Core Viewpoint - The article discusses the advancements in synthetic biology tools for customizing yeast cell factories, highlighting their potential in producing high-value compounds efficiently [3]. Group 1: Innovative Tools for Yeast Cell Factories - The paper titled "Innovative tools for customized yeast cell factory" outlines significant progress in synthetic biology tools, including genome editing, computational tools, adaptive laboratory evolution, and standardization of biological DNA components [3]. - These tools aim to provide practical guidelines for the effective development of customized yeast cell factories [3]. Group 2: Genome Editing Tools - Genome editing has evolved from single-gene editing to simultaneous multi-gene editing, with CRISPR-Cas systems enabling precise modifications in yeast genomes, including knockouts, insertions, and replacements [6]. - New variants of CRISPR-Cas, such as base editing and prime editing, allow for single nucleotide changes to alter gene functions [6]. Group 3: Computational Tools - Computational tools, including metabolic modeling and the integration of omics technologies, guide engineering strategies and expected flux adjustments [7]. - Genome-scale metabolic models (GEMs) have been widely applied in yeast metabolic engineering, with large-scale kinetic models playing a crucial role in designing and understanding metabolic reactions [7]. Group 4: Adaptive Laboratory Evolution - Adaptive laboratory evolution (ALE) is a powerful strategy for enhancing yeast strain performance by applying selective pressure over generations, leading to the emergence of more adaptive strains [8]. - Combining ALE with whole-genome sequencing helps identify beneficial mutations and provides insights into the genetic basis of adaptability [8]. Group 5: Standardization of Biological DNA Components - The increasing complexity of yeast cell factory designs necessitates precise control and regulation of biological components, gene circuits, or biological systems [9]. - Synthetic biology offers standardized biological components, allowing researchers to assemble these components into complex systems with predictable behaviors [9].

全球政策进展 | 上海市 2025 年度关键技术研发计划 "合成生物学 "项目立项清单 | 序号 | 1 | | --- | --- | | 项目编号 | 25HC2810100 | | | 基于喷墨打印微阵列芯片的高通量高精度 | | 项目名称 | 低成本长片段核酸合成 | | 项目承担单位 | 上海迪赢生物科技有限公司 | | 项目负责人 | 张满仓 | | 项目实施周期 | 2025.08.01-2028.07.31 | | 序号 | 2 | | 项目编号 | 25HC2810200 | | 项目名称 | 高通量长片段 DNA 酶促合成系统研发 | | 项目承担单位 | 上海人工智能研究院有限公司 | | 项目负责人 | 夏 凯 | | 项目实施周期 | 2025.08.01-2028.07.31 | | 序号 | 3 | 项目编号 25HC2810300 项目名称 重要天然产物生物合成功能元件挖掘及共 享元件库的构建 项目承担单位 上海中医药大学 项目负责人 陈万生 项目实施周期 2025.08.01-2028.07.31 序号 4 项目编号 25HC2810400 项目名称 生物合成新元件的挖掘表征 ...

"此次大会以'发展合成生物，培育未来产业'为主题，恰逢其时，意义深远。"中国生物发酵产业协会理 事长于学军说，"我们应聚焦关键，精准发力。一是强化科技创新引领，持续加大投入，鼓励高校、科 研机构与企业携手，开展联合攻关，突破关键技术瓶颈，释放创新活力，提升关键领域的核心竞争力， 让科技创新成为产业发展的强大引擎；二是促进产业协同发展，加强产业链上下游企业间的合作，形成 产业集群效应，推动合成生物学技术在医药、食品、农业、化工、能源等多领域的广泛应用，实现跨产 业的深度融合与协同发展，构建起互利共赢的产业生态；三是加强人才培养与引进，合成生物学作为一 门交叉学科，对复合型人才的需求迫切，应加强高校相关专业建设，完善人才培养体系，同时积极引进 海外高层次人才，为产业发展注入源头活水，提供坚实的人才保障；四是完善政策生态体系，政府部门 需精准施策，制定针对性政策，在税收优惠、财政补贴、项目支持等方面给予产业更多扶持，为合成生 物学产业的茁壮成长创造良好的政策环境，助力产业腾飞。" 本报讯 （记者 闫 利）日前，2025合成生物学技术创新发展大会在江苏宜兴举行。大会以"发展合成生 物 培育未来产业"为主题，8位两院院 ...

《科创板日报》23日讯，今日下午，"2025国际合成生物学产业发展论坛"在上海张江科学会堂举办。市 政府副秘书长夏科家出席并致辞。市科委主任骆大进，张江科学城建设管理办公室主任肖健，上海合成 生物学创新中心理事长金勤献等出席。夏科家表示，上海正抢抓战略机遇、加快布局合成生物学等前沿 科技与未来产业新赛道。面向未来，上海将全力支持合成生物学高质量发展，在政策支持、资金保障、 产品推广、人才引育、开放合作等方面不断强化服务保障，让更多创新成果在上海落地生根、开花结 果。 2025国际合成生物学产业发展论坛在沪举办 ...

