脑机接口技术快速迭代升级，多家企业积极布局。当前，脑机接口技术正经历前所未有的高速迭代升 级。在信号采集端，非侵入式设备在信号质量与便携性上不断突破；在侵入式领域，柔性电极等核心器 件的研发将持续提升系统安全性、舒适度与长期稳定性。系统层面，肌电信号与脑电信号等多模态融 合，正成为提升整体稳定性与可靠性的关键趋势。与此同时，材料科学、微纳加工与芯片设计的多学科 协同创新，正持续推动核心器件性能提升与规模化生产成本下降。这些贯穿技术链条的突破性进展，共 同驱动脑机接口系统加速从实验室研究迈向实际应用，并为其从医疗级专业市场向广阔的消费级领域扩 展，并最终实现规模化商业应用提供强大技术支撑。 截至01月05日12:49，科创生物医药ETF（588250.SH）上涨4.93%，其关联指数科创生物（000683.SH） 上涨5.01%；主要成分股中，百济神州-U上涨11.46%，联影医疗上涨4.36%，益方生物-U上涨9.21%，泽 璟制药-U上涨6.74%，博瑞医药（维权）上涨7.58%。 今日早盘市场情绪积极，上证指数盘中重回4000点，科创板相关指数表现强势。盘面上，脑机接口概念 集体爆发，相关板块多只个股涨停 ...

Core Viewpoint - The biopharmaceutical sector in China is experiencing a positive trend in innovation and investment, with significant growth in the approval of innovative drugs and a recovery in market conditions [1][2] Industry Summary - As of September 8, 2025, the Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index (000683) increased by 0.89%, with notable gains from companies such as United Imaging Healthcare (688271) up 11.48% and BGI Genomics (688114) up 9.35% [1] - The "National Drug Safety Publicity Week" launched on September 1 highlights the positive development of the pharmaceutical industry, with 210 innovative drugs approved in the past five years, indicating a sustained growth trend [1] - Currently, approximately 30% of the world's innovative drugs under research are from China, showcasing the country's significant role in global pharmaceutical innovation [1] Company Summary - The top ten weighted stocks in the Sci-Tech Innovation Board Biopharmaceutical Index as of August 29, 2025, include United Imaging Healthcare (688271), BeiGene (688235), and others, collectively accounting for 50.27% of the index [2] - The Sci-Tech Biopharmaceutical ETF (588250) closely tracks the performance of the Sci-Tech Innovation Board Biopharmaceutical Index, reflecting the overall performance of representative biopharmaceutical companies listed on the Sci-Tech Board [2]

Core Insights - The Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index (000683) has shown a strong increase of 1.32% as of September 5, 2025, with notable gains in constituent stocks such as Zai Lab (688266) up 5.31%, Junshi Biosciences (688180) up 3.89%, and Huatai Medical (688617) up 3.85% [1] - Novartis continues to invest in siRNA technology, recently entering into a significant business development deal with BGI Genomics, involving an upfront payment of $160 million and a total potential milestone value of $5.2 billion [1] - According to Dongfang Securities, the performance of innovative drugs and the industry chain is strong, driven by the commercialization of domestic innovative products and the potential for international expansion [1] Industry Overview - The Sci-Tech Innovation Board Biopharmaceutical Index comprises 50 large-cap companies in the biopharmaceutical, biomedical engineering, biomedicine, and other related sectors, reflecting the overall performance of representative biopharmaceutical companies listed on the Sci-Tech Innovation Board [2] - As of August 29, 2025, the top ten weighted stocks in the index account for 50.27% of the total index, including companies like United Imaging Healthcare (688271) and BeiGene (688235) [2] - The Sci-Tech Biopharmaceutical ETF (588250) closely tracks the performance of the index, providing investors with exposure to the biopharmaceutical sector [2]

Group 1 - The core viewpoint is that the innovative drug sector is experiencing significant growth, driven by strong mid-year performance from multiple companies and increased market liquidity and risk appetite [2][3] - The Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index (000683) has risen by 4.02%, with notable increases in constituent stocks such as Maiwei Biotech (688062) up 20.00% and ZhiXiang JinTai (688443) up 11.60% [1][2] - The Sci-Tech Biopharmaceutical ETF (588250) closely tracks the performance of the Biopharmaceutical Index and has also seen a rise of 4.12%, with the latest price reported at 1.34 yuan [1][2] Group 2 - The top ten weighted stocks in the Biopharmaceutical Index account for 50.27% of the index, including companies like United Imaging Healthcare (688271) and BeiGene (688235) [3] - Investment strategies are recommended to focus on domestic clinical CROs benefiting from supportive policies, life sciences upstream companies with recovering overseas business, and companies involved in weight loss drugs, Alzheimer's treatments, ADCs, and AI concepts [2]

