Core Insights - The global pharmaceutical industry is witnessing a significant shift in the rankings of best-selling drugs, with several products surpassing $10 billion in sales for 2025 [1][2]. Group 1: Sales Performance - Novo Nordisk's semaglutide briefly topped the sales chart in Q1 2025 but was ultimately surpassed by Eli Lilly's tirzepatide, with both drugs exceeding $30 billion in sales [1][3]. - Tirzepatide achieved a remarkable year-on-year sales growth of 121%, while semaglutide's growth was only 13% [3]. - The sales figures for semaglutide in the first half of 2025 reached $16.683 billion, maintaining its position as a top-selling drug [3]. Group 2: Competitive Landscape - The GLP-1 drug class is experiencing intense competition, with both tirzepatide and semaglutide being key players [4][5]. - The market is dominated by Novo Nordisk and Eli Lilly, but Chinese pharmaceutical companies are also making significant strides in this area [5][6]. - New GLP-1 drugs are under development, including Novo Nordisk's CagriSema and Eli Lilly's retatrutide, which shows potential for greater weight loss than tirzepatide [5]. Group 3: Oncology and Autoimmune Drugs - The PD-1 inhibitor pembrolizumab (Keytruda) remains a top seller in oncology, with sales reaching $31.68 billion in 2025, despite falling to third place [7]. - Nivolumab (Opdivo) also crossed the $10 billion mark, achieving sales of $10.29 billion [8]. - In the autoimmune disease sector, drugs like dupilumab and risankizumab achieved sales of $17.8 billion and $17.562 billion, respectively [8]. Group 4: Anticoagulants - The anticoagulant apixaban continues to show strong sales growth, with BMS reporting $14.443 billion in sales, a year-on-year increase of 8% [9]. - Pfizer's reported revenue from apixaban reached $8 billion, making it their second-largest selling product [9].

Group 1 - The core message emphasizes the increased risk of infectious disease transmission during the Spring Festival due to increased population movement and gatherings, alongside health risks from low temperatures and lifestyle changes [1] - The Beijing CDC advises travelers to check weather, transportation, and infectious disease information for their destinations, especially for those traveling abroad [1] - Recommendations include avoiding contact with wild animals in outdoor settings, using proper protective gear for winter sports, and being aware of safety exits in crowded public places [1] Group 2 - The importance of maintaining food hygiene during the Spring Festival is highlighted, advising against the consumption of food from unknown sources and ensuring proper cooking methods [2] - The need for adequate sleep is stressed, with adults recommended to have 7-8 hours and children needing more, alongside maintaining a regular schedule to support immune health [2] - Engaging in daily physical activity for at least 30 minutes is encouraged, with options like walking, jogging, cycling, or home workouts [2]

Core Viewpoint - The Hainan Provincial Private Entrepreneurs Association has officially removed Gan Jun from his position as vice president due to serious legal violations, emphasizing a zero-tolerance policy towards illegal activities among its members [1][2]. Group 1: Association's Actions - The association held a special meeting and decided to terminate Gan Jun's membership and vice presidency, placing him on a warning list for illegal activities [1][2]. - The association will enhance the scrutiny of membership qualifications to maintain the integrity and self-discipline of its members, thereby preserving the industry's order and the image of entrepreneurs [2]. Group 2: Stance on Legal Compliance - The association firmly adheres to national laws and regulations, demonstrating zero tolerance for illegal actions and behaviors that harm society [2]. - It will publicly disclose actions taken against member enterprises and individuals who violate laws and regulations, including suspension of membership rights and expulsion [2]. - The association supports government and judicial authorities in holding accountable those responsible for illegal actions [2].

2月11日，智利一群歹徒拦截车辆意图劫车，其中一名歹徒被撞飞的画面曝光。该案7日发生在基利库 拉，两名蒙面歹徒从一辆汽车下车。其中一人持枪指向后车司机，另一人试图迫使司机停车。司机几乎 未作犹豫，加速撞向站在车前的歹徒，致使对方跌出高速公路。事后驾车的男子前往警察局报案，警方 认定其行为属于正当防卫。警方表示歹徒已将车辆遗弃在附近，目前警方仍在追捕歹徒。 ...

Core Viewpoint - The article discusses former President Trump's contemplation of potentially withdrawing from the United States-Mexico-Canada Agreement (USMCA), although he has not made any formal threats to do so [1] Group 1: USMCA Context - Trump questioned his aides about the reasons for not exiting the USMCA, which he signed during his previous term [1] - The USMCA was designed to update and replace the North American Free Trade Agreement (NAFTA), which took effect in January 1994 [1] - The USMCA officially came into effect in July 2020 [1] Group 2: Reactions and Statements - Mexican President López Obrador downplayed the likelihood of the US exiting the USMCA, stating, "We do not believe this news" [1] - The article references a previous statement from the White House indicating that Trump signed a memorandum on January 7, 2026, directing the US to withdraw from 66 international organizations deemed "not in the interest of the US" [1]

