Core Viewpoint - The article discusses the upcoming Fourth China Plastic Surgery and Regenerative Medicine Development Conference and the 14th Beijing International Aesthetic Surgery Conference, scheduled for October 31 to November 2, 2025, in Beijing, aimed at promoting the development of plastic surgery in China and enhancing collaboration among related disciplines [3]. Event Details - The event will feature the Third Ba Da Chu Aesthetic Industry Forum, a competition final, and nine sub-forums [3]. - Participation is free, and there will be an exhibition of enterprise products on-site [4]. Organizers - The event is organized by Ba Da Chu Plastic Surgery Medical Concept Verification Center, Si Yu MedTech, Jin Yu Mao Wu, and Zi Niu Fund [5]. Agenda Highlights - The conference will include various presentations, such as: - "Current Status and Opportunities in the Medical Aesthetic Industry from an Investment Perspective" by Sun Hai Shun, Investment Vice General Manager, Jin Yu Mao Wu [6]. - "Development Trends in the Light Medical Aesthetic Industry from an Investment Perspective" by Yu Bo, Partner, Zi Niu Fund [6]. - "Application of Stem Cells and Exosomes in Postoperative Wound Repair" by Zhao Yong, Chairman, Bei Zheng Sai Ou (Beijing) Biotechnology Co., Ltd. [6]. - A roundtable forum is scheduled for discussion among experts [6]. Additional Sessions - Afternoon sessions will cover topics such as: - Non-invasive treatments supported by technology and the application of functional nucleic acid nanotechnology in the light medical aesthetic industry [7]. - New generation needle-free drug delivery technology in the medical aesthetic field [7]. - Development practices of high-end domestic laser medical equipment [7]. Target Audience - The conference aims to attract representatives from medical device and aesthetic enterprises, clinical doctors, researchers, investment institutions, regulatory experts, and industry observers [10].

Group 1 - The National Development and Reform Commission reported that the approval amount for real estate whitelist projects has exceeded 7 trillion yuan, indicating a growing scale in the existing housing market [2] - The Ministry of Industry and Information Technology emphasized the need for innovation in specialized and innovative enterprises, particularly in the chemical sector, to enhance safety and promote digital transformation [3] - The Ministry of Industry and Information Technology announced a plan to deepen the integration of 5G and industrial internet, focusing on the construction of new information infrastructure [3] Group 2 - The People's Bank of China conducted a total of 11,370 billion yuan in reverse repurchase operations, achieving a net withdrawal of 4,263 billion yuan [3] - The Guangdong-Hong Kong-Macao Greater Bay Area is projected to reach an economic total of 14.79 trillion yuan by 2024, positioning it among the top global economic and innovation centers [4] - The latest brokerage reports indicate a strong focus on technology sectors, particularly electronics and power equipment, as key investment areas for October [5] Group 3 - The automotive market saw a retail volume of 2.239 million units in September, with new energy vehicles accounting for 1.307 million units, reflecting a penetration rate of 58.5% [8] - Shenzhen is revising regulations to support the development of intelligent connected vehicles, allowing for fully unmanned testing scenarios [8] - The Ministry of Industry and Information Technology reported that China's computing power ranks second globally, with key technology developments in 5G-A and 6G [7] Group 4 - The third quarter saw a 9.3% year-on-year increase in the issuance of dim sum bonds, totaling 221.06 billion yuan, indicating a recovery in the offshore bond market [14] - The Guangdong provincial government plans to issue up to 7.5 billion yuan in offshore RMB local government bonds [14] - Country Garden is restructuring nine domestic bonds, with eight bondholder meetings approving the restructuring plan [14]

