Group 1 - The Hong Kong stock market saw a significant rise on June 9, with the innovative drug sector leading the gains, highlighted by companies like Genscript Biotech rising over 16% and Innovent Biologics increasing over 13% [1] - The Hong Kong innovative drug ETF (159567) recorded an average daily trading volume exceeding 1.2 billion yuan over the past five trading days, indicating high market enthusiasm [1] - Upcoming events such as the European League Against Rheumatism (EULAR) conference and the American Diabetes Association (ADA) scientific meeting are expected to provide positive catalysts for the innovative drug sector [1] Group 2 - The innovative drug ETF (159567) tracks the National Index of Hong Kong Innovative Drugs, with 90% of its weight in innovative drug companies, making it the highest among all pharmaceutical-themed indices [2] - The innovative drug ETF (159992) tracks a broader innovative drug index, including leading companies in the innovative drug industry chain, benefiting from trends like AI-enabled drug development and the international expansion of domestic innovative drugs [2] - Recent key events, such as the partnership between 3SBio and Pfizer for a PD-1/VEGF dual antibody deal worth $1.25 billion, highlight the increasing competitiveness of Chinese innovative drug companies on a global scale [2]

信达生物 20250608 摘要 363 项目的数据表现优异。在混合组（剂量为 1~1.5 毫克）中，中位总生存期 （OS）达到 15.3 个月，而 12 个月 OS 率也显示出积极预期。鳞癌组数据显示， 该品种疗效在研品种中表现突出，中位无进展生存期（mPFS）达到 9.3 个月。 此外，高剂量组（3 毫克）的未来 OS 水平预期较高，这些数据表明 363 在非 Q&A 信达生物在创新药领域的最新进展是什么？ 信达生物近期在创新药领域取得了显著进展，特别是在 PD-1/CTLA-4 双抗 363 项目上。该项目目前在黑色素瘤、非小细胞肺癌和结直肠癌等适应症上积 累了大量数据，成功率较高。2025 年 1 月，信达生物与 Kakao 合作启动了黑 色素瘤的临床试验。363 项目作为 first in class 品种，其机制有效性和特异性 激活免疫系统的潜力得到了临床前研究和 ASCO 会议上的数据验证。 为什么 PD-1 类药物值得关注？ PD-1 类药物因其广泛的适应症拓展能力而备受关注，特别是在非小细胞肺癌 （NSCLC）中的应用。全球范围内，NSCLC 占据 PD-1 销售比例最高，大约 为 43%。 ...

Group 1 - During the period from June 2 to June 6, 141 listed companies disclosed institutional research minutes, with over 70% of the companies experiencing positive stock performance, notably Jinling Sports with an increase of 88.24% [1] - Baili Tianheng attracted 136 institutional inquiries, focusing on its self-developed EGFRXHER3 dual-target ADC drug, iza-bren, which showed excellent data in lung cancer treatment, particularly in patients previously treated with PD-(L)1 inhibitors combined with platinum-based chemotherapy [3] - Zhongke Chuangda received 130 institutional inquiries, with a focus on its mobile robot product series, which has rapidly developed in scenarios such as latent robots, unmanned forklifts, and inspection robots, aiming to deepen its logistics and manufacturing sectors [3] Group 2 - Zhongqi New Materials addressed institutional concerns regarding industry integration and future asset acquisitions, indicating a structured approach to support the development of semiconductor materials and the integration of high-end equipment with existing materials business [4] - The company plans to enhance traditional materials technology and explore collaborations with Xingkong Technology to create synergistic effects [4]

多重因素催化创新药行情 创新药近期为什么表现如此强势？ □本报记者 王宇露 今年以来，创新药板块表现十分亮眼，尤其是港股创新药，在近期市场震荡中走出了独立行情。在此背 景下，港股创新药主题ETF"霸榜"ETF涨幅榜，多只相关ETF今年以来涨幅超过50%。 机构认为，国产创新药在全球市场的竞争力不断提升，国际投资者对我国创新药企业的投资信心不断增 强，国产创新药正实现从"跟跑"到"领跑"的跨越式发展，投资机会值得重视。而港股作为布局创新药的 核心市场，可优先关注具备全球竞争力的前沿领域稀缺标的。 港股创新药主题ETF"霸榜" 近期，创新药板块表现十分亮眼，尤其是港股创新药。Wind数据显示，截至6月8日，港股通创新药ETF （159570）今年以来上涨51.30%，位列全市场ETF榜首。恒生创新药ETF（520500）和港股创新药ETF （159567）今年以来也已涨超50%。此外，港股创新药ETF基金（520700）、港股创新药ETF （513120）、恒生医疗ETF（159506）等今年以来涨幅均超过40%。 业内人士认为，港股创新药的优势表现一部分来源于市场环境。富国基金分析，港交所自2018年以来， 允 ...

