Core Viewpoint - Zhongyin International reports that CSPC Pharmaceutical Group (01093) experienced a 6% quarter-on-quarter revenue growth in Q3 2025, reaching 6.6 billion RMB, primarily due to the absorption of negative impacts on traditional oncology products. However, net profit decreased by 10% to 964 million RMB due to a significant increase in operating expenses. The target price is adjusted to HKD 8.5, maintaining a "Hold" rating, which corresponds to a 20x P/E ratio for 2026 [1]. Revenue and Profit Analysis - Q3 2025 revenue reached 6.6 billion RMB, reflecting a 6% quarter-on-quarter increase [1] - Net profit for Q3 2025 decreased by 10% to 964 million RMB, attributed to rising operating expenses [1] Management Guidance - Management maintains guidance for a mid-single-digit recovery in H2 2025 compared to H1 2025, despite uncertainties from the upcoming national centralized procurement renewal and strict control of medical insurance fund expenditures [1] - Anticipated product launches in H1 2026 include innovative products (e.g., Bai Zi II, KN026) and biosimilars (e.g., Omadubmab, Pertuzumab), although management remains cautious about the domestic market outlook for 2026 [1] Strategic Focus - To address domestic uncertainties, internationalization is emphasized as a key strategic priority [1] - R&D expenses are expected to increase by 15% to 20% year-on-year in 2026 [1] Revenue Forecast Adjustments - Zhongyin International maintains its 2025 revenue forecasts due to Q3 performance meeting expectations, but lowers revenue forecasts for 2026 and 2027 by 5.8% and 8.5%, respectively, due to uncertainties from national centralized procurement and potentially slower new product sales growth [1]

Core Insights - Zhongjin International reported that CSPC Pharmaceutical Group (01093) achieved a quarterly revenue growth of 6% to 6.6 billion RMB in Q3 2025, primarily due to the absorption of negative impacts on traditional oncology products [1] - However, net profit decreased by 10% to 964 million RMB, mainly due to a significant increase in operating expenses [1] - The target price has been adjusted down to 8.5 HKD, maintaining a "Hold" rating, which corresponds to a 20x P/E ratio for 2026 [1] Revenue and Profit Analysis - All core therapeutic areas experienced sales growth, indicating a positive trend in the company's product performance [1] - The management maintains guidance for a mid-single-digit recovery in performance for the second half of 2025 compared to the first half [1] - The anticipated uncertainty from the upcoming national centralized procurement renewal and strict control of medical insurance fund expenditures has led to a cautious outlook for the domestic market in 2026 [1] Strategic Focus and R&D - The management emphasized that internationalization is a key strategic focus to address domestic uncertainties [1] - R&D expenses are expected to increase by 15% to 20% year-on-year in 2026, reflecting the company's commitment to innovation [1] - Despite the expected launch of innovative products and biosimilars in the first half of 2026, the management remains cautious about the growth rate of new product sales [1] Forecast Adjustments - Zhongjin International has maintained its 2025 forecasts due to Q3 performance meeting expectations [1] - However, revenue forecasts for 2026 and 2027 have been reduced by 5.8% and 8.5%, respectively, due to uncertainties surrounding the first to eighth batches of national centralized procurement and potential slower-than-expected sales growth of new products [1]

Core Viewpoint - The report from Zhongyin International indicates that the revenue of CSPC Pharmaceutical Group increased by 6% quarter-on-quarter to 6.6 billion yuan, primarily due to the recovery from negative impacts on traditional oncology products, with sales growth across all core therapeutic areas [1] Financial Performance - Revenue for the third quarter reached 6.6 billion yuan, reflecting a 6% increase compared to the previous quarter [1] - Net profit decreased by 10% to 964 million yuan, attributed to a significant rise in operating expenses [1] Management Guidance - Management maintains guidance for a mid-single-digit recovery in performance for the second half of 2025 compared to the first half [1] - Despite the anticipated launch of innovative products and biosimilars in the first half of 2026, management expresses caution regarding the domestic market outlook due to uncertainties from upcoming national procurement renewals and strict control of medical insurance fund expenditures [1] Forecast Adjustments - The firm has kept its 2025 revenue forecast unchanged, but has lowered the revenue projections for 2026 and 2027 by 5.8% and 8.5% respectively, due to uncertainties surrounding the national procurement renewals and potentially slower-than-expected sales growth of new products [1] - The target price has been adjusted down to 8.5 HKD, while maintaining a "Hold" rating [1]

