Summary of Gilead Sciences (GILD) Conference Call Company Overview - **Company**: Gilead Sciences (GILD) - **Date of Conference**: September 03, 2025 - **Key Speaker**: Dietmar Berger, CMO of Gilead Core Industry Insights Virology - Gilead has a strong portfolio in virology, with industry-leading capabilities and positive data readouts, particularly with the S2Go launch and upcoming ARTIS studies [7][10] - The company is focusing on both prevention and treatment options, including a once-a-year lenacapavir study (Purpose 365) [7][16] - ARTISTRY one and two are phase three trials for a new HIV treatment combining bictegravir and lenacapavir, targeting patients on complex regimens [11] Oncology - Gilead's oncology strategy includes a strong focus on Trodelvy, with recent positive data from ASCENT studies in breast cancer [7][30] - The company is expanding its oncology portfolio with multiple studies in various cancer types, including hormone receptor-positive breast cancer and small cell lung cancer [31][32] - Gilead has acquired Enterius to enhance its CAR T cell therapy capabilities, focusing on both outpatient settings and next-generation CAR T approaches [38][39] Inflammation - Gilead is developing an early-stage inflammation portfolio, including an oral alpha four beta seven molecule in phase two for inflammatory bowel disease (IBD) [8][44] - The company is exploring combination therapies to enhance efficacy in IBD treatment, recognizing the need to break the efficacy ceiling of current monotherapies [47] Key Developments and Future Outlook - Gilead has 52 molecules in development, indicating a diverse and rich pipeline [9] - The company is committed to maintaining high efficacy standards, particularly in prevention strategies, aiming for 99% effectiveness [16] - Upcoming data releases and studies are expected to provide further insights into the efficacy and tolerability of Gilead's therapies, particularly in oncology and inflammation [18][19][32] Additional Considerations - Gilead is actively looking to build a sustainable portfolio in immunology, with a focus on early-stage assets and potential business development opportunities [45] - The company is also evaluating its GLP-1 program, currently in phase one, to assess its impact on obesity and diabetes [50] This summary encapsulates the key points discussed during the conference call, highlighting Gilead's strategic focus areas, ongoing developments, and future opportunities in the biopharmaceutical landscape.

Strategic Transformation & Growth - Gilead is making meaningful progress on strategic transformation with a strong 2023 execution, leading to a catalyst-rich 2024[5, 11, 28, 65] - The company's pipeline has grown by 88% since 2019, positioning it to deliver 10+ new transformative therapies by the end of 2030[18, 19] - Gilead's base business has returned to consistent growth, with an expected 7-8% year-over-year growth in 2023 driven by HIV and Oncology[21, 22] Oncology - Gilead is accelerating its oncology business, aiming for >$3 billion/year[7, 13, 30, 67] - Oncology revenue has grown significantly, reaching ~$3 billion in FY23, representing ~12% of total revenue compared to 2% in FY19[36] - Trodelvy programs reinforce pan-tumor potential, with >30 active or planned trials and >30,000 patients treated[40, 41] - In 1L mNSCLC, Trodelvy plus pembrolizumab demonstrated a strong 69% ORR in PD-L1 TPS>50% and 44% ORR in PD-L1 TPS<50% in the Phase 2 EVOKE-02 trial[48] - Yescarta is the 1 cell therapy in 2L+ LBCL with long-term, 5-year OS of 43% in 3L LBCL and delivered >6,000 cell therapies to patients in 2023[54] HIV - Gilead has a leading HIV portfolio poised for durable growth[9, 15, 32, 69] - Biktarvy is a global leader in HIV treatment, with >47% U S market share in Q3 2023 and projected U S and EU LOE in 2033[72, 73] - The company has an industry-leading HIV development portfolio with 10 clinical programs with lenacapavir[75, 76] - Gilead anticipates 5 potential new HIV product launches by 2030 in treatment & PrEP[17, 71, 78]

Summary of Gilead's Conference Call Company Overview - **Company**: Gilead Sciences - **Industry**: Pharmaceuticals and Biotechnology Key Points and Arguments Macro Environment and Strategy - Gilead is focused on delivering its strategy, emphasizing top-line growth and operational discipline despite macroeconomic uncertainties [2][3] - The company is managing scenario planning with a small team to navigate the fluid environment [3][6] Product Pipeline and Launches - Gilead has several product launches in progress, including: - **Libdelzi** launched in August [4] - **Lenacapavir** for prevention, with a PDUFA date of June 19 [4][32] - Upcoming data for needle cell therapy expected by year-end [4] - The company is well-prepared with an average effective tax rate of about 20% over the last four years, benefiting from its IP being primarily in the US [5] Drug Pricing and Market Access - Gilead is actively considering the implications of potential drug pricing reforms, including the Most Favored Nation (MFN) policy and its impact on pricing strategies [10][17] - The company believes that the value of its medicines will be recognized, and it is committed to ensuring access to its products [15][16] HIV Business Segment - The HIV segment constitutes approximately two-thirds of Gilead's total revenues [20] - Gilead is concerned about potential funding cuts at the CDC and HHS, which could impact HIV surveillance and treatment efforts [21][22] - The company is focused on education and advocacy to ensure lawmakers understand the importance of CDC funding for HIV initiatives [21] Lenacapavir Launch Strategy - Lenacapavir is expected to redefine HIV prevention with a dosing schedule of every six months, showing over 96% efficacy in trials [29][30] - Gilead anticipates achieving approximately 75% access within six months post-launch and 90% by the end of the first year [34] - The company is exploring flexible distribution options, including specialty pharmacies and alternate sites of care [49][50] Competitive Landscape - Gilead is aware of the competitive landscape, particularly regarding the Glaxo product, and is leveraging learnings from previous launches to optimize its strategy [55][56] - The company aims to capture market share from existing PrEP users and expand awareness among high-risk populations [65][66] Biktarvy Performance - Biktarvy is projected to generate around $14 billion in revenue, accounting for nearly 50% of Gilead's total revenues [68] - The product has over 51% market share in the integrase inhibitor market and continues to grow despite challenges from Part D redesign [70][71] - Gilead believes there is still significant growth potential for Biktarvy, especially as it continues to address the needs of patients not currently virologically suppressed [75] Additional Important Insights - Gilead emphasizes the importance of prevention in reducing new HIV cases and is committed to increasing awareness and education for at-risk populations [27][66] - The company is preparing for a switch strategy at the launch of Lenacapavir, targeting existing PrEP users while also focusing on expanding the market [62][65] This summary encapsulates the critical insights from Gilead's conference call, highlighting the company's strategic focus, product pipeline, market dynamics, and competitive positioning in the pharmaceutical industry.

