Group 1 - The core viewpoint of the articles highlights the performance of the CSI Medical Index, which rose by 0.44% to 6508.47 points, with a trading volume of 14.766 billion yuan [1] - The CSI Medical Index has shown a slight increase of 0.14% over the past month, a decline of 5.12% over the last three months, and a year-to-date decrease of 1.20% [1] - The index includes companies involved in medical devices, medical services, and medical information technology, reflecting the overall performance of the medical theme listed companies [1] Group 2 - The top ten weighted companies in the CSI Medical Index include WuXi AppTec (10.43%), Mindray Medical (9.87%), United Imaging (8.28%), Aier Eye Hospital (7.55%), Tigermed (3.41%), Amcare (3.4%), Huatai Medical (3.27%), New Industry (2.87%), Yuyue Medical (2.8%), and Kanglong Chemical (2.75%) [1] - The market share of the CSI Medical Index holdings is 57.10% from the Shenzhen Stock Exchange and 42.90% from the Shanghai Stock Exchange [1] - The industry composition of the CSI Medical Index holdings shows that 95.96% is in the healthcare sector, 2.50% in information technology, and 1.54% in consumer goods [1] Group 3 - The index samples are adjusted every six months, with adjustments implemented on the next trading day following the second Friday of June and December [2] - Weight factors are adjusted in accordance with the sample adjustments, which are fixed until the next scheduled adjustment unless special circumstances arise [2] - Companies that are delisted or undergo mergers, acquisitions, or splits are handled according to the calculation and maintenance guidelines [2]

Core Viewpoint - The domestic innovative drug sector has shifted from a previous upward trend to a phase of volatility, with market participants showing a tendency to buy more as prices drop, indicating a potential long-term investment interest despite short-term fluctuations [1][2]. Group 1: Market Trends - From June 16 to June 25, medical-themed ETFs saw a net inflow of over 6.4 billion yuan, with several leading innovative drug ETFs attracting more than 1.5 billion yuan [1]. - Despite a significant drop of 8.51% in the Hong Kong innovative drug index from June 16 to June 20, funds continued to flow into innovative drug ETFs, with net inflows of 8.89 billion yuan and 7.10 billion yuan for specific ETFs during that period [2]. - The innovative drug sector experienced a brief recovery at the beginning of the week, with continued strong inflows into ETFs, totaling over 6.4 billion yuan since June 16 [2]. Group 2: Company Developments - On June 26, the innovative drug sector faced another decline, influenced by the announcement from Rongchang Biopharmaceuticals regarding a licensing deal with Vor Bio, which raised concerns about the actual value of business development (BD) deals compared to market expectations [3]. - Rongchang Biopharmaceuticals will receive 125 million USD in cash and warrants, with potential milestone payments reaching up to 4.105 billion USD, but the initial payment was perceived as low, leading to market skepticism [3]. - Following the announcement, Rongchang's A-shares fell over 18% and H-shares dropped over 11%, impacting several ETFs heavily invested in the stock [3]. Group 3: Investment Insights - Analysts suggest that the innovative drug sector's high volatility necessitates a longer-term investment perspective, as short-term trading often fails to yield satisfactory returns [5]. - Companies with higher confidence, better competitive positioning, and more complete business logic are viewed as more favorable investment targets in the innovative drug space [5]. - The innovative drug sector's underlying logic for recent growth includes asset revaluation and the influx of multinational corporations (MNCs) into China for business development opportunities [4].

Core Viewpoint - The article discusses the performance and holdings of the China Europe Medical Innovation Stock C fund, highlighting its recent net value, returns, and top stock holdings [1]. Fund Performance - The latest net value of China Europe Medical Innovation Stock C is 1.2877 yuan, reflecting a decrease of 1.98% - The fund has achieved a return of 7.99% over the past month, ranking 75 out of 793 in its category - Over the last six months, the fund's return is 27.89%, ranking 30 out of 775 - Year-to-date, the fund has returned 29.77%, ranking 26 out of 775 [1]. Fund Holdings - The top ten stock holdings of the fund account for a total of 75.62%, with the following key positions: - WuXi AppTec (10.35%) - Kelun-Biotech (10.15%) - WuXi Biologics (9.82%) - WuXi AppTec (9.60%) - CanSino Biologics (7.89%) - Hangzhou Tigermed Consulting (7.01%) - Hengrui Medicine (6.20%) - Kintor Pharmaceutical (5.87%) - Baillie Gifford (4.70%) - Tigermed (4.03%) [1]. Fund Background - China Europe Medical Innovation Stock C was established on February 28, 2019, and as of March 31, 2025, it has a total scale of 3.524 billion yuan - The fund manager is Ms. Ge Lan, who has extensive experience in the investment management field [1][2].