Investment Rating - The industry investment rating is "Outperform the Market" (预计6个月内，行业指数表现强于市场表现5%以上) [31] Core Insights - The acquisition of Crown Bioscience International by the report's subject company,艾迪康, for a base consideration of $204 million (approximately 1.48 billion RMB), marks a strategic shift from clinical testing services to drug development, aligning with the trend of collaborative development in precision medicine [3][13] - The report emphasizes the importance of CROs possessing translational medicine capabilities to facilitate the rapid transition from preclinical biomarkers to clinical trials and diagnostic processes [3] Summary by Sections Industry Overview -艾迪康 announced the acquisition of Crown Bioscience International, a global CRO focused on oncology and immuno-oncology drug discovery and development, with the transaction expected to complete by mid-2026 [3] Investment Strategy - The report suggests focusing on innovative pharmaceutical companies with rich pipeline layouts, such as 恒瑞医药, 百济神州, and 中国生物制药, as well as companies with significant single-product potential like 一品红 and 三生制药 [5] - It also highlights the importance of companies with leading positions in cutting-edge technology platforms, such as 东诚药业 and 远大医药, and suggests monitoring the CXO sector for stable growth in R&D investment [5] Market Performance - The pharmaceutical sector saw a 3.29% increase last week, ranking 4th among 28 industries, while the Hong Kong pharmaceutical sector rose by 6.80%, ranking 2nd among 11 industries [7][30] - The report notes that the valuation of the pharmaceutical sector is currently at 30.89 times (TTM), with a premium of 22.29% over the overall A-shares [23]

Core Viewpoint - Fosun Pharma's subsidiary, Shanghai Fuhong Hanlin Biotechnology Co., Ltd., received FDA approval for its self-developed injectable drug POHERDY®1 (HLX11), indicating a significant advancement in the treatment of HER2-positive metastatic breast cancer [1] Group 1: FDA Approval Details - The FDA approved the biologics license application (BLA) for POHERDY®1, which is an injectable solution for intravenous use [1] - The approved indications include treatment for adult patients with HER2-positive metastatic breast cancer who have not previously received anti-HER2 therapy or chemotherapy [1] - The drug is also indicated for use in combination with trastuzumab and chemotherapy for early-stage breast cancer as part of a comprehensive treatment plan [1] Group 2: Treatment Applications - POHERDY®1 is indicated for neoadjuvant treatment in adult patients with HER2-positive locally advanced, inflammatory, or early breast cancer [1] - It is also approved for adjuvant treatment in adult patients with HER2-positive early breast cancer who are at high risk of recurrence [1]

Core Viewpoint - Fosun Pharma's subsidiary, Shanghai Fuhong Hanlin Biotech Co., Ltd., has received FDA approval for its self-developed injection POHERDY®1, indicating a significant advancement in the treatment of HER2-positive metastatic breast cancer [1]. Group 1: FDA Approval Details - The FDA approved the biologics license application (BLA) for POHERDY®1, which is an injection for intravenous use [1]. - The approved indications include treatment for adult patients with HER2-positive metastatic breast cancer who have not previously received anti-HER2 treatment or chemotherapy [1]. - The drug is also approved for use in combination with trastuzumab and chemotherapy for early-stage breast cancer as part of a comprehensive treatment plan [1]. Group 2: Treatment Applications - POHERDY®1 is indicated for neoadjuvant treatment in adult patients with HER2-positive locally advanced, inflammatory, or early breast cancer [1]. - It is also approved for adjuvant treatment in adult patients with HER2-positive early breast cancer who are at high risk of recurrence [1].

Core Viewpoint - Fosun Pharma's subsidiary, Shanghai Fuhong Hanlin Biotechnology Co., Ltd., received FDA approval for its self-developed injectable drug POHERDY®1, indicating a significant advancement in the treatment of HER2-positive metastatic breast cancer and early-stage breast cancer [1] Group 1: FDA Approval Details - The FDA approved the biologics license application (BLA) for POHERDY®1, which is an injectable solution for intravenous use [1] - The approved indications include treatment for adult patients with HER2-positive metastatic breast cancer who have not previously received anti-HER2 treatment or chemotherapy [1] - The drug is also approved for use in combination with trastuzumab and chemotherapy for early-stage breast cancer patients, specifically for those with locally advanced, inflammatory, or early-stage breast cancer [1] Group 2: Treatment Combinations - POHERDY®1 is indicated for use in conjunction with trastuzumab and docetaxel for treating metastatic breast cancer [1] - It is also part of a comprehensive treatment regimen for early-stage breast cancer patients with high recurrence risk [1] - The drug serves as neoadjuvant therapy for adult patients with HER2-positive, locally advanced, inflammatory, or early-stage breast cancer [1]