吉利德和其他制药公司面临的挑战在于，税务改革虽然在某些方面有所推进，但公司利用低税区的税收优惠并未 完全消失，且这一现象可能会因即将实施的关税政策而进一步加剧。对此，花旗集团（ Citigroup ）的一位医疗 保健策略师特雷弗 • 戴维斯（ Traver Davis ）表示， " 对于那些拥有复杂供应链的公司而言，将面临更大的风险 暴露。 " 随着特朗普政府实施新一轮关税政策，部分生物科技公司开始受到华尔街投资者的青睐。尤其是那些将知识产权 和生产基地设在美国的公司，它们通常面临较高的税率，但也因此被视为能够有效抵御关税风险的"避风港"。 // 关税政策加剧行业压力 // 在 4 月的财报电话会议上，吉利德科学（ Gilead Sciences ）首席执行官丹尼尔 • 奥戴（ Daniel O'Day ）表示，该 公司约 20% 的企业税率 " 反映了我们大部分知识产权已经在美国注册 " 的事实。这种公开强调高税率的做法，恰 恰迎合了投资者对美国本土制造和知识产权保护的偏好。 特朗普上任时期，通过 2017 年的税改削减了海外利润转移的空间，但关键漏洞仍然存在。而现在，美国政府似 乎正准备利用关税手段，进一 ...

Core Insights - The report maintains a positive outlook on the HIV sector, highlighting Gilead's long-acting therapy, Lenacapavir, as a potential game-changer in HIV treatment and prevention [1][3]. Group 1: HIV Mechanism and Treatment - HIV is a retrovirus that selectively targets CD4+ cells, integrating its genetic material into the host's genome, leading to viral replication [5][7]. - The primary treatment for AIDS is the "cocktail therapy," which combines multiple antiviral drugs to minimize resistance and maximize viral suppression [5][7]. Group 2: Lenacapavir's Impact - Lenacapavir is Gilead's first long-acting HIV capsid inhibitor, showing promising results in clinical trials for treating multi-drug resistant HIV in adults [9][11]. - In the CAPELLA study, 83% of participants using Lenacapavir achieved a viral load of less than 50 copies/mL after 52 weeks, compared to only 11% in the placebo group [13][14]. - Lenacapavir has significant potential in post-exposure prophylaxis (PrEP), with studies indicating a 100% reduction in HIV infection risk among participants receiving biannual injections [20][21]. Group 3: Market Potential and Future Developments - The global HIV infection rate in 2023 was approximately 39.9 million, with a significant portion of the population being women [15][18]. - Lenacapavir's approval for PrEP is anticipated to set a new standard in HIV prevention, potentially generating substantial revenue for Gilead [23]. - Other recent advancements in HIV treatments include Merck's dual-drug therapy achieving positive results in Phase III trials and ViiV Healthcare's long-acting antibody therapy showing good efficacy [24][26].

Core Viewpoint - The health care sector is leading the market in 2025, contrary to expectations regarding the new administration's impact on pharmaceutical stocks [1] Sector Performance - The S&P 500 Health Care sector has shown a year-to-date performance of 8.45%, outperforming other sectors such as Consumer Staples (8.23%) and Financials (6.83%) [2] - Despite the overall S&P 500 Index being down 0.54% for the year, 9 out of 11 sectors remain in positive territory [2] Market Dynamics - There has been significant sector rotation, with investors moving away from growth and technology stocks towards more defensive sectors like health care and utilities [3] - The Zacks Medical – Biomedical and Genetics industry is currently ranked in the top 29% of approximately 250 Zacks Ranked Industries, indicating strong relative strength [8] Stock Analysis - Gilead Sciences (GILD) is highlighted as a leading stock within the biomedical industry, with a diversified product pipeline and expected FDA approval for its Lenacapavir solution for HIV prevention [10] - Gilead Sciences has a Zacks Rank of 2 (Buy) and has exceeded earnings expectations in the last four quarters, averaging a positive EPS surprise of 19.5% [11] - The stock has appreciated over 65% in the past year and is making new 52-week highs [11] Investment Strategy - The Zacks Rank System is designed to help identify winning stocks and outperform the market by focusing on industries and stocks with positive earnings estimate revisions [6] - The emphasis is on investing in leading stocks to maximize potential returns, particularly in the current market environment characterized by volatility [5][13]