Financial Data and Key Metrics Changes - The total revenue for the first half of 2025 amounted to RMB 1.57 billion, representing an increase of 67.6% compared to the same period last year [21] - Revenue from automotive solutions surged by 67%, with product solutions revenue increasing by 250% to RMB 777.8 million [21][22] - The overall gross margin was 65.4%, maintaining a strong position compared to other automotive solution providers [22] Business Line Data and Key Metrics Changes - The company shipped approximately 2 million units of automotive-grade processing hardware, more than doubling year on year [10] - Shipments of mid to high-level intelligent driving solutions accounted for half of total shipments, with a sixfold increase compared to the same period last year [10][12] - The average selling price (ASP) of solutions increased by 70% compared to last year, driven by a higher mix of mid to high-end solutions [15] Market Data and Key Metrics Changes - The penetration rate of intelligent driver assistance in domestic brands rose from 51% in 2024 to 59% in 2025 [6] - The market share of the company in the ADAS basic assisted driving market was 45.8%, and 32.4% in the overall intelligent assisted driving computing solutions market among Chinese domestic brands [9] Company Strategy and Development Direction - The company aims to advance its position in the high-end intelligent driving market, focusing on the development of the Horizon SuperDrive (HSD) as a foundation for future robotaxi solutions [14][19] - Strategic investments in cloud services and R&D are expected to drive growth opportunities and enhance the company's competitive edge in the intelligent driving sector [15][63] - The company plans to expand its global footprint and deepen partnerships with leading international automakers [19] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about sustained growth potential in the intelligent driving market, driven by rising volumes and prices [6][12] - The company anticipates achieving shipments of around 4 million units in 2025, with a significant portion coming from mid to high-end solutions [32][42] - The management highlighted the importance of adhering to strict standards for L2 intelligent driving, which will benefit the entire ecosystem [56] Other Important Information - The company recorded an adjusted operating loss of RMB 1.1 billion, reflecting increased R&D investments [24][25] - Cumulative shipments of the Journey series processing hardware exceeded 10 million units, setting a new benchmark for the industry [17] Q&A Session Summary Question: Can management elaborate on major customers for mid to high-end products in the first half of this year? - Major customers included BYD and Auto Li, with both being early adopters of the company's solutions [30][31] Question: What is the outlook for revenue contribution from Journey 6E and Horizon SuperDrive? - The ASP for Journey 6P and HSD is expected to be significantly higher, contributing to future revenue growth [35] Question: Can management provide guidance for volume and ASP for the second half of this year? - The company expects continued growth in shipments and ASP, driven by new product launches and market penetration [40][45] Question: What are the details about global customers and their chosen solutions? - The company is working with global automotive groups and joint ventures, providing ADAS and new generation solutions [48][50] Question: Does the company anticipate actual deployments of robotaxi within this year? - The company plans to launch robotaxi technologies within the next three to five years, collaborating with operators to validate data [59] Question: What are the plans regarding R&D expenditure? - The company will continue to invest heavily in R&D, particularly for HSD, to capture structural transformations in the intelligent driving industry [63]

Financial Data and Key Metrics Changes - The company reported a revenue growth of 4.9% for the first half of 2025, with an adjusted EBITDA margin maintained at 15.7% [48][49][64] - Adjusted net profit increased by 4.6%, reaching a net profit margin of 5.2% [49][64] - The gross profit margin improved by 1.4 percentage points for core product categories [55] Business Line Data and Key Metrics Changes - The ANC business grew by 5.9%, BNC by 2.9%, and P&C by 8.6% [22] - Nutritional supplements accounted for 65.6% of total revenue, up by 4.1% [18] - The P&C segment saw a 15.5% growth, while the probiotic business experienced a decline of around 10% [9][19] Market Data and Key Metrics Changes - China contributed 70% of total revenue, with a growth driven by IMF sales and nutritional products [20] - The North American market grew by 4.6%, while the ANZ market saw a decline of 