胶原蛋白赛道再生变局。近日，崇山生物和艾佰瑞的两款胶原蛋白新品获得国家药品监督管理局批准，持证产品阵营由此扩充。前者凭借45mg/ml的高浓度 主打性价比，后者则从适应症细分切入，试图在日益拥挤的动物胶原赛道中建立差异化优势。与此同时，在赛道另一端的重组胶原领域，企业正以安全性与 规模化生产加速市场扩张，预计2023—2027年，其复合年增长率将赶超动物源胶原蛋白。 随着两款新产品获批，国内已获第三类医疗器械证书的胶原蛋白产品增至14款。然而，拿到"入场券"只是开始，真正的考验在于：在这条日益拥挤的赛道 上，谁能从性价比、品牌认知、产品安全性与有效性等方面构建差异化优势，实现最终突围。 动物源胶原赛道形成"八强"竞争 新入局者意图明确，不再满足于市场跟随，而是瞄准关键技术指标寻求差异化立足。崇山生物的新品是全球首款浓度达45mg/ml的牛跟腱来源I型胶原蛋白植 入剂。相比此前最高浓度为35mg/ml的同类产品，该公司试图以"高浓度"树立产品形象。 | 注册证编号 | 国械注准20253132516 | | --- | --- | | 注册人名称 | 浙江崇山生物制品有限公司 | | 注册人住所 | 浙江省杭州 ...

丸美生物旗下拥有"丸美"与"恋火"两大核心品牌。弗若斯特沙利文报告显示，以2024年零售额计，丸美 品牌已连续四年位列中国国内眼部护理品牌第一，而恋火品牌则在中国国货底妆品牌中排名第三。 此次发行将助力公司把握中国抗衰护肤品市场的增长机遇。弗若斯特沙利文报告指出，抗衰护肤品是中 国护肤品行业中增速最快的细分领域。通过本次募资，公司将持续投入以重组胶原蛋白为代表的核心技 术研发，进一步巩固其技术壁垒。截至2025年9月30日，公司已在全球申请专利651项，获得授权发明专 利265项，研发实力位居国内美妆企业前列。此举将增强公司在激烈市场竞争中的差异化优势，巩固其 行业领先地位。 针对核心原料，公司已建立覆盖从基础研究到应用的闭环价值链。截至2025年9月30日，已开发出重组 双胶原蛋白、SPGβ－葡聚糖、超分子木棉花提取物、超分子弹性蛋白等80余款自有成分，其中30余款 实现规模化生产。其自有的生产基地能够开展用于重组胶原生产的高密度发酵与纯化工艺，有效衔接基 础研究与产业化生产。 公司强调，此次H股发行不会导致公司控制权发生变更，孙怀庆博士与王晓蒲仍为公司实际控制人。公 司拟通过本次发行募集资金，在扣除相关发 ...

中证报中证网讯（王珞）近日，广东丸美生物（603983）技术股份有限公司（以下简称"丸美生物"）发 布H股申请资料，公司拟通过本次发行募集资金，在扣除相关发行费用后，全部用于强化公司核心战 略，包括加强全渠道销售体系、提升品牌价值与孵化新品牌、增强研发能力、优化供应链以及补充公司 营运资金，旨在全面提升公司的综合竞争力。 深耕抗衰二十余年 胶原蛋白领军品牌之一 资料显示，丸美生物以合成生物学技术驱动，深耕抗衰护肤品行业二十余年，不断通过专注于研发及以 重组胶原蛋白为代表的核心技术突破，将前沿科技创新应用到具有抗皱、紧致和修护等功效的护肤产品 中。 基于弗若斯特沙利文报告，以2024年零售额计，丸美生物是重组胶原蛋白护肤品细分领域的中国第三大 美妆企业。 自企业创立以来，丸美生物坚持产品的成分及功效研究，已建立一个一体化研发平台。通过涵盖合成生 物学、蛋白工程、绿色化学、天然植物提取及生物发酵的系统研发，持续推出支持业务增长的新成分与 产品。 针对核心原料，公司已建立覆盖从基础研究到应用的闭环价值链。截至2025年9月30日，已开发出重组 双胶原蛋白、SPGβ－葡聚糖、超分子木棉花提取物、超分子弹性蛋白等80余 ...

今年以来，上美股份（02145.HK）飙升逾150%，毛戈平（01318.HK）也涨超50%，表现不俗。 招股书披露，丸美生物通过线上线下渠道销售产品。线上渠道主要包括（i）通过抖音、天猫、京东等电商平台进行的直接销售及（ii）向线上经销商销售； 线下渠道包括向线下经销商销售，再由其主要转售至（i）日化化妆品专营店、（ii）百货商场专柜及（iii）美容院。 而同属国货美妆赛道的A股上市企业——丸美生物（603983.SH）也于近日向港交所递交了招股书，拟在主板上市，联席保荐人为高盛、中信证券。 中国领先美妆企业，年内A股微涨5% 丸美生物的历史可追溯到2002年4月，经过多年发展，其A股于2019年7月在上海证券交易所上市。 值得一提的是，2025年以来，丸美生物的股价先是在上半年出现显著拉升，随后又在下半年遭遇大幅回落，最终年内仅累涨5.30%，股价表现明显跑输上述 港股同行。 业务方面，作为一家中国领先美妆企业，丸美生物以合成生物学技术驱动，不断通过专注于研发及以重组胶原蛋白为代表的核心技术突破，将前沿科技创新 应用到具有抗皱、紧致和修护等功效的护肤产品中。基于弗若斯特沙利文报告，以2024年零售额计，丸 ...

