ile 77 ock Code : 1093) 2025 Results Presentation Mar. 2026 INNOVAT 2025 Updates Regulatory Updates New drugs approved (including new indications): Breakthrough Therapy Designations: Major Clinical Trial Progress IND approvals : North America (18) China (58) New pivotal clinical trials: From 2025 to the present, ■ BD transactions have been completed, with a billion US dollars. total amount of In 2025, the Licence fee income of billion vuan was booked in. 2 HD Envitan · Duoenvi - 1L Pancreatic cancer • Shanz ...

Market Overview - The A-share pharmaceutical and biotechnology index increased by 0.50% last week, underperforming the CSI 300 index by 0.58 percentage points and the ChiNext index by 1.82 percentage points, ranking 25th among 31 sub-industries [4] - The Hong Kong Hang Seng Healthcare Index fell by 6.07%, underperforming the Hang Seng Index by 4.96 percentage points [4] R&D Progress - Last week, several clinical applications were newly undertaken, including CMS-D008 injection by Kangzhe Pharmaceutical and KC1036 tablets by Kangchen Pharmaceutical [4] - Other IND applications included HSK46575 tablets by Haishi Pharmaceutical, injection of Lankangyilong monoclonal antibody by Bailitianheng, and injection of BL-M11D1 [4] - Notable ongoing clinical trials include ICP-538 by Nocera Biopharma and DC6001 by China Resources Sanjiu in Phase I, HLX43 by Fuhong Hanlin and Punanli monoclonal antibody by Tianjing Biopharma in Phase II, and SYH2053 and SYS6010 by Shiyao Group in Phase III [4] Investment Outlook - The company maintains a positive outlook on the pharmaceutical sector's recovery, reiterating the investment thesis based on the three stages of clinical value: 1. "0→1" technological breakthroughs in innovative drugs, particularly in oncology, weight loss, and autoimmune diseases, as well as advancements in innovative medical devices like brain-machine interfaces [5] 2. "1→10" clinical validation with high-quality domestic innovative drugs accelerating overseas authorization and the rise of high-end medical devices [5] 3. "10→100" efficiency in China, where CXO companies leverage low costs and high efficiency to build competitive advantages, particularly in the disposable medical supplies sector [5] - The focus is on the accelerated overseas expansion of innovative drugs and their upstream CXO, as well as the innovation and upgrade of high-end medical devices and high-value consumables [5]

Investment Rating - The report maintains a "Buy" rating for the pharmaceutical sector, emphasizing a positive outlook for the recovery of the industry [3][4]. Core Viewpoints - The report expresses a strong belief in the recovery of the pharmaceutical sector, reiterating the investment thesis based on the "three stages of clinical value": 1) "0→1" technological breakthroughs in innovative drugs and devices; 2) "1→10" clinical validation of high-quality domestic innovative drugs; 3) "10→100" efficiency in the Chinese pharmaceutical industry [2][19][20]. - The report highlights the acceleration of BD (Business Development) for innovative drugs and the growth of domestic CXO (Contract Research Organization) companies, as well as the rise of high-end medical devices and high-value consumables [2][20]. Summary by Sections Market Review - Last week, the A-share pharmaceutical index rose by 0.50%, underperforming the CSI 300 index by 0.58 percentage points and the ChiNext index by 1.82 percentage points, ranking 25th among 31 sub-industries [1][14]. - The Hong Kong Hang Seng Medical Health Index fell by 6.07%, underperforming the Hang Seng Index by 4.96 percentage points [1][14]. R&D Progress - Recent clinical applications include CMS-D008 injection from Kangzhe Pharmaceutical and KC1036 tablets from Kangchen Pharmaceutical, both newly undertaken; IND applications for HSK46575 tablets from Haishike and other products are also in progress [1][24]. Key Company Recommendations - The report recommends several companies based on their potential in the innovative drug sector and medical devices: - Innovative drugs: Innovent Biologics (H), Yifang Biologics (U), Tianjin Pharmaceutical - CXO companies: WuXi AppTec (A+H), Proprius - High-end medical devices: Mindray Medical, United Imaging Healthcare, Weisi Medical [2][20]. Financial Forecasts and Valuations - The report provides earnings per share (EPS) and price-to-earnings (PE) ratios for key companies, indicating a positive outlook for their financial performance [3]. - For instance, Tianjin Pharmaceutical is projected to have an EPS of 0.77 yuan in 2025 with a PE of 19, while Innovent Biologics is expected to reach an EPS of 0.49 yuan with a significantly higher PE of 154 [3]. Important Updates - The report includes updates on clinical trial approvals and progress for various companies, indicating ongoing innovation and development within the sector [23][24]. - It also notes the stability of prices for key pharmaceutical raw materials and the overall performance of the pharmaceutical manufacturing industry, which saw a year-on-year revenue decline of 1.2% [28][45].