Core Insights - The report indicates that the short-term liquidity in the Hong Kong stock market may face tightening, influenced by geopolitical tensions and uncertainties in US-China relations, leading to a potential volatile market [2] - Long-term prospects for the Hong Kong stock market remain positive due to strong overall profitability and the scarcity of assets in sectors like internet, new consumption, and innovative pharmaceuticals, suggesting a favorable long-term investment value [2] Market Data Summary - The domestic new fund market is experiencing a surge with 50 new funds launched, primarily equity mixed funds, while the net value of equity funds has collectively declined [3] - Notably, the net inflow into stock ETFs reached 14.669 billion yuan, with a focus on small-cap and sci-tech boards, while large-cap ETFs saw net outflows [3] Industry Research Summary Automotive Industry - The commercialization of Robotaxi is accelerating, with a significant growth inflection point expected in 2025, driven by advancements in reinforcement learning and large models [4] - Recommended companies include Tesla for L4 pure vision Robotaxi and suppliers like Nidec for steer-by-wire systems, along with Xpeng Motors and a focus on Li Auto and NIO [4] High-end Manufacturing - Optimus robots are set for major improvements, with a positive outlook on humanoid robotics and specific attention to high-complexity dexterous hands and rolling screw technology [5] - The engineering machinery sector is facing short-term domestic pressure but maintains a growth trend in exports, with recommended companies including Zoomlion and SANY Heavy Industry [5] Non-ferrous Metals - Domestic air conditioning sales increased by 2.3% in May, while production fell by 1.8%, indicating potential demand weakness [6] - The report suggests that copper prices may stabilize in the short term but are expected to rise gradually with domestic stimulus policies and potential US interest rate cuts [6] Basic Chemicals - The report highlights the long-term value of leading companies in the chemical industry, with recommendations for major players in oil and gas, low-valuation chemical leaders, and new materials sectors [8] - Specific companies to watch include Wanhua Chemical and China Petroleum [8] Pharmaceutical Industry - The acceleration of innovative drug reviews is expected to enhance the value of quality pipelines and improve market sentiment towards the innovative drug sector [9] - Key companies to focus on include Hansoh Pharmaceutical and BeiGene, which are positioned for rapid development and internationalization [9] Steel Industry - The report notes a decline in the domestic alumina capacity utilization rate to a new low for 2023, with expectations for steel sector profitability to recover to historical averages [10] - The revised steel industry standards are anticipated to support this recovery [10]

简历显示：葛兰女士:中国籍。美国西北大学生物医学工程专业博士。历任国金证券股份有限公司研究 所研究员,民生加银基金管理有限公司研究员。2014年10月加入中欧基金管理有限公司,曾任研究员、中 欧明睿新起点灵活配置混合型证券投资基金基金经理(2015年1月29日起至2016年4月22日)、中欧瑾泉灵 活配置混合型证券投资基金基金经理(2015年3月16日起至2016年4月22日)、中欧瑾源灵活配置混合型证 券投资基金基金经理(2015年3月31日起至2016年4月22日)、中欧瑾和灵活配置混合型证券投资基金基金 经理(2015年4月13日起至2016年4月22日)。现任中欧医疗健康混合型证券投资基金基金经理(自2016年9 月29日起至今),中欧明睿新起点混合型证券投资基金基金经理(自2018年7月12日起至今)、中欧阿尔法混 合型证券投资基金基金经理(2020年8月20日起至2023年9月28日)。 来源：金融界 金融界2025年6月23日消息，中欧医疗健康混合A(003095) 最新净值1.6675元，增长1.10%。该基金近1个 月收益率1.79%，同类排名725|2535；近3个月收益率5.36%，同类 ...

