来源：滚动播报 （来源：经济参考报） 尽管通过多款上市产品构建出较为清晰的商业化发展路径，但从康哲药业旗下业务单元，向独立上市公 司的身份转变，德镁医药仍需直面多重挑战。 日前，康哲药业（00867.HK）旗下皮肤业务子公司德镁医药有限公司（以下简称"德镁医药"）向港交 所提交上市申请，拟以介绍方式上市，此次分拆上市不涉及融资。 梳理近期医药企业集中分拆上市的案例不难发现，行业正共同勾勒出一幅"育雏离巢"的资本图景。但分 拆企业自身的造血能力和独立运营能力同样备受关注，证监会的反馈意见也要求德镁医药说明与康哲药 业在研发、营销、财务、人员、资产等方面的独立性情况。 聚焦皮肤健康 成立于2020年的德镁医药，自2021年起作为康哲药业的独立业务单元开始运营。2024年，德镁医药的皮 肤处方药收入在中国创新药企中排名首位，在所有中国药企中排名第五，公司将自身定位为聚焦皮肤健 康的创新型医药企业。 据招股书，皮肤病常有易反复发作、需长期治疗等慢性疾病特征。根据灼识咨询报告，中国的皮肤病治 疗与护理市场在2024年的市场规模为899亿元，2024年至2035年预计将以10.4%的复合年增长率增长。 业绩方面，2022 ...

时近2025年尾声，医药领域风起云涌，多家药企正通过战略合作加速整合资源，进一步聚焦细分赛道领 域。近期，康哲药业(00867.HK)宣布与全球制药巨头诺华签署经销协议，获得诺华就雷珠单抗注射液 (诺适得)、布西珠单抗注射液(倍优适)两款眼科药物在中国大陆的独家进口、经销、销售、推广权利。 此次合作不仅是康哲药业在眼科领域的重磅加码，更彰显了其深耕专科疾病领域的发展决心。 这一战略眼光同样体现在其对皮肤健康赛道的布局上。在六个月前，康哲药业推动旗下皮肤健康业务 ——德镁医药有限公司(以下简称：德镁医药)向港交所递交上市申请，助力其更好地聚焦核心业务。这 家从康哲药业分拆而来的公司，正凭借专业聚焦，挖掘皮肤健康高增长专科赛道的潜力。 在皮肤病诊疗需求持续升级的背景下，自身免疫性皮肤病、炎症性皮肤病等高发疾病领域备受市场关 注，其中白癜风、银屑病、特应性皮炎、痤疮四大细分领域因患者基数庞大、治疗方案有限，成为医药 企业竞争的核心战场。 面对特应性皮炎这一快速增长的市场，德镁医药采取了多管线布局策略。除芦可替尼乳膏正在开展治疗 轻中度特应性皮炎的新药上市申请工作外，德镁医药还拥有MG-K10，一款新型的长效(每四周 ...

Core Viewpoint - The company plans to spin off Dermagene Pharmaceuticals, which will enhance its focus on the skin health sector and unlock significant value from its innovative pipeline [1] Group 1: Business Strategy - The spin-off of Dermagene Pharmaceuticals signifies a systematic layout in the skin health field, with its innovative pipeline covering all indications in skin health, potentially leading to high growth and independent value [1] - The company has five innovative drugs commercialized in China, with three more in the NDA stage, driving growth through a dual strategy of collaboration and self-research [1][2] Group 2: Financial Performance - The company reported a revenue of 4.002 billion yuan in the first half of 2025, a year-on-year increase of 10.83%, and a net profit of 941 million yuan, up 3.38% year-on-year, indicating a potential turning point in performance [1] - The impact of centralized procurement on the company's main products is expected to be fully absorbed by 2024, leading to a stabilization in revenue and a potential performance turnaround [2] Group 3: Future Projections - Revenue projections for the company from 2025 to 2027 are estimated at 8.166 billion yuan, 9.628 billion yuan, and 12.069 billion yuan, with growth rates of 9.3%, 17.9%, and 25.4% respectively [3] - The estimated market value for the company in 2026 is projected to be 67.7 billion HKD, based on a combination of existing and incremental values from both the company and Dermagene Pharmaceuticals [3]

