（原标题：港股医疗ETF、港股医药ETF涨超2%，一季度公募基金加仓创新药） 医药股上涨，港股医药ETF领涨。永赢港股医疗ETF、平安港股医药ETF涨超2%；嘉实恒生医疗指数 ETF、华宝医疗ETF、创新药ETF华泰柏瑞、博时恒生医疗ETF、易方达恒生创新药ETF、银华港股通医 药ETF、南方恒生生物科技ETF、易方达港股通医药ETF、大成恒生医疗ETF基金、银华港股创新药ETF 涨超1%。 2025Q1全部基金持股TOP3：恒瑞、康德、迈瑞，主动增持TOP3：泽璟、科伦、百济，主动减持 TOP3：迈瑞、三九、莱士；主动药基持股TOP3：恒瑞、康德、泽璟；主动全基持股TOP3：康德、迈 瑞、恒瑞。 华福证券指出，Q1医药持仓出台，创新药为共识度最高的加仓方向。医药板块经过4年调整，今年以来 底部反转趋势凸显，国际环境搞定不确定性下，医药诸多方向安全性强，创新药持续有催化兑现，医药 板块仍是最值得重点配置的方向，重点关注：1）创新主线：创新药依旧是医药最明确的长期主线，建 议配置龙头及存在明确催化的创新药标的；2）消费医疗：医药兼具消费属性，重点关注医药自主可控 及医药内需，也是内需消费刺激的受益板块；3）困境 ...

Group 1 - The global innovative drug investment and financing environment is recovering, with significant growth in sub-sectors like peptides and ADCs, which is expected to boost the CXO industry's performance [1] - WuXi AppTec reported Q1 2025 revenue of approximately 9.655 billion yuan, a year-on-year increase of 20.96%, and a net profit of about 3.672 billion yuan, up 89.06% year-on-year [1] - The Hong Kong innovative drug sector is experiencing a significant valuation correction, with the Hong Kong innovative drug index's P/E ratio dropping from 64 times to 27 times in less than two months, indicating attractive investment opportunities [1] Group 2 - The Hong Kong innovative drug ETF (159567) tracks the National Securities Hong Kong Stock Connect Innovative Drug Index, which has a 90% weight in innovative drug companies, positioning it to benefit from trends like AI-enabled drug development and the expansion of domestic innovative drugs [2] - The innovative drug ETF (159992) tracks an index that includes leading companies in the innovative drug industry chain, benefiting from AI advancements and new healthcare policies aimed at supporting innovative drugs [2] - Policies from Beijing and Shenzhen are promoting the development of innovative drugs and devices, focusing on R&D innovation, clinical trials, and regulatory approvals, which will enhance the competitiveness of innovative drug companies [2]

Core Viewpoint - The company reported a 12.66% year-on-year increase in net profit attributable to shareholders, reaching 55.44 million yuan, and achieved a positive operating cash flow of 120 million yuan in 2024, highlighting significant improvements in its financial performance [1] Financial Performance - The company's net profit attributable to shareholders increased by 12.66% year-on-year, amounting to 55.44 million yuan [1] - Operating cash flow turned positive, achieving 120 million yuan in 2024 [1] - The medical device segment significantly reduced losses by 42.49%, while the South African business turned profitable with a year-on-year net profit growth of 211.68% [1][2] Business Segments - The South African business segment achieved profitability after years of effort, marking a key highlight in the company's operational performance [2] - The company has established a strong presence in the medical device sector, with multiple orthopedic implant products certified by the FDA and CE, and a robust pipeline of new products under development [2] - The company has been focusing on the South African market for medical device distribution and maintenance services, building a stable customer base and market reputation [2][3] Innovation and R&D - The company has made significant breakthroughs in new drug development, particularly in the field of neurological drugs, with a focus on the development of the huperzine A series and methionine preparations [1][4] - As of the end of the reporting period, the company had seven new drug pipelines under research, with five of them being dual-filed in China and the U.S., indicating high-quality pipeline development [4] - The company has received FDA clinical trial approvals for WP107 and WP103, both of which are based on huperzine A, a potent cholinesterase inhibitor [4][6] Future Outlook - The company plans to enhance its international strategy by increasing the export of domestic medical devices, aiming to create a new profit contribution point [3] - The company is committed to advancing its R&D capabilities by leveraging artificial intelligence in drug development and production quality control [7] - The company aims to become a leading enterprise in the pharmaceutical and health industry through technological innovation and collaboration with academic institutions [7]

2024 年，公司仿制药业务受集采、MAH 制度等政策的影响，营业收入下降，2024 年实现收入8.02 亿 元，同比下降21.18%；归母净利润-0.53 亿元，同比下降119.39%；扣非归母净利润-0.73 亿元，同比下 降128.07%。25Q1实现收入1.29 亿元，归母净利润-0.26 亿元，扣非归母净利润-0.36 亿元。 盈利预测与评级：我们预计公司2025-2027 年收入分别为7.04/7.78/8.75 亿元，同比增 长-12.2%/10.6%/12.4%；归母净利润分别为0.55/1.03/1.19 亿元，同比增长204.4%/87.9%/15.0%。考虑到 公司受政策影响短期业绩不确定性加大，短期利润承压，但25 年有望扭亏，下调至"增持"评级。 风险提示：成果转化不及预期，新签订单不及预期，行业竞争加剧。 截至24 年底，自主研发项目已经立项尚未转化的自主研发项目近300 项，完成小试阶段91 项，完成中 试放大阶段53 项，在验证生产阶段78 项，2024年研发成果技术转化58 个。创新驱动技术转化，新药研 发团队已逾200 人，截至年报披露公司已取得1 类新药的2 个IND 批 ...