Group 1 - The core viewpoint of the news highlights the strong performance of the biotech sector in the STAR Market, with the STAR Biomedicine Index rising by 1.39% and individual stocks like CanSino and Huaxi Bio showing significant gains [1] - In 2024, the retail pharmacy (DTP) innovative drug sales are projected to reach 88.7 billion yuan, marking a year-on-year growth of 16.6%, while the first quarter of 2025 is expected to see sales of 23.3 billion yuan, a 15.0% increase [1] - The innovative drug sector continues to maintain double-digit growth, significantly outpacing the growth of tiered hospitals, indicating a qualitative leap in channel value [1] Group 2 - According to Shenwan Hongyuan, the innovative drug sector has experienced rapid growth in product revenue and external licensing over the past three years, with significant BD transactions this year driving a trend of expansion across the overall sector [1] - The adjustment of the medical insurance catalog will include commercial insurance for innovative drugs for the first time, which is expected to further support the sector [1] - The STAR Biomedicine ETF closely tracks the STAR Biomedicine Index, which consists of 50 large-cap companies in the biomedicine and related fields, reflecting the overall performance of representative companies in the sector [2]

Group 1 - Novo Nordisk announced that the supplemental new drug application (sNDA) for semaglutide (Wegovy) has been approved by the FDA for the treatment of metabolic dysfunction-associated fatty liver disease (MAFLD) in patients with moderate to advanced liver fibrosis, boosting the performance of the innovative drug sector [1] - As of August 19, 09:45, the Sci-Tech Biomedicine ETF (588250.SH) rose by 1.47%, with its associated index, Sci-Tech Biomedicine (000683.SH), increasing by 1.58%. Key constituent stocks such as Baillie Gifford (百利天恒) rose by 5.95%, United Imaging (联影医疗) by 2.32%, Rongchang Biopharma (荣昌生物) by 5.08%, Yirui Technology (奕瑞科技) by 5.40%, and Maiwei Biopharma-U (迈威生物-U) by 5.74% [1] Group 2 - Jianghai Securities pointed out that the preliminary review of the medical insurance and commercial insurance catalog has significantly increased the enthusiasm of innovative drug companies, with the government continuously optimizing the adjustment mechanism of the medical insurance catalog and using "clinical value" as the core evaluation standard [2] - The continuous and predictable nature of the policy allows companies to better plan the commercialization path of innovative drugs. In the oncology field, ADC drugs have become a highlight, with multiple domestic ADC drugs passing the preliminary review [2] - Guojin Securities analyzed that the global oncology immunotherapy has entered a new era of PD-1 combined with TAA and cytokines, with China's innovative drug business development (BD) accounting for 40% of the global total. The evolution from PD-1 to PD-1/VEGF or IL-2 bispecific antibodies is underway, with early data from Innovent Biologics' PD-1/IL-2 in multiple indications [2]

Group 1 - The core viewpoint of the news highlights the positive performance of the biotech sector, particularly driven by a significant collaboration in the AI pharmaceutical space, which has boosted investor sentiment and stock prices of key companies in the sector [1][2] - The Kexin Biopharmaceutical ETF (588250.SH) rose by 0.89%, with its associated index Kexin Biopharmaceutical (000683.SH) increasing by 0.90%. Notable stock performances included Junshi Biosciences-U up by 10.92% and CanSino up by 7.96% [1] - A major order of approximately $59.9 billion was announced by Crystal Technology Holdings, which is expected to enhance the innovation drug sector's outlook and positively impact related stocks [1] Group 2 - Research from Guolian Minsheng Securities indicates a strong net subscription performance for pharmaceutical and biotech theme funds in Q2 2025, with notable funds like Huatai Fuyou Innovation Medicine A and Yongying Medicine Innovation Smart Selection C leading in net subscriptions [2] - The innovative drug industry is reportedly at a turning point, with domestic pharmaceutical companies achieving commercial closure through business development collaborations, which is expected to improve the financing environment and support valuation recovery for innovative drug companies [2]

