Core Viewpoint - The article explores the extreme anti-aging regimen of Bryan Johnson, a Silicon Valley billionaire, who spends $2 million annually on a team of doctors to pursue his "Blueprint" for longevity, claiming to have reversed his biological age by 5.1 years [5][15][19]. Group 1: Bryan Johnson's Anti-Aging Practices - Bryan Johnson maintains a daily routine that includes extreme dietary restrictions, such as consuming no more than 2,000 calories and following a strict vegan diet [12][14]. - He employs various health monitoring techniques, including blood tests and body measurements, to track his biological markers, aiming to be the slowest aging person in the world [33][34]. - Johnson's regimen includes the use of numerous supplements and medications, initially taking 110 pills daily, which he has since reduced to 35 [31][36]. Group 2: Public Perception and Media Strategy - Johnson has embraced a public persona, leveraging social media to share his anti-aging journey, which has garnered significant attention and a growing following [39][41]. - His philosophy, encapsulated in the slogan "Don't Die," aims to inspire others to adopt healthier lifestyles and embrace technological advancements in health [42][44]. - The article highlights the contrast between Johnson's extreme lifestyle choices and the more conventional approaches to health and longevity, raising questions about the sustainability and practicality of his methods [15][19][45]. Group 3: Scientific and Medical Community Response - The medical community has expressed skepticism regarding Johnson's aggressive approach to anti-aging, with some experts warning that the multitude of interventions may not yield clear results [34][36]. - Despite the criticism, Johnson remains committed to his regimen, emphasizing data-driven results over anecdotal evidence [34][36]. - The article discusses the potential risks associated with his practices, including adverse reactions to treatments and the psychological impact of his extreme lifestyle [16][18].

Core Insights - The research led by Professor Luo Qingming from Hainan University and the Huazhong University of Science and Technology has successfully created a three-dimensional brain atlas of mice with a precision of 1 micron, providing a crucial tool for understanding brain science [2][3] - The findings were published in the international academic journal "Nature," marking a significant breakthrough in global brain science research [2][3] Research Methodology - The research team developed a method for Nissl staining and resin fixation of the entire mouse brain, transforming it into a transparent "crystal brain" to capture detailed images of brain cell structures [2] - A total of 14,000 coronal sections, 11,400 sagittal sections, and 9,000 horizontal sections were obtained, resulting in sub-micron resolution images of the entire mouse brain [2] Findings and Applications - The team delineated and labeled a three-dimensional adjustable map of 916 brain regions, including 236 newly discovered subregions, revealing unknown neural connectivity networks [3] - This brain atlas serves as a precise "brain Lego model," significantly enhancing the understanding of normal brain functions and dysfunction mechanisms in various diseases, including Alzheimer's disease, epilepsy, and depression [3]

Core Insights - A breakthrough research achievement by a team led by Professor Luo Qingming from Hainan University has resulted in a three-dimensional brain atlas of mice, published in the journal Nature, achieving unprecedented precision of 1 micron [1][3] Group 1: Research Methodology - The research utilized a self-developed microscopic optical sectioning tomography technique to transform mouse brains into transparent "crystal brains," capturing 14,000 coronal sections, 11,400 sagittal sections, and 9,000 horizontal sections, all at sub-micron resolution [3] - The number of images obtained in three standard anatomical orientations is two orders of magnitude higher than traditional anatomical atlases, allowing for clear differentiation of individual cells and tissue characteristics [3] Group 2: Findings and Contributions - The team constructed a three-dimensional mouse brain reference atlas with isotropic 1-micron resolution, delineating and labeling 916 brain regions, including 236 newly named subregions [3][4] - The three-dimensional boundaries of these brain regions are continuous and seamless, eliminating gaps and blank areas, thus creating a highly detailed "spatial navigation map" of the brain [3] Group 3: Future Implications - The research team has established a visualization and sharing platform for the atlas data, promoting public access and cloud computing services, which will facilitate the dissemination of neuroscience knowledge and research [4] - This mouse brain atlas is expected to provide powerful research tools and new perspectives for studying mammalian brain development and evolution, potentially leading to significant advancements in the field [4]

