悦康药业、康希诺等》 2026-01-26 东吴证券研究所 1 / 45 请务必阅读正文之后的免责声明部分 ◼ 本周、年初至今 A 股医药指数涨幅分别为 0.14%、3.28%，相对沪深 300 的超额收益分别为 1.41%、0.85%；本周、年初至今恒生生物科技指数涨 跌幅分别为-1.31%、7.34%，相对于恒生科技指数跑赢 5.20%、10.41%； 本周中药（2.56%）、医疗服务 ...

Core Viewpoint - Sichuan Kelun Pharmaceutical Co., Ltd. announced that its subsidiary, Sichuan Kelun Botai Biopharmaceutical Co., Ltd., received approval from the National Medical Products Administration (NMPA) for the fourth indication of its core product, TROP2 ADC, sac-TMT, for the treatment of 2L+ HR+/HER2- breast cancer [2][6]. Drug Basic Information - The approval is based on positive results from the OptiTROP-Breast02 Phase III clinical study, which was presented at the 2025 European Society for Medical Oncology (ESMO) Congress [2][3]. - The new indication is for adult patients with unresectable or metastatic HR+/HER2- breast cancer who have previously received endocrine therapy and at least one line of chemotherapy [2][3]. Clinical Study Results - The OptiTROP-Breast02 study evaluated the efficacy and safety of sac-TMT compared to investigator's choice of chemotherapy in patients with HR+/HER2- breast cancer [3]. - Among enrolled patients, 95.7% had visceral metastases, and 75.9% had liver metastases [3]. - The study showed a significant improvement in progression-free survival (PFS) for the sac-TMT group compared to the chemotherapy group (8.3 months vs. 4.1 months; hazard ratio (HR): 0.35; 95% confidence interval (CI): 0.26-0.48; p<0.0001) [3]. - The overall survival (OS) benefit trend and objective response rate (ORR) were also significantly higher in the sac-TMT group (41.5% vs. 24.1%) [3]. Product Overview - Sac-TMT is a novel TROP2 ADC developed by Kelun Botai, targeting various advanced solid tumors, including non-small cell lung cancer (NSCLC), breast cancer (BC), gastric cancer (GC), and gynecological tumors [5]. - The drug utilizes a new linker and has a drug-antibody ratio (DAR) of 7.4, delivering a topoisomerase I inhibitor as an effective payload [5]. - Sac-TMT has received six breakthrough therapy designations (BTD) from the NMPA [6]. Ongoing Research - Currently, sac-TMT is involved in nine registration clinical studies in China, with Merck conducting 16 ongoing global Phase III clinical studies for various cancer types [7].