Summary of Conference Call on China's CDMO Industry and WuXi Companies Industry Overview - The Chinese Contract Development and Manufacturing Organization (CDMO) segment has seen increased investor interest since early 2025, driven by favorable fundamentals despite geopolitical tensions [1] - Concerns about overcapacity in the CDMO industry are being evaluated, with current capacity utilization reported at approximately 80%, indicating a healthy demand-supply balance [2] Key Insights on WuXi Companies WuXi Biologics - The company faces significant geopolitical risks, particularly from U.S. trade initiatives aimed at reshoring drug manufacturing and price cuts on prescription drugs [2] - Approximately 60% of WuXi Biologics' revenue is derived from U.S. customers, leading to stock trading within a forward P/E range of 20x to 45x based on these geopolitical developments [2] WuXi XDC - WuXi XDC is projected to have capital expenditures exceeding RMB 1.4 billion in 2025, with a cash balance of RMB 3.5 billion at the end of 2024 and a net profit of RMB 1.1 billion in 2024 [3] - The company indicated a preference for raising funds through debt rather than equity if necessary [3] WuXi AppTec - WuXi AppTec is significantly involved in the rapidly growing GLP-1 market, with contracts for peptides and oligonucleotides contributing 23% of its revenue in Q1 2025 [4] - The company expects its backlog and capacity to double in 2025, with segment revenue anticipated to increase by over 60% [4] - WuXi AppTec holds a market share of approximately 20% in CDMO contracts and has over 20 ongoing projects in the GLP-1 market [4] Additional Considerations - The complexity of drug modalities is leading to increased outsourcing from biopharma companies, with outsourcing rates ranging from 30% to 80% of R&D spending [2] - The demand for bioconjugates and peptides is outpacing supply, which is beneficial for WuXi XDC and WuXi AppTec [2] - The overall industry view remains attractive, with potential for growth driven by increasing orders and successful product launches [7] Risks and Opportunities - Risks include geopolitical tensions, potential funding deceleration in biotech, and competition in the global market [15][17] - Opportunities may arise from favorable government policies, margin expansion, and increased outsourcing of R&D globally [15][16] This summary encapsulates the key points discussed in the conference call regarding the Chinese CDMO industry and the performance and outlook of WuXi companies.

更多资料加入知识星球：水木调研纪要 关注公众号：水木Alpha June 4, 2025 09:55 AM GMT China Healthcare | Asia Pacific Chart of the Week – CDMO Valuation Trends Key Takeaways See our Asia Insight: China's CDMOs – What Are the Leading Indicators Telling Us? for a comprehensive analysis of the drivers and a survey of each region's competitive positioning (US, EU, China, Korea, Japan, India, Taiwan). WuXi Biologics, WuXi XDC, and WuXi AppTec A/H are up 44%, 37%, and 23%/28% year-to-date (vs. HSI +21%). Based on our recent investor convers ...