2025 年 04 月 29 日 阳光诺和(688621.SH) 新签订单快速增长且创新研发持续投 入，期待公司经营边际向好 事件： 公司发布了 2025 年第一季度报告，2025Q1 公司分别实现营收和归母 净利润 2.31 亿元和 0.30 亿元，分别同比下降 8.49%和 59.34%。 新签订单快速增长，期待公司业绩边际改善： 2025Q1 公司分别实现营收和归母净利润 2.31 亿元和 0.30 亿元，分 别同比下降 8.49%和 59.34%。当前创新药投融资持续复苏，公司相关 订单快速增长（2024 年新签订单金额达 17.86 亿元，同比增长 18.74%），随着新签订单的陆续交付，期待公司业绩边际改善。 创新研发持续投入，致力于构建具备竞争力的创新药管线： 公司在研发创新上持续投入，致力于开发具有全球自主知识产权的创 新药物，构建具备市场竞争力的研发管线。截至 2024 年底，公司新 立项自研项目达 89 余项，全面覆盖多肽、长效微球制剂、缓控释制 剂、局部递送与透皮吸收药物、细胞治疗、小核酸以及核酸偶联药物 等前沿领域。其中，多肽创新药方面，公司布局了以 kappa 阿片受体 （KOR）为 ...

Group 1 - WuXi AppTec, a leading player in the CXO sector, reported better-than-expected performance with double-digit growth in both revenue and net profit, maintaining a revenue guidance of RMB 41.5 billion to RMB 43 billion for 2025 [1] - In 2024, WuXi AppTec generated RMB 16.64 billion from the top 20 global pharmaceutical companies, highlighting its significant role in the global CXO market [1] - The Hong Kong innovation drug index saw a significant drop in P/E ratio from 64 times on February 21 to 27 times on April 28, indicating a strong value proposition for investors [1] Group 2 - The innovation drug ETF (159992) tracks an index that includes leading companies in the innovation drug industry, benefiting from trends such as AI-enabled drug development and the international expansion of domestic innovative drugs [2] - According to Insight database, there were 79 new drug license-out transactions in 2024, with 24 transactions completed in the first five months of 2025, totaling over USD 2 billion, showcasing the growing international recognition of Chinese innovative drugs [2] - Chinese pharmaceutical companies are demonstrating strong competitiveness in the global market through high-standard R&D, particularly in areas like antibodies and ADCs [2]

Core Viewpoint - The company reported a significant decline in performance for 2024, with a revenue of 2.467 billion yuan, down 5.48% year-on-year, and a net loss of 299 million yuan, marking a drastic shift from a profit of 263 million yuan in the previous year [1][4][10] Revenue and Profitability - The company's revenue has been on a downward trend since 2022, with figures of 2.676 billion yuan in 2022, 2.611 billion yuan in 2023, and 2.467 billion yuan in 2024 [2] - The traditional Chinese medicine segment generated 1.318 billion yuan, accounting for 53.93% of total revenue, while chemical drugs contributed 899 million yuan, or 36.81% [2] - The average price of the core product, Compound XueShuanTong series, dropped by 52% after entering national procurement, leading to a revenue decrease of approximately 120 million yuan despite an 18% increase in sales volume [3] Business Segments - The company is undergoing a transformation from traditional Chinese medicine to an innovative pharmaceutical company, focusing on three main business areas: traditional Chinese medicine, chemical drugs, and innovative drugs [1][10] - The chemical generic drug sector is being refined, with six products approved in 2024, while the raw materials and intermediates segment saw a revenue drop of 26.98% to 30.49 million yuan [3][5] R&D and Innovation - The company has a strong commitment to R&D, with a research expense ratio of 10.68% in 2024, despite a decrease from 12.5% in 2023 [8] - The company has halted several clinical projects, resulting in a one-time impairment loss of 207 million yuan, reflecting a focus on core pipelines [8][9] - The innovative drug RAY1225 is projected to generate significant sales in the diabetes and obesity management market, with estimated contributions of 1.369 billion yuan for diabetes and 700 million yuan for weight management by 2033 [9] Asset Management and Impairment - The company recorded an asset impairment loss of 547 million yuan in 2024, primarily due to goodwill impairment related to subsidiaries and R&D projects [6][7] - The goodwill value at the end of 2024 was 318 million yuan, significantly reduced from 530 million yuan in 2023, indicating challenges in integrating acquired assets [6][7] Market Position and Future Outlook - The company is positioned in a critical transition phase, aiming to redefine its industry status and enhance its innovative capabilities [1][10] - The next 2-3 years are crucial for the company to validate its innovative drug commercialization capabilities, with potential risks if core projects face obstacles [10]