15.6% due to Daigou channel sales [20][21] - Expansion markets contributed 66% of revenue, growing by 18.6% [21] Company Strategy and Development Direction - The company aims to maintain its number one position in the ANC market in China and expand into new markets [44][45] - Focus on premiumization and diversification strategies to enhance profitability and market share [46] - Continued investment in product innovation and consumer education to drive growth [15][44] Management Comments on Operating Environment and Future Outlook - Management acknowledged fierce competition in the Chinese market and emphasized the importance of adapting strategies [3] - The company expects to achieve high single-digit sales growth for the full year, with a stable EBITDA margin around 15% [66] - Confidence in overcoming challenges from the Guo Biao transition and maintaining growth momentum [8][49] Other Important Information - The interim dividend payout is set at HKD0.19 per share [12] - The company completed a refinancing of USD 300 million, which is expected to lower financial expenses [11][51] Q&A Session Summary Question: Do you have any guidance update for the whole year's performance? - The company expects high single-digit growth for the whole group, with adjusted EBITDA margin around 15% and adjusted net profit margin close to 5% [66] Question: What are the key drivers for the B&C business growth? - Main drivers include innovative products and penetration into new channels, with a focus on retail and online channels [70][71] Question: Will the IMF gross profit margin be restructured? - Adjustments are being made to improve profitability, with 80% of product categories returning to expected growth [72][73] Question: What is the expectation for the ANC business in ANZ? - The company will continue to promote domestic business growth to offset declines in the Daigou channel, maintaining guidance for the whole year [85][86]

Financial Data and Key Metrics Changes - The company reported a net profit growth of over 20% year on year for H1 2025, indicating strong financial performance [2][4]. Business Line Data and Key Metrics Changes - The Drilling Services segment experienced growth in both volume and price, with a 28% year-on-year increase in daily rates for jackup drilling rigs [5][8]. - The Well Services segment saw a decline in revenue by approximately $400 million and a profit decrease of about $110 million to $130 million, attributed to a reduced customer base and increased competition [6][14]. Market Data and Key Metrics Changes - The company operates 13 drilling rigs overseas, with contracts secured until 2029 or 2030 in regions like Norway and the Middle East, suggesting stability in overseas operations [5][11]. - The oil price is forecasted to remain stable at around USD 65 to USD 70, which is considered a reasonable level for the industry [5][10]. Company Strategy and Development Direction - The company aims to become an internationally first-rate oilfield service provider, focusing on technological leadership and innovation [33][34]. - There is a clear goal to broaden the customer base and enhance innovation capabilities, with significant investments in technology [35][36]. Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in maintaining daily rates due to secured contracts and a stable operational environment despite macroeconomic uncertainties [12][20]. - The company plans to control costs and increase revenue, emphasizing the importance of operational efficiency [17][20]. Other Important Information - The company completed a loan repayment of $1 billion, utilizing both self-owned capital and borrowed funds to optimize its debt structure [15][16]. - The company is focusing on developing made-in-China drilling rigs, which are expected to provide cost-effective solutions in a low to medium oil price environment [26][27]. Q&A Session Summary Question: Concerns about Drilling Services segment and daily rate stability - Management indicated that the daily rates for drilling services are expected to remain stable due to secured contracts and a favorable market outlook [5][10]. Question: Reasons for decline in Well Services segment - The decline was attributed to a reduced customer base in China and increased competition, leading to changes in the charging model [6][14]. Question: CapEx adjustments and fund utilization - Management confirmed that the decline in revenue was more pronounced overseas, particularly in Southeast Asia, and discussed the repayment of debts using self-owned capital [13][15]. Question: Future plans for old and new vessels - The company is optimizing its vessel fleet and has made progress in this area, focusing on both the disposal of older vessels and the development of new ones [25][30].