Investment Rating - The report gives an initial investment rating of "Buy" for the company 康哲药业 (00867.HK) [4][8]. Core Views - The company is positioned as a leading innovative platform in the pharmaceutical industry, with a focus on commercializing its innovative pipeline and expanding its market presence [4][7]. - The planned spin-off of 德镁医药 is expected to unlock additional value in the skin health segment, which has a comprehensive pipeline covering all indications in this area [7][8]. - The company has shown signs of a performance turnaround, with a 10.83% year-on-year increase in revenue for the first half of 2025, indicating a potential inflection point in its financial performance [7][17]. Summary by Sections Financial Performance - The company reported a total revenue of 8,013 million RMB in 2023, with a projected revenue of 8,166 million RMB in 2025, reflecting a growth rate of 9.3% [6][8]. - The net profit attributable to shareholders is expected to increase from 1,620 million RMB in 2024 to 1,681 million RMB in 2025, with a growth rate of 3.8% [6][8]. - The company’s earnings per share (EPS) is projected to be 0.69 RMB in 2025, with a return on equity (ROE) of 9.3% [6][8]. Business Strategy - 康哲药业 has undergone multiple transformations over its 30-year history, evolving from a sales agent to a company that controls product rights and now focuses on innovative product development [13][14]. - The company has diversified its business into three main segments: cardiovascular/digestive, skin health, and ophthalmology, aiming to create specialized teams for each area [21][24]. - The internationalization strategy has been accelerated with the recent listing on the Singapore Exchange, marking a significant milestone in its global expansion efforts [24][25]. Innovation and Pipeline - The company has five innovative drugs that have been commercialized in China, with several others in the NDA stage, indicating a robust pipeline for future growth [7][8]. - Key innovative products include 德昔度司他片 for chronic kidney disease anemia and ABP-671 for gout, both of which are expected to contribute significantly to future revenues [43][45]. - The company is leveraging a dual approach of collaboration and self-research to drive innovation, aiming to meet unmet clinical needs and enhance its product offerings [40][41].

Core Viewpoint - Haitong International slightly adjusted the revenue forecast for Kangzheng Pharmaceutical (00867) for 2025-26E to 8.33/9.30 billion HKD, representing a year-on-year increase of +11.5%/+11.6% [1] - The net profit forecast for the same period was also adjusted to 1.67/1.88 billion HKD, with year-on-year growth of +3.4%/+12.9% [1] - The valuation model was changed to a discounted cash flow (DCF) model to better reflect the long-term value of the pipeline cash flow from Demy Pharmaceutical, with a target price of 18.38 HKD (+85%) [1] Financial Performance - Kangzheng Pharmaceutical achieved a revenue of 4 billion HKD in the first half of the year, a year-on-year increase of +11% [2] - Revenue from exclusive/brand products and innovative products reached 2.9 billion HKD, up +21% year-on-year, which is the core driver of the company's performance recovery [2] - The gross profit margin was 72%, with R&D expenses of 570 million HKD (down -8% year-on-year) and a net profit of 940 million HKD (up +3% year-on-year) [2] Business Growth - The recovery in revenue is attributed to the clearance of the impact from existing centralized procurement products and the steady growth of core products such as Weifurui and Meitai Tong [3] - Exclusive/brand and innovative product sales accounted for 62.1% of total revenue, up from 56.1% in the same period last year [3] - Revenue by segment includes: cardiovascular segment 2.2 billion HKD (+0.6% YoY), digestive/immunity segment 1.4 billion HKD (+4.9% YoY), skin health segment 500 million HKD (+104% YoY), and ophthalmology segment 360 million HKD (+18% YoY) [3] Innovation and Pipeline - The company has three New Drug Applications (NDA) under review, including Dexamethasone and Luracitinib [4] - Approximately ten clinical trials are progressing in China, including treatments for ischemic stroke and specific dermatitis [4] - Other potential products include Povorcitinib and CMS-D001, which are in various stages of clinical trials [4] Spin-off Plans - Kangzheng Pharmaceutical plans to spin off Demy Pharmaceutical for independent listing on the Hong Kong Stock Exchange by April 2025 [5] - The spin-off will be executed through a distribution method, allowing shareholders to directly hold shares in Demy Pharmaceutical [5] - Demy Pharmaceutical's pipeline addresses significant unmet clinical needs in skin diseases, supported by over 650 sales professionals covering more than 10,000 hospitals [5]