Core Viewpoint - The focus of institutional investors on Yipinhong's innovative drug AR882 highlights its potential in the gout treatment market, with significant clinical trial progress and FDA fast track designation [1][2][3]. Group 1: Clinical Trial Progress - Yipinhong's AR882 has received FDA fast track designation for treating visible tophi in gout patients, indicating a potential gap in the oral medication market for this condition [2]. - The Phase III clinical trials for AR882 have commenced, with the first patient enrolled on March 4, 2025, and the global REDUCE2 trial completing patient enrollment shortly thereafter [2]. - The REDUCE1 trial, parallel to REDUCE2, also began patient enrollment on March 17, 2025, focusing on the drug's efficacy in lowering serum uric acid levels [2]. Group 2: Competitive Landscape - Current treatments for hyperuricemia and gout are limited, with existing drugs primarily focused on disease prevention and pain management, while AR882 aims to provide a more effective solution [3]. - Yipinhong asserts that AR882's clinical data shows it can not only lower serum uric acid but also dissolve gout tophi, setting it apart from competitors that only demonstrate uric acid reduction [3]. Group 3: Drug Development and Safety - AR882's molecular design aims to reduce liver toxicity and enhance efficacy, with a prolonged action time of up to 24 hours, addressing safety concerns associated with existing treatments [4]. - The company is optimistic about AR882's market potential, given its unique clinical data and the significant demand in the gout treatment market [4]. Group 4: Research and Development Pipeline - Yipinhong has a total of 71 projects in development, including 15 innovative drug projects, with AR882 and another drug, APH01727, currently in clinical trials [5]. - The company is building a smart manufacturing base compliant with FDA and EU standards, integrating advanced automation and information management systems to support global drug manufacturing needs [5]. Group 5: Subsidiary Developments - Yipinhong's subsidiary, Fendi Pharmaceutical, is focused on developing targeted protein degradation agents for cancer and viral infections, utilizing advanced technologies to enhance drug discovery [6]. - Another subsidiary, Alpha Molecular, is leveraging AI and original biocomputing for drug research targeting GPCRs, with several self-developed pipelines nearing clinical application [6].

4月28日，凯因科技(688687)披露2024年年度报告和2025年一季报。公司2024年度实现营业收入12.30亿 元，归母净利润1.42亿元，同比增长22.18%；2025年一季度实现营收2.32亿元，同比增长8.90%，归母 净利润2566.85万元，同比增长15.92%。公司维持较高研发投入强度，2024年研发投入1.57亿元，占营 业收入比例为12.79%，同比增加0.57个百分点。核心项目取得突破性进展 报告期内，公司多个研发项目取得突破性进展：KW-001(培集成干扰素α-2注射液乙肝适应症)完成Ⅲ期 临床试验并提交药品注册上市许可申请；KW-045(人干扰素α2b喷雾剂)针对儿童疱疹性咽峡炎适应症 Ⅱa期临床试验全部受试者完成治疗及随访；KW-051(培集成干扰素α-2注射液带状疱疹适应症)Ⅱ期临床 试验全部受试者完成治疗及随访；KW-053人干扰素α2b阴道泡腾片辅助治疗尖锐湿疣适应症取得药物临 床试验批准通知书，Ⅱ期试验推进中；GL-004(马来酸阿伐曲泊帕片)取得药品注册证书。 公司于2024年共申请发明专利9项，获得发明专利授权7项；至报告期末，累计申请发明专利175项，累 计获得发 ...

证券代码：301263 证券简称：泰恩康 广东泰恩康医药股份有限公司投资者关系活动记录表 编号：投-002 | | √ 特定对象调研 □ 分析师会议 | | --- | --- | | 投资者关系活动 | □ 媒体采访 □ 业绩说明会 | | 类别 | □ 新闻发布会 □ 路演活动 | | | □ 现场参观 | | | □ 其他 宝盈基金管理有限公司、浙江浙商证券资产管理有限公司、上海 | | | 保银投资管理有限公司、鹏华基金管理有限公司、华夏基金管理 | | | 有限公司、深圳正圆投资有限公司、上海鑫垣私募基金管理有限 | | | 公司、交银施罗德基金管理有限公司、前海人寿保险股份有限公 | | | 司、东证资管、卓瑜资本、东吴证券、上海五地私募基金管理有 | | 参与单位名称及 | 限公司、光大保德信基金管理有限公司、中海基金管理有限公司 | | 人员姓名 | 、东方香港销售、华安证券、国泰海通证券、方正医药、卓瑜资 | | | 本、天风证券、优益增、西部证券、智合远见私募基金、华福证 | | | 券、森锦、中信医药、调兵投资、东方证券、申万宏源证券、招 | | | 商证券、银河证券、华创证券、华源证券 ...