Core Viewpoint - Jiuzhou Pharmaceutical's stock has experienced fluctuations, with a year-to-date increase of 46.97% but a recent decline of 2.02% on October 17, 2023 [1] Financial Performance - For the period from January to September 2025, Jiuzhou Pharmaceutical achieved a revenue of 4.16 billion yuan, representing a year-on-year growth of 4.92%, and a net profit attributable to shareholders of 748 million yuan, which is an 18.51% increase compared to the previous year [2] - Cumulative cash dividends since the company's A-share listing amount to 2.183 billion yuan, with 1.245 billion yuan distributed over the last three years [3] Shareholder Information - As of September 30, 2025, the number of Jiuzhou Pharmaceutical's shareholders increased by 10.22% to 59,200, while the average circulating shares per person decreased by 9.27% to 15,035 shares [2] - The top ten circulating shareholders include Hong Kong Central Clearing Limited, which holds 20.368 million shares, an increase of 7.8125 million shares from the previous period [3]

Core Viewpoint - The company, Wanbang Medical (301520.SZ), clarified that it is a CRO (Contract Research Organization) and does not engage in the independent research and development of anti-cancer drugs, although it provides clinical trial research services for cancer medications [1]. Group 1 - The company specializes in providing professional pharmaceutical research outsourcing services to pharmaceutical companies and research institutions [1]. - Wanbang Medical has undertaken projects that include providing clinical trial research technical services for medications used by cancer patients [1].

Core Viewpoint - 康龙化成's stock increased by 4.33% on October 15, with a trading volume of 9.50 billion and a market capitalization of 557.46 billion [1] Company Overview - 康龙化成 (Beijing) New Drug Technology Co., Ltd. specializes in integrated drug research, development, and production services, covering the entire process from drug discovery to drug development [2][7] - The company's main revenue sources include laboratory services (60.43%), CMC (small molecule CDMO) services (21.58%), clinical research services (14.58%), and other services [7] Financial Performance - For the first half of 2025, 康龙化成 achieved a revenue of 64.41 billion, representing a year-on-year growth of 14.93%, while the net profit attributable to shareholders decreased by 37.00% to 7.01 billion [8] - The company has distributed a total of 17.94 billion in dividends since its A-share listing, with 10.07 billion distributed in the last three years [9] Market Position and Trends - 康龙化成 is a leader in the CRO (Contract Research Organization) sector, providing comprehensive CRMO solutions for drug discovery and development, focusing on small molecule drug research [2] - The company benefits from the depreciation of the RMB, with overseas revenue accounting for 84.95% of total revenue [3] Digital Transformation and Innovation - 康龙化成 has made significant progress in digital and intelligent construction within its clinical services, establishing a "Digital Innovation Technology Department" to enhance efficiency through AI and automation [3] - The integration of AI technology is expected to improve clinical service efficiency and reduce labor costs, although there may be risks related to management and technology integration [2][3]

Core Viewpoint - The stock of Yaoshi Technology has experienced fluctuations, with a recent decline of 2.01% and a year-to-date increase of 18.33%, indicating volatility in its market performance [1]. Financial Performance - As of September 30, Yaoshi Technology reported a revenue of 920 million yuan for the first half of 2025, reflecting a year-on-year growth of 23.48%. However, the net profit attributable to shareholders decreased by 26.54% to 72.5 million yuan [2]. - Cumulatively, since its A-share listing, Yaoshi Technology has distributed a total of 231 million yuan in dividends, with 137 million yuan distributed over the past three years [3]. Shareholder Information - The number of shareholders for Yaoshi Technology as of September 30 is 46,500, a decrease of 2.94% from the previous period. The average number of circulating shares per person increased by 3.03% to 4,363 shares [2]. - Among the top ten circulating shareholders, Hong Kong Central Clearing Limited holds 2.1466 million shares, a decrease of 1.2259 million shares from the previous period, while Southern CSI 1000 ETF increased its holdings by 278,200 shares to 1.4751 million shares [3]. Business Overview - Yaoshi Technology, established on December 26, 2006, and listed on November 10, 2017, is primarily engaged in the research, development, production, and sales of drug molecular building blocks. Its revenue composition includes 83.14% from drug development and commercialization services, 16.72% from drug research services, and 0.14% from other sources [1]. - The company operates within the pharmaceutical and biotechnology sector, specifically in medical services and medical research outsourcing, and is involved in synthetic biology, biopharmaceuticals, innovative drugs, and cancer drugs [1].

