Core Viewpoint - The introduction of the domestic nine-valent HPV vaccine "Xinkening®9" at a price of 499 yuan per dose intensifies competition in the HPV vaccine market, prompting a potential price war among manufacturers [1][8]. Market Expansion - The global coverage rate for the first dose of the HPV vaccine among girls is projected to reach 27% by 2024, while the coverage rate for women aged 9 to 45 in China is only 10.15%, showing significant room for growth compared to the global average and the 67% coverage in Western countries [5][6]. Market Challenges - Expanding market space is a major challenge for all companies involved in HPV vaccine development. Companies are actively seeking to open up the market, with the approval of new indications for the "Jiadaxiu9" vaccine, which is now the first and only nine-valent HPV vaccine approved for both males and females in China [7][8]. Competitive Landscape - Domestic HPV vaccine manufacturers are shifting focus to price competition after missing the first-mover advantage. However, raising public awareness and vaccination rates is seen as a more effective strategy than price cuts [9][10]. Vaccine Efficacy Evidence - Real-world studies have shown significant reductions in HPV infection rates and cervical cancer cases due to vaccination, with a Scottish study indicating a 90% decrease in HPV infections since the vaccine's introduction in 2008 [11][12]. Conclusion - The competition in the HPV vaccine market is expected to evolve, with data on vaccine efficacy becoming a crucial factor in establishing trust and market presence for new entrants [12].

Core Insights - The first domestically produced nine-valent HPV vaccine "Xinkening 9" by Wantai Biological has been priced at 499 yuan per dose, approximately 40% of the price of imported counterparts [1] - The vaccine was developed in collaboration with Xiamen University and has undergone 18 years of research, with an investment of around 1 billion yuan by 2025 [1] - The approval of "Xinkening 9" marks a significant milestone in the domestic HPV vaccine market, previously dominated by Merck's "Gardasil 9" [1][2] Pricing and Market Impact - The full vaccination cost for the imported vaccine is nearly 4000 yuan, while the domestic vaccine reduces this to about 1500 yuan, and for ages 9-17, the cost is only 998 yuan for two doses [1] - The approval of "Xinkening 9" is expected to enhance HPV vaccination rates in China, which currently stands at 27.43% for the first dose among women aged 9-45, compared to 67% in Western countries [3] Marketing and Distribution Strategy - The company plans to implement a new marketing strategy that combines regional grid management, digital management, and personalized services to cater to different demographics and healthcare resources [3] - Wantai Biological is actively pursuing WHO PQ certification for the nine-valent HPV vaccine and aims to expedite its international market entry based on its previous successes with its bivalent HPV vaccine [3] Financial Performance - Wantai Biological reported a revenue of 2.245 billion yuan for 2024, a decline of 59.25% year-on-year, with a net profit of 106 million yuan, down 91.49%, marking a five-year low [5] - In the first quarter of 2025, the company reported a net loss of 52.78 million yuan, a significant drop from a profit of 126 million yuan in the same period the previous year [5] Competitive Landscape - The nine-valent HPV vaccine market is becoming increasingly competitive, with several domestic companies like Watson Bio, Kangla Weishi, and Ruike Bio also preparing to launch their products [4]

Core Viewpoint - The launch of the domestic nine-valent HPV vaccine "Xinkening 9" by Wantai Biological Pharmacy at a price of 499 yuan per dose, significantly lower than the imported vaccine priced at approximately 1318 yuan, ignites a price war in the HPV vaccine market [1][3][5] Pricing Strategy - Wantai's pricing strategy directly addresses market pain points, offering a two-dose regimen for females aged 9-17 at a total cost of 998 yuan and a three-dose regimen for those aged 18-45 at 1497 yuan, representing a price reduction of about 60% compared to imported options [3][4] - The imported nine-valent HPV vaccine from Merck costs around 1318 yuan per dose, with total costs for two doses for ages 9-14 reaching approximately 2636 yuan and three doses for ages 15-45 amounting to 3954 yuan [3][5] Market Potential - A study from the Chinese Center for Disease Control and Prevention indicates that the HPV vaccine first-dose coverage rate among women aged 9-45 in China is only 27.43%, compared to about 67% in Western countries, suggesting significant room for growth in vaccine penetration [3][4] - Wantai emphasizes that its vaccine is the only one approved for a "two-dose regimen" for ages 9-17, which could enhance vaccination compliance among younger populations [3][4] Competitive Landscape - The HPV vaccine market has shifted from scarcity and high prices to increased supply and competitive pricing, with Wantai's low-cost strategy posing a challenge to both imported products and other domestic competitors like Kanglaisheng, Ruike Biological, and Shanghai Bowei, which are also in the process of launching their nine-valent vaccines [5][6] - Merck's HPV vaccine sales have also seen a decline, with the company announcing a suspension of supply to China starting February 2025 [5][6] Future Growth Opportunities - Domestic vaccine companies, including Wantai, are exploring international markets, particularly in countries with lower HPV vaccination rates, to leverage their cost advantages [6] - The ongoing research into male-targeted HPV vaccines presents another potential growth avenue for the industry [6] - The price competition in the HPV vaccine market is expected to advance cervical cancer prevention efforts, making vaccines more accessible as multiple products enter the market [6]