Financial Data and Key Metrics Changes - The company reported a revenue growth of 4.9% for the first half of 2025, with an adjusted EBITDA margin maintained at 15.7% [48][49][64] - Adjusted net profit increased by 4.6%, reaching a net profit margin of 5.2% [49][64] - The gross profit margin improved by 1.4 percentage points for core product categories [55] Business Line Data and Key Metrics Changes - The ANC business grew by 5.9%, BNC by 2.9%, and P&C by 8.6% [22] - Nutritional supplements accounted for 65.6% of total revenue, showing a 4.1% increase [18] - The P&C business globally saw a 14% growth, with SOLIGO returning to 17.5% growth [10][36] Market Data and Key Metrics Changes - China contributed 70% of total revenue, with a 13% growth in the ANC business [20][5] - The ANZ market experienced a 5.6% growth, while the North American market saw a 4.6% growth [7][38] - Expansion markets contributed 66% of revenue, growing by 18.6% [21] Company Strategy and Development Direction - The company aims to diversify its market and brands while consolidating its core market [24] - Focus on premiumization and innovation in product offerings to drive growth [44][45] - Continued investment in new markets and channels to enhance profitability [46] Management's Comments on Operating Environment and Future Outlook - Management acknowledged fierce competition in the Chinese market and emphasized the importance of strategic adjustments [3] - The company remains confident in achieving high single-digit sales growth for the full year [66] - Future strategies include focusing on super premium segments and expanding into new markets [45][46] Other Important Information - The interim dividend payout is set at HKD0.19 per share [12] - The company completed a refinancing of USD 300 million, which is expected to lower financial expenses [11][51] Q&A Session Summary Question: Do you have any guidance update for the whole year's performance? - The company expects high single-digit growth for the whole group, with adjusted EBITDA margin around 15% and adjusted net profit margin close to 5% [66] Question: What are the key drivers for the B&C business growth? - The main drivers include innovative products and penetration into new channels [70][71] Question: Will the product mix and brand be restructured strategically? - Yes, adjustments are being made to improve profitability, particularly in the non-core IMF and probiotic segments [71][73] Question: What is the expectation for the ANC business in ANZ? - The company will continue to promote growth in domestic channels to offset declines in the Daigou channel [85][87]

Financial Data and Key Metrics Changes - The company reported a net profit growth of over 20% year on year for the first half of 2025 [3][5][35] - Operational efficiency has improved, and the company's value creation capabilities have strengthened both domestically and internationally [3][4] Business Line Data and Key Metrics Changes - In the Drilling Services segment, daily rates for jackup drilling rigs increased by 28% year on year [10][12] - The Well Services segment experienced a revenue decline of approximately $400 million and a profit decrease of about $110 million to $130 million [7][16] - The customer base for Well Services in China decreased, impacting revenue and profitability [8][16] Market Data and Key Metrics Changes - The company has 13 drilling rigs overseas, with contracts secured until 2029 or 2030 in regions like Norway and the Middle East [6][12] - The oil price is forecasted to remain stable at around USD 65 to USD 70, which is considered a reasonable medium level for the industry [6][12] Company Strategy and Development Direction - The company aims to become an internationally first-rate oilfield service provider, with a focus on technological leadership and innovation [35][36] - Plans include broadening the customer base and developing new products based on technological innovations [38][39] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in maintaining daily rates due to stable contracts and investments in key regions despite macroeconomic uncertainties [14][20] - The company is focused on cost management and efficiency improvements to navigate market volatility [20][23] Other Important Information - The company completed a loan repayment of $1 billion using self-owned capital and borrowed funds, optimizing its debt structure [17][18] - The company is actively working on designing and promoting made-in-China drilling rigs, with positive industry recognition [29][30] Q&A Session Summary Question: Concerns about Drilling Services segment and daily rate stability - Management indicated that overseas contracts are stable, and daily rates are expected to remain steady despite low oil prices [6][12] Question: Reasons for decline in Well Services segment - The decline was attributed to a decrease in the customer base in China and increased competition in the oilfield chemical industry [8][16] Question: Future CapEx adjustments and fund utilization - Management confirmed that the revenue decline was primarily from China, and they have optimized their debt structure to manage funding needs [17][18] Question: Impact of old vessel disposal and new vessel plans - The company is focusing on optimizing its vessel fleet and has made progress in this area [28] Question: Future prospects for new drilling rigs - Management is optimistic about the prospects for new drilling rigs and plans to move into concrete building works in the near future [29][30]

Financial Data and Key Indicators Changes - In the first half of 2025, net profit attributable to shareholders reached RMB 69.5 billion, a decrease of 12.8% year on year, primarily due to a 15.1% decline in Brent oil prices [18][19] - Oil and gas sales revenue was RMB 171.7 billion, with all-in costs remaining stable at USD 26.94 per barrel [7][21] - The company maintained a gearing ratio of 8.4%, indicating a healthy financial position, with total assets increasing by RMB 62.7 billion from the beginning of the period [20][21] Business Line Data and Key Indicators Changes - Net oil and gas production reached 384.6 million BOEs, up 6.1% year on year, with natural gas production rising by 12% [2][11] - The company made five new discoveries and successfully appraised 18 oil and gas structures, with 10 new projects commencing production [2][6] Market Data and Key Indicators Changes - Brent oil prices decreased by 15.1%, yet the company's net profit decline was less than the drop in oil prices, showcasing effective cost control and production increases [19][20] - The company reported strong performance in the domestic natural gas market, with total production of natural gas amounting to 216.2 million cubic meters, up 2% [27][63] Company Strategy and Development Direction - The company aims to enhance oil and gas reserves and production while promoting green energy transition and independent technological innovation [23][49] - The focus remains on maintaining high-quality development and efficiency improvements, with a commitment to shareholder returns through a dividend payout ratio of 45.5% [22][32] Management's Comments on Operating Environment and Future Outlook - Management acknowledged the challenges posed by fluctuating oil prices but emphasized the company's robust value creation capabilities and commitment to cost control [6][39] - The outlook for oil prices in 2025 is projected to be around USD 65 to USD 70, influenced by various geopolitical factors [42][46] Other Important Information - The company has initiated its first offshore CCUS project and is developing offshore wind power projects, indicating a commitment to new energy initiatives [15][50] - The interim dividend of HKD 0.73 per share is the second highest in the company's history, reflecting a strong commitment to returning value to shareholders despite lower profits [3][22] Q&A Session Summary Question: Natural gas production and pricing outlook - Management highlighted that natural gas production increased due to additional reserves and projects, with a stable pricing mechanism in place [26][28][29] Question: Dividend payout improvement - The interim dividend payout ratio has increased to 45.5%, with management indicating that future dividends will be assessed based on production, operations, and financial position [31][32][33] Question: Cost reduction and efficiency improvement - Management confirmed ongoing efforts in cost control and efficiency improvements, with specific measures outlined for the second half of the year [34][35][36] Question: New energy business development - The company is exploring new energy projects, including offshore wind power, while maintaining a focus on oil and gas as the core business [49][50][51] Question: Investment loss in Argentina - The investment loss was primarily due to a joint venture in Argentina, with management clarifying that it is not a long-term loss but reflects current operating results [59][60]