Industry Overview - Synthetic biology has gained significant attention from both the scientific and investment communities, with increasing research and application prospects across various fields [1][2] - The global synthetic biology market was approximately $12.2 billion in 2022, showing a year-on-year growth of 28.42%, and is projected to reach $15.1 billion in 2023 and $19 billion in 2024, with a forecast of $24.3 billion by 2025 [1] - Major countries, including the US, UK, EU, and China, are intensifying their strategic investments and policy support in synthetic biology, positioning it as a strategic high ground in future global competition [1][3] Company Developments - Haizheng Pharmaceutical has established a joint venture, Lian Sheng Synthetic, with a registered capital of 350 million yuan, aiming to enter the synthetic biology sector [2] - Shenghe Biotechnology has launched China's first production line for natural product biosynthesis, which will serve various industries including cosmetics and pharmaceuticals [2] - Lian Sheng Synthetic is set to invest 170 million yuan in a flexible production line for synthetic biology, with its first product expected to be launched in August [5] Market Dynamics - The economic value of synthetic biology and bio-manufacturing is projected to reach $100 billion by 2025, with an expectation that 60% of material production will be achieved through bio-manufacturing methods [5] - The industry is characterized by a competitive landscape where companies are striving to convert midstream technologies into marketable products, emphasizing the importance of industrialization capabilities [5][9] Challenges and Opportunities - The transition from laboratory to commercial application in synthetic biology faces multiple challenges, including technical feasibility, engineering conversion, and market adaptability [7][8] - The industry is experiencing a "valley of death" in industrialization, where many promising technologies fail to scale up due to the lack of pilot testing [8] - Despite the challenges, the integration of AI and machine learning is expected to enhance research capabilities and support the development of synthetic biology [6] Strategic Insights - The current landscape indicates a need for innovation to avoid price competition and to develop high-value products that can lead the market [9] - The establishment of supportive policies at the provincial and national levels in China is anticipated to further guide and promote the healthy development of the synthetic biology industry [6]

Investment Rating - The report maintains a "Recommended" rating for the new materials industry [1]. Core Insights - The new materials sector is positioned as a crucial direction for the chemical industry, currently experiencing rapid growth in downstream demand. With policy support and technological breakthroughs, domestic new materials are expected to accelerate their long-term growth. The report emphasizes that "one generation of materials leads to one generation of industries," highlighting the foundational role of the new materials industry in supporting other sectors [4][14]. Summary by Sections 1. Electronic Information Sector - Focus on semiconductor materials, display materials, and 5G materials. Recent developments include Meta Platforms planning to launch a next-generation AI ASIC chip by Q4 2025, and Huawei applying for a quad-chiplet packaging design patent for its next AI chip [5][21][22]. 2. Aerospace Sector - Key areas of interest include PI films, precision ceramics, and carbon fibers. The report notes the participation of China's new generation stealth fighters at the Paris Air Show, showcasing advancements in military aviation technology [7][8]. 3. New Energy Sector - Emphasis on photovoltaic materials, lithium-ion batteries, proton exchange membranes, and hydrogen storage materials. The report anticipates a significant breakthrough in China's new energy revolution by 2030, driven by hydrogen energy development [9][10]. 4. Biotechnology Sector - Focus on synthetic biology and scientific services. The establishment of a new synthetic biology company by Haizheng Pharmaceutical marks a strategic move into the high-end synthetic biology industry [11][12]. 5. Energy Conservation and Environmental Protection Sector - Attention on adsorbent resins, membrane materials, and biodegradable plastics. The report highlights the development of hazardous waste disposal facilities in Zhejiang Province, indicating a comprehensive approach to waste management [13][14]. 6. Industry Rating and Investment Strategy - The new materials sector is expected to benefit from downstream application sectors, entering a favorable economic cycle. The report maintains a "Recommended" rating for the new materials industry [14].

Core Viewpoint - Zhiyan Zhaowu (Shaoxing) Biotechnology Co., Ltd. is a high-tech enterprise driven by artificial intelligence and synthetic biology innovation, focusing on the integration of AI technology with biological manufacturing to advance biotechnological progress and commercialization [1][3]. Company Overview - Founded in 2020 in Silicon Valley, Cardinal Biocraft has developed an AI-driven synthetic biology platform, investing over 50 million yuan and establishing a leading research and development platform for synthetic biological strains [1]. - The company has established three major R&D centers in California, Hefei, and Hangzhou, and aims to create a comprehensive R&D, production, and operation center in Shaoxing by 2024 [1]. Core Advantages - The company utilizes AI algorithms to accelerate gene design, metabolic pathway optimization, and strain modification, overcoming traditional R&D efficiency bottlenecks and enabling rapid conversion from laboratory to industrial production [3]. - It focuses on large-scale biological manufacturing needs, developing low-cost and high-stability biological synthesis solutions to empower green biological manufacturing [3]. Talent Acquisition - The company is seeking talented individuals in the fields of synthetic biology and industrial biotechnology, including positions for assistant researchers, fermentation engineers, and research assistants [4][7][12]. - Candidates are expected to have strong professional knowledge and experience in areas such as enzyme and metabolic pathway optimization, high-throughput strain screening, and fermentation process scaling [9][11][13]. Upcoming Events - The Fourth Synthetic Biology and Green Bio-Manufacturing Conference (SynBioCon 2025) will be held from August 20-22 in Ningbo, Zhejiang, focusing on AI and biological manufacturing, and exploring trends in the bio-manufacturing industry [14][15].

