Core Viewpoint - Kelong Pharmaceutical is a leading enterprise in the domestic large infusion industry, with strong R&D capabilities and a full industry chain advantage [1] Group 1: Business Performance - As of Q3 2025, Kelong Pharmaceutical reported revenue of 13.277 billion, ranking 5th in the industry, exceeding the industry average by 2.8 billion and the median by 0.838 billion, but lower than the top two competitors [2] - The net profit for the same period was 1.245 billion, ranking 9th in the industry, above the industry average of 299 million and the median of 78.29 million, but below the top two competitors [2] Group 2: Financial Ratios - Kelong Pharmaceutical's debt-to-asset ratio was 28.63% in Q3 2025, down from 31.68% year-on-year and below the industry average of 35.26%, indicating good solvency [3] - The gross profit margin for the same period was 47.89%, down from 52.51% year-on-year and below the industry average of 57.17%, suggesting a need for improvement in profitability [3] Group 3: Executive Compensation - Chairman Liu Gexin's salary decreased from 6.9 million in 2023 to 5.6 million in 2024, a reduction of 1.3 million [4] - General Manager Liu Sicong's salary remained stable at 4.8 million in 2024 [4] Group 4: Shareholder Information - As of September 30, 2025, the number of A-share shareholders increased by 8.35% to 37,100, while the average number of shares held per shareholder decreased by 7.70% [5] Group 5: Future Outlook - Kelong Pharmaceutical's H1 2025 performance showed a decline, with revenue of 9.083 billion, down 23.2% year-on-year, and net profit of 1.001 billion, down 44.41% [6] - The company expects revenues for 2025-2027 to be 17.886 billion, 20.569 billion, and 22.626 billion, with respective year-on-year changes of -18.0%, +15.0%, and +10.0% [6] - Net profits for the same period are projected to be 2.022 billion, 2.801 billion, and 3.204 billion, with year-on-year changes of -31.1%, +38.5%, and +14.4% [6] Group 6: Innovation and R&D - Kelong Pharmaceutical's innovative drugs are showing rapid sales growth, with the newly approved product contributing to sales [6] - The company has over 30 items in its innovative R&D pipeline, primarily focused on cancer treatment [6][7]

Core Viewpoint - Kolon Biotech Inc. (06990) shares rose nearly 5%, currently up 3.42% at 436 HKD, with a trading volume of 88.67 million HKD, following the announcement of multiple clinical research results at the ESMO conference held in Berlin from October 17 to 21, 2025 [1] Group 1: Clinical Research Results - The company's core product SKB264 was selected for two oral presentations at ESMO, demonstrating BIC potential in the treatment of EGFRm NSCLC in the 2L+ setting, with good safety profile; the indication was approved for market in October [1] - SKB264 showed significantly better results than chemotherapy for HR+/HER2- BC in the 2L+ treatment, with expectations for approval in 2026 [1] - Clinical data for the core product A166 indicated that it surpassed T-DM1 in the treatment of HER2+ BC in the 2L+ setting, with this indication also approved for market in October [1]

Core Viewpoint - Keren Biotechnology-B (06990) has seen a stock increase of nearly 5%, currently trading at 436 HKD with a transaction volume of 88.67 million HKD, following the announcement of multiple clinical research results at the ESMO conference in Berlin from October 17 to 21, 2025 [1] Group 1: Clinical Research Results - The company's core product SKB264 was selected for two oral presentations at ESMO, demonstrating BIC potential in the treatment of EGFRm NSCLC in the 2L+ setting, with good safety profile; the indication was approved for market in October [1] - SKB264 showed significantly better results than chemotherapy for HR+/HER2- BC in the 2L+ treatment, with expectations for approval in 2026 [1] - Clinical data for the core product A166 was announced, showing that it outperformed T-DM1 in the treatment of HER2+ BC in the 2L+ setting, with this indication also approved for market in October [1]