Core Viewpoint - The domestic innovative drug industry is experiencing a significant revaluation of value, with major indices showing substantial increases in 2023, indicating a potential turning point for the sector [1][3]. Group 1: Driving Factors for Growth - The innovative drug sector has seen a rise of over 20% in the index, driven by companies with sustainable innovation capabilities amidst constrained payment abilities in some medical fields [3][4]. - Key sustainable factors include the aging population leading to unmet clinical needs, supportive policies, enhanced R&D capabilities, emerging new technologies, and accelerated internationalization [4][5]. - The supportive policy environment and the increasing clinical value orientation have strengthened the business development logic for overseas expansion [5][6]. Group 2: Industry Development Stage - The Chinese innovative drug industry is in a rapid growth phase, transitioning from "follow-up innovation" to "global leadership," with many companies approaching profitability by 2025 [6][7]. - The industry is expected to enter a collective revenue growth phase starting in 2025, with a significant number of companies likely to cross the profitability threshold between 2025 and 2028 [4][6]. - The current R&D level is significantly improving, with China's contribution to global IP transactions rising to about 30% [6][7]. Group 3: Competitive Landscape - The competitive landscape varies by disease area, with the fastest or best products capturing significant market shares, indicating a "Matthew effect" where the first two drugs to market dominate [9][10]. - Chinese innovative drugs are showing notable global competitiveness, with expectations that they could capture 30% to 50% of the global market share in the future [9][10]. - The industry is witnessing a shift where Chinese companies are becoming preferred partners for multinational corporations in early-stage drug development [10][11]. Group 4: Valuation Levels - Despite recent gains, the valuation levels of innovative drug companies remain relatively low, with the PS ratio for the Wind pharmaceutical index at 2.75, indicating a historical low [11][12]. - The A-share market shows a higher absolute valuation compared to Hong Kong stocks, but with a lower historical percentile, suggesting a favorable valuation opportunity [11][12]. - The overall sentiment in the market is shifting towards a recovery in confidence and value reassessment for the pharmaceutical sector [12][13]. Group 5: Challenges Facing the Industry - The innovative drug sector faces challenges such as high costs, intense competition, and the need for improved international clinical trial capabilities [16][17]. - The industry is also grappling with a limited number of original disease targets and increasing internal competition, which could hinder growth [16][17]. - The payment market for innovative drugs in China requires further development, with commercial health insurance playing a crucial role in supporting long-term payment capabilities [16][17].

www.hczq.com 证券研究报告 | 医药生物 | 2025年6月7日 | 华创医药团队： | | --- | | 首席分析师 郑辰 | | 联席首席分析师 刘浩 | | 医疗器械组组长 李婵娟 | | 中药和流通组组长 高初蕾 | | 分析师 王宏雨 | | 分析师 朱珂琛 | | 执业编号：S0360520110002 | 邮箱：zhengchen@hcyjs.com | | --- | --- | | 执业编号：S0360520120002 | 邮箱：liuhao@hcyjs.com | | 执业编号：S0360520110004 | 邮箱：lichanjuan@hcyjs.com | | 执业编号：S0360524070002 | 邮箱：gaochulei@hcyjs.com | | 执业编号：S0360523080006 | 邮箱：wanghongyu@hcyjs.com | | 执业编号：S0360524070007 | 邮箱：zhukechen@hcyjs.com | 华创医药投资观点&研究专题周周谈 · 第129期 痛风用药蓝海大市场，关注在研新药进展 本周专题联系人：朱珂琛 本报告由华 ...

www.hczq.com 证券研究报告 | 医药生物 | 2025年6月7日 华创医药投资观点&研究专题周周谈 · 第129期 痛风用药蓝海大市场，关注在研新药进展 本周专题联系人：朱珂琛 | 华创医药团队： | | --- | | 首席分析师 郑辰 | | 联席首席分析师 刘浩 | | 医疗器械组组长 李婵娟 | | 中药和流通组组长 高初蕾 | | 分析师 王宏雨 | | 分析师 朱珂琛 | | 执业编号：S0360520110002 | 邮箱：zhengchen@hcyjs.com | | --- | --- | | 执业编号：S0360520120002 | 邮箱：liuhao@hcyjs.com | | 执业编号：S0360520110004 | 邮箱：lichanjuan@hcyjs.com | | 执业编号：S0360524070002 | 邮箱：gaochulei@hcyjs.com | | 执业编号：S0360523080006 | 邮箱：wanghongyu@hcyjs.com | | 执业编号：S0360524070007 | 邮箱：zhukechen@hcyjs.com | 本报告由华 ...