Core Viewpoint - WuXi AppTec's stock price has experienced significant fluctuations, with a year-to-date increase of 83.13% but a recent decline of 7.17% over the past five trading days [1] Company Overview - WuXi AppTec, established on December 1, 2000, and listed on May 8, 2018, operates in the pharmaceutical industry, providing comprehensive services in drug discovery, development, and manufacturing [1] - The company's revenue composition includes: 78.37% from chemical business, 12.93% from testing services, 6.02% from biological services, 1.90% from other supplementary services, and 0.79% from miscellaneous [1] Financial Performance - For the first half of 2025, WuXi AppTec reported revenue of 20.799 billion yuan, a year-on-year increase of 20.64%, and a net profit attributable to shareholders of 8.561 billion yuan, reflecting a substantial growth of 101.92% [2] - The company has distributed a total of 14.06 billion yuan in dividends since its A-share listing, with 10.406 billion yuan distributed over the past three years [3] Shareholder Information - As of June 30, 2025, WuXi AppTec had 235,500 shareholders, with the Hong Kong Central Clearing Limited being the second-largest shareholder, holding 302 million shares, an increase of 5.603 million shares from the previous period [2][3] - Other notable shareholders include Huaxia SSE 50 ETF and China Europe Medical Health Mixed A, with varying changes in their holdings [3]

Core Viewpoint - Zhaoyan New Drug's stock price has shown significant volatility, with a year-to-date increase of 100.36% but a recent decline in the last five trading days by 5.81% [1] Group 1: Stock Performance - As of October 14, Zhaoyan New Drug's stock price was 33.26 CNY per share, with a market capitalization of 24.928 billion CNY [1] - The stock has experienced a 27.38% increase over the past 60 days, while it has decreased by 4.01% over the last 20 days [1] - The company has appeared on the "Dragon and Tiger List" three times this year, with the most recent occurrence on September 15 [1] Group 2: Financial Performance - For the first half of 2025, Zhaoyan New Drug reported a revenue of 669 million CNY, a year-on-year decrease of 21.28%, while the net profit attributable to shareholders was 60.932 million CNY, reflecting a year-on-year increase of 135.90% [2] - Cumulative cash dividends since the company's A-share listing amount to 703 million CNY, with 356 million CNY distributed over the past three years [3] Group 3: Shareholder Structure - As of June 30, 2025, the number of shareholders increased to 61,200, a rise of 25.59% compared to the previous period [2] - The top circulating shareholder, Huabao Zhongzheng Medical ETF, holds 14.6531 million shares, an increase of 2.2669 million shares from the previous period [3] - Hong Kong Central Clearing Limited, ranked as the eighth largest circulating shareholder, reduced its holdings by 9.4387 million shares to 8.2811 million shares [3]

Group 1 - Guangqi Technology's subsidiary signed mass production contracts for metamaterials totaling 516 million yuan, with products to be delivered by June 30, 2026 [1][2] - Mingyang Smart Energy plans to invest 1.5 billion pounds (approximately 14.21 billion yuan) to build a comprehensive wind power manufacturing base in Scotland, with the first phase expected to be operational by the end of 2028 [3][4] - Wentech Technology's control over Anshi Semiconductor is temporarily restricted due to a ministerial order from the Dutch government, affecting operational efficiency but not economic benefits [4][5] Group 2 - Baotailong's mine has officially resumed production with an annual design capacity of 900,000 tons [6] - New Lai Materials reported no significant changes in its operating environment, maintaining normal production and operations [7][8] - Tailing Micro plans to issue H-shares and list on the Hong Kong Stock Exchange [9] Group 3 - Times New Material announced a cash dividend of 0.07 yuan per share, totaling 65.18 million yuan, with the ex-dividend date set for October 17, 2025 [10] - Times New Material signed blade sales contracts totaling approximately 4.49 billion yuan, with 4.048 billion yuan from onshore wind projects and 442 million yuan from offshore projects [11][12] - Sunshine Nuohuo's new drug BTP4507 has received approval for clinical trials, targeting patients with poorly controlled primary hypertension [13] Group 4 - BGI Genomics expects to receive over 120 million USD in licensing fees for its CoolMPS sequencing technology [14] - Shandong Environmental Energy won a project for kitchen waste treatment in Xingtai, with an 8-year service period [15] - Kelun Pharmaceutical's product sac-TMT received approval for a third indication for treating advanced non-small cell lung cancer [16] Group 5 - Zhongzhi Holdings' major shareholder plans to publicly transfer 24.73% of the company's shares, which may lead to a change in control [17] - Yunnan Copper reported uncertainty regarding the future prices of cathode copper and gold, while maintaining normal operations [18] - Xiyang Co. announced that its tin smelting processing fees remain low despite rising tin prices [19] Group 6 - TEBIO's product Peginterferon has received approval for an additional indication for chronic hepatitis B treatment [20] - Yirui Biotech's major shareholder plans to reduce their stake by up to 3% due to personal funding needs [21] - China Nuclear Power reported a 14.95% year-on-year increase in power generation for the first three quarters, totaling 184.364 billion kWh [22] Group 7 - Shanghai Hejing's shareholder plans to reduce their stake by up to 1% due to personal funding needs [23] - Baili Tianheng's subsidiary triggered a milestone payment of 250 million USD from a collaboration with Bristol-Myers Squibb [24] - Hengdian East Magnetic expects a net profit increase of 50.1% to 65.2% year-on-year for the first three quarters [25]