春节过后，这股"暖流"还将持续。北京市、区人社部门将在各大交通枢纽继续开设"暖心就业服务站"， 并携带重点企业的优质岗位再次"进站"，将机会直接对接至返京劳动者，实现从"出站口"到"就业路"的 无缝衔接。 在春节前后离京、返京高峰期，活动将就业服务直接送到机场、火车站。东城、西城、朝阳、海淀、丰 台、通州、顺义、大兴等8区人社部门联动出击，职业指导师等专业力量共同进驻，在北京站、北京西 站、北京朝阳站、北京丰台站等八大火车站以及首都、大兴两座机场，同步设立流动宣传站点，把招聘 信息、技能培训、职业规划和权益保障等"一站式"服务，直接送到劳动者的归乡起点和返京第一站。 活动现场，"暖心就业服务站"化身旅途中的"充电站"，就业服务专员们为求职者，送上一份汇集了公共 就业服务指引、就业政策清单和精选岗位信息的"机会锦囊"。除了"就业礼包"，现场还提供岗位推介、 职业指导和技能培训等三项就业服务，专员们主动引导旅客关注"就业在北京"线上服务平台，帮助劳动 者一键获取北京就业市场最新动态，实现"人未返京 岗先锁定"，让节后返京就业路更清晰、更有底。 新京报讯（记者耿子叶）近日，在北京南站候车大厅里，多了一批身披服务绶带 ...

2月11日深夜，北京西站，乘坐G4375次列车的旅客排队检票。随着节前春运高峰临近，京广、京沪、 京哈线上的夜间高铁陆续上线，不少旅客也通过候补购票的方式，抢到了夜间加开的高铁列车。 ...

谢元表示，天津将充分发挥区位、港口、科教人才、产业、城乡空间资源和公共服务等方面的优势，全 力推动《规划》落地实施。 具体而言，将牢牢牵住北京非首都功能疏解这个"牛鼻子"，充分利用天开高教科创园、滨海-中关村科 技园、武清京津产业新城等平台，全力服务重大生产力系统布局，加快建设北方国际（000065）航运核 心区，打造首都和雄安新区的便捷出海口。同时，高水平共建京津冀国家技术创新中心。 此外，强化通勤保障，推动站产城融合发展，提升京津城际的运输能力，加开津兴城际、京滨城际车 次；扩大政务服务的"跨省通办""资质资格"的互认范围。 新京报讯(记者姜慧梓)"天津滨海新区与河北雄安新区、北京城市副中心错位联动发展。"2026年初，一 份重磅都市圈规划再次向京津冀三地释放利好。 1月22日，《现代化首都都市圈空间协同规划(2023-2035年)》正式批复，这是全国首部由党中央、国务 院批复的都市圈规划。2月12日，国新办举行新闻发布会，介绍该《规划》有关情况。 天津市副市长谢元表示，《规划》将天津市武清区纳入通勤圈，天津全域纳入功能圈，提出高质量谱写 京津"双城记"；明确支持天津滨海新区与河北雄安新区、北京城市副中心 ...

据介绍，近年来，京津跨城出行规模稳步上升，2025年双城日均出行量达到22.5万人次。《规划》将京 津全域纳入功能圈，天津武清区纳入通勤圈，两地人员交流、经济融合将更加紧密。目前，京津、津 兴、京滨、京沪4条高铁，京津塘等6条高速直通北京，交通"一卡通"覆盖全部地铁和公交。 天津市相关负责人表示，下一步，将加快完善联通京津的立体交通网，进一步提升城际铁路运力，提质 扩容改造天津南站、武清站，持续增投公交和定制快巴运力，提升京津主城之间交通便捷度，加强通武 廊、平蓟三兴等跨界地区交通联系，高质量谱写便捷高效的京津"双城记"。 新京报讯(记者姜慧梓)2月12日，国务院新闻办举行新闻发布会，介绍《现代化首都都市圈空间协同规 划(2023-2035年)》(以下简称《规划》)。记者从会上获悉，天津将提质扩容改造天津南站、武清站，提 升京津主城之间交通便捷度。 ...

具体而言，要利用大数据和人工智能精准预测关键领域人才培养供需情况，为专业动态调整提供科学依 据。探索建立新专业增设快速响应通道，面向新兴产业和未来产业，重点增设低空经济、人工智能、高 端装备、城市更新、民生紧缺等领域新专业。同时《意见》提到，要及时裁撤办学条件弱、水平差、就 业率低的专业点，避免专业布局"大而散""弱而全"。 围绕智能化、绿色化、融合化方向，改造升级现有专业，持续推进专业人才培养方案的迭代更新。鼓励 和支持地方因地制宜设置区域特色专业。鼓励校企联合开发、申报国家专业教学标准，特色鲜明的专业 可以括号形式冠以学校、企业或地区名称。推动建立省级部门间会商机制，定期发布重点紧缺专业、改 造升级专业、限制撤销专业"三张清单"。 教育部要求，各省域现代职业教育体系建设省份(以下简称试点省份)要根据区域重点产业发展规划编制 专业设置规划，每年发布职业教育专业设置与产业发展匹配分析报告。各市域产教联合体(以下简称联 合体)、行业产教融合共同体(以下简称共同体)要围绕本区域、行业产业发展趋势，研究发布技能人才需 求预测与专业设置指导报告。 新京报讯(记者冯琪)2月12日记者获悉，教育部印发《关于深化职业教育教 ...