作者： 林京 来源： Tech星球 医美巨头华熙生物，依旧在经历阵痛期。 以下文章来源于Tech星球 ，作者林京 ------------------------------- Tech星球 . Tech星球，聚焦互联网前沿科技和新商业。 随着玻尿酸市场红利消退，华熙生物的业绩还在不断承压。 今年前三季度，华熙生物营业收入同比 减少18.36%至31.63亿元，归母净利润较上年同期下滑30.29%至2.52亿元。 12月5日，华熙生物股价更是以45.57元收盘， 跌破47.79元的发行价，总市值仅剩220亿， 相较 昔日最高峰1400亿市值，已经蒸发千亿。 此外，据凤凰网科技等报道，华熙生物发布了一封"同舟共济、共克时艰"的全员邮件，称受市场环 境波动影响，公司经营业绩面临较大压力。为确保长期稳健发展，公司需对现有福利政策进行合规 性优化调整。 其中，白2025年12月起，华熙生物及各分子公司的住房公积金缴存比例统一调整为5%。 自2025 年12月起，原设定的节日礼金将暂停发放。后续公司将通过员工关怀活动、弹性福利平台等方式， 持续关注大家的工作与生活需求。 截至发稿，华熙生物对此邮件内容暂无公开回应。 尽 ...

Core Viewpoint - Marubi Biotechnology has submitted a listing application to the Hong Kong Stock Exchange, with Goldman Sachs and CITIC Securities as joint sponsors. The company ranks third in the Chinese market for recombinant collagen skincare products by retail sales in 2024, focusing on anti-aging skincare through synthetic biology technology [1][2]. Group 1: Company Overview - Marubi operates two main brands: Marubi (丸美) and L'HOTEL (恋火). The Marubi brand specializes in eye and facial anti-aging care, holding the top position in retail sales for eye care brands in China from 2021 to 2024. L'HOTEL focuses on base makeup products, ranking third among domestic base makeup brands and fifth overall in China for retail sales in 2024 [2]. - The company has developed over 80 proprietary ingredients, including recombinant double collagen and SPGβ-glucan, with more than 30 products achieving large-scale production. It operates two production bases in Guangzhou, equipped with high-density fermentation and purification processes for recombinant collagen production [2]. Group 2: Industry Position and Innovations - According to a report by Frost & Sullivan, Marubi ranks third in the recombinant collagen skincare segment in China by retail sales for 2024. The company has successfully developed recombinant double collagen, an engineered product that combines type I and type III collagen using translation pause and C-PRO loop technology [1]. - As of September 30, 2025, Marubi is the first and only company in China approved as a national research center for recombinant functional protein technology, having been recognized as a key drafting unit for the industry standard "Recombinant Soluble Collagen" by the Ministry of Industry and Information Technology [1].

Company Overview - Guangdong Marubi Biotechnology Co., Ltd. has submitted a listing application to the Hong Kong Stock Exchange, with Goldman Sachs and CITIC Securities as joint sponsors [1] - Marubi is the third largest beauty company in China's recombinant collagen skincare segment based on retail sales projected for 2024 [1] - The company focuses on providing anti-aging solutions and has over 20 years of experience in the skincare industry, leveraging synthetic biology technology [1] Product Development - Marubi has successfully developed recombinant double collagen, which combines type I (profile) collagen and type III (filling) collagen into a single molecule [1] - The company has established a comprehensive value chain covering basic research to application, having developed over 80 proprietary ingredients, with more than 30 achieving large-scale production [3] Brand Performance - Marubi and its brand "Lianhuo" are the main brands, with Marubi ranking first in China's eye care brand market from 2021 to 2024 based on retail sales [2] - Lianhuo ranks third among domestic foundation brands and fifth among all foundation brands in China, with a compound annual growth rate (CAGR) of 77.5% from 2022 to 2024 [2] Financial Performance - The company recorded revenues of RMB 1.732 billion, RMB 2.226 billion, RMB 2.970 billion, and RMB 2.450 billion for the years 2022, 2023, 2024, and the nine months ending September 30, 2025, respectively [4] - The annual profits for the same periods were RMB 167 million, RMB 278 million, RMB 342 million, and RMB 247 million [5] - Gross profits for the respective years were RMB 1.175 billion, RMB 1.560 billion, RMB 2.177 billion, and RMB 1.834 billion [6] Industry Overview - The Chinese beauty industry is projected to grow from RMB 460.3 billion in 2019 to RMB 566.3 billion in 2024, with a CAGR of 4.2% [7] - The skincare market is expected to grow from RMB 355.9 billion in 2019 to RMB 451.4 billion in 2024, with a CAGR of 4.9% [8] - The makeup market is anticipated to grow from RMB 104.5 billion in 2019 to RMB 114.8 billion in 2024, with a CAGR of 1.9% [9]