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Investment Rating - The report maintains an investment rating of "Positive" for the pharmaceutical and biotechnology sector [2]. Core Insights - The recent FDA priority review of Enhertu in combination with pertuzumab is expected to reshape first-line treatment for HER2-positive breast cancer, with a decision anticipated in Q1 2026 [16][31]. - The pharmaceutical sector has experienced a recent overall pullback, primarily due to a lack of significant business development and catalysts in the innovative drug space during August and September [14]. - The report suggests focusing on stocks with potential high growth or exceeding expectations for Q3 earnings as the third-quarter reports approach [14]. Summary by Sections 1. Industry Overview - The pharmaceutical and biotechnology sector's return was -2.20% last week, underperforming the CSI 300 by 3.27%, ranking 24th among 31 primary sub-indices [13]. - Over the past month, the sector's return was -4.73%, with a relative performance of -6.92% against the CSI 300, ranking 21st [13]. 2. Market Performance - The recent one-month performance of the pharmaceutical sector was -4.73%, with a relative performance of -6.92% against the CSI 300 [38]. - The sector's current PE (TTM) stands at 30.72, which is above the historical average of 29.33 [39]. 3. Focus Areas for Investment - The report highlights several focus areas for investment: 1. Demand recovery in the innovative drug supply chain, particularly in CXO and life sciences [15]. 2. High-end medical device import substitution and accelerated overseas expansion [15]. 3. AI in healthcare, emphasizing the performance of AI-driven pharmaceutical e-commerce and marketing [15]. 4. Innovative drugs with significant breakthroughs in product pipelines, recommending companies like Innovent Biologics and Hengrui Medicine [15]. 4. Enhertu's Clinical Data - Enhertu in combination with pertuzumab demonstrated a significant improvement in median progression-free survival (mPFS) from 26.9 months to 40.7 months, reducing the risk of disease progression or death by 44% [18][31]. - The safety profile of the Enhertu + pertuzumab combination aligns with known safety characteristics of both drugs, showing a lower rate of treatment discontinuation due to adverse events compared to the THP regimen [28][31].

Investment Highlights - The company is covered for the first time by CICC with an "outperform" rating and a target price of HKD 102.91, based on DCF valuation, positioning it as a leading innovative biopharmaceutical enterprise in China [1] - The company has adopted a dual strategy of innovation and internationalization, achieving domestic and international approvals for 6 and 4 products respectively by the end of 2024, establishing itself as a leader in domestic biopharmaceuticals [1] - Revenue has grown significantly from CNY 91 million in 2019 to CNY 5.724 billion, with a CAGR of 129%, while overseas revenue increased from CNY 2.62 million to CNY 678 million, expected to account for 11.9% of total revenue in 2024 [1] Innovation Pipeline - The company has developed a diverse innovation pipeline covering approximately 50 molecules, focusing on cutting-edge areas such as monoclonal antibodies, multi-antibodies, and ADCs [1] - HLX43 is the world's first PD-L1 ADC to enter clinical phase II, offering safety and competitive advantages, with low hematologic toxicity supporting its future use in first-line treatments and combination immunotherapy [1] - HLX22 has entered phase III international multicenter clinical trials for first-line treatment of advanced gastric cancer, with expectations to redefine standard therapies based on efficacy and safety data [1] Biosimilar Development - The company has a rich pipeline of biosimilars, leveraging first-mover advantages in the domestic market, with smooth commercialization progress anticipated [2] - It is expected that the domestic biosimilar procurement price reduction will be rational, allowing the company to achieve volume-based pricing [2] - The company has made strides in internationalization, with overseas revenue from Hanquyou reaching approximately CNY 120 million in 2024, a year-on-year increase of nearly 30%, and FDA approval achieved [2] Financial Forecast and Valuation - The company’s EPS is projected to be CNY 1.46 and CNY 1.55 for 2025 and 2026 respectively, with a CAGR of 1.2% [2] - Using a DCF valuation method with a WACC of 9.0% and a perpetual growth rate of 2.0%, the reasonable valuation for 2025 corresponds to a target price of HKD 102.91, implying an upside potential of 28.6% [2]