Drugs 第 15 期 本周 熟点 2025年11月10日—11月6日 周临床研究 创新药临床试验 进度在临床试验 登记信息 II期及以上 37条 94条 资本眼 医药生物指数 创新药(BK1106) 周内涨跌 ▲2.19% 周内涨跌 ▲.93% 恒生医疗保健业指数 港股创新药ETF (HSCICH) (513120) 周内涨跌 ▲7.18% 周内涨跌 ▲5.90% 打开百度APP畅享高清图片 资本眼 一周行情 11月10日至11月14日，医药生物指数上涨2.19%，跑赢上证指数2.65个百分点，结束近2个月的低迷行 情。创新药（BK1106）周内上涨4.93%；恒生医疗保健业指数（HSCICH）周内上涨7.18%；港股创新 药ETF（513120）周内上涨5.90%。 一周点评 港股18A首例反向收购案新进展：嘉和生物披露私有化计划 11月14日，嘉和生物药业（开曼）控股有限公司（以下简称"嘉和生物"）再次向港交所提交有关建议合 并的上市申请。今年4月15日，嘉和生物向港交所提交有关建议合并的上市申请，该招股书目前已失 效。 《每日经济新闻》记者注意到，上述文件内容涉及一项需独立股东批准的私有化建议或重大 ...

第 15 日 本周 热点 2025年11月10日-11月6日 一周临床研究 创新药临床试验 进度在临床试验 登记信息 Ⅱ期及以上 37条 94条 资本眼 医药生物指数 创新药(BK1106) 周内涨跌 ▲2.19% 周内涨跌 ▲4.93% 恒生医疗保健业指数 港股创新药ETF (513120) (HSCICH) 内涨跌) - 7.18% 周内涨跌 ▲5.90% - A股当周涨跌幅 - 富祥药业 必贝特 周内涨跌 64.46% [周内涨跌 6.42% - 港股当周涨跌幅 - 歌礼制药-B | 药明生物 周内涨跌 ^ 33.04% 周内涨跌 5.27% 聚焦前沿 一周行情 11月10日至11月14日，医药生物指数上涨2.19%，跑赢上证指数2.65个百分点，结束近2个月的低迷行情。创新药（BK1106）周内上涨 4.93%；恒生医疗保健业指数（HSCICH）周内上涨7.18%；港股创新药ETF（513120）周内上涨5.90%。 一周点评 嘉和生物于2020年登陆港股市场。2024年9月13日，嘉和生物与亿腾医药集团有限公司（以下简称"亿腾医药"）订立合并协议。亿腾医药拟 通过换股方式反向收购嘉和生物，这是港股1 ...

Core Viewpoint - Citibank hosted its 2025 China Summit and reaffirmed its "Buy" rating for Fosun International (00656.HK), raising the target price to HKD 6.5, highlighting the company's strategic focus on core businesses and global expansion [1] Group 1: Strategic Focus and Financial Health - Fosun International is committed to a "streamlining and focusing" strategy, optimizing its financial structure, and demonstrating a strong determination in deleveraging and disposing of non-core assets [1] - Multiple domestic and international brokerages, including Citibank and UBS, maintain a "Buy" or "Overweight" rating for Fosun, with target prices ranging from HKD 6.5 to HKD 7.5, reflecting confidence in the company's business resilience and innovation potential [1] Group 2: Health Sector Innovations - Fosun's health sector is driven by innovation, with several breakthrough drugs, including the first PD-1 monoclonal antibody approved for small cell lung cancer treatment, now available in nearly 40 countries [2] - Another innovative drug, HLX43, is undergoing clinical trials in multiple countries and has the potential to become a highly effective and safe broad-spectrum anti-cancer drug [2] Group 3: Tourism and Consumer Sectors - During the 2025 National Day and Mid-Autumn Festival, Fosun's tourism sector saw significant visitor numbers and revenue growth, with Club Med resorts reporting a 36% increase in total revenue year-on-year [3] - The consumer sector is adjusting its strategy, with expectations for recovery in the jewelry segment, supported by improving performance and market conditions [3] Group 4: Asset Management and Fintech Innovations - Fosun is innovating in asset management and fintech, with its subsidiary, Xinglu Technology, becoming a leading player in Hong Kong's fintech market, focusing on AI-driven wealth technology [4] - The company is advancing into the virtual asset market and has launched the FinRWA Platform, providing compliant and efficient Web3 access services [4] - Brokerages view Fosun's core industries as stable, with a focus on leveraging strengths and potential, enhancing global presence, and increasing technological innovation [4]