Summary of Conference Call Records Industry Overview - The consumer electronics upstream costs have increased, leading to higher downstream product prices and a valuation correction for related stocks, resulting in weakened revenue contributions [1][2] - The overall market performance showed good gains in large-cap and small-cap indices, while mid-cap indices like the CSI 500 performed slightly worse [3] Key Points and Arguments Market Performance - The convertible bond market did not outperform the indices last month due to a lack of significant risk appetite in technology and consumer sectors [2] - The banking sector showed notable gains, with some bank convertible bonds facing strong redemption triggers, potentially leading to a reduction in supply [3] Recommendations - Recommended stocks in the new consumer sector include Li Ziyuan, Huakang, Xianle, and Zhongchong, all of which have upward momentum [1][6] - In the technology and high-end manufacturing sectors, recommended stocks include Weicai, Anji, Guoli Co., and Huarui, with Weicai experiencing growth in third-party testing and Anji holding a significant market share in polishing liquids [1][7] Convertible Bond Market Outlook - The average price of convertible bonds in June was approximately 120 yuan, with a valuation percentile of 73.4% [5] - A reduction in fixed income + funds is expected, but a significant contraction is unlikely as asset-side pressures remain high [5] Specific Company Insights - **Huakang Co.**: A leader in functional sugar alcohols with stable gross margins and high market shares in xylitol and maltitol. The new Zhoushan base is expected to contribute significantly to revenue [10][11] - **Xianle Health**: A leading CDMO in nutritional health foods, showing double-digit growth in the new consumer sector and expanding partnerships with emerging brands [12] - **Guoli Co.**: Continuous recommendations due to its involvement in vacuum electronic devices, with expected revenue growth driven by the new energy vehicle sector and military orders [13][14] - **Huarui Precision**: Benefiting from improved demand in the hard alloy tool market, with significant growth in sales and expansion into humanoid robot components [15][20] Additional Important Content - The agricultural sector is showing marginal improvements, with potential investment opportunities arising from changes in pig prices and policy catalysts [4][8] - New Dairy's low-temperature products are maintaining double-digit growth, with strong channel control and innovation driving performance [16][21] - YunKang Group is expanding into overseas markets with significant orders locked in, indicating strong revenue growth potential [18] This summary encapsulates the key insights and recommendations from the conference call, highlighting the performance of various sectors and specific companies within the investment landscape.

Investment Rating - The investment rating for WuXi AppTec is "Buy" with a target price of HK$95.00, indicating an expected share price return of 43.2% and an expected total return of 46.0% [5]. Core Insights - WuXi AppTec's CFO maintained the 2025 revenue guidance of Rmb41.5-43.0 billion, reflecting a year-over-year growth of 10-15% for continuing business, with faster bottom line growth than topline [1]. - The company expects TIDES revenue to grow over 60% year-over-year in 2025, with involvement in key GLP-1 projects such as tirzepatide, orforglipron, and retatrutide [2]. - WuXi AppTec currently has the world's largest peptide capacity of 41,000L, aiming to expand to 100,000L by the end of 2025 [2]. - The Testing and Biology businesses are anticipated to recover in the second half of 2025, with management noting that over 50% of Testing revenue comes from Chinese clients [3]. - The CDMO business is viewed as a cornerstone, with over 90% retention of projects in the Chemistry business for Phase 2/3/CMO projects [4]. Summary by Sections Financial Performance - Revenue guidance for 2025 is set at Rmb41.5-43.0 billion, with a projected growth rate of 10-15% year-over-year for continuing business [1]. - The expected share price return is 43.2%, with a total expected return of 46.0% [5]. Business Segments - TIDES revenue is expected to grow over 60% year-over-year in 2025, with significant involvement in GLP-1 projects [2]. - The company is confident in adding approximately 10 commercial projects to its pipeline annually [4]. - The Testing and Biology segments are expected to show double-digit growth in volume, with a recovery anticipated in the second half of 2025 [3]. Capacity and Expansion - WuXi AppTec currently operates with a peptide capacity of 41,000L, the largest globally, and aims to increase this to 100,000L by the end of 2025 [2]. - The company retains over 90% of projects in the Chemistry business for Phase 2/3/CMO projects, indicating strong project management capabilities [4].

May 28, 2025 12:00 PM GMT China Healthcare M Asia Pacific Insight China's CDMOs – What Are the Leading Indicators Telling Us? China's leading CDMOs (Contract Development and Manufacturing Organizations) have come in and out of the spotlight in the past five years as Covid-19 waxed and waned, and as geopolitics evolved. We recommend taking a look at current valuation levels, with WuXi XDC (2268.HK) our Top Pick. Key Takeaways Morgan Stanley Asia Limited+ Laurence Tam Equity Analyst In this report, we examine ...