Core Viewpoint - The research highlights the role of dietary cysteine in enhancing intestinal stem cell function and promoting tissue repair after gut damage, particularly in patients undergoing cancer treatments like chemotherapy and radiotherapy [4][10]. Group 1: Research Findings - The study published in Nature demonstrates that dietary cysteine stimulates CD8+ T cells to secrete IL-22, which is crucial for intestinal stem cell proliferation and tissue repair [4][10]. - Cysteine enhances the biosynthesis of coenzyme A (CoA) in intestinal epithelial cells, leading to the unexpected secretion of IL-22 by CD8αβ+ T cells, thereby improving gut repair capabilities [7][10]. - The research team confirmed that CoA supplementation can replicate the effects of cysteine, while the absence of specific cysteine transport proteins blocks these effects [8]. Group 2: Clinical Implications - The findings suggest that a diet rich in cysteine could serve as a potential adjunct therapy for cancer patients experiencing gut damage due to treatments, significantly improving recovery rates from intestinal injuries [10][11]. - The study opens avenues for developing nutritional strategies and possible supplement formulations aimed at enhancing gut health and repair during cancer treatments and inflammatory bowel diseases [10][11]. Group 3: Broader Impact - Initial research indicates that cysteine may also promote regeneration in other stem cell populations and organs, suggesting a wider impact on various tissue types [11]. - The study emphasizes the need for human clinical trials to validate the translational potential of these findings, which could revolutionize approaches in oncology, gastroenterology, and regenerative medicine [11].

医院以整形美容、修复重建、皮肤学科为核心，将打造覆盖全生命周期的医美健康生态。涵盖眼耳 鼻颌面整形、显微外科修复、肿瘤术后重建、先天畸形矫正、创伤疤痕整复等"刚需型"治疗；发展躯体 轮廓整形、抗衰美容、中医美容、私密整形等"品质型"服务，同步探索运动美学、营养美学、身心美学 等交叉领域；聚焦慢性创面修复、血管畸形治疗、器官再造等复杂课题，推动整形医学从"改善外 观"向"提升生命质量"跨越。 此外，医院还将建设超显微外科实验室、数字化医学整形实验室、3D打印实验室、整形医学组织 工程实验室等科研平台，建立专门的临床研究中心（GCP）病房，以细胞治疗技术、生物工程技术为关 键，发展整形美容相关的再生医学专业，特别应用于器官再造重建、美容再生等领域，打造"临床—科 研—产业"闭环。 近日，浙江省整形医院（未来医院）、浙江省皮肤病医院总部院区开工建设。作为全国首家公立省 级整形医院，该项目的顺利落地，标志着浙江省在规范化、高品质医疗整形服务领域迈出战略性一步。 浙江省整形医院、浙江省皮肤病医院总部院区是浙江省"千项万亿"工程2025年重大建设工程，由浙 江省人民医院负责建设，也是省人民医院萧山院区。该建设工程位于萧山 ...

Core Insights - The company shows signs of short-term recovery with revenue and profit growth, but faces long-term stagnation in core business growth and structural challenges [1] - The core business, particularly the hard dura mater patch segment, is under pressure from multiple factors including price system disruptions due to centralized procurement policies and competition from domestic products [1][6] - The company has not successfully developed a second growth curve, with ongoing reductions in R&D investment and low efficiency in technology transfer [1][8] Financial Performance - In the first half of 2025, the company reported revenue of 201 million yuan, a slight increase of 5.89% year-on-year, and a net profit of 20.4 million yuan, with a growth rate of only 1.27% [2] - Over the past five years, revenue has declined from 437 million yuan in 2020 to 377 million yuan in 2024, a cumulative decrease of 13.7% [2] - The first half of 2025 revenue represents only 53.3% of the total revenue for 2024, indicating potential challenges in achieving a full-year revenue of 400 million yuan [2] Core Business Challenges - The hard dura mater patch, which is the company's main product, generated 74.44 million yuan in the first half of 2025, accounting for 50.6% of the medical device segment's revenue [4] - Revenue growth for the biological dura mater patch was only 1.35%, and it experienced a decline of 14.7% in 2024 [4][6] - The average revenue growth rate for the biological dura mater patch from 2022 to 2024 was only 1.2%, significantly lower than the double-digit growth seen from 2019 to 2021 [4] Competitive Pressures - Centralized procurement policies have led to a price drop of approximately 30% for the hard dura mater patch, which has not been offset by volume increases [6] - Domestic competitors are rapidly advancing in technology, further intensifying market competition [6][10] - The company has not introduced significant upgrades to its hard dura mater patch products in over a decade, leading to stagnation in growth [7] R&D and Innovation - R&D spending has decreased from 57.9 million yuan in 2022 to 42.31 million yuan in 2024, with the proportion of R&D expenses to revenue falling from 15.4% to 9.6% [8] - The company has maintained a stable number of R&D personnel but has not achieved any capitalized R&D projects, indicating a lack of progress in converting R&D into revenue [8] - The company is exploring advanced fields like artificial liver and CAR-T but lacks synergy with its core dura mater patch business [8] Dependency on Core Product - The company is overly reliant on the hard dura mater patch, with other products in the medical device segment unable to significantly contribute to revenue [9] - Other medical device products, such as the chest repair membrane, have shown declining revenues, and the pharmaceutical and cell technology segments have also underperformed [9][10] - The hard dura mater patch holds a market share of 30%, but faces significant pricing pressure from centralized procurement [10]