Core Viewpoint - WanTai Biologics has officially launched its nine-valent HPV vaccine "Xinkening®9" at a price of 499 yuan per dose, significantly undercutting the imported vaccine price and marking the end of the "high-price era" for HPV vaccines in China [1][6]. Pricing and Market Impact - The imported nine-valent HPV vaccine "Gardasil 9" is priced at approximately 1318 yuan per dose, with a total cost of nearly 4000 yuan for three doses, while "Xinkening®9" costs about 1497 yuan for three doses [1]. - "Xinkening®9" is the only HPV vaccine approved for a two-dose regimen for ages 9-17, reducing the cost for this age group to 998 yuan, thereby enhancing accessibility and compliance [1]. Historical Context and Market Dynamics - Prior to the launch of "Xinkening®9", the nine-valent HPV vaccine market in China was monopolized by Merck's "Gardasil 9," which faced a dramatic shift from high demand and scarcity to excess inventory [2]. - In 2023, the batch issuance of "Gardasil 9" reached 36.55 million doses, a year-on-year increase of 136.16%, making Merck the highest-grossing multinational pharmaceutical company in China that year [2]. Sales Performance and Challenges - Merck's global sales of the HPV vaccine in 2024 were $8.583 billion, a 3% decline year-on-year, primarily due to weak performance in the Chinese market [3]. - To address high inventory levels, Merck announced a suspension of supply to China starting in early 2025, expected to last until at least mid-2025 [3]. Financial Performance of WanTai Biologics - WanTai Biologics reported a 59.25% year-on-year decline in revenue for 2024, totaling 2.245 billion yuan, with a net profit drop of 91.49% to 106 million yuan [3]. - The company faced significant challenges due to a price collapse in its two-valent vaccine, leading to a drastic reduction in government procurement prices [3]. Market Potential and Future Outlook - The potential market for HPV vaccines in China is substantial, with 70%-80% of the 300 million women aged 9-45 yet to be vaccinated [4]. - National Investment Securities predicts that WanTai's nine-valent HPV vaccine could reach a sales peak of 22.8 billion yuan, with projected revenues of 3.17 billion yuan, 11.4 billion yuan, and 28.63 billion yuan for 2025-2027 [4]. Competitive Landscape - Several domestic pharmaceutical companies are in the late clinical stages of developing their own nine-valent HPV vaccines, creating a competitive environment for WanTai [5]. - WanTai has initiated a Phase III clinical trial for a male indication, but competitors like Kanglaite have already started their trials earlier [5]. International Expansion - WanTai aims to become a leading global vaccine supplier by 2030, with plans to have 3 to 5 WHO pre-qualified products [5]. - Competitors are also pursuing international markets, with Kanglaite planning to submit for approval in Indonesia and Ruike Biologics exploring the Middle East [5]. Industry Trends - The World Health Organization has warned that global HPV vaccine supply may exceed demand from 2025 to 2030, potentially leading to a price war and industry reshuffling [5]. - The WHO's recommendation for a single-dose HPV vaccination regimen could further intensify market competition [5].