金融界2025年6月23日消息，中欧医疗创新股票A(006228) 最新净值1.3629元，增长2.04%。该基金近1个 月收益率6.36%，同类排名28|561；近6个月收益率28.48%，同类排名18|548；今年来收益率31.07%，同 类排名17|550。 中欧医疗创新股票A股票持仓前十占比合计75.62%，分别为：药明合联（10.35%）、科伦博泰生 （10.15%）、药明生物（9.82%）、药明康德（9.60%）、康方生物（7.89%）、康龙化成（7.01%）、 恒瑞医药（6.20%）、凯莱英（5.87%）、百利天恒（4.70%）、泰格医药（4.03%）。 公开资料显示，中欧医疗创新股票A基金成立于2019年2月28日，截至2025年3月31日，中欧医疗创新股 票A规模46.75亿元，基金经理为葛兰。 简历显示：葛兰女士:中国籍。美国西北大学生物医学工程专业博士。历任国金证券股份有限公司研究 所研究员,民生加银基金管理有限公司研究员。2014年10月加入中欧基金管理有限公司,曾任研究员、中 欧明睿新起点灵活配置混合型证券投资基金基金经理(2015年1月29日起至2016年4月22日)、中欧瑾泉灵 ...

Investment Rating - The report maintains an "Accumulate" rating for the pharmaceutical and biotechnology industry [6]. Core Viewpoints - The acceleration of innovative drug reviews is expected to enhance the market's risk appetite for the innovative drug sector, with a focus on companies capable of rapid research, internationalization, and commercialization [3][24]. - The report suggests that the approval efficiency improvements will shorten product launch cycles, benefiting companies like Heng Rui Medicine, BeiGene, and Rongchang Biologics [3][27]. - The 2025 investment strategy emphasizes structural selection of investment opportunities based on payment willingness and ability, focusing on three payment channels: hospital payments, out-of-pocket payments, and overseas payments [3][28]. Summary by Sections Market Review - Last week, the A-share pharmaceutical and biotechnology index fell by 4.35%, underperforming the CSI 300 index by 3.90 percentage points [1][18]. - The Hong Kong Hang Seng Medical Health Index dropped by 7.72%, lagging behind the Hang Seng Index by 6.24 percentage points [1][18]. Company R&D Progress Tracking - Recent IND applications include ABSK043 by He Yu Pharmaceutical and clinical applications for BGB-B455 by BeiGene and SA102-CAR-T by Sanofi [2][31]. - RAY1225 by Zhongsheng Pharmaceutical and HRS-1893 by Heng Rui Medicine are in Phase III clinical trials, while HS-10370 by Hansoh Pharmaceutical and SSGJ-612 by Sanofi are in Phase I [2][31]. Policy and Regulatory Updates - The National Medical Products Administration has proposed a draft to optimize the clinical trial review process, aiming to shorten approval times to 30 working days for eligible innovative drugs [3][26]. - The policy is expected to support key areas such as pediatric drugs and rare disease treatments, enhancing the commercialization speed of innovative drugs [3][26]. Key Company Profit Forecasts and Valuation - Heng Rui Medicine: 2024 EPS forecast at 0.99 CNY, with a PE ratio of 52, rated as "Accumulate" [5]. - Fish Leap Medical: 2024 EPS forecast at 1.80 CNY, with a PE ratio of 20, rated as "Buy" [5]. - Mindray Medical: 2024 EPS forecast at 9.62 CNY, with a PE ratio of 24, rated as "Buy" [5]. - United Imaging Healthcare: 2024 EPS forecast at 1.53 CNY, with a PE ratio of 84, rated as "Buy" [5].

19 June 2025 Equity Research Report China Healthcare Equities Demand for innovative drug clinical trials shifting to China amid supportive policies China's clinical efficiency leap: Catching up with the world with strengthened competitiveness. The National Medical Product Administration (NMPA) published a circular in June, proposing to reduce the review and approval time of clinical trial applications for all innovative drugs to 30 days from the previous 60 days, following the pilot programme in July 2024. ...