Financial Data and Key Indicators Changes - In the first half of 2025, net profit attributable to shareholders reached RMB 69.5 billion, a decrease of 12.8% year on year, primarily due to a 15.1% decline in Brent oil prices [20][10][24] - Oil and gas sales revenue was RMB 171.7 billion, with all-in costs remaining stable at USD 26.94 per barrel, down 2.9% year on year [10][23] - The company maintained a gearing ratio of 8.4%, indicating a healthy financial position, with total assets increasing to RMB 1,119 billion [22][23] Business Line Data and Key Indicators Changes - Net oil and gas production reached 384.6 million BOEs, up 6.1% year on year, with natural gas production rising by 12% [4][14] - The company made five new discoveries and successfully appraised 18 oil and gas structures, with 10 new projects commencing production [4][9] - The interim dividend was set at HKD 0.73 per share, with a payout ratio of 45.5%, marking the second highest in the company's history [5][24] Market Data and Key Indicators Changes - Brent oil prices decreased by 15.1%, impacting overall profitability but the decline in net profit was less severe than the drop in oil prices [20][21] - The company reported strong performance in the domestic natural gas market, with production volume increasing due to new projects in the Bohai region and South China Sea [30][72] Company Strategy and Development Direction - The company aims to enhance oil and gas reserves and production while promoting green energy transition and independent technological innovation [25][64] - There is a commitment to maintaining oil and gas as the core business, with new energy development seen as a supplementary growth area [64][60] - The focus remains on high-quality development and efficiency improvement to ensure sustainable growth [25][44] Management's Comments on Operating Environment and Future Outlook - Management acknowledged the challenges posed by fluctuating oil prices but emphasized the company's resilience and ability to control costs [20][44] - The outlook for oil prices in 2025 is projected to be around USD 65 to USD 70, influenced by various geopolitical factors [46][47] - The company plans to continue investing in technological innovations to drive down costs and improve operational efficiency [40][88] Other Important Information - The company has made significant advancements in technological capabilities, including intelligent drilling and completion initiatives, which have improved operational efficiency [17][88] - The company is actively exploring new energy projects, including offshore wind power and solar energy, while ensuring that these initiatives align with internal investment thresholds [55][60] Q&A Session Summary Question: What are the reasons behind the increase in natural gas production and pricing? - The increase in natural gas production was attributed to additional reserves and production from new projects in the Shanghai and Bozhong areas, with stable pricing due to long-term contracts [30][31] Question: Will the dividend payout ratio improve for the whole year? - The interim dividend payout ratio was set at 45.5%, and while future dividends will be evaluated based on various factors, the company aims to maintain a high-quality development principle [33][34] Question: What are the expectations for cost reduction and efficiency improvement in the second half of the year? - The company plans to continue its low-cost strategy through technological improvements, lean management, and increased production to enhance overall economic benefits [40][42] Question: What are the plans for new energy business development? - The company is focusing on offshore wind power and other renewable energy projects, ensuring that they meet internal investment criteria and contribute to overall sustainability [55][60] Question: What caused the investment loss in the first half of the year? - The investment loss was primarily due to the performance of a joint venture in Argentina, which was recognized in accordance with accounting standards [66][68] Question: What is the outlook for natural gas production growth? - The company anticipates strong growth in natural gas production, supported by ongoing projects and a stable domestic market [70][72]

Financial Data and Key Metrics Changes - Operating revenue for the first half of the year was 74.44 billion RMB, with total profit at 11.94 billion RMB, down 28.6% year over year [4] - Net profit attributable to shareholders was 7.7 billion RMB, down 21.3% year over year, with basic earnings per share at 0.58 RMB, down 21.6% [4] - Under international accounting standards, profit before tax was 11.6 billion RMB, down 35.5% year over year [4] - The asset to liability ratio improved to 45%, down 1.3 percentage points from the beginning of the year [12] Business Line Data and Key Metrics Changes - The company produced 67.34 million tons of commercial coal, an increase of 0.84 million tons or 1.3% year over year [5] - Self-produced commercial coal sales reached 67.11 million tons, up 0.92 million tons or 1.4% year over year [6] - Sales of key coal chemicals totaled 3.166 million tons, an increase of 83,000 tons or 2.7% year over year [6] - The unit sales cost of self-produced commercial coal was 2,262.97 RMB per ton, down 10.2% year over year [7] Market