Group 1: Market Performance and Opportunities - The MSCI China Healthcare Index has increased by 58.6% year-to-date, outperforming the MSCI China Index which rose by 24.2% [1] - The recent slight pullback in the healthcare sector (10% decline in MSCI China Healthcare Index since October) presents a buying opportunity [1] - The recovery in capital market financing and the increase in overseas transactions for innovative drugs indicate a rebound in domestic innovative drug R&D demand [1] Group 2: Clinical Data and Drug Development - SKB264 is the only drug showing statistically significant overall survival (OS) in a Phase III trial for EGFR-TKI resistant NSCLC, with a hazard ratio (HR) of 0.56 compared to chemotherapy [2] - Ivonescimab demonstrated a median progression-free survival (mPFS) of 11.1 months in first-line sqNSCLC, outperforming the comparator at 6.9 months (HR=0.60) [2] - The uORR for drug 707 in first-line colorectal cancer reached 82.6%, with a cORR of 65.2%, indicating strong efficacy [2] Group 3: Strategic Collaborations and Future Outlook - The company suggests focusing on the clinical advancement of authorized pipelines overseas, as this has a higher certainty of success and can act as a catalyst for stock price increases [3] - The strategic collaboration between Innovent Biologics and Takeda for IBI363 involves shared global R&D costs and commercial rights, reflecting confidence in the drug and commitment to global strategy [3] - Pfizer is expected to announce overseas clinical plans for drug 707 within the year, with a focus on its combination with multiple ADC products [3]

Group 1 - The MSCI China Healthcare Index has increased by 58.6% since the beginning of 2025, outperforming the MSCI China Index by 24.2% [1] - The recent slight pullback in the healthcare sector (10% since October) presents a buying opportunity, driven by a recovery in capital market financing and an increase in the scale of innovative drug exports [1] - The CXO industry is expected to see performance recovery in the second half of 2025 due to the anticipated interest rate cuts in the U.S. [1] Group 2 - Significant clinical data was released at the ESMO conference, highlighting key drugs such as SKB264, which shows statistical significance in overall survival for NSCLC patients resistant to EGFR-TKI [2] - The mPFS for lvonescimab in first-line sqNSCLC was reported at 11.1 months, compared to 6.9 months for the control group [2] - The uORR for drug 707 from 三生制药 in first-line colorectal cancer reached 82.6%, indicating strong efficacy [2] Group 3 - The impact of business development (BD) on stock prices is diminishing, prompting a focus on the clinical advancement of authorized pipelines overseas [3] - 信达生物 has entered a global strategic partnership with Takeda for IBI363, sharing 40% of global R&D costs and U.S. commercial rights, reflecting confidence in the drug and commitment to globalization [3] - The company anticipates that clinical progress will serve as a catalyst for stock price increases, with most value realization dependent on successful commercialization rather than upfront payments from licensing deals [3]

Investment Rating - The report assigns a "Buy" rating to several companies in the pharmaceutical sector, indicating a potential upside of over 15% in their stock prices over the next 12 months [2][33]. Core Insights - The MSCI China Healthcare Index has increased by 58.6% from early 2025, outperforming the MSCI China Index by 24.2%. However, there has been a recent pullback of 10% in the healthcare sector, presenting a buying opportunity [1]. - The report highlights a recovery in the demand for domestic innovative drug research and development, driven by a resurgence in capital market financing and an increase in overseas clinical trials for authorized innovative drugs [1]. - The CXO industry is expected to see performance recovery in the second half of 2025, aided by the recent interest rate cuts in the U.S. [1]. - The report emphasizes the importance of monitoring the clinical progress of authorized innovative drug pipelines overseas, as this could serve as a catalyst for stock price increases [4]. Summary by Sections Industry Overview - The report discusses the recent clinical data released at the ESMO conference, focusing on several key drugs and their performance in clinical trials, such as SKB264 and ivonescimab, which show promising results in treating specific types of cancer [4]. - It notes that while business development (BD) activities for innovative drugs are ongoing, stock prices have not reflected this positively, primarily due to valuation concerns [4]. Company Ratings and Valuations - The report provides a detailed valuation table for several companies, including: - **Sangamo Therapeutics (1530 HK)**: Market cap of $8.76 billion, target price of $37.58, with a 34% upside potential [2]. - **Gusongtang (2273 HK)**: Market cap of $932.7 million, target price of $48.28, with a 62% upside potential [2]. - **Giant Biologics (2367 HK)**: Market cap of $5.74 billion, target price of $58.35, with a 40% upside potential [2]. - **WuXi AppTec (2268 HK)**: Market cap of $10.87 billion, target price of $74.00, with a 5% upside potential [2]. - **China National Pharmaceutical Group (1177 HK)**: Market cap of $16.80 billion, target price of $9.40, with a 35% upside potential [2]. - **Innovent Biologics (1801 HK)**: Market cap of $18.94 billion, target price of $110.62, with a 29% upside potential [2].