Core Viewpoint - The launch of the domestic nine-valent HPV vaccine "Xinkening 9" by Wantai Biological Pharmacy is a significant advancement in the market, offering a cost-effective alternative to imported vaccines, priced at approximately 40% of the import cost [1][6]. Group 1: Vaccine Efficacy and Safety - "Xinkening 9" has demonstrated comparable immune response and safety to imported nine-valent HPV vaccines, as evidenced by head-to-head clinical trial results published in The Lancet Infectious Diseases [2]. - The vaccine effectively prevents persistent infections from seven high-risk HPV types associated with cervical cancer, establishing a protective barrier for women aged 18-45 [2]. Group 2: Market Impact and Accessibility - As the only approved HPV vaccine for ages 9-17 with a two-dose regimen, "Xinkening 9" is expected to significantly improve vaccination compliance and rates among young girls in China [3]. - The pricing strategy of "Xinkening 9" is anticipated to enhance the willingness of eligible women to receive the vaccine, contributing to the establishment of a national immunity barrier against cervical cancer [6]. Group 3: Research and Development Achievements - The development of "Xinkening 9" reflects over 18 years of collaborative research between Xiamen University and Wantai Biological, showcasing China's advancements in HPV vaccine technology [4]. - Wantai Biological has invested approximately 1 billion yuan in the research and development of the nine-valent HPV vaccine, highlighting the commitment to innovation in this field [5]. Group 4: Public Health Implications - The introduction of a more affordable HPV vaccine aligns with global and national strategies to accelerate the elimination of cervical cancer, with a significant portion of the target population in China yet to receive vaccination [2][6].

《每日经济新闻》记者注意到，每支499元的定价大幅拉低了九价HPV疫苗价格。 与此同时，国产HPV疫苗企业中，还有沃森生物（SZ300142）、康乐卫士（BJ 833575）、瑞科生物 （HK02179）等公司的产品正排队上市。这意味着，九价疫苗的价格竞争或许刚刚开始。 每经记者｜陈星 每经编辑｜文多 7月8日，首个国产九价HPV疫苗公布定价。 据万泰生物（SH603392）消息，该公司旗下的"馨可宁9"定价499元/支，定价约为进口九价HPV疫苗的 40%。 此前，默沙东旗下九价HPV疫苗先后通过扩龄、降低接种剂次、获批男性接种等方式尽可能地占领先发 优势。而万泰生物九价疫苗除了祭出价格优势外，在"出海"、男性接种等方面也试图发力。 万泰生物在8日发布的投资者关系活动记录中写道，公司正在全力推进九价HPV疫苗WHO PQ（世界卫 生组织预认证）认证进程，依托公司二价HPV疫苗已取得的国际化成果（已在海外获得20多个国家的市 场准入，并被纳入8个国家的免疫规划项目）和公司构建的全球化网络，万泰生物有信心将以更快的速 度推动九价HPV疫苗的海外准入及拓展。 二剂次接种费用约998元 7月8日，万泰生物公开旗下" ...

商报讯(记者王然通讯员严敏)作为2025年浙江省重点民生项目，6月5日，拱墅区东新街道社区卫生服务 中心迎来适龄女生免费接种二价HPV疫苗杭州市首针接种。在医护人员的专业操作下，13周岁的小美 (化名)顺利完成注射。 HPV疫苗是专门预防人乳头瘤病毒(HPV)感染的疫苗。HPV是一类常见病毒，通过性接触、皮肤接触等 传播，目前已发现200多种亚型，其中部分高危型(如16、18型)持续感染会导致宫颈癌、肛门癌、阴道 癌等疾病。尤其是约有90%的宫颈癌是HPV感染引起，严重影响妇女健康及生命安全。 杭州市疾控中心免疫所专家介绍，我国年轻的性活跃女性HPV感染率最高，感染高峰年龄在20岁左右。 随着年龄增长子宫颈HPV感染率明显下降。第二个感染高峰年龄段在40-45岁左右。世界卫生组织 (WHO)推荐9-14岁女生作为HPV疫苗接种的主要目标人群，小年龄女生接种HPV疫苗可诱导更高的免疫 应答水平，在首次性行为前接种有更好的预防效果。 年龄重点：为13-14周岁女生； 接种限制：无HPV疫苗接种禁忌，且既往未接种过HPV疫苗。 接种注意事项 疫苗选择：民生项目提供国产二价HPV疫苗； 接种程序：9-14岁女生可接种 ...