Core Viewpoint - Haitong International slightly adjusted the revenue forecast for Kangzheng Pharmaceutical (00867) for 2025-26E to 8.33/9.30 billion HKD, representing a year-on-year increase of 11.5%/11.6% [1] - The net profit forecast for the same period was adjusted to 1.67/1.88 billion HKD, reflecting a year-on-year growth of 3.4%/12.9% [1] - The valuation model was changed to a discounted cash flow (DCF) model to better reflect the long-term value of the pipeline cash flow from Demy Pharmaceutical, with a target price of 18.38 HKD (+85%) [1] Financial Performance - Kangzheng Pharmaceutical achieved a revenue of 4 billion HKD in the first half of the year, a year-on-year increase of 11% [2] - The revenue from major exclusive/brand products and innovative products was 2.9 billion HKD, up 21% year-on-year, which is the core driver of the company's performance recovery [2] - The gross profit margin was 72%, with R&D expenses of 570 million HKD (down 8% year-on-year) and a net profit of 940 million HKD (up 3% year-on-year) [2] Business Growth Drivers - The recovery in revenue is attributed to the clearance of the impact from existing centralized procurement products and the steady growth of core products such as Weifurui and Meitai Tong [3] - Exclusive/brand and innovative product sales accounted for 62.1% of total revenue, up from 56.1% in the same period last year [3] - Revenue by segment includes 2.2 billion HKD from cardiovascular, 1.4 billion HKD from digestive/immunity, 500 million HKD from skin health (up 104%), and 360 million HKD from ophthalmology [3] Innovation and Pipeline - The company has three NDA applications under review and approximately ten clinical trials progressing in China, including treatments for ischemic stroke and atopic dermatitis [4] - Potential products in development include Povorcitinib and CMS-D001, targeting various conditions [4] Spin-off Plans - Kangzheng Pharmaceutical plans to spin off Demy Pharmaceutical for independent listing on the Hong Kong Stock Exchange by April 2025 [5] - Demy Pharmaceutical's pipeline addresses significant unmet clinical needs in skin diseases and has over 650 sales professionals covering more than 10,000 hospitals [5]

Investment Rating - The report maintains an "Outperform" rating for the company with a target price of HK$18.38, representing an upside of 85% from the current price of HK$14.35 [2][7]. Core Insights - The company reported a net sales increase of CNY4 billion in 1H25, reflecting an 11% year-on-year growth, driven by strong sales of exclusive and innovative products, which accounted for CNY2.9 billion, a 21% increase year-on-year [3][13]. - The gross margin for the period was 72%, down 2.4 percentage points year-on-year, while net profit attributable to shareholders was CNY940 million, up 3% year-on-year [3][13]. - The recovery in main business growth is attributed to the sustained increase in sales of exclusive/branded and innovative products, with these products making up 62.1% of total revenue, up from 56.1% in 1H24 [4][15]. Financial Performance - Revenue projections for FY2025 and FY2026 are adjusted to CNY8.33 billion and CNY9.30 billion, respectively, indicating year-on-year growth of 11.5% and 11.6% [7][17]. - The net profit forecasts for FY2025 and FY2026 are revised to CNY1.67 billion and CNY1.88 billion, representing year-on-year growth of 3.4% and 12.9% [7][17]. - The company’s R&D expenses totaled CNY570 million, a decrease of 8% year-on-year, with an R&D expense ratio of 5.1% [3][13]. Product Pipeline and Developments - The company has three New Drug Applications (NDAs) under review, including Desidustat Tablets and Ruxolitinib Cream, with approximately ten clinical trials ongoing in China [5][15]. - The spin-off and independent listing of Dermavon Pharma is expected to be completed within the year, which will allow shareholders to directly hold shares in the new entity [5][16]. Segment Performance - Revenue by segment includes CNY2.2 billion from cardiovascular products (up 0.6% year-on-year), CNY1.4 billion from digestive/autoimmune products (up 4.9% year-on-year), and CNY500 million from skin health products (up 104% year-on-year) [19][14].

Core Viewpoint - The company reported a stable revenue growth in the first half of 2025, driven by the recovery from previous negative impacts and the strong performance of innovative products Group 1: Financial Performance - In the first half of 2025, the company achieved a revenue of 4.002 billion yuan, representing a year-on-year increase of 10.8% [1] - The net profit attributable to shareholders was 941 million yuan, reflecting a growth of 3.38% [1] Group 2: Product Development and Innovation - The sales of exclusive/brand and innovative products increased by 20.6% year-on-year, accounting for 62.1% of total revenue, up from 56.1% in the same period last year [2] - The company is advancing its innovative drug pipeline, with several products in various stages of clinical trials, including NDA reviews and Phase III trials [2] - The company has recently acquired rights for new products targeting Alzheimer's disease and asthma, enhancing its product matrix in cardiovascular, central nervous system, digestive, and renal fields [2] Group 3: Segment Performance - The dermatology segment (Demey Pharmaceutical) showed significant growth, with revenue reaching 498 million yuan, a remarkable increase of 104.3% [3] - Demey Pharmaceutical has a strong pipeline with three marketed products and four in clinical stages, indicating potential for continued high growth [3] - The company plans to spin off Demey Pharmaceutical for independent listing, which is expected to help in the revaluation of its dermatology products and pipeline [3] Group 4: Revenue and Profit Forecast - Revenue projections for 2025 to 2027 are 8.053 billion yuan, 9.439 billion yuan, and 11.651 billion yuan, with year-on-year growth rates of 7.8%, 17.2%, and 23.4% respectively [4] - Net profit forecasts for the same period are 1.685 billion yuan, 1.956 billion yuan, and 2.465 billion yuan, with growth rates of 4.0%, 16.1%, and 26.1% respectively [4] - The company is rated with a "buy" recommendation based on its projected PE ratios of 17.7, 15.3, and 12.1 for the years 2025, 2026, and 2027 respectively [4]