Investment Rating - The report maintains an investment rating of "Outperform" with a rating of A [5] Core Insights - The report highlights the significant performance of domestic new drugs showcased at the ESMO 2025 conference, with several companies presenting excellent clinical data [3][21] - The report emphasizes the importance of academic conferences as key catalysts for the innovative drug sector, particularly mentioning ESMO, ASCO, and WCLC as critical events for Chinese pharmaceutical companies [20] Weekly New Drug Market Review - From October 20 to October 26, 2025, the top five gainers in the new drug sector were: - 欧康维视 (+8.87%) - 君圣泰 (+8.21%) - 诺思兰德 (+7.07%) - 友芝友 (+4.42%) - 海创药业 (+3.73%) - The top five losers were: - 康宁杰瑞 (-17.72%) - 北海康成 (-14.42%) - 创胜集团 (-14.29%) - 宜明昂科 (-13.40%) - 来凯医药 (-12.40%) [16][17] Recommended Focus Stocks - The report suggests focusing on several stocks with potential catalysts, including: 1. Products with high overseas volume certainty after MNC certification: - PD-1 upgraded product: 三生制药 - GLP-1 asset: 联邦制药 - ADC assets: 科伦博泰, 百利天恒 2. Potential heavyweights for overseas MNC authorization: - PD-1 upgraded products: 康方生物, 信达生物 - Breakthroughs in autoimmune fields: 益方生物, 中国抗体 - Innovative target ADC: 复宏汉霖, 石药集团 3. Stocks likely to benefit from medical insurance negotiations and commercial insurance innovative drug directories: - Beneficiaries of medical insurance directory: 恒瑞医药, 康诺亚, 迈威生物, 智翔金泰, 海创药业 - Beneficiaries of commercial insurance innovative drug directory: 药明巨诺, 科济药业 [2][20] New Drug Approval and Acceptance - This week, four new drug or new indication applications were approved, and five new drug or new indication applications were accepted in the domestic market [9] - A total of 46 new drug clinical applications were approved, and 31 new drug clinical applications were accepted [10] Key Domestic Market Events - 信达生物 announced a global strategic partnership with Takeda to accelerate the development of new generation tumor immunotherapy and antibody-drug conjugate therapies [11] - 康宁杰瑞 and 石药集团 announced that their HER2 bispecific antibody-drug conjugate JSKN003 received breakthrough therapy designation from the CDE [11] - 和黄医药 presented clinical data for HMPL-A251 at the AACR-NCI-EORTC conference [11] Key Overseas Market Events - 罗氏 received FDA approval for Gazyva/Gazyvaro for the treatment of active lupus nephritis in adult patients [12] - Electra Therapeutics announced that its therapy ELA026 received breakthrough therapy designation from the FDA and PRIME qualification from the EMA [12] - 安斯泰来 announced that the FDA accepted its supplemental biologics license application for the antibody-drug conjugate Padcev in combination with Keytruda [12]

Investment Rating - The report maintains a "Positive" investment rating for the pharmaceutical and biotechnology industry in China [5]. Core Insights - The ESMO conference showcased significant breakthroughs in both foreign and domestic innovative drugs, highlighting the competitive strength of Chinese pharmaceutical companies on the international stage [3][12]. - The report emphasizes the potential of domestic innovative drugs to redefine standard therapies, particularly in the context of PD-1/VEGF dual antibodies and antibody-drug conjugates (ADCs) [8][29]. Summary by Sections 1. PD-1 plus and Domestic Dual Antibodies - The PD-(L)1/VEGF dual antibody, Ivosidenib, demonstrated strong positive results in a Phase III trial for first-line treatment of advanced squamous non-small cell lung cancer (NSCLC), showing a progression-free survival (PFS) improvement of 4.2 months compared to the PD-1 group [13][16]. - SSGJ-707, a PD-1/VEGF dual antibody, showed promising results in treating microsatellite stable (MSS) colorectal cancer, with an overall response rate (ORR) of 68.7% and a disease control rate (DCR) of 98.5% [18][19]. - HB0025, another PD-L1/VEGF dual antibody, reported an ORR of 83.3% in squamous NSCLC patients, indicating strong anti-tumor efficacy [20][21]. 2. ADCs: Accelerated Breakthroughs - SKB264, an ADC, has shown significant PFS and overall survival (OS) benefits in a Phase III trial for EGFR-mutant NSCLC, with PFS HR of 0.49 and OS HR of 0.60, indicating its potential as a new standard therapy [29][30]. - In the breast cancer domain, SKB264 demonstrated an ORR of 41.5% in CDK4/6i pre-treated HR+/HER2- advanced breast cancer, significantly outperforming chemotherapy [31][32]. - The report highlights the global potential of SKB264, with ongoing studies expected to further validate its efficacy and safety profile [23][29].