Core Insights - Lifecore Biomedical has appointed Mark DaFonseca as chief commercial officer, bringing nearly 30 years of pharmaceutical industry experience, particularly in contract development and manufacturing organizations (CDMOs) [1][2] - DaFonseca will focus on executing a three-pronged growth strategy aimed at enhancing Lifecore's brand, expanding customer partnerships, and growing the business portfolio through new collaborations [1][3] Company Background - Lifecore Biomedical is a fully integrated CDMO specializing in the development, fill, and finish of sterile injectable pharmaceutical products, including complex formulations [7] - The company has over 40 years of expertise in manufacturing premium, injectable-grade hyaluronic acid and serves global biopharmaceutical and biotechnology companies [7] Leadership Experience - Prior to joining Lifecore, DaFonseca held significant roles at CordenPharma, AmbioPharma, and CoreRx, where he led sales, marketing, and project management efforts [2] - His track record includes consistently exceeding key performance indicators in various sales leadership positions within the CDMO sector [2] Strategic Goals - DaFonseca expressed eagerness to leverage Lifecore's assets to strategically grow the business by expanding current customer relationships and increasing the overall customer base [4] - The company aims to enhance its market presence and address the industry's capacity needs through investments in state-of-the-art facilities and equipment [4] Compensation Details - As part of his appointment, Lifecore will grant DaFonseca a restricted stock unit (RSU) award for 20,000 shares and an option for 30,000 shares of common stock [4][5] - The RSU will vest on the third anniversary of the grant date, while the stock option will have a vesting schedule based on continued employment [6]

Group 1 - The Hong Kong Innovation Drug Index (987018) has seen a strong increase of 2.33% as of May 21, 2025, with notable gains in constituent stocks such as CanSino Biologics (06185) up 8.87%, Junshi Biosciences (01877) up 8.16%, and Kelun Pharmaceutical (06821) up 7.02% [1] - The Hong Kong Innovation Drug ETF (159567) has risen by 1.56%, marking its fourth consecutive increase, with the latest price reported at 1.3 HKD. Over the past week, the ETF has accumulated an increase of 8.63% [1] - The trading activity for the Hong Kong Innovation Drug ETF has been robust, with an intraday turnover of 10.03% and a transaction volume of 171 million HKD, indicating active market participation. The average daily trading volume over the past month reached 736 million HKD, with the ETF's latest scale reaching 1.667 billion HKD, a new high in nearly a year [1] Group 2 - The CDMO sector is expected to see rapid growth driven by the increasing demand for chemical macromolecules and XDC CDMO production, particularly in polypeptides and oligonucleotides, presenting investment opportunities in the related industry chain [1] - The CRO sector is anticipated to benefit from improving overseas financing conditions and a gradual shift towards a rate-cutting environment, with expectations of revenue recovery for integrated CRO/CDMO and domestic preclinical CROs, suggesting potential valuation recovery opportunities [2] - The CRO sector has been significantly impacted by domestic and international financing challenges, but with supportive domestic policies, there is an expectation for gradual recovery, highlighting investment opportunities in clinical CROs [2]