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Investment Rating - The industry investment rating is "Overweight" [1] Core Views - The report highlights the ongoing active research in life sciences and the global wave of biotechnology revolution, which is accelerating integration into economic and social development. This provides new solutions for major challenges such as health, climate change, resource security, and food security. The National Development and Reform Commission has issued the "14th Five-Year Plan for the Development of the Bioeconomy," indicating a trillion-yuan market potential in the bioeconomy sector [3][4]. Summary by Sections 1.1 Secondary Market Performance - The synthetic biology sector saw a significant increase of 9.36% in the week from June 9 to June 13, 2025, outperforming the Shanghai Composite Index by 9.61 percentage points [17][20]. 1.2 Company Business Progress - Domestic companies are making strides in synthetic biology, such as Hongmo Bio partnering with Yizhi Weisi to establish an AI-driven bio-manufacturing center, and Yike Bio launching a PHA bioplastic production base in Suzhou [26][27]. 1.3 Industry Financing Tracking - Financing activities in the synthetic biology sector are accelerating, with nearly a hundred companies completing new financing rounds since the beginning of 2025. Notable examples include Jingjiahang's angel round financing and Mosanna Therapeutics' $80 million Series A financing [33][34]. 1.4 Company R&D Directions - Companies are focusing on innovative technologies, such as the development of non-grain bio-based insulation materials by Nanjing Forestry University and the strategic collaboration between AstraZeneca and Stone Pharmaceutical for drug discovery [9][29]. 1.5 Industry Research Dynamics - The report notes the establishment of key technology R&D projects in Shanghai for synthetic biology, covering various innovative areas such as AI cell design and 3D printing of tissues [8].

Investment Rating - Industry investment rating: Overweight [1] Core Views - The chemical sector's overall performance ranked 14th this week, with a slight decline of -0.01%, outperforming the Shanghai Composite Index by 0.24 percentage points and underperforming the ChiNext Index by 0.21 percentage points [3][22]. - The chemical industry is expected to continue its trend of divergence in 2025, with recommendations to focus on synthetic biology, pesticides, chromatography media, sweeteners, vitamins, light hydrocarbon chemicals, COC polymers, and MDI [4]. Summary by Sections 1. Industry Review - The chemical sector's performance for the week of June 9-13, 2025, showed a slight decline of -0.01%, ranking 14th among sectors [3][22]. - The top three performing sectors were non-ferrous metals (+3.79%), oil and petrochemicals (+3.5%), and agriculture (+1.62%) [22]. 2. Key Industry Dynamics - Synthetic biology is at a pivotal moment, with low-energy products expected to gain a longer growth window due to the shift in energy structure [4]. - The upcoming quota policy for refrigerants is anticipated to lead to a high-growth cycle for third-generation refrigerants, with demand expected to grow steadily due to market expansion [5]. - The electronic specialty gases market is characterized by high technical barriers and value, presenting significant domestic substitution opportunities [6][8]. - The trend towards light hydrocarbon chemicals is becoming global, with a shift from heavy naphtha to lighter raw materials like ethane and propane [8]. - The COC polymer industry is accelerating its domestic industrialization process, driven by supply chain security concerns and the shift of downstream industries to China [9]. - Potash fertilizer prices are expected to rebound as major producers reduce output, leading to a supply-demand imbalance [10]. - The MDI market is characterized by oligopoly, with a favorable supply structure expected as demand gradually recovers [12]. 3. Company Performance - The top three performing chemical stocks this week were Jinjis Co. (+53.3%), Suzhou Longjie (+18.5%), and Akali (+16.7%) [28]. - The companies to watch in the synthetic biology sector include Kasei Bio and Huaheng Bio [4]. - Key players in the refrigerant market include Juhua Co., Sanmei Co., and Haohua Technology [5]. - In the electronic specialty gases sector, companies like Jinhong Gas, Huate Gas, and China Shipbuilding Gas are recommended [6][8]. - For light hydrocarbon chemicals, Satellite Chemical is highlighted as a key player [8]. - In the COC polymer space, Akali is noted for its potential breakthroughs [9]. - In the potash fertilizer sector, companies such as Yaji International and Salt Lake Co. are recommended [10]. - For MDI, Wanhua Chemical is a key focus due to its significant market share [12].