Core Viewpoint - The report highlights the strong innovative research and development capabilities of the company, particularly in the oncology and chronic disease sectors, and its establishment of an international business development ecosystem, leading to significant licensing agreements. Group 1: Financial Projections - The company is projected to have EPS of 0.55, 0.75, and 0.70 CNY for the years 2025-2027, with growth rates of 48%, 36%, and -7% respectively [1] - A target price of 16.58 HKD is set for the company, with an initial coverage rating of "Buy" [1] Group 2: Oncology Pipeline - The EGFR ADC pipeline is noted as the fastest progressing globally, with several early-stage pipelines awaiting data catalysts in 2026 [1] - SYS6010 is identified as the fastest progressing topoisomerase EGFR ADC, with initial human study data to be disclosed in 2025 [1] - Multiple early clinical assets, including CDK2/4/6 inhibitors and PD1*IL15 fusion proteins, are expected to have data released in 2026 [1] Group 3: Strategic Collaborations - On January 30, 2026, the company signed a strategic R&D collaboration and licensing agreement with AstraZeneca to develop innovative long-acting peptide drugs [2] - The collaboration includes eight innovative long-acting peptide drug projects, with one project (SYH2082) ready for clinical trials and three in preclinical stages [2] - The total deal value is estimated at 18.5 billion USD, including 1.2 billion USD upfront payment and potential milestone payments of up to 3.5 billion USD for R&D and 13.8 billion USD for sales [2] Group 4: International Strategy - The company's international strategy is progressing steadily, with ongoing business development and deep collaboration with AstraZeneca [2] - The company is expected to have over 20 innovative drug assets entering clinical stages annually, indicating a strong outlook for future licensing agreements [2]

Investment Rating - The report assigns an "Accumulate" rating to the company [1][6]. Core Insights - The report highlights the strong innovative research and development capabilities of the company, which is entering a harvest period for innovative drugs while establishing an international business development ecosystem with several significant collaborations [2][10]. - The company is expected to achieve a compound annual growth rate (CAGR) in earnings per share (EPS) of 48% from 2025 to 2027, with a target price set at HKD 16.58 [10]. Financial Summary - Total revenue is projected to be RMB 31,450.11 million in 2023, with a slight increase of 1.7% year-on-year. However, a decline of 7.8% is expected in 2024, followed by a gradual recovery in subsequent years [4][11]. - Gross profit is forecasted to be RMB 22,177 million in 2023, with net profit expected to be RMB 5,873 million, reflecting a decrease of 3.6% [4][11]. - The price-to-earnings (P/E) ratio is projected to be 18.26 in 2023, increasing to 24.78 in 2024 before declining to 16.80 in 2025 [4][11]. Pipeline Overview - The company has a leading position in the oncology pipeline, with SYS6010 being the fastest progressing EGFR ADC globally, and multiple early-stage assets expected to report data in 2026 [10][14]. - In the weight loss and metabolic fields, the company has established a leading position domestically, with a strategic collaboration with AstraZeneca to develop innovative long-acting peptide drugs [10][24]. - The company has secured a total deal value of USD 18.5 billion from collaborations, including upfront payments and potential milestone payments [10][24]. Clinical Development - The report outlines several key clinical trials, including SYS6010, which is in Phase III for EGFRm NSCLC, and various other assets in different stages of development [18][20]. - The company is actively recruiting for multiple trials, with significant data expected to be released in 2026 [18][20]. Market Position - The company is positioned as a leader in the domestic market for small nucleic acid technology, with a strong pipeline in siRNA [10][24]. - The report emphasizes the company's competitive edge in the next-generation weight loss drugs and cardiovascular metabolic therapies, supported by strategic partnerships with multinational corporations [10][24].