Data and Key Metrics Changes - Average sales price of self-produced commercial coal was 470 RMB per ton, down 19.5% [9] - Thermal coal price was 436 RMB per ton, down 14.7%, while coking coal price dropped to 885 RMB per ton, down 35.4% [9] - The overall market saw a decline in coal prices, impacting profitability significantly [10] Company Strategy and Development Direction - The company is committed to high-quality development goals and will strengthen production sales coordination to achieve annual targets [15] - Focus on enhancing lean management and cost control to maintain profitability levels [15] - Plans to accelerate key project construction and implement innovation-driven strategies [16] Management Comments on Operating Environment and Future Outlook - Management expressed confidence in maintaining stable operations despite falling coal prices and lower industry profitability [10] - Future coal prices are expected to stabilize around 675 RMB for long-term contracts and slightly over 700 RMB for spot prices [24][42] - The company aims to continue enhancing corporate governance and investor communication [16] Other Important Information - The company plans to distribute an interim cash dividend of 2.198 billion RMB or 0.166 RMB per share, consistent with the previous year [14] - Capital expenditures for the first half increased by 32%, with a total of 6.972 billion RMB invested [46] Q&A Session All Questions and Answers Question: Impact of supply changes on coal prices - Management noted a drop in prices followed by a recovery, with spot prices expected to stabilize around 700 RMB per ton [21][24] Question: Cost management strategies - The company reported a 10% reduction in sales costs due to optimized procurement and cost management [27] Question: Long-term contract coal prices - Long-term contract coal prices dropped by 3.6%, while spot prices saw a larger decline of nearly 11% [32] Question: Profitability of subsidiaries - Profitability improved for certain subsidiaries due to effective cost management despite price declines [39] Question: Production volume changes - Production volume was impacted by accidents and weather conditions, but the company remains confident in meeting annual targets [51] Question: Dividend payout standards - The company will continue to use the lower of international or Chinese accounting standards for dividend payouts [76]

Financial Data and Key Indicator Changes - Operating revenue for the first half of the year was 74.44 billion RMB, with total profit at 11.94 billion RMB, down 28.6% year over year [4] - Net profit attributable to shareholders was 7.7 billion RMB, down 21.3% year over year, with basic earnings per share at 0.58 RMB, down 21.6% [4][5] - Under international accounting standards, profit before tax was 11.6 billion RMB, down 35.5% year over year [4] Business Line Data and Key Indicator Changes - The company produced 67.34 million tons of commercial coal, an increase of 0.84 million tons or 1.3% year over year [5] - Self-produced commercial coal sales were 67.11 million tons, up 0.92 million tons or 1.4% year over year [6] - Sales of key coal chemicals totaled 3.166 million tons, an increase of 83,000 tons or 2.7% year over year [6] Market Data and Key Indicator Changes - Average sales price of self-produced commercial coal was 470 RMB per ton, down 19.5% year over year [9] - Thermal coal price was 436 RMB per ton, down 14.7%, while coking coal price was 885 RMB per ton, down 35.4% [9] - The unit sales cost of self-produced commercial coal was 2,262.97 RMB per ton, down 10.2% year over year [7] Company Strategy and Development Direction - The company aims to strengthen production sales coordination and enhance lean management and cost control to maintain profitability [15] - There is a commitment to high-quality development goals and the implementation of an innovation-driven strategy [16] - The company is focused on accelerating key project construction and enhancing corporate governance and investor communication [16] Management Comments on Operating Environment and Future Outlook - Management expressed confidence in maintaining stable operations despite falling coal prices and lower industry profitability [10] - The company actively strengthened cash flow management, achieving a cash collection ratio of 110.1% [12] - Future coal prices are expected to stabilize, with long-term contract prices projected around 690 RMB per ton [42] Other Important Information - The company plans to distribute an interim cash dividend of 2.198 billion RMB or 0.166 RMB per share for 2025 [14] - Capital expenditures for the first half increased by 32%, with 92% of the annual target already completed [46] Q&A Session Summary Question: Impact of supply changes on