Group 1: Company Overview - Citibank hosted its 2025 China Summit and reaffirmed a "Buy" rating for Fosun International, raising the target price to HKD 6.5, reflecting confidence in the company's strategic focus on core businesses and global expansion [1] - Multiple domestic and international brokerages maintain a "Buy" or "Overweight" rating for Fosun International, with target prices ranging from HKD 6.5 to 7.5, indicating strong market sentiment towards the company's resilience and innovation potential [1] Group 2: Health Sector - Fosun's health segment is driven by innovation, with several breakthrough drugs, including the first PD-1 monoclonal antibody approved for first-line treatment of small cell lung cancer, now available in nearly 40 countries [2] - The insurance segment, exemplified by Fidelidade, is projected to achieve steady growth with a 12.7% year-on-year increase in insurance revenue and a net profit of EUR 253 million, maintaining a strong market position [2] Group 3: Tourism and Consumption - During the 2025 National Day and Mid-Autumn Festival, Fosun's tourism sector saw significant visitor numbers, with Club Med resorts reporting a 36% year-on-year increase in total revenue and a 213% surge in inbound tourists [3] - The consumption sector is undergoing strategic adjustments, with expectations for recovery in core businesses, particularly in jewelry, as market conditions improve and global expansion deepens [3] Group 4: Asset Management and Fintech - Fosun is innovating in asset management and fintech, with its subsidiary, Xinglu Technology, emerging as a leading player in Hong Kong's fintech market, focusing on AI-driven wealth technology [4] - The company is advancing into the virtual asset market with the FinRWA Platform, providing compliant Web3 access services and launching several innovative projects, including the first tokenized fund in Hong Kong [4]

Group 1: Core Business Strategy - Citibank hosted its 2025 China Summit and reiterated a "Buy" rating for Fosun International, raising the target price to HKD 6.5, highlighting the company's focus on core business and global expansion [1] - Fosun is committed to optimizing its financial structure, with a strong determination to reduce leverage and dispose of non-core assets, which is expected to enhance financial stability and focus on core operations [1][2] - Multiple domestic and international brokerages maintain a "Buy" or "Increase" rating for Fosun International, with target prices ranging from HKD 6.5 to 7.5, reflecting confidence in the company's business resilience and innovation [1] Group 2: Health Sector Innovations - Fosun's health sector is driven by innovation, with several breakthrough drugs, including the first PD-1 monoclonal antibody approved for first-line treatment of small cell lung cancer, now available in nearly 40 countries [2] - Another innovative drug, HLX43, is undergoing clinical research in various countries and has the potential to become a highly effective and safe broad-spectrum anti-cancer drug [2] Group 3: Tourism and Consumer Sectors - During the 2025 National Day and Mid-Autumn Festival, the Taicang Alps International Resort received over 50,000 visitors, and Club Med resorts saw a nearly 10% increase in average daily room rates [3] - The consumer sector is adjusting strategies, with expectations for growth in the jewelry segment, as indicated by the resilience of Fosun's consumer business [3] Group 4: Asset Management and Fintech Innovations - Fosun is innovating in asset management and fintech, with its subsidiary, Xinglu Technology, becoming a leading fintech company in Hong Kong, focusing on AI-driven wealth technology [4] - Xinglu Technology has launched the FinRWA Platform, providing compliant and efficient Web3 access services, and has been recognized as a key enterprise by the Hong Kong government [4] - Brokerages express optimism about Fosun's core industries and its focus on technological innovation, which is expected to enhance its long-term growth potential [4]

