香港交易及結算所有限公司、香港聯合交易所有限公司（「聯交所」）及香港中央結算有限公司 （「香港結算」）對本公告的內容概不負責，對其準確性或完整性亦不發表聲明，並明確表示概不 會就因本公告全部或任何部分內容而產生或因依賴該等內容而引致的任何損失承擔任何責任。 本公告不得直接或間接於或向美國（包括其領土及屬地、美國任何州以及哥倫比亞特區）發佈、 刊發或派發。本公告並不構成或組成在美國境內或於任何其他司法權區購買或認購發售股份的 任何要約或招攬的一部分。發售股份並無亦不會根據《1933年美國證券法》（經不時修訂）（「美 國證券法」）或美國任何州或其他司法權區的證券法登記。發售股份不得在美國境內提呈發售、 出售、質押或以其他方式轉讓，除非已根據美國證券法及《1940年美國投資公司法》（經修訂） （「美國投資公司法」）的登記規定獲豁免，並已符合任何州的適用證券法。發售股份根據美國證 券法S規例在美國境外向非美籍人士投資者或並非為美籍人士或為其利益進行收購的投資者提 呈發售及出售。發售股份不會在美國公開發售。 本公告僅作說明用途，並不構成收購、購買或認購證券的邀請或要約。本公告並非招股章程。 潛在投資者於決定是否投資所提 ...

Group 1 - The core viewpoint of the report indicates that Shanghai, Shenzhen, and Beijing are leading the Chinese venture capital market in both vitality and innovation indices for 2024 [1][2] - The report highlights a significant gap between the top three cities and the subsequent ones, showcasing a "head-led, tiered differentiation" pattern in venture capital vitality [2] - In terms of fundraising, investment, and exit indices, Beijing ranks first in fundraising due to its concentration of top financial institutions and national funding platforms [2] Group 2 - In the innovation index, Beijing maintains a clear lead, supported by national laboratories, central enterprise R&D headquarters, and top universities [2] - The semiconductor integrated circuit sector ranks among the top three in most major cities, indicating a strong capital aggregation effect [3] - The healthcare sector, particularly biopharmaceuticals and medical devices, remains highly active across multiple cities, reflecting sustained interest in the medical health field [3]

Group 1 - The stock price of BGM increased by 5.37% to $9.81 per share, with a total market capitalization of $1.805 billion as of July 31 [1] - For the fiscal year ending March 31, 2025, BGM reported total revenue of $14.3114 million, representing a year-over-year growth of 13.92%, while the net profit attributable to shareholders was a loss of $0.8612 million, a decrease of 307.79% compared to the previous year [1] - BGM, formerly known as Qilian International Holdings Group, is headquartered in Chengdu, China, and focuses on innovative solutions in the biopharmaceutical, biorefining, and healthcare sectors [1] Group 2 - The company's product range includes raw materials for oxytetracycline, licorice preparations, and crude heparin sodium, which are essential for both human pharmaceuticals and the global livestock industry [1] - Oxytetracycline raw materials are used to produce human antibiotics and support the safety of poultry and seafood in the livestock sector [1] - Crude heparin sodium is processed into refined heparin sodium and injectable heparin sodium solutions, serving as a major anticoagulant, while licorice preparations, such as compound licorice tablets, are used as cough remedies supplied to retail pharmacies [1]

目前，九天开曼在中国上海、杭州和美国波士顿设有研发及生产基地，旗下拥有5家公司。 "公司希望从一个以产品和技术为中心的企业转变为一个能运用多平台、多工具、多手段解决疾病问题 的企业，未来将充分运用收购公司的技术平台和优势，结合公司的深厚积累，在免疫和代谢领域，探索 多技术平台协同解决疾病问题的综合方案，为患者提供更多治疗选择。"上述负责人称。 特宝生物相关负责人表示，公司此次收购主要基于未来技术布局的战略考量，而非短期利润诉求。此次 收购的核心资产包括其自主研发的AAV平台，以及针对脊髓性肌萎缩症(SMA)、视网膜眼底疾病等适应 症的在研产品管线。其中，AAV平台具备显著的技术开发与升级能力，未来有望拓展至退行性组织细 胞、心脏及肝脏等领域的靶向治疗，为多类疾病提供创新解决方案。 中证报中证网讯(记者罗京)7月30日晚，特宝生物公告称，公司全资子公司厦门伯赛基因转录技术有限 公司(简称"伯赛基因")收购Skyline Therapeutics Limited(简称"九天开曼")部分资产完成交割。 公告显示，7月29日交割日当天，伯赛基因已根据协议支付首笔合并对价。同时，九天开曼与伯赛基因 在开曼设立的合并子公 ...

周三，部分生物制药公司股价飙升，截至发稿，Replimune(REPL.US)飙升逾85%， Sarepta Therapeutics (SRPT.US)上涨超16%， Capricor Therapeutics(CAPR.US)大涨超18%。消息面上，美国FDA生物制品评 估与研究中心主任普拉萨德在上任不到三个月后离职，正值FDA对多款基因疗法和疫苗采取严格监管措 施，引发市场关注。分析人士指出，他的离任可能有助于缓解监管压力，被视为基因疗法和疫苗企业的 利好消息。 ...