Summary of Conference Call Records Industry Overview - The pharmaceutical sector, particularly the innovative drug segment, remains a core focus despite recent adjustments, which may present entry opportunities [1][2] - The industry is benefiting from overseas expansion and positive data from high-quality drugs, with expectations for continued growth over the next two to three years [1][2] - The Hong Kong innovation index shows significant room for growth compared to its peak in 2021, currently at historical median levels [1][2] Key Catalysts for Future Growth - Upcoming catalysts include: - June: R&D Day for BeiGene and other leading companies - August: Mid-year performance reports - September: World Lung Cancer Conference (WCLC) - October: American Society of Clinical Oncology (ASCO) meeting - December: American Society of Hematology (ASH) annual meeting - Adjustments in the medical insurance catalog and collaboration with commercial insurance are also noteworthy developments [4] Recommended Companies - Top recommendations include BeiGene, which is currently undervalued in the Hong Kong market, and Heng Rui Medicine [5] - Mid-cap companies to watch include Innovent, CSPC, and Kangfang, with potential for over 30% growth [5] - Small-cap companies with pipeline value reassessment logic are also highlighted, including Yifang Bio and Dize Pharmaceutical in A-shares, and Yuanda Pharmaceutical in Hong Kong [6] Performance Expectations - Companies in the innovative drug supply chain, such as WuXi AppTec, Kelun Pharmaceutical, and Kanglong Chemical, are expected to maintain strong performance in their mid-year reports [7] - CXO companies like Tigermed and Zhaoyan New Drug are seeing good order trends, although a rapid recovery in performance may not be immediate [7] Life Sciences Sector - Life sciences upstream companies have seen stock price adjustments but are showing early signs of recovery, with revenue growth guidance generally above 15% for the year [8] - Companies like WuXi AppTec, Haoyuan, and Bide are noted for their strong fundamentals and potential for mergers and acquisitions [8] Potential Recovery Areas - The medical device, OTC, and consumer sectors may show signs of recovery in the second half of the year, with some companies already indicating marginal improvements [9] PROTAC Technology Insights - PROTAC technology is recognized for its potential to address challenges in small molecule drug development, particularly in targeting hard-to-drug proteins [3][10] - The technology has shown promise in treating blood diseases, with BeiGene's BTK PROTAC entering Phase III clinical trials [18] - PROTAC's advantages include the ability to degrade multiple target proteins and improved selectivity, which may reduce toxicity compared to traditional small molecules [12][14] Clinical Research and Development - Clinical studies are demonstrating PROTAC's advantages over traditional small molecules in various therapeutic areas, including oncology and autoimmune diseases [15][24] - Companies like BeiGene are leading in the development of PROTAC platforms, with several products in advanced clinical stages [25] Challenges and Risks - The development of PROTAC technology faces challenges, including the need for sophisticated molecular design capabilities and potential competition among small molecules [17][30] - The market for AR PROTAC in prostate cancer is limited due to existing competition and established treatment standards [22] Conclusion - The innovative drug sector, particularly through the lens of PROTAC technology, presents significant investment opportunities despite current market adjustments. Companies with strong pipelines and upcoming catalysts are positioned for potential growth in the coming years [1][4][5][25]

Group 1 - The core viewpoint of the news is that the China Europe Medical Innovation Stock A (006228) has experienced a decline of 2.62% on June 19, with a cumulative drop of 9.02% over the last five trading days, indicating a downward trend in its performance [1] - As of the end of 2024, the fund has a total size of 4.675 billion yuan and has achieved a cumulative return of 33.78% since its establishment in February 2019 [1] - The holder structure shows that institutional investors hold 0.23 million shares, accounting for 0.61% of the total shares, while individual investors hold 38.37 million shares, making up 99.39% of the total [1] Group 2 - The current fund manager, Ms. Ge Lan, has a Ph.D. in Biomedical Engineering from Northwestern University and has extensive experience in the investment management field, having joined China Europe Fund Management in October 2014 [2] - Ms. Ge has managed several funds, including the China Europe Medical Health Mixed Securities Investment Fund since September 29, 2016, and has held various managerial positions in other funds [2] Group 3 - As of March 31, 2025, the top ten holdings of China Europe Medical Innovation Stock A account for a total of 75.62%, with the largest positions being WuXi AppTec (10.35%), Kelun-Biotech (10.15%), WuXi Biologics (9.82%), and WuXi AppTec (9.60%) [3]