"HPV是一种常见病毒，通过性接触、皮肤接触等传播，目前已发现200多种亚型。患者如持续感染 其中16、18型等高危型病毒，可能导致宫颈癌、肛门癌、阴道癌等疾病。尤其是宫颈癌，九成是由HPV 感染引起，是全球范围内最常见的妇科恶性肿瘤之一。"市疾控中心免疫所所长刘艳提到，HPV疫苗是 一种专门预防人乳头瘤病毒感染的疫苗，接种的目的是刺激人体产生抗体，提前"识别"并抵御特定的 HPV病毒亚型，从而降低感染和患上相关疾病的风险。 据悉，"为适龄女生免费接种二价HPV疫苗"已连续2年被列入市政府民生实事项目，自2024年启动 以来，已为全市一万余名13岁—14岁适龄女生筑起健康防线。记者从拱墅区卫生健康局了解到，目前辖 区已有600余名适龄女生完成了首针接种；接下来，区各街道社区卫生服务中心将采取常规门诊加节假 日专场模式为适龄女生接种HPV疫苗，确保愿接尽接。 登记核对个人信息、说明注意事项、接受疫苗注射……日前，今年杭州市首针二价HPV（人乳头瘤 病毒）疫苗在拱墅区东新街道社区卫生服务中心正式开打。在医护人员的专业操作下，首位女生顺利完 成疫苗接种。 在我国，女性HPV感染的高峰年龄段分别为20岁左右以及40岁 ...

出品 | 妙投APP 作者 | 张贝贝 头图 | 视觉中国 6月4日盘后，万泰生物公告称，其申报的9价HPV疫苗在国内获批了，引起市场较大关注。 主要系，万泰生物的9价HPV疫苗是国产首款，打破了国外产品长达十余年的市场垄断。同时，万泰新产品获批上市情况 下，能带来业绩增量，有望扭转公司这几年营收、利润不断下滑的局面。 此情况下，资本市场上的估值有望重估，这或许是6月5日公司股价涨停的重要原因。 那么，万泰生物真的能借9价HPV疫苗获批，挽救业绩颓势吗？这决定了，公司在资本市场的向上行情能否持续，接下来 详细看下。 短期看，2025年业绩将得到提振 万泰生物这几年的业绩可谓惨不忍睹，营收、利润连续下滑。 财报显示，2022-2024年实现营收分别为111.85亿元、55.11亿元和22.45亿元，归母净利润分别为47.36亿元、12.48亿元和 1.06亿元。 2025年第一季度依旧延续颓势，公司实现营收4.01亿元，同比下降46.76%；归母净利润为-0.53亿元，同比降幅高达 141.98%。 曾经的国内疫苗"明星企业"，无疑陷入了业绩寒冬。 犹记得，万泰生物的二价HPV疫苗"馨可宁"在2019年12月3 ...

6月5日上午，一位上海万泰九价HPV疫苗代理商在见过厂商后，告诉长江商报记者："现在价格还没公 布，他们也没拿到产品说明书。" 此前，万泰生物的王牌产品是二价HPV疫苗，依靠二价HPV疫苗，万泰生物曾实现年度百亿元营收、47 亿元净利。不过，随着竞品相继出现，万泰生物疫苗销量及收入出现滑坡，业绩也断崖式下滑。 随着首个国产九价HPV疫苗获批上市，万泰生物的经营业绩有望修复。目前，其九价HPV疫苗累计已完 成研发投入约10亿元。 首个国产九价HPV疫苗获批上市 6月4日盘后，万泰生物发布公告，公司全资子公司厦门万泰沧海生物技术有限公司申报的九价人乳头瘤 病毒疫苗（大肠埃希菌）（商品名称：馨可宁9）近日获批上市。同时该子公司通过九价HPV疫苗上市 前的首次药品GMP符合性检查。 万泰生物表示，公司本次获批上市的九价HPV疫苗适用于9—45岁女性，其中9—17岁可采用二剂次接种 程序（0、6月），18—45岁采用三剂次接种程序（0、1和6月）。该疫苗覆盖HPV16/18/31/33/45/52/58 七种高危型和HPV6/11两种低危型，可预防上述型别人乳头瘤病毒感染引起的相关疾病。 长江商报消息 全国首个！全球第 ...