中国的创新药，最近腰杆很硬。 五月下旬，辉瑞用约12.5亿美元的代价换取了三生制药一款抗癌药非中国内地区域的权益，如果顺利的 话，未来三生制药还能收获最高约48亿美元的里程碑付款收益外加1亿美金的股份认购。 石药集团也迫不及待于近期宣布其即将完成50亿美元的BD交易。 今年的ASCO（美国临床肿瘤学会）年会中国有73项研究入选了口头报告环节，创亚洲国家新的记录。 这一切，距离2024年锐格医药与罗氏的8.5亿美元首付款交易还不到一年，距离康方生物与Summit Therapeutics达成的最高50亿美元的BD协议，以及百利天恒与百时美施贵宝最高84亿美元的BD协议，也 仅短短两年时间。 泼天富贵从天而降，中国创新药出海交易的爆发式增长引人侧目。 相关统计数据显示，2024年中国创新药对外授权交易总金额高达519亿美元，同比增长26%；2025年仅 第一季度，出海交易额已达369.29亿美元，再创同期历史新高。 股市从来不亏待好消息，创新药相关概念股票在端午节后迎来一波暴涨。 恒瑞医药、石药集团等传统巨头与新兴Biotech企业，正将自主研发的ADC（抗体偶联药物）、双抗等 管线推向欧美市场，辉瑞、默克、BM ...

行 业 及 产 业 海外消费服务 行 业 研 究 / 行 业 点 评 2025 年 06 月 06 日 2025 下半年港股消费服务投资策略——关注 茶饮新股，把握出行链机会 看好 ——海外消费周报（20250530-20250605） 本期投资提示： ⚫ 海外社服：2025 下半年港股消费服务投资策略——关注茶饮新股，把握出行链机 会 1）现制茶饮板块效应凸显，核心比拼供应链。蜜雪和古茗建立了深厚的竞争壁 垒，蜜雪的供应链建立时间最早规模最大，古茗在水果采购和冷链的规模最大，雪 王 IP 提升了营销效率，并有全球扩张的逻辑，古茗作为大众价格带第一的公司冷 链规模最大，门店数量增长确定性最高，两家公司预计 6 月 9 日进港股通。 2）在线旅游国内竞争改善，布局出境和海外。同程旅行业绩兑现度高，利润率预 计逐步改善。携程集团 Trip.com 投入短期影响利润率但是看好长期发展。 3）澳门博彩收入具备韧性，估值处在底部。5 月博彩毛收入 212 亿澳门元，创疫 后新高，同比增长 5%，对比 2019 年同期恢复 82%。1 至 5 月的累计博彩毛收入 同比增长 1.7%。 本研究报告仅通过邮件提供给 中庚基金 ...

Core Viewpoint - The pharmaceutical industry in China is experiencing a significant influx of capital, driven by a wave of refinancing and large business development (BD) transactions, which are reshaping the funding landscape for innovative drug development [1][6][10] Company Summary - Kolon Biotech (科伦博泰) announced a placement of 5.918 million H-shares at a price of HKD 331.8, raising approximately USD 250 million (around CNY 1.796 billion), setting a record for new share placements in the Hong Kong biopharmaceutical market this year [1] - The company has completed three rounds of financing, raising a total of approximately CNY 2.894 billion, with the latest placement supported by existing shareholders and new heavyweight investors [5] - Kolon Biotech has a strong pipeline with over 30 candidates in development, including three products in commercialization, which are under continuous cash flow pressure due to the high costs associated with drug development [4][5] Industry Summary - The Chinese pharmaceutical sector is transitioning from a phase of "scale expansion" to "value creation," with R&D investments growing at an average annual rate exceeding 20% during the 14th Five-Year Plan period [6][7] - The total R&D expenditure in China's pharmaceutical industry reached USD 32.6 billion in 2022, accounting for 13.5% of global pharmaceutical R&D spending, and is projected to reach USD 67.5 billion by 2030 [6][7] - The recent surge in refinancing and BD transactions indicates a structural shift in the market, allowing innovative drug companies to secure funding earlier in the development process, thus shortening the investment return cycle [2][10]