Group 1 - CRISPR Therapeutics AG (CRSP) has an average brokerage recommendation (ABR) of 1.88, indicating a consensus between Strong Buy and Buy based on 27 brokerage firms' recommendations [2][5] - Out of the 27 recommendations, 15 are classified as Strong Buy, accounting for 55.6%, while one is classified as Buy, accounting for 3.7% [2] - Despite the positive ABR, reliance solely on brokerage recommendations may not be advisable, as studies suggest they often fail to guide investors effectively towards stocks with high price appreciation potential [5][10] Group 2 - Brokerage analysts tend to exhibit a strong positive bias in their ratings due to vested interests, often resulting in a disproportionate number of Strong Buy recommendations compared to Strong Sell [6][10] - The Zacks Rank, a proprietary stock rating tool, is presented in whole numbers and is based on earnings estimate revisions, which have shown a strong correlation with near-term stock price movements [8][11] - The Zacks Consensus Estimate for CRISPR Therapeutics has declined by 1.4% over the past month to -$5.61, indicating growing pessimism among analysts regarding the company's earnings prospects [14][15] Group 3 - The recent change in the consensus estimate, along with other earnings-related factors, has led to a Zacks Rank of 4 (Sell) for CRISPR Therapeutics, suggesting caution despite the favorable ABR [15] - The ABR may not always reflect the most current information, while the Zacks Rank is updated more frequently to reflect changes in earnings estimates [13]

Core Viewpoint - The resignation of Vinay Prasad from the FDA after a brief tenure is seen as a significant event impacting the biopharmaceutical industry, particularly regarding gene therapies and vaccine approvals [1][5]. Group 1: Impact on Biopharmaceutical Companies - Following the news of Prasad's resignation, biopharmaceutical companies such as Replimmune surged nearly 70%, Sarepta increased by 14%, and Capricor rose by 21.2% in pre-market trading [2]. - Prasad's departure is perceived as a positive development for gene therapy and vaccine companies, as his tenure included critical decisions that limited patient options and raised concerns among investors [6]. Group 2: Regulatory Environment - During Prasad's short time at the FDA, the agency tightened the usage of COVID-19 vaccines and rejected new drug applications from Replimmune and Capricor, leading to significant declines in their stock prices [5]. - The FDA's recent unconventional regulatory actions regarding Sarepta Therapeutics' gene therapy Elevidys coincided with Prasad's resignation, indicating a potential shift in the agency's approach [5]. Group 3: Leadership and Public Perception - Prasad's resignation was reportedly under pressure from the White House due to public criticism, highlighting the challenges faced by FDA officials in maintaining credibility [5]. - Analysts suggest that appointing a more experienced official to replace Prasad could help restore market confidence in the FDA [6].

Core Points - Watson Bio announced a board meeting on July 30, 2025, to approve a revised agreement that expands the scope of "core microbiome therapy" into precision microbiome health and functional nutrition intervention [1] - The revision includes granting exclusive rights for development, manufacturing, and commercialization in mainland China, Hong Kong, and Macau for non-patient populations [1] - The financial terms, duration, and due diligence clauses of the agreement have been amended, but the signing will not significantly impact the company's operating performance for the current year [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準 確性或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部份內容而產生 或因倚賴該等內容而引致的任何損失承擔任何責任。 CSPC PHARMACEUTICAL GROUP LIMITED SYH2086是本集團開發的具有完全自主知識產權的臨床前候選藥物，屬於一種新型口服小 分子GLP -1受體激動劑。GLP -1受體激動劑是一類通過GLP -1受體發揮作用的藥物，已被開 發 為 用 於 2 型 糖 尿 病 和 肥 胖 症 管 理 的 治 療 方 法 ， 其 核 心 作 用 機 制 包 括 促 進 胰 島 素 分 泌 、 抑 制 胰 高 血 糖 素 釋 放 、 延 緩 胃 排 空 及 降 低 食 欲 ， 從 而 兼 具 降 糖 和 減 重 效 果 。 臨 床 前 數 據 顯 示，SYH2086具有優異的體外激動活性和體內降糖、減重效果，並在不同動物種屬上具有 寬劑量範圍線性化的藥物動力學(PK)行為，且無明顯安全性風險。 – 1 – 關於Madrigal Madrigal（ NASDAQ：MDGL ）是一家專注於提供代謝功能 ...

每经AI快讯，7月30日，汇宇制药(688553.SH)公告称，公司全资子公司汇宇海玥自主研发的1类生物创 新药注射用HY0001a用于治疗晚期实体瘤的I期临床试验近日成功完成首例受试者给药。该产品为抗体 偶联药物，注册分类为1类创新型治疗用生物制品，国内外尚无同靶点产品获批上市。 ...