Investment Rating - The investment rating for the company is "Buy" [1] Core Views - The company has shown continuous growth in innovative products, with a notable performance in the skin health line [4] - The company reported a revenue of 4.002 billion yuan in the first half of 2025, representing a year-on-year increase of 10.8%, and a net profit attributable to shareholders of 941 million yuan, up 3.38% [5] - The sales of exclusive/brand and innovative products increased by 20.6% year-on-year, accounting for 62.1% of total revenue [5] - The company is advancing its innovative drug pipeline, with several products in various stages of clinical trials [5] - The skin health line (Demeg Pharmaceuticals) achieved a revenue of 498 million yuan, a significant increase of 104.3% [5] - The company plans to spin off Demeg Pharmaceuticals for independent listing, which is expected to help in the revaluation of its skin care product line [5] - Revenue forecasts for 2025 to 2027 are 8.053 billion yuan, 9.439 billion yuan, and 11.651 billion yuan, with corresponding net profits of 1.685 billion yuan, 1.956 billion yuan, and 2.465 billion yuan [6] Summary by Sections Company Overview - The company is focused on innovative pharmaceuticals, particularly in cardiovascular, central nervous system, digestive, and renal fields [5] Financial Performance - The company’s current P/E ratio is 18.12, with a market capitalization of 32.787 billion HKD [5] - The projected revenue growth rates for 2025, 2026, and 2027 are 7.8%, 17.2%, and 23.4% respectively [6] Product Pipeline - The company has a robust pipeline with several innovative drugs under development, including those for chronic kidney disease and asthma [5] Market Position - The company has established a strong market presence with a comprehensive product matrix and experienced commercialization capabilities [5]

Core Viewpoint - 康哲药业 reported a revenue of 40.02 billion yuan for the first half of 2025, representing a year-on-year increase of 10.83%, and a net profit of 9.41 billion yuan, up 3.38% year-on-year, indicating positive growth in both revenue and profit [1] Financial Performance - The company's expense ratio was 56.75%, an increase of 1.52 percentage points year-on-year; gross margin was 72.26%, down 2.41 percentage points year-on-year; R&D expenses reached 2.02 billion yuan, up 91.79% year-on-year, with an R&D expense ratio of 5.06%, up 2.14 percentage points year-on-year [1] - Sales expense ratio was 35.59%, down 3.19 percentage points year-on-year; management expense ratio was 15.82%, up 2.89 percentage points year-on-year; financial expense ratio was 0.28%, down 0.32 percentage points year-on-year [1] Business Segments - Traditional business in cerebrovascular disease generated sales of 22.16 billion yuan, up 0.6% year-on-year, accounting for 47.5% of total sales; sales from digestive and autoimmune disease lines were 14.11 billion yuan, up 4.9% year-on-year, accounting for 30.2% [1] - New business in dermatology and aesthetics (德镁医药) achieved sales of 4.98 billion yuan, up 104.3% year-on-year, accounting for 10.7%; ophthalmology sales were 3.58 billion yuan, up 17.7% year-on-year, accounting for 7.7% [1] - The company has five innovative drugs commercialized, including 莱芙兰, 美泰彤, 维福瑞, 益路取, and 维图可, with rapid commercialization progress [1] Product Development - Three products are currently under NDA review: 德昔度司他片 for anemia treatment in CKD patients, 芦可替尼乳膏 for vitiligo, and ZUNVEYL for Alzheimer's disease [2] - Two self-developed innovative drugs have received IND approval and are set to begin clinical trials: CMS-D001片 for psoriasis and CMS-D003胶囊 for obstructive hypertrophic cardiomyopathy [2] International Expansion - The company is in the process of splitting 德镁健康 for independent listing on the Hong Kong Stock Exchange, enhancing its position in the dermatology sector [3] - 康哲药业 is advancing its international commercial system, with a focus on Singapore as a regional hub, and has submitted product registration applications in several Southeast Asian countries [3] Investment Outlook - Revenue projections for 康哲药业 from 2025 to 2027 are 83.20 billion yuan, 94.54 billion yuan, and 110.43 billion yuan, with year-on-year growth rates of 11%, 14%, and 17% respectively; net profit estimates are 16.28 billion yuan, 18.92 billion yuan, and 22.52 billion yuan, with growth rates of 0%, 16%, and 19% respectively [3]