Macro Insights - Policy financial tools are being rapidly deployed, with Agricultural Development Bank and China Development Bank announcing a total of CNY 2,895 billion in funding as of October 17, which is expected to support short-term credit and infrastructure investment growth [2][4] - The third quarter GDP growth rate for China was reported at 4.8%, matching expectations but down from 5.2% in the previous quarter, while the industrial value-added growth for September was 6.5%, exceeding the forecast of 5% [5][11] Fixed Income - The construction and building materials sector is seeing a gradual improvement in funding, with infrastructure investment showing a cumulative year-on-year increase of 1.1% for the first nine months of 2025, while real estate investment has decreased by 13.9% [10] - The establishment of a new debt management department by the Ministry of Finance indicates a shift towards a long-term debt management mechanism, moving away from emergency measures [6] Real Estate - The real estate sector is stabilizing, with a marginal improvement in construction and sales figures, although housing prices continue to face downward pressure [7][8] - Recommendations for real estate stocks focus on companies with strong credit ratings and resources in core cities, including China Resources Land and China Overseas Development [7] Power Equipment and New Energy - The release of the "Wind Energy Beijing Declaration 2.0" at the Beijing International Wind Energy Conference sets a target for annual new wind power installations of no less than 120GW during the 14th and 15th Five-Year Plans, reinforcing industry confidence [8] - The wind power industry is expected to enter a recovery phase, with recommendations for leading wind turbine manufacturers [8] Consumer Goods - The retail sales growth for September was reported at 3.0%, with expectations for continued moderate growth in October due to the upcoming Double Eleven shopping festival [9] - Structural opportunities in consumer sectors such as emotional consumption and domestic brands are highlighted as areas for investment [9] Industrial and Machinery - The domestic multi-directional forging market is expanding, with sales expected to grow from USD 1.205 billion in 2024 to USD 1.576 billion by 2031, driven by demand in high-end manufacturing sectors [14] - Recommendations include companies that have achieved key technological breakthroughs and are expanding internationally, such as Diwei [14] Key Companies - China Life Insurance is expected to see a 50%-70% year-on-year increase in net profit for the first three quarters of 2025, driven by strong investment returns [19] - Sinomach Electric reported a 32.86% year-on-year increase in revenue for the first three quarters of 2025, with significant growth in overseas orders [19]

Group 1 - The core viewpoint is that the innovative drug sector remains a strong investment theme despite a recent 15% pullback, with a year-to-date performance still among the best in the market [2] - From January to September, the total contract value for Chinese innovative drugs going overseas exceeded $100 billion, marking a 170% year-on-year increase, indicating a robust long-term outlook for the innovative industry chain [2] - The trend of innovative drugs going global is expected to continue, with more business development (BD) deals anticipated by year-end, reinforcing confidence in the innovative sector [2] Group 2 - The innovative drug sector is expected to receive significant catalysts in the fourth quarter, with 23 Chinese studies selected for presentation at the upcoming ESMO conference, a substantial increase from 7 studies in 2024 [3] - Macroeconomic conditions are favorable for the innovative drug sector, as recent comments from Powell suggest potential interest rate cuts, which are beneficial for rate-sensitive innovative drugs [3] - The innovative drug sector is seen as a good investment choice amid market resistance and a rotation in tech growth, with BD deals expected to drive recovery in the sector [3] Group 3 - The fourth quarter typically sees BD transactions account for about 40% of annual totals, with large products also expected to contribute positively [3] - Recent adjustments in the market provide a favorable entry point for long-term investors in the innovative drug sector [3] - Investors are encouraged to consider ETFs focused on innovative drugs, particularly those targeting the STAR Market and smaller-cap stocks, which may show stronger resilience [3]