Group 1: Xiaomi's Response to SU7 Incident - Xiaomi's first car, SU7, was involved in a serious collision and fire incident, resulting in three fatalities, with the specific cause yet to be disclosed [4] - The incident has led Xiaomi to recognize the heightened public expectations regarding safety and responsibility, emphasizing the company's commitment to industry leadership [4] - Lei Jun's public remarks reflect Xiaomi's serious approach to automotive safety issues and a determination for self-improvement, indicating potential enhancements in future safety performance [4] - The short-term negative impact of the incident is significant, necessitating ongoing monitoring of Xiaomi's automotive safety improvements, market feedback, and sales performance to assess the long-term effects on the brand and business growth [4] Group 2: Automotive Parts Sector Trends - The automotive parts sector is entering a new valuation reconstruction cycle driven by multiple policies and technological themes, with a focus on companies that integrate "robotics + smart vehicles" [3] - Companies that can expand into a second growth curve and demonstrate actual delivery capabilities and order validation are particularly favored [3] - The new mandatory standards for light vehicle automatic emergency braking systems (AEBS) are expected to significantly increase the installation rate of AEBS [5] Group 3: Citigroup's Investment Strategy - In Q1, Citigroup significantly increased its holdings in Nvidia (+48%), Apple (+62%), and Microsoft (+76%), collectively accounting for nearly 8% of its investment portfolio, reflecting a strong bullish outlook on the tech sector driven by AI [6] - Citigroup is also heavily invested in SPDR Gold ETF call options and long-term U.S. Treasury ETF call options, indicating a strategy to hedge against macroeconomic risks such as inflation and interest rate changes [7] - Notably, Citigroup has increased its position in Nasdaq 100 put options by over 300%, with a market value of $12 billion, representing 6.12% of its total assets, highlighting a strategy to hedge against potential systemic risks, particularly in overvalued tech stocks [7] Group 4: Walmart's Pricing Strategy - Walmart's CFO announced plans to raise prices on various products starting in late May, particularly in toys, electronics, and grocery items, with June expected to be the peak for price increases [8] - This strategy may attract middle- and low-income consumers amid high inflation and weak consumption, potentially increasing Walmart's market share in grocery and essential goods, although it may pressure profit margins [8] - The consumer sentiment shows a shift, with some large items like cars experiencing a "pre-purchase wave," while other categories are seeing a wait-and-see attitude, indicating inflation expectations are significantly influencing consumer decision-making [8] Group 5: WuXi Biologics' Strategic Shift - WuXi Biologics announced the sale of its biopharmaceutical manufacturing facility in Leverkusen, Germany, for €150 million (approximately 1.21 billion RMB) to Japan's Terumo [5] - The company is reallocating resources to a large CRDMO center in Singapore, with a total investment of $1.4 billion and a planned capacity of 120,000 liters, which will become Singapore's first end-to-end biopharmaceutical service platform [5] - This restructuring reflects confidence in optimizing the Southeast Asian supply chain, policy stability, and nearshore service capabilities for global clients, while also reducing exposure to policy risks in the European and American markets [5] - The sale of the German facility allows WuXi to free up management and capital resources, transitioning to a new large integrated platform that enhances end-to-end service efficiency and client integration capabilities [5]

Investment Rating - The report does not explicitly provide an investment rating for the China drug industry but discusses potential impacts of US drug pricing changes on the sector [5]. Core Insights - The report highlights significant uncertainty regarding the Trump administration's plans for US drug pricing, which could affect the Chinese drug industry in various ways [5]. - Changes in US drug pricing could hinder the Chinese drug industry's international expansion due to a perceived smaller US market, but may also create opportunities for Chinese innovative drugs to be licensed out due to R&D cost advantages [5]. - The report notes that Chinese CRO/CDMO companies may face mixed impacts; reduced R&D expenses from US clients could negatively affect them, while increased outsourcing demand could arise as companies seek cost-saving measures [5]. Summary by Sections Impact of US Drug Pricing Changes - The report discusses the uncertainty surrounding the implementation of a "most favored nation" pricing model and its potential opposition in the US [5]. - It emphasizes that the actual impact on the Chinese drug industry remains unclear due to various factors, including whether Medicare or Medicaid pricing will be affected [5]. Opportunities and Challenges for Chinese Companies - If US drug prices decrease, it could limit the Chinese drug industry's ability to expand internationally [5]. - Conversely, innovative drugs from China may have better licensing opportunities due to their potential R&D cost and speed advantages [5]. - For Chinese CRO/CDMO companies, the report suggests that while some clients may cut R&D expenses, the overall demand for outsourcing could increase [5].

夯实底部、改善可期，持续看好创新+AI | | | 执业证书编号：S0740519040001 Email：zhujq@zts.com.cn | 基本状况 | | | --- | --- | | 上市公司数 | 498 | | 行业总市值(亿元) | 62,240.01 | | 行业流通市值(亿元) | 55,873.42 | 医药生物 证券研究报告/行业定期报告 2025 年 05 月 11 日 1、《底部拐点可期，创新行情有望 延续》2025-05-08 2、《ASCO 会议标题发布；基金持 仓占比分析》2025-04-28 3、《药械创新享支持，持续看好创 新成长》2025-04-20 | 增持（维持） 评级： | | | 重点公司基本状况 | | | | | | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | | 简称 | 股价 | | | EPS | | | | | PE | | | 评级 | | 分析师：祝嘉琦 | | | （元） ...