Group 1 - Overseas business development (BD) continues to exceed expectations, with CSPC Pharmaceutical Group licensing its oral GLP-1 small molecule to Madrigal for an upfront payment of $120 million, setting a record for similar transactions and highlighting the premium capability of Chinese technology platforms [1] - Breakthrough in treatment paradigm with Shuyou's C5a antibody BDB-001, which outperformed hormone therapy in treating anti-neutrophil cytoplasmic antibody vasculitis, achieving a complete response rate that is ten times higher, laying the foundation for subcutaneous formulations to enter international markets [1] - The National Healthcare Security Administration's Department of Drug Pricing and Procurement supports high-level innovative drugs to achieve returns that correspond with high investment and risk during the initial market phase, indicating a satisfactory price level, and is actively facilitating the rapid clinical introduction of new drugs through streamlined approval processes [1] Group 2 - As of August 1, 2025, the Sci-Tech Innovation Biopharmaceutical ETF (588250) has risen by 2.5%, with Zhongyin Securities noting that pharmaceutical companies are gradually overcoming the impact of centralized procurement, highlighting revaluation opportunities in the pharmaceutical sector [2] - The pharmaceutical sector is witnessing a shift in policy attitudes, with optimization of centralized procurement rules, and after years of R&D investment, new pipelines are entering a harvest phase, further evidenced by the accelerating trend of overseas BD, indicating that China's innovative drugs are becoming more competitive globally [2] - The Sci-Tech Innovation Biopharmaceutical ETF closely tracks the Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index, which selects 50 large-cap companies from various sectors, reflecting the overall performance of representative biopharmaceutical companies listed on the Sci-Tech Innovation Board [2] Group 3 - As of July 31, 2025, the top ten weighted stocks in the Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index (000683) include United Imaging Healthcare, Boryung Pharmaceutical, BeiGene, Baillie Gifford, Huatai Medical, Aier Eye Hospital, Zai Lab, Junshi Biosciences, Yifan Biotech, and Teva Pharmaceutical, collectively accounting for 49.14% of the index [3]

Core Insights - The recent performance of the Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index shows mixed results, with notable gains from companies like Teabo Bio and Yifang Bio, while Baili Tianheng led the declines [1] - The underlying logic of innovative drugs has shifted from "from nothing to something" to "from something to refinement," emphasizing the importance of advanced engineering and specific technology tracks in China [1] - The market for innovative drugs is expected to see significant growth, with projections indicating that Chinese gene-based innovative drugs could achieve sales of $200 billion to $250 billion in the global pharmaceutical market [1] Market Overview - The current valuation of leading companies in the ADC and PD1 plus sectors suggests that the market has not yet reached a reasonable valuation, indicating potential for further growth [1] - The overall market capitalization of the innovative drug sector has increased from 1.3 trillion to 2.4 trillion, reflecting a substantial market expansion [1] - The potential market capitalization increase could range from 1.8 trillion to 2.7 trillion, suggesting that the sector has realized 40-60% of its potential growth [1] Future Catalysts - There are still opportunities for companies to secure business development (BD) orders, which could drive further growth [2] - The backdrop of multinational corporations facing patent cliffs is likely to lead to continued significant investments in innovative drugs [2] - The commercialization of Chinese gene-based innovative drugs in overseas markets is expected to ramp up, contributing to overall market growth [3] Index Composition - The Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index comprises 50 major companies in the biopharmaceutical sector, with the top ten stocks accounting for 50.3% of the index [3]

Group 1 - The Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index (000683) increased by 0.73% as of July 28, 2025, with notable gains from companies such as Junshi Biosciences (688180) up 3.74% and Zai Lab (688266) up 3.30% [1] - The recent outbreak of Chikungunya fever in Guangdong Province has led to nearly 3,000 new local cases, primarily concentrated in Foshan and Guangzhou, with a cumulative total exceeding 4,800 confirmed cases [1] - The Sci-Tech Biopharmaceutical ETF (588250) rose by 0.82%, with the latest price reported at 1.23 yuan [1] Group 2 - Short-term focus on beneficiaries of the Chikungunya fever outbreak includes the vaccine sector, which may see valuation recovery due to market sentiment stabilizing despite anticipated performance pressure in 2024 [2] - The pharmacy sector is adapting to changes in medical insurance and regulatory environments, with companies like Yao Yi Tang exploring new business models, such as health and beauty products, to enhance profitability [2] - The diagnostics sector may experience renewed demand due to the Chikungunya fever, following the normalization of COVID-19 related demand [2] Group 3 - As of June 30, 2025, the top ten weighted stocks in the Shanghai Stock Exchange Sci-Tech Innovation Board Biopharmaceutical Index accounted for 50.3% of the index, including companies like United Imaging Healthcare (688271) and BeiGene (688235) [3]