Market Overview - The market experienced a rebound with the ChiNext Index leading the gains. The military industry sector saw significant growth, with over 20 stocks including Changcheng Military and Hunan Tianyan hitting the daily limit. The stablecoin concept also surged, with stocks like Hopu Co. and Xiexin Energy reaching their limits. Brain-computer interface stocks rose, with Xiangyu Medical and Innovation Medical hitting the limit. Overall, more than 4,000 stocks in Shanghai and Shenzhen markets were in the green, with a total transaction volume of 1.51 trillion [1]. Hot Topics Military Industry - The military sector continued its upward trend, with stocks like Changcheng Military, Feiyada, and Zhongguang Defense hitting consecutive limits. Hunan Tianyan and Beifang Navigation also saw significant rebounds [4]. RWA (Real World Assets) - The RWA sector experienced substantial gains, with stocks like Hopu Co. and Hangzhou Garden hitting their limits. The market is witnessing a rapid growth of RWA ecosystem participants, including issuers, custodial banks, and investors, which may present investment opportunities in asset operation, banking IT, and cross-border payments [6][8]. Brain Science - The brain science sector saw significant increases, with stocks like Rongtai Health and Innovation Medical hitting their limits. Recent developments from Neuralink, including clinical trials for brain-computer interfaces, have generated excitement in the market. The brain-computer interface market in China is projected to reach 3.2 billion by 2024 and exceed 5.5 billion by 2027, with global applications expected to reach between 40 billion to 145 billion by 2030-2040 [9][10][11].

Group 1 - Beijing has achieved significant progress in building a global digital economy benchmark city, particularly in key areas such as artificial intelligence, brain science, and embodied intelligence, with 132 large models registered, accounting for nearly 35% of the national total [1] - The city has established 14.12 million 5G base stations, with an average of over 64 stations per 10,000 people, ranking first in the country [2] - Beijing's AI sector includes over 2,400 companies, generating core industry revenue exceeding 350 billion, with applications in education, healthcare, and transportation [2] Group 2 - The "North Brain No. 1" brain-machine system has successfully completed the world's first human implantation of a flexible high-throughput semi-invasive wireless brain-machine system, now entering clinical validation [1] - The city is focused on accelerating digital technology innovation, supporting the establishment of digital technology innovation consortia, and advancing key areas such as AI, blockchain, brain-machine interfaces, quantum information, and advanced new materials [3] - Beijing aims to deepen the construction of a data factor market and support the Beijing International Big Data Exchange in reforming its institutional mechanisms [3]

Market Overview - On June 17, the brain science sector experienced a collective surge, with stocks like Aipeng Medical and Innovation Medical hitting the daily limit, while others like Nanjing Panda and Beilu Pharmaceutical also saw significant gains [1][2]. Industry Developments - Chinese concept stocks in brain regeneration technology surged by 283% in the US market, with a cumulative increase of over 50 times this year [3]. - A research team from the University of California, Davis, developed a brain-machine interface that could help individuals with speech loss due to neurological diseases regain their ability to "speak" [3]. - Researchers have created a neuromorphic computer that mimics the human brain structure, potentially operating 250,000 to 1,000,000 times faster than a biological brain while consuming only 10 kilowatts of power [3]. - China has successfully conducted its first prospective clinical trial for invasive brain-machine interfaces, becoming the second country after the US to enter this stage [3]. Institutional Insights - The advancement of invasive brain-machine interface technology in China is expected to drive rapid growth in related industries, including high-end imaging equipment, surgical robots, and AI medical applications, benefiting leading companies in these sectors [4]. - The potential of neuromorphic computing could revolutionize fields such as AI, robotics, and healthcare, with applications in smart medical devices and autonomous vehicles [4]. - The brain-machine interface industry is witnessing breakthroughs in applications for movement recovery, communication, and hearing restoration, supported by favorable national policies [5].

Core Concept - The article discusses the rapid development and potential of brain-like intelligence (neuromorphic intelligence) in China, highlighting its distinction from artificial intelligence and brain simulation technologies [1][3]. Group 1: Development and Characteristics of Neuromorphic Intelligence - Neuromorphic intelligence is not a simple imitation of the brain but is designed to mimic the brain's structure and functioning, enabling intelligent systems to perceive, understand, learn, and make decisions [3][4]. - The field has gained momentum due to advancements in neuroscience and related technologies, with significant progress made in the last decade, positioning China as a global leader in this domain [3][4]. - Neuromorphic intelligence differs from artificial intelligence and brain simulation in definitions, technical principles, and application scenarios, indicating a unique development path [3][5]. Group 2: Applications and Future Prospects - Neuromorphic intelligence is in its early application stage, with potential uses in various fields, particularly in medicine and communication technology, supported by national policies promoting interdisciplinary research [5][6]. - Breakthroughs in brain-computer interface technology are expected to enhance memory and improve sleep quality, indicating transformative impacts on human health [5][6]. - The future may see widespread adoption of compact, energy-efficient neuromorphic computers in households and workplaces, fundamentally changing lifestyles and making intelligent services more accessible [5][6]. Group 3: Economic and Social Implications - The development of neuromorphic intelligence is anticipated to position China as a leader in intelligent design and manufacturing, benefiting various industries including IoT and telecommunications [6]. - China's large population and diverse application scenarios provide a robust foundation for the growth of neuromorphic intelligence, with significant demand in areas like pain management [6]. - The emphasis on independent intellectual property rights in neuromorphic intelligence development reflects a commitment to domestic innovation while remaining open to international collaboration [6].