Investment Rating - The report maintains a "Market Weight" rating for the pharmaceutical and biotechnology industry [2][24]. Core Viewpoints - The SW pharmaceutical and biotechnology industry underperformed the Shanghai and Shenzhen 300 index, declining by 0.23% from September 26, 2025, to October 9, 2025, lagging behind the index by approximately 2.76 percentage points [9][24]. - Most sub-sectors within the industry recorded negative returns during the same period, with the medical research outsourcing and in vitro diagnostics sectors showing gains of 1.99% and 0.55%, respectively, while the raw materials and chemical preparations sectors fell by 2.23% and 1.73% [10][24]. - Approximately 54% of stocks in the industry achieved positive returns, with the top performer, Zhendemedical, increasing by 21.43%, while the largest decline was seen in Guangshentang, which fell by 21.86% [11][14]. - The overall price-to-earnings (PE) ratio for the SW pharmaceutical and biotechnology industry was approximately 55.04 times as of October 9, 2025, indicating a decrease in industry valuation [15][24]. Summary by Sections 1. Market Review - The SW pharmaceutical and biotechnology industry underperformed the Shanghai and Shenzhen 300 index, with a decline of 0.23% from September 26, 2025, to October 9, 2025 [9]. - Most sub-sectors recorded negative returns, with medical research outsourcing and in vitro diagnostics performing better than others [10]. - About 54% of stocks in the industry recorded positive returns, with significant variations in individual stock performance [11]. 2. Industry News - The 11th batch of national procurement will begin accepting applications on October 21, 2025, with 55 major varieties included [22]. - The National Medical Products Administration issued guidelines for the quality management of medical device online sales [20][21]. 3. Company Announcements - Zhejiang Haizheng Pharmaceutical announced that its product achieved Self-GRAS certification in the U.S., allowing it to enter the U.S. market [23]. 4. Weekly Industry Perspective - The report suggests focusing on investment opportunities in innovative drugs and sectors with expected business development catalysts, including medical devices and pharmaceutical commerce [24][26].

Core Viewpoint - Pharmaceutical stocks have declined again, with significant drops in various companies' stock prices, indicating a challenging market environment for the sector [1] Group 1: Stock Performance - Nocera Health (09969) fell by 11.37%, trading at HKD 14.73 [1] - Saint Noble Pharmaceuticals-B (02257) decreased by 11.05%, trading at HKD 13.36 [1] - Rongchang Biopharmaceutical (09995) dropped by 10.4%, trading at HKD 95.15 [1] - Gilead Sciences-B (01672) declined by 8.57%, trading at HKD 9.6 [1] - Viatris (01873) fell by 8.14%, trading at HKD 2.82 [1] Group 2: Investment Trends - According to CMB International, domestic investors have increased their holdings in pharmaceutical stocks through the Hong Kong Stock Connect since September, while foreign investment has slightly decreased since mid-year [1] - The overall trend of increasing investment in innovative drugs remains unchanged for both domestic and foreign investors [1] Group 3: Future Outlook - The ESMO conference is scheduled for mid to late October, with a recommendation to focus on companies like CanSino Biologics, Kelun-Biotech, Rongchang Biopharmaceutical, and Hengrui Medicine (600276) that are expected to release significant data [1] - The pharmaceutical sector in Hong Kong has shown relatively flat performance in September, but with the increase in industry catalysts (various academic conferences and favorable policies), the market is expected to rebound in October [1] Group 4: Market Analysis - Dongguan Securities reports that the pharmaceutical and biotechnology sector has consistently underperformed compared to the CSI 300 index, with some previously high-performing innovative drug companies experiencing corrections [1] - The medical research outsourcing sector has been strengthening due to improved expectations of U.S. interest rate cuts and better financing data, entering a performance vacuum period [1] - Future investment opportunities are suggested in innovative drugs and sectors with expected business development catalysts [1]

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" and the rating has been maintained [1] Core Insights - The pharmaceutical and biotechnology industry index experienced a decline of 2.72%, ranking 23rd among 31 primary industries, underperforming the CSI 300 index which declined by 2.62% [4][16] - The industry valuation as of September 30, 2025, is a PE (TTM overall method, excluding negative values) of 31.23x, down from 31.79x in the previous period, indicating a downward trend and below the average [21] - The top three sub-industries in terms of PE (TTM overall method, excluding negative values) are vaccines (55.74x), medical devices (41.29x), and hospitals (39.51x), with the median at 33.19x, while pharmaceutical circulation has the lowest valuation at 14.34x [21] Industry Review - The report highlights that during the reporting period, 51 listed companies in the pharmaceutical and biotechnology sector had a net reduction in shareholders amounting to 2.435 billion yuan, with 14 companies increasing their holdings by 681 million yuan and 37 companies reducing their holdings by 3.116 billion yuan [4] - The report emphasizes the importance of upcoming clinical data and the strong fundamentals of companies ahead of the ESMO 2025 conference, which is expected to showcase significant clinical research results from various domestic pharmaceutical companies [7][8] Important Industry News - AstraZeneca plans to list on the New York Stock Exchange [6] - The report mentions the approval of a new oral SERD drug by Eli Lilly, marking it as the second such drug approved globally [8][45] - The approval of the first domestic quadrivalent HPV vaccine in China is expected to expand the coverage population and potentially be priced lower than imported versions [8][50][52]