Core Insights - Mamei Bio is a leading Chinese beauty company focused on anti-aging solutions, leveraging synthetic biology technology and over 20 years of experience in the skincare industry [4][5] - The company has developed a recombinant double collagen, a unique engineered protein that combines type I and type III collagen into a single molecule, enhancing its skincare products [4] - Mamei Bio has been recognized as the primary drafting unit for the national standard of "Recombinant Soluble Collagen" by the Ministry of Industry and Information Technology in 2023 [4] Company Overview - Mamei Bio operates two main brands: Mamei, focusing on anti-aging eye and facial care products, and Lianhuo, a cost-effective makeup brand [4] - The company has established a comprehensive value chain for core ingredients, developing over 80 proprietary components, with more than 30 achieving large-scale production [7] - Mamei Bio's production facilities are located in Guangzhou, China, and are equipped for high-density fermentation and purification processes for recombinant collagen production [7] Financial Performance - Mamei Bio's revenue for the years ending December 31 and the nine months ending September 30 are as follows: RMB 1.732 billion in 2022, RMB 2.226 billion in 2023, RMB 2.977 billion in 2024, and RMB 2.450 billion for the nine months of 2025 [8] - The company's profit for the same periods is reported as RMB 167 million in 2022, RMB 278 million in 2023, RMB 342 million in 2024, and RMB 247 million for the nine months of 2025 [9] - Gross profit figures are RMB 1.175 billion in 2022, RMB 1.560 billion in 2023, RMB 2.177 billion in 2024, and RMB 1.834 billion for the nine months of 2025 [10] Industry Overview - The Chinese beauty market is projected to grow from RMB 460.3 billion in 2019 to RMB 566.3 billion by 2024, with a compound annual growth rate (CAGR) of 4.2% [11] - The skincare segment is expected to expand from RMB 355.9 billion in 2019 to RMB 451.4 billion by 2024, with a CAGR of 4.9% [14] - The makeup segment is anticipated to grow from RMB 104.5 billion in 2019 to RMB 114.8 billion by 2024, with a CAGR of 1.9% [17]

Company Overview - Mamei Biotechnology is a leading Chinese beauty company focused on providing anti-aging solutions, leveraging synthetic biology technology and over 20 years of experience in the anti-aging skincare industry [4] - The company has successfully developed recombinant double collagen, a unique engineered collagen that combines type I and type III collagen into a single molecule, enhancing its skincare products [4] - Mamei Biotechnology has been recognized as a key drafting unit for the industry standard "Recombinant Soluble Collagen" by the Ministry of Industry and Information Technology in 2023 [4] Market Position - According to Frost & Sullivan, Mamei has ranked first in the Chinese domestic eye care brand market by retail sales from 2021 to 2024 [5] - The brand "Lianhuo" ranks third among domestic foundation brands and fifth among all foundation brands in China, with a compound annual growth rate (CAGR) of 77.5% from 2022 to 2024, the highest among the top five foundation brands [5] Product Development - Mamei has established a comprehensive value chain covering basic research to application for its core ingredients, having developed over 80 proprietary ingredients, with more than 30 achieving large-scale production [7] - The company operates two production bases in Guangzhou, which are capable of high-density fermentation and purification processes for recombinant collagen production [7] Financial Performance - The company reported revenues of RMB 1.73 billion, RMB 2.23 billion, RMB 2.97 billion, and RMB 2.45 billion for the years ending December 31, 2022, 2023, 2024, and the nine months ending September 30, 2025, respectively [9] - The annual profits for the same periods were RMB 167.43 million, RMB 277.59 million, RMB 342.36 million, and RMB 246.65 million [10] - Gross profits for the respective years were RMB 1.17 billion, RMB 1.56 billion, RMB 2.18 billion, and RMB 1.83 billion [11] Industry Overview - The Chinese beauty industry is projected to grow from RMB 460.3 billion in 2019 to RMB 566.3 billion by 2024, with a CAGR of 4.2% [12] - The skincare market is expected to expand from RMB 355.9 billion in 2019 to RMB 451.4 billion by 2024, with a CAGR of 4.9% [15] - The makeup market is anticipated to grow from RMB 104.5 billion in 2019 to RMB 114.8 billion by 2024, with a CAGR of 1.9% [18]

Group 1 - The core viewpoint of the article is that Guangdong Marubi Biotechnology Co., Ltd. has submitted an application for listing on the Hong Kong Stock Exchange, with Goldman Sachs and CITIC Securities as joint sponsors [1] - Marubi Biotechnology is a leading Chinese beauty company focused on providing anti-aging solutions, leveraging synthetic biology technology and over 20 years of experience in the anti-aging skincare industry [1] - The company emphasizes research and development, particularly in core technologies such as recombinant collagen, to innovate skincare products with anti-wrinkle, firming, and repairing effects [1] Group 2 - According to a report by Frost & Sullivan, Marubi Biotechnology is the third largest beauty company in China in the recombinant collagen skincare segment, based on retail sales projected for 2024 [1]