Core Insights - The company shows signs of short-term recovery with revenue and profit growth, but long-term growth challenges and structural issues are becoming apparent [2][3] - The core business, particularly the dura mater patch segment, faces multiple pressures including pricing impacts from centralized procurement policies and competition from domestic products [2][9] - The company is struggling with a lack of innovation and slow product iteration, which hampers the emergence of a second growth curve [2][11] Financial Performance - In the first half of 2025, the company reported revenue of 201 million yuan, a slight increase of 5.89% year-on-year, and a net profit of 20.4 million yuan, with a growth rate of only 1.27% [3][4] - Over a five-year period, revenue has declined from 437 million yuan in 2020 to 377 million yuan in 2024, with a cumulative decrease of 13.7% [4] - The first half of 2025 revenue is only 53.3% of the total revenue for 2024, indicating potential challenges in achieving annual revenue targets [4] Business Segment Challenges - The dura mater patch business, which is the main revenue driver, generated 74.44 million yuan in the first half of 2025, accounting for 50.6% of the medical device segment's revenue [5][7] - Despite high gross margins of around 90%, the revenue growth for dura mater patches has stagnated, with a cumulative decline of 15.1% from 2022 to 2024 [8][9] - The company’s reliance on a single product line exposes it to risks, as other product lines have not been able to significantly contribute to revenue [12][13] Competitive Landscape - The dura mater patch market is highly competitive, with international giants holding 60% market share, and domestic competitors are rapidly advancing in technology [13] - The company’s market share for dura mater patches is approximately 30%, but it faces pressure from centralized procurement and declining prices [13] - The lack of significant product upgrades over the past decade has resulted in a stagnation of growth, with competitors making advancements in areas such as biodegradable materials [10][11] Research and Development Issues - The company has reduced R&D spending from 57.9 million yuan in 2022 to 42.31 million yuan in 2024, with R&D expenses as a percentage of revenue dropping from 15.4% to 9.6% [11] - The R&D team remains stable at 60-70 personnel, but the lack of capitalized projects indicates a slow transition from research to revenue-generating products [11] - The company’s focus on advanced fields like artificial liver and CAR-T lacks synergy with its core dura mater patch business, leading to a disconnect in innovation [11]

《自然·通讯》30日发表的一项研究称，美国俄勒冈健康与科学大学研究团队利用人类皮肤细胞育成了 可受精的功能性卵子，为治疗不孕症提供了新的潜在路径。该成果标志着再生医学与发育生物学领域取 得重要进展，但进入临床应用尚需深入研究和严格评估。 该研究作为一项概念验证性工作，表明通过细胞重编程技术可能克服人类某些类型不育问题，但在应用 前仍需进一步研究以确保其安全性和有效性。 （文章来源：科技日报） 全球有数百万不孕症患者，其中部分病例是由于无法产生正常的卵子或精子所致。在传统体外受精 （IVF）技术无效的情况下，科学家一直在探索替代方案。一种可能的方法是体细胞核移植，即将患者 自身的体细胞（如皮肤细胞）的细胞核植入去核的供体卵母细胞中，以诱导其发育为功能性卵子。然 而，这一方法面临一个关键障碍——体细胞含有完整的46条染色体（二倍体），而正常卵子只含23条染 色体（单倍体）。若直接使用这样的细胞进行受精，将导致胚胎染色体数目异常。 为解决这一难题，研究团队开发了一种名为"有丝减数分裂"的新技术。研究人员将人类皮肤细胞的细胞 核移植到去核的人类卵母细胞中，随后通过模拟自然减数分裂的机制，促使其中一套染色体被选择性地 ...