Investment Rating - The report assigns an "Accumulate" rating to the company [1][6]. Core Insights - The report highlights the strong innovation and R&D capabilities of the company, which is entering a harvest period for innovative drugs and has established an international business development ecosystem with several significant licensing agreements [2][10]. - The company is expected to achieve a significant increase in EPS from 0.37 in 2024 to 0.75 in 2025, with a projected growth rate of 48% [10]. - The target price for the company is set at 16.58 HKD, reflecting a favorable valuation based on comparable company analysis [10]. Financial Summary - Total revenue is projected to be 31,450.11 million RMB in 2023, with a slight increase of 1.7% [4]. - Net profit is expected to decrease by 3.6% in 2023, followed by a significant recovery of 47.5% in 2025 [4]. - The company’s PE ratio is forecasted to decrease from 18.26 in 2023 to 12.34 in 2026, indicating an improving valuation over time [4]. Pipeline Overview - The company has a leading position in the oncology pipeline, particularly with SYS6010, which is the fastest progressing EGFR ADC globally, with multiple early-stage assets expected to report data in 2026 [10][16]. - In the weight loss and metabolic areas, the company has established a leading position domestically and has signed a strategic collaboration with AstraZeneca for the development of innovative long-acting peptide drugs [10][24]. - The company has a robust pipeline in the small nucleic acid technology sector, positioning it as a leader in the domestic siRNA market [10][24]. Business Development and International Strategy - The company is making steady progress in its international strategy, with ongoing collaborations with AstraZeneca and other multinational corporations, reflecting its competitive edge in innovative drug development [10][24]. - The company is expected to continue achieving external licensing agreements, with over 20 innovative drug assets entering clinical stages annually [10][24].

Investment Rating - The report assigns a "Buy" rating to the company, indicating an expected stock price increase of over 15% in the next six months [3]. Core Insights - The company is advancing its innovative pipeline, with a focus on expanding its cancer treatment portfolio. The recent approval of SYS6090 for clinical trials highlights its potential in treating advanced lung cancer [1][2]. - SYS6090 is a recombinant fully human anti-PD-1 antibody fused with IL-15, showing significant efficacy and safety in preclinical studies, outperforming other PD-1 monoclonal antibodies [1]. - The company has a rich pipeline with multiple drugs in critical clinical trial phases, including SYS6010 and DP303c, which have demonstrated promising results in their respective trials [2]. Financial Summary - The company’s revenue is projected to decline from 2,539 million in 2023 to 1,981 million in 2024, before recovering to 2,970 million by 2027, reflecting a compound annual growth rate (CAGR) of approximately 14.67% from 2025 to 2027 [4]. - The net profit attributable to the parent company is expected to recover significantly from 54 million in 2024 to 246 million in 2027, with an EPS increase from 0.04 to 0.18 during the same period [4]. - The company’s market valuation is projected to decrease from a PE ratio of 967 in 2025 to 212 in 2027, indicating an improving profitability outlook [4].