coal prices - Management noted a drop in prices followed by a recovery, with spot prices expected to stabilize around 700 RMB per ton [21][24] Question: Cost management strategies - The company reported a 10% reduction in sales costs due to optimized procurement and cost management [27] Question: Long-term contract coal pricing - Long-term contract coal prices dropped by 3.6%, while spot prices fell by nearly 11% [32] Question: Profitability of subsidiaries - Profitability improved for certain subsidiaries due to effective cost management despite price declines [39] Question: Production volume changes - Production volume was impacted by accidents and weather conditions, but the company remains confident in meeting annual targets [51] Question: Dividend policy - The company will consider both international and Chinese accounting standards for dividend payouts, balancing shareholder interests with sustainable development [75][77]

Financial Data and Key Metrics Changes - As of June 30, 2025, the company's bank deposits and cash and cash equivalents were $2,075.3 million, representing a decrease of $338.1 million or 14% compared to $2,413.4 million at the end of 2024 [26] - Other income for the first half of the year was $28.1 million, a decrease of $42.8 million or 60.4% compared to $70.9 million for the same period in 2024 [27] - Research and development expenses for the first half of the year declined by 7.3% to $117 million from $126.2 million in 2024 [28] - Administrative expenses were $58.2 million in the first half of the year, declining 26% compared to $78.6 million in 2024 [28] Business Line Data and Key Metrics Changes - The HBV functional cure strategy is built on three differentiated assets: BRE-179, elapsirin, and tolivibart, each targeting distinct mechanisms of HBV pathogenesis [7] - The ongoing clinical programs have collectively been studied in more than 1,600 patients, with three fully enrolled Phase IIb combination studies [9] - In cohort four of the INSURE study, 61% of BRE-179 responders achieved HB surface antigen loss at week 48, compared to about 10% of non-responders [10] Market Data and Key Metrics Changes - The company out-licensed the Greater China rights of Xarelin mixing to ensure efficient progress of non-core programs without diverting focus from HBV [5] - The company is seeking strategic partnerships to develop other assets in its pipeline, including long-acting HBV candidates [6] Company Strategy and Development Direction - The company is focused on advancing its core HBV functional cure program through multiple Phase 2b studies and is shaping its late-stage development strategy based on emerging data [4] - The company aims to achieve a higher rate of functional cure through a multimodal parallel approach, which is critical to solving the complexity of HBV cure [24] - The company plans to report 24-week follow-up data from cohort four of the INSURE study in 2025, with end-of-treatment data from the ENRICH and ENHANCE studies expected in 2026 [24] Management's Comments on Operating Environment and Future Outlook - Management expressed excitement about the development of new treatment modalities for HBV and the company's focus on providing a curative regimen [48] - The company believes that the recent launch of a new reporting system by the China CDC will improve the diagnostic rate of HBV, potentially increasing treatment demand [44] Other Important Information - The company has maintained a strong cash position with sufficient funds to support operations through 2028 [26] - The company is committed to pairing internal innovation with external collaboration to drive sustainable growth and broaden patient access to meaningful treatment options [28] Q&A Session Summary Question: Given the encouraging 61% seroclearance rate in BRE-179 responders from INSURE study cohort number four, how is the company thinking about patient enrichment strategy moving forward? - Management acknowledged the potential of BRE-179 to categorize chronic HBV patients into immune responsive and non-responsive groups and is exploring biomarker-driven approaches for Phase III trials [32][34] Question: What is the company's view on the competitive landscape considering recent phase three trials initiated by OSPER Bio? - Management expressed excitement about new treatment modalities for HBV and noted the importance of long-term follow-up data from competitors to evaluate the evolving landscape [38][40] Question: How does the company assess the potential impact of the new reporting system launched by the China CDC on treatment demands? - Management views the new reporting system as a positive development that could increase diagnosis rates and improve disease awareness, ultimately benefiting patients [44][46]