As filed with the Securities and Exchange Commission on September 29, 2025. Registration No. 333-285692 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, DC 20549 AMENDMENT NO. 5 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 REGENTIS BIOMATERIALS LTD. (Exact name of registrant as specified in its charter) | State of Israel | 2834 | Not Applicable | | --- | --- | --- | | (State or other jurisdiction of | (Primary Standard Industrial | (I.R.S. Employer | | incorporation or org ...

Core Insights - A breakthrough in regenerative medicine has been achieved by a research team from the University of Zurich, demonstrating the ability to reverse brain damage caused by stroke through stem cell transplantation, promoting neuron regeneration and significantly restoring motor function [1][2] Group 1: Research Findings - One in four adults will experience a stroke in their lifetime, with about half suffering long-term consequences such as paralysis or speech disorders due to irreversible brain cell death caused by hemorrhage or hypoxia [1] - The research utilized human-induced pluripotent stem cell-derived neural stem cells, which can be reprogrammed from ordinary somatic cells and have the ability to differentiate into various neural system cells [1] - In animal models, the team induced permanent brain damage similar to that in humans and transplanted neural stem cells into the damaged area one week post-stroke, tracking changes for five weeks [1][2] Group 2: Regeneration Effects - The transplanted stem cells survived in the damaged brain area, with most differentiating into mature neurons that established functional connections with the host's existing neural network, indicating successful integration into brain operations [1] - The team observed widespread regeneration effects, including the formation of new blood vessels, significant reduction in brain inflammation, and restoration of blood-brain barrier integrity, revealing how transplanted cells activate the brain's "regeneration program" [2] Group 3: Future Applications - Collaboration with Kyoto University ensures that all stem cells are prepared without using animal-derived reagents, laying the groundwork for safe human applications [2] - A critical finding is that transplantation is more effective when performed one week after the stroke, providing a valuable preparation window for clinical treatment [2] - The team is developing a "safety switch" system to minimize potential risks and optimize the technology for human application, allowing for the termination of stem cell proliferation if necessary [2]

Core Insights - A breakthrough in regenerative medicine has been achieved by a research team from the University of Zurich, demonstrating the ability to reverse brain damage caused by stroke through stem cell transplantation, promoting neuron regeneration and significantly restoring motor function [1][2] Group 1: Research Findings - The study published in Nature Communications indicates that one in four adults will experience a stroke in their lifetime, with about half suffering from long-term sequelae such as paralysis or speech disorders due to irreversible brain cell death [1] - The research utilized human-induced pluripotent stem cell-derived neural stem cells, which can be reprogrammed from ordinary somatic cells and have the ability to differentiate into various neural system cells [1] - In the experiment, a permanent brain injury similar to that in humans was induced in genetically modified mice, which do not reject transplanted human cells [1] Group 2: Results of Stem Cell Transplantation - The transplanted stem cells successfully survived in the damaged brain area, with most differentiating into mature neurons that established functional connections with the host's existing neural network, indicating integration into the brain's operational system [2] - A broad regeneration effect was observed, including the formation of new blood vessels in the damaged area, a significant reduction in brain inflammation, and restoration of the blood-brain barrier integrity [2] - The collaboration with Kyoto University ensured that all stem cells were prepared without using animal-derived reagents, laying the groundwork for future safe applications in humans [2] Group 3: Clinical Implications - The research highlights a critical one-week window for transplantation post-stroke, suggesting that delayed intervention may yield better outcomes, providing a valuable preparation period for clinical treatment [2][3] - The study opens new clinical prospects by achieving biological repair of structural brain damage rather than merely alleviating symptoms, potentially offering a treatment paradigm for other neurodegenerative diseases such as Parkinson's or spinal cord injuries [3] - Future human trials could significantly alter the landscape of neuro-rehabilitation medicine if the efficacy of this approach is validated [3]