Investment Rating - The report provides a positive outlook for CSPC Pharmaceutical Group, indicating a clear roadmap for internationalization and significant revenue growth expected from completed business development transactions by 2026 [5][6]. Core Insights - CSPC is projected to convert its completed business development transactions into recurring revenue by 2026, supported by major research milestones and successful overseas development progress [6]. - The company has secured approximately $10.2 billion in upfront and milestone payments from significant partnerships with AstraZeneca and Madrigal, which are expected to enhance profitability from 2025 to 2027 [5][6]. - Key products such as KN026 and SYS6010 are anticipated to drive domestic business recovery and accelerate growth post-2027 [7]. Summary by Sections Business Development and Revenue - CSPC's completed business development transactions are expected to yield around $9 billion in free cash flow from milestone payments by 2030, with AstraZeneca's recent $1.2 billion non-refundable upfront payment being a significant contributor [6]. - The company has established eight innovative R&D platforms, transitioning from a raw material producer to a complex generics and innovative drug enterprise, achieving a compound annual growth rate of 3.1% in profitability from 2019 to 2023 [10]. Market Position and Financials - As of February 2, 2026, CSPC's stock price was HKD 9.15, with a market capitalization of $13.54 billion [13]. - The company ranks among the top ten in the Chinese pharmaceutical industry by drug revenue, with a significant portion of its income derived from the Asian market [11]. Catalysts for Growth - Key catalysts include the progress of overseas R&D projects, particularly the core product EGFR ADC, and the clinical development plans of major partners like AstraZeneca [8]. - The anticipated launch of innovative drugs and the entry of early-stage products into clinical phases are expected to validate the company's R&D capabilities [8].

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Core Viewpoint - Haitong International maintains an "outperform" rating for CSPC Pharmaceutical Group (01093) with a target price of HKD 11.34, noting a revenue decline in the first three quarters but signs of recovery in Q3, with a 10% quarter-on-quarter growth in prescription drug revenue and a 27% year-on-year increase in net profit attributable to shareholders [1][2]. Financial Performance - For the first nine months of 2025, CSPC achieved revenue of CNY 19.9 billion, a 12% year-on-year decline, with prescription drug revenue at CNY 15.5 billion (down 17%), API revenue at CNY 3 billion (up 10%), and functional foods and other businesses at CNY 1.4 billion (up 11%) [2]. - The gross margin was 65.6%, down 4.9 percentage points year-on-year; R&D expenses were CNY 4.2 billion (up 8%), with an R&D expense ratio of 21.0% (up 3.9 percentage points); the sales expense ratio was 24.1% (down 5.1 percentage points) [2]. - In Q3 2025, CSPC reported revenue of CNY 6.6 billion, a 3% year-on-year increase and a 6% quarter-on-quarter increase, with prescription drug revenue at CNY 5.2 billion (up 2% year-on-year, up 10% quarter-on-quarter) [2]. Prescription Drug Business - In Q3 2025, all segments of the prescription drug business showed improvement, confirming the bottom of the fundamentals, with total prescription drug revenue of CNY 4.7 billion and drug revenue of CNY 4.7 billion (up 8% quarter-on-quarter) [3]. - Specific revenue breakdown includes: - Neurological system: CNY 1.91 billion (down 4% year-on-year, up 4% quarter-on-quarter) - Oncology: CNY 590 million (down 47% year-on-year, up 19% quarter-on-quarter) - Anti-infection: CNY 830 million (down 9% year-on-year, up 12% quarter-on-quarter) - Cardiovascular: CNY 470 million (up 18% year-on-year, up 4% quarter-on-quarter) - Respiratory: CNY 320 million (up 73% year-on-year, up 28% quarter-on-quarter) - Metabolism: CNY 250 million (up 14% year-on-year, up 8% quarter-on-quarter) - Other therapeutic areas: CNY 360 million (up 26% year-on-year, down 4% quarter-on-quarter) [3]. - The company expects a 5% revenue growth in the second half of the year for the prescription drug segment (excluding authorized revenue) [3]. Asset Expansion and R&D Progress - The SYS6010 (EGFRADC) clinical trial is progressing well, with significant potential for external licensing; multiple technology platforms and products are also expected to expand internationally [4]. - Management plans to present clinical data for SYS6010 at major conferences next year and publish data in top academic journals [5]. - The small RNA platform has five assets entering clinical stages, focusing on liver-targeted and multi-target products, with plans for new products in weight loss and muscle gain to enter clinical trials next year [6]. - The PD-1/IL15 pipeline is a key focus, with over 90 patients enrolled in dose-exploration trials, showing promising safety and efficacy results [6].