Core Insights - The Zhiyuan Research Institute launched the "Wujie" series of large models, including Emu3, Brainμ, RoboOS 2.0, RoboBrain 2.0, and OpenComplex2, at the 2025 Beijing Zhiyuan Conference [1] Group 1: Emu3 and Brainμ Models - Emu3 is a native multimodal world model that utilizes a next-token prediction paradigm for unified multimodal learning, allowing for the encoding of images/videos into discrete symbol sequences [2] - Brainμ, built on the Emu3 architecture, integrates brain signals as a new modality, enabling a single model to perform various neuroscience tasks, potentially becoming the "AlphaFold" of brain science [2][3] Group 2: RoboOS 2.0 and RoboBrain 2.0 - RoboOS 2.0 is the world's first open-source framework for embodied intelligence SaaS platforms, significantly reducing development barriers and improving performance by 30% compared to its predecessor [4] - RoboBrain 2.0 enhances multi-agent task planning capabilities, achieving a 74% improvement in task planning accuracy over RoboBrain 1.0 [5] Group 3: OpenComplex2 Model - OpenComplex2 represents a breakthrough in modeling biological molecules, capturing molecular interactions at atomic resolution and providing insights into the relationship between microscopic fluctuations and macroscopic biological functions [6][7] Group 4: Open Source Initiatives - Zhiyuan has open-sourced approximately 200 models and 160 datasets, with the FlagOS software stack upgraded to support various AI hardware and improve performance by up to 23% [8] Group 5: Applications and Collaborations - The Brainμ model has shown potential in consumer-grade brain-computer interface applications, collaborating with leading neuroscience laboratories and companies to expand its industrial applications [3][11] - The development of a digital twin heart and a drug safety evaluation platform demonstrates the application of advanced modeling techniques in pharmacology and personalized medicine [12]

Core Viewpoint - The passing of Academician Gu Yudong, a pioneer in hand surgery and limb reconstruction, marks a significant loss for the medical community, particularly in the field of upper limb functional reconstruction and brain science research [1][3][4]. Group 1: Contributions to the Field - Under Gu Yudong's leadership, Huashan Hospital's hand surgery department evolved from traditional hand trauma treatment to upper limb functional reconstruction, and eventually to limb reconstruction and brain science [1][4]. - Gu Yudong was instrumental in establishing hand surgery as an independent specialty in China, with Huashan Hospital being the first to do so in 1961 [3]. - He pioneered the "dual blood supply system" method, achieving a 100% success rate in toe-to-thumb transplantation, which earned him the National Science and Technology Progress Second Prize [4]. Group 2: Recognition and Awards - In 2023, the project led by Professor Xu Wendong and Academician Gu Yudong, focusing on repairing limb movement disorders through peripheral-central pathway breakthroughs, won the National Science and Technology Progress First Prize [4]. - Gu Yudong held several prestigious positions, including Director of the National Clinical Research Center for Geriatric Diseases and Editor-in-Chief of the Chinese Journal of Hand Surgery [3]. Group 3: Personal Impact and Legacy - Gu Yudong's sudden passing on May 24, 2023, was met with deep sorrow from colleagues and students, highlighting his dedication as he continued to work until his last moments [3][4]. - His vision for the future of hand surgery included the restoration and reconstruction of intrinsic muscle function, which he regarded as a significant challenge in the field [4].

Group 1 - A Hubei-based company has developed and received the first Class III medical device registration certificate for a transcranial magnetic stimulation (TMS) device in the mental health field in China [1][5] - The TMS technology is a non-invasive treatment method that stimulates brain neurons using magnetic fields, which can be beneficial for conditions such as depression [5][6] - The Chinese brain-computer interface (BCI) market is projected to reach 3.2 billion yuan in 2024, with an 18.8% year-on-year growth, and is expected to grow to 5.58 billion yuan by 2027, with a growth rate of 20% [6] Group 2 - The TMS technology is recognized as one of the four major brain science technologies of the 21st century, alongside PET, fMRI, and magnetoencephalography [5] - Hubei has emerged as a leader in the brain science sector, with several companies like Yirui, Zhonghua Brain Machine, and Green Tech making significant advancements [6] - The conference also showcased other innovations in brain science, including the Ami 3S navigation robot and the T-FUS technology [5]