Core Insights - Merck's PD-1 monoclonal antibody, Keytruda, has achieved global sales exceeding $20 billion in both 2023 and 2024, solidifying its position as the leading drug in the lung cancer market [1] Industry Overview - Lung cancer remains the leading cause of cancer globally, with 2.4 million new cases each year, and China reporting significantly higher new cases than other countries [3] - The rise of targeted and immunotherapy treatments has transformed the treatment landscape for lung cancer, with new therapies such as ADCs, bispecific antibodies, and tumor vaccines expanding treatment options [3] Competitive Landscape - A race is underway among pharmaceutical companies to establish the next generation of immunotherapy leaders in lung cancer, with companies like Junshi Biosciences, Kintor Pharmaceutical, and Innovent Biologics actively competing [2][3] - Junshi Biosciences has reported promising results for its PD-L1 ADC, HLX43, showing an objective response rate (ORR) of 33.3% in squamous non-small cell lung cancer (NSCLC) patients and 48.6% in non-squamous patients [2] - Kintor Pharmaceutical's PD-1/VEGF bispecific antibody, Ivoris, is currently undergoing eight pivotal phase III clinical trials [5] - Innovent Biologics has announced a collaboration with Takeda Pharmaceutical to co-develop a new generation of immunotherapy, IBI363, which targets PD-1 and IL-2α [6] Clinical Development - Junshi Biosciences plans to initiate at least eight phase III clinical trials for HLX43 in the lung cancer space, with additional studies planned for cervical cancer, esophageal squamous cancer, and colorectal cancer [2][7] - The cost of each global phase III clinical trial is estimated to be around $200 million, presenting a significant financial challenge for companies [7] Financial Performance - Junshi Biosciences reported revenue of 2.82 billion yuan in the first half of the year, a year-on-year increase of 2.7%, with net profit remaining stable at 390 million yuan [7]

Core Viewpoint - Merck's PD-1 monoclonal antibody, Keytruda, has achieved over $20 billion in annual sales in both 2023 and 2024, solidifying its position as the global leader in the lung cancer treatment market [3]. Group 1: Company Updates - Jun Zhu, CEO of Junshi Biosciences, announced plans for at least eight Phase III clinical trials for HLX43, a PD-L1 ADC targeting non-small cell lung cancer (NSCLC) [5]. - HLX43 demonstrated an objective response rate (ORR) of 33.3% and a disease control rate (DCR) of 75.8% in squamous NSCLC patients, with ORR rising to 48.6% and DCR reaching 94.3% in non-squamous patients [4]. - Junshi Biosciences reported a revenue of 2.82 billion yuan in the first half of the year, a 2.7% increase year-on-year, with a net profit of 390 million yuan, remaining stable compared to the previous year [10]. Group 2: Industry Trends - The competition for the next generation of immune therapies in lung cancer is intensifying, with companies like Junshi Biosciences, Kintor Pharmaceutical, and Innovent Biologics all vying for leadership [6]. - The rise of targeted and immune therapies has reshaped the treatment landscape for lung cancer, expanding the boundaries of treatment options from ADCs to bispecific antibodies and tumor vaccines [5]. - Kintor Pharmaceutical is advancing its PD-1/VEGF bispecific antibody, Ivorin, with plans for eight Phase III clinical studies, while Innovent Biologics is collaborating with Takeda Pharmaceutical on a new generation immune therapy, IBI363 [8].

Core Insights - The approval of PD-1 inhibitors Keytruda and Opdivo a decade ago has significantly transformed cancer treatment, particularly in lung cancer, melanoma, and lymphoma, marking the beginning of the immunotherapy era [1] - As key patents near expiration and biosimilars enter the market, the market share of leading products is under pressure, with Merck's Keytruda sales growth slowing to 8% and BMS's Opdivo experiencing a 1% decline [1][2] - The oncology market is evolving into a 2.0 era, with companies like Merck and BMS focusing on combination therapies involving ADCs (antibody-drug conjugates) to maintain competitive advantages [1][2] Industry Trends - The global oncology drug market is projected to grow from $168 billion in 2020 to $247 billion by 2024, with a compound annual growth rate (CAGR) of 10.2%, while the ADC market is expanding rapidly with a CAGR of 41.7% [1] - Merck is actively building a "PD-1+ADC" treatment matrix, acquiring ADC technologies and collaborating with various companies to enhance the efficacy and application of Keytruda [2] - The KEYNOTE-905 study presented at ESMO 2025 demonstrated significant clinical benefits of combining Keytruda with Padcev in treating muscle-invasive bladder cancer, potentially changing clinical practices [3] Company Developments - Domestic companies like Fuhong Hanlin are making strides in ADC development, with promising clinical data for their PD-L1 ADC HLX43 in non-small cell lung cancer (NSCLC) [4] - The Chinese market is witnessing a shift towards innovative therapies, with a focus on combination strategies involving PD-1 inhibitors and ADCs, as well as dual-targeting antibodies [5][6] - Major pharmaceutical companies are increasingly interested in acquiring innovative assets in the PD-1 and ADC space, indicating a trend towards collaboration and co-development in the industry [6]

Core Insights - The approval of PD-1 inhibitors Keytruda and Opdivo a decade ago has significantly transformed cancer treatment, particularly in lung cancer, melanoma, and lymphoma, marking the beginning of the immunotherapy era [1] - As key patents near expiration and biosimilars enter the market, the market share of leading products is under pressure, with Merck's Keytruda sales growth slowing to 8% and BMS's Opdivo experiencing a 1% decline [1] - The oncology market is evolving into a "2.0 era," with companies like Merck and BMS focusing on combination therapies involving PD-1 and ADCs to maintain competitive advantages [1][2] Industry Overview - The global oncology drug market is projected to grow from $168 billion in 2020 to $247 billion by 2024, with a compound annual growth rate (CAGR) of 10.2%, while the ADC market is expected to exceed $35 billion with a CAGR of 41.7% [1] - The shift in market dynamics indicates a move towards a multi-target competition era, emphasizing ADCs and combination therapies [1] Company Strategies - Merck is actively building a "PD-1+ADC" treatment matrix through acquisitions and partnerships, aiming to extend the lifecycle of Keytruda [2] - Recent FDA approvals for combination therapies, such as Keytruda with Padcev for bladder cancer, highlight the potential for these combinations to change clinical practices [3] - BMS has also expanded its combination therapies, with its dual immunotherapy for liver cancer becoming the first approved in China [3] Domestic Innovations - Chinese biotech companies are rapidly advancing in the "PD-1+ADC" space, with companies like Junshi Biosciences reporting promising clinical data for their PD-L1 ADC, HLX43, in non-small cell lung cancer [4] - The industry is moving towards "dual antibodies/multi-antibodies + ADC" strategies, with companies like Rongchang Bio and Pfizer exploring innovative combinations [5] Future Directions - The next generation of IO and ADC therapies is expected to become a focal point for multinational corporations in the oncology sector, with a strong emphasis on business development in China [6] - Companies are increasingly inclined to pursue co-development models as clinical data becomes more robust, indicating a trend towards strategic partnerships in the industry [6]

Core Insights - The article highlights the significant advancements in China's innovative drug sector, particularly focusing on the achievements of the company, Junshi Biosciences, in the field of lung cancer treatment [1][14][19] - The company has made notable progress with its core products, HLX43 and HLX07, which are positioned to address unmet medical needs in lung cancer therapy [3][15] Product Development and Clinical Data - HLX43, a leading PD-L1 ADC drug, has shown impressive clinical data in treating non-small cell lung cancer (NSCLC), with an objective response rate of 33.3% in squamous cell carcinoma patients and 48.6% in non-squamous patients [3][4] - The drug demonstrated a 38.5% objective response rate in previously treated squamous NSCLC patients, significantly outperforming historical data for docetaxel [4][5] - HLX07 targets EGFR high-expressing squamous NSCLC, achieving an objective response rate of 69.2% to 71.4% when combined with H drug and chemotherapy [9][8] Market Potential and Strategic Positioning - HLX43 is projected to reach risk-adjusted sales of $3.8 billion by 2036, contributing approximately 54% to the company's valuation [5][6] - The company has established a comprehensive product ecosystem in lung cancer treatment, including H drug, which is the first PD-1 monoclonal antibody approved for first-line treatment of small cell lung cancer [14][15] - The company is also developing over five innovative drugs targeting lung cancer in the preclinical stage, indicating a robust pipeline for future growth [15][18] Global Expansion and Recognition - The company has successfully expanded its products to approximately 60 countries, showcasing its commitment to global market presence [19] - Goldman Sachs has initiated coverage with a "buy" rating and a target price of HKD 100.7, indicating over 50% upside potential, reflecting confidence